JP2019510740A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019510740A5 JP2019510740A5 JP2018540460A JP2018540460A JP2019510740A5 JP 2019510740 A5 JP2019510740 A5 JP 2019510740A5 JP 2018540460 A JP2018540460 A JP 2018540460A JP 2018540460 A JP2018540460 A JP 2018540460A JP 2019510740 A5 JP2019510740 A5 JP 2019510740A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- rifamycin
- iii
- semi
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OOEZYSSDDKSGEC-RMKNXTFCSA-N CC(C)C(C)(C(NC(/C=C/CCNC(N)=O)C(Nc1ccc(CCl)cc1)=O)=O)NC(CCCCCN(C(C=C1)=O)C1=O)=O Chemical compound CC(C)C(C)(C(NC(/C=C/CCNC(N)=O)C(Nc1ccc(CCl)cc1)=O)=O)NC(CCCCCN(C(C=C1)=O)C1=O)=O OOEZYSSDDKSGEC-RMKNXTFCSA-N 0.000 description 1
- GKRANPZNJXRBRR-ALWPUHSVSA-N C[C@@H](C[C@@H](C)[C@@H]([C@H](C)C/C=C/O[C@](C)(C(c1c2C(C=C3N4)=O)=O)Oc1c(C)c(O)c2C3=O)OC(C)=O)C[C@@H](C)/C=C/C=C(/C)\C4=O Chemical compound C[C@@H](C[C@@H](C)[C@@H]([C@H](C)C/C=C/O[C@](C)(C(c1c2C(C=C3N4)=O)=O)Oc1c(C)c(O)c2C3=O)OC(C)=O)C[C@@H](C)/C=C/C=C(/C)\C4=O GKRANPZNJXRBRR-ALWPUHSVSA-N 0.000 description 1
- MDCULZTYOKLIGU-UHFFFAOYSA-N Nc(c(O)cc(F)c1)c1O Chemical compound Nc(c(O)cc(F)c1)c1O MDCULZTYOKLIGU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662303556P | 2016-03-04 | 2016-03-04 | |
| US62/303,556 | 2016-03-04 | ||
| PCT/US2017/020711 WO2017152083A1 (en) | 2016-03-04 | 2017-03-03 | Process for the preparation of an antibody-rifamycin conjugate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000874A Division JP2020090506A (ja) | 2016-03-04 | 2020-01-07 | 抗体−リファマイシン複合体の製造プロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510740A JP2019510740A (ja) | 2019-04-18 |
| JP2019510740A5 true JP2019510740A5 (enExample) | 2020-02-20 |
| JP6705904B2 JP6705904B2 (ja) | 2020-06-03 |
Family
ID=58361102
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540460A Expired - Fee Related JP6705904B2 (ja) | 2016-03-04 | 2017-03-03 | 抗体−リファマイシン複合体の製造プロセス |
| JP2020000874A Pending JP2020090506A (ja) | 2016-03-04 | 2020-01-07 | 抗体−リファマイシン複合体の製造プロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000874A Pending JP2020090506A (ja) | 2016-03-04 | 2020-01-07 | 抗体−リファマイシン複合体の製造プロセス |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10336683B2 (enExample) |
| EP (1) | EP3423457B1 (enExample) |
| JP (2) | JP6705904B2 (enExample) |
| KR (1) | KR102204805B1 (enExample) |
| CN (1) | CN108713020A (enExample) |
| AR (1) | AR107800A1 (enExample) |
| AU (1) | AU2017228468B2 (enExample) |
| BR (1) | BR112018014355A2 (enExample) |
| CA (1) | CA3012046C (enExample) |
| IL (1) | IL260465B (enExample) |
| MX (1) | MX2018010491A (enExample) |
| SG (1) | SG11201807537RA (enExample) |
| WO (1) | WO2017152083A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108713020A (zh) | 2016-03-04 | 2018-10-26 | 豪夫迈·罗氏有限公司 | 制备抗体-利福霉素缀合物的方法 |
| CN108047250B (zh) * | 2018-02-12 | 2020-08-14 | 丹诺医药(苏州）有限公司 | 一种利福霉素-硝基咪唑偶联分子的应用 |
| CN110687218B (zh) * | 2018-08-07 | 2021-04-23 | 中国科学院大连化学物理研究所 | 液相色谱测定苯并噁嗪利福霉素的方法 |
| CN110687217B (zh) * | 2018-08-07 | 2021-04-23 | 中国科学院大连化学物理研究所 | 液相色谱测定利福霉素s的方法 |
| CA3123607A1 (en) * | 2018-12-21 | 2020-06-25 | Regeneron Pharmaceuticals, Inc. | Rifamycin analogs and antibody-drug conjugates thereof |
| CN118076353A (zh) * | 2021-08-20 | 2024-05-24 | 罗格斯新泽西州立大学 | 双重靶向RNA聚合酶抑制剂：苯并噁嗪并-和螺-利福霉素与Nα-芳酰基-N-芳基-苯基丙氨酰胺的缀合物 |
| CN114436864A (zh) * | 2022-02-17 | 2022-05-06 | 浙江鼎龙科技股份有限公司 | 一种2-甲基-5氨基苯酚的制备方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB877732A (en) | 1958-08-12 | 1961-09-20 | Lepetit Spa | The antibiotic rifomycin, its components and methods of preparing same |
| US4690919A (en) | 1984-01-04 | 1987-09-01 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Benzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same |
| JPS63183587A (ja) | 1985-02-05 | 1988-07-28 | Kanegafuchi Chem Ind Co Ltd | ベンゾキサジノリフアマイシン誘導体 |
| CA1304363C (en) | 1988-11-01 | 1992-06-30 | Takehiko Yamane | 3'-hydroxybenzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same |
| US6322788B1 (en) | 1998-08-20 | 2001-11-27 | Stanley Arthur Kim | Anti-bacterial antibodies and methods of use |
| ES2544527T3 (es) | 2002-07-31 | 2015-09-01 | Seattle Genetics, Inc. | Conjugados de fármacos y su uso para tratar el cáncer, una enfermedad autoinmune o una enfermedad infecciosa |
| EP1663107A4 (en) | 2003-08-22 | 2010-06-23 | Activbiotics Pharma Llc | RIFAMYCIN ANALOGS AND USES THEREOF |
| EP3434275A1 (en) | 2003-11-06 | 2019-01-30 | Seattle Genetics, Inc. | Assay for cancer cells based on the use of auristatin conjugates with antibodies |
| WO2005062882A2 (en) | 2003-12-23 | