JP2019510740A5 - - Google Patents
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- Publication number
- JP2019510740A5 JP2019510740A5 JP2018540460A JP2018540460A JP2019510740A5 JP 2019510740 A5 JP2019510740 A5 JP 2019510740A5 JP 2018540460 A JP2018540460 A JP 2018540460A JP 2018540460 A JP2018540460 A JP 2018540460A JP 2019510740 A5 JP2019510740 A5 JP 2019510740A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- rifamycin
- iii
- semi
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OOEZYSSDDKSGEC-RMKNXTFCSA-N CC(C)C(C)(C(NC(/C=C/CCNC(N)=O)C(Nc1ccc(CCl)cc1)=O)=O)NC(CCCCCN(C(C=C1)=O)C1=O)=O Chemical compound CC(C)C(C)(C(NC(/C=C/CCNC(N)=O)C(Nc1ccc(CCl)cc1)=O)=O)NC(CCCCCN(C(C=C1)=O)C1=O)=O OOEZYSSDDKSGEC-RMKNXTFCSA-N 0.000 description 1
- GKRANPZNJXRBRR-ALWPUHSVSA-N C[C@@H](C[C@@H](C)[C@@H]([C@H](C)C/C=C/O[C@](C)(C(c1c2C(C=C3N4)=O)=O)Oc1c(C)c(O)c2C3=O)OC(C)=O)C[C@@H](C)/C=C/C=C(/C)\C4=O Chemical compound C[C@@H](C[C@@H](C)[C@@H]([C@H](C)C/C=C/O[C@](C)(C(c1c2C(C=C3N4)=O)=O)Oc1c(C)c(O)c2C3=O)OC(C)=O)C[C@@H](C)/C=C/C=C(/C)\C4=O GKRANPZNJXRBRR-ALWPUHSVSA-N 0.000 description 1
- MDCULZTYOKLIGU-UHFFFAOYSA-N Nc(c(O)cc(F)c1)c1O Chemical compound Nc(c(O)cc(F)c1)c1O MDCULZTYOKLIGU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662303556P | 2016-03-04 | 2016-03-04 | |
| US62/303,556 | 2016-03-04 | ||
| PCT/US2017/020711 WO2017152083A1 (en) | 2016-03-04 | 2017-03-03 | Process for the preparation of an antibody-rifamycin conjugate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000874A Division JP2020090506A (ja) | 2016-03-04 | 2020-01-07 | 抗体−リファマイシン複合体の製造プロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510740A JP2019510740A (ja) | 2019-04-18 |
| JP2019510740A5 true JP2019510740A5 (enExample) | 2020-02-20 |
| JP6705904B2 JP6705904B2 (ja) | 2020-06-03 |
Family
ID=58361102
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540460A Expired - Fee Related JP6705904B2 (ja) | 2016-03-04 | 2017-03-03 | 抗体−リファマイシン複合体の製造プロセス |
| JP2020000874A Pending JP2020090506A (ja) | 2016-03-04 | 2020-01-07 | 抗体−リファマイシン複合体の製造プロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000874A Pending JP2020090506A (ja) | 2016-03-04 | 2020-01-07 | 抗体−リファマイシン複合体の製造プロセス |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10336683B2 (enExample) |
| EP (1) | EP3423457B1 (enExample) |
| JP (2) | JP6705904B2 (enExample) |
| KR (1) | KR102204805B1 (enExample) |
| CN (1) | CN108713020A (enExample) |
| AR (1) | AR107800A1 (enExample) |
| AU (1) | AU2017228468B2 (enExample) |
| BR (1) | BR112018014355A2 (enExample) |
| CA (1) | CA3012046C (enExample) |
| IL (1) | IL260465B (enExample) |
| MX (1) | MX2018010491A (enExample) |
| SG (1) | SG11201807537RA (enExample) |
| WO (1) | WO2017152083A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102204805B1 (ko) | 2016-03-04 | 2021-01-20 | 제넨테크, 인크. | 항체-리파마이신 접합체의 제조 방법 |
| CN108047250B (zh) * | 2018-02-12 | 2020-08-14 | 丹诺医药(苏州）有限公司 | 一种利福霉素-硝基咪唑偶联分子的应用 |
| CN110687218B (zh) * | 2018-08-07 | 2021-04-23 | 中国科学院大连化学物理研究所 | 液相色谱测定苯并噁嗪利福霉素的方法 |
| CN110687217B (zh) * | 2018-08-07 | 2021-04-23 | 中国科学院大连化学物理研究所 | 液相色谱测定利福霉素s的方法 |
| PH12021551476A1 (en) * | 2018-12-21 | 2022-04-25 | Regeneron Pharma | Rifamycin analogs and antibody-drug conjugates thereof |
| EP4387618A4 (en) * | 2021-08-20 | 2025-07-09 | Univ Rutgers | DUAL-TARGETED RNA POLYMERASE INHIBITORS: CONJUGATES OF BENZOXAZINO- AND SPIRO-RIFAMYCINS WITH N-AROYL- N-ARYL-PHENYLALANINAMIDES |
| CN114436864A (zh) * | 2022-02-17 | 2022-05-06 | 浙江鼎龙科技股份有限公司 | 一种2-甲基-5氨基苯酚的制备方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB877732A (en) | 1958-08-12 | 1961-09-20 | Lepetit Spa | The antibiotic rifomycin, its components and methods of preparing same |
| US4690919A (en) | 1984-01-04 | 1987-09-01 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Benzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same |
| JPS63183587A (ja) | 1985-02-05 | 1988-07-28 | Kanegafuchi Chem Ind Co Ltd | ベンゾキサジノリフアマイシン誘導体 |
| CA1304363C (en) | 1988-11-01 | 1992-06-30 | Takehiko Yamane | 3'-hydroxybenzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same |
| US6322788B1 (en) | 1998-08-20 | 2001-11-27 | Stanley Arthur Kim | Anti-bacterial antibodies and methods of use |
| DK1545613T3 (da) | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom |
| CN1894259A (zh) | 2003-08-22 | 2007-01-10 | 活跃生物工艺学公司 | 利福霉素类似物及其应用 |
| EP2478912B1 (en) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy |
| CN1918172B (zh) | 2003-12-23 | 2011-09-14 | 活跃生物工艺学公司 | 利福霉素类似物及其用途 |
| US7265107B2 (en) | 2004-03-10 | 2007-09-04 | Cumbre Pharmaceuticals Inc. | Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| CN101395259A (zh) | 2005-12-14 | 2009-03-25 | 活跃生物药物学有限公司 | 利福霉素类似物及其应用 |
| WO2008008480A2 (en) | 2006-07-12 | 2008-01-17 | Cumbre Pharmaceuticals Inc. | Nitroheteroaryl-containing rifamycin derivatives |
| DK2121920T3 (da) | 2007-03-01 | 2011-11-21 | Symphogen As | Fremgangsmåde til kloning af sammenhørende antistoffer |
| CL2008001334A1 (es) | 2007-05-08 | 2008-09-22 | Genentech Inc | Anticuerpo anti-muc16 disenado con cisteina; conjugado que lo comprende; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso para tratar el cancer. |
| NZ584514A (en) | 2007-10-19 | 2012-07-27 | Genentech Inc | Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates |
| WO2009064792A1 (en) | 2007-11-16 | 2009-05-22 | Cumbre Pharmaceuticals Inc. | Quinolone carboxylic acid-substituted rifamycin derivatives |
| WO2009086277A1 (en) * | 2007-12-20 | 2009-07-09 | Envivo Pharmaceuticals, Inc. | Tetrasubstituted benzenes |
| WO2010019511A2 (en) | 2008-08-13 | 2010-02-18 | Targanta Therapeutics Corp. | Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections |
| CA2799540A1 (en) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| WO2013168965A2 (ko) | 2012-05-07 | 2013-11-14 | 목암생명공학연구소 | 포도상구균 감염 예방용 백신 조성물 |
| JP6371758B2 (ja) | 2013-03-12 | 2018-08-08 | 全薬工業株式会社 | 抗ブドウ球菌抗体、その製造方法並びにその使用 |
| TWI692483B (zh) * | 2013-05-31 | 2020-05-01 | 美商建南德克公司 | 抗壁磷壁酸抗體（ａｎｔｉ-ｗａｌｌ ｔｅｉｃｈｏｉｃ ａｃｉｄ ａｎｔｉｂｏｄｉｅｓ）及結合物 |
| MX369022B (es) | 2013-05-31 | 2019-10-25 | Genentech Inc | Anticuerpos anti-ácido teicoico de la pared celular y conjugados. |
| RU2687044C2 (ru) | 2013-05-31 | 2019-05-06 | Дженентек, Инк. | Антитела против стеночной тейхоевой кислоты и их конъюгаты |
| HK1243931A1 (zh) * | 2014-12-03 | 2018-07-27 | F. Hoffmann-La Roche Ag | 抗金黄色葡萄球菌抗体利福霉素缀合物及其用途 |
| RU2017118792A (ru) * | 2014-12-03 | 2019-01-09 | Дженентек, Инк. | Конъюгаты антитела к staphylococcus aureus с рифамицином и их применение |
| KR102204805B1 (ko) | 2016-03-04 | 2021-01-20 | 제넨테크, 인크. | 항체-리파마이신 접합체의 제조 방법 |
-
2017
- 2017-03-03 KR KR1020187027989A patent/KR102204805B1/ko not_active Expired - Fee Related
- 2017-03-03 SG SG11201807537RA patent/SG11201807537RA/en unknown
- 2017-03-03 AR ARP170100538A patent/AR107800A1/es unknown
- 2017-03-03 BR BR112018014355-3A patent/BR112018014355A2/pt not_active Application Discontinuation
- 2017-03-03 MX MX2018010491A patent/MX2018010491A/es unknown
- 2017-03-03 CN CN201780014867.4A patent/CN108713020A/zh active Pending
- 2017-03-03 US US15/448,894 patent/US10336683B2/en not_active Expired - Fee Related
- 2017-03-03 CA CA3012046A patent/CA3012046C/en not_active Expired - Fee Related
- 2017-03-03 WO PCT/US2017/020711 patent/WO2017152083A1/en not_active Ceased
- 2017-03-03 JP JP2018540460A patent/JP6705904B2/ja not_active Expired - Fee Related
- 2017-03-03 AU AU2017228468A patent/AU2017228468B2/en not_active Ceased
- 2017-03-03 EP EP17712298.3A patent/EP3423457B1/en not_active Not-in-force
-
2018
- 2018-07-08 IL IL260465A patent/IL260465B/en active IP Right Grant
-
2019
- 2019-05-17 US US16/415,612 patent/US10689325B2/en not_active Expired - Fee Related
-
2020
- 2020-01-07 JP JP2020000874A patent/JP2020090506A/ja active Pending
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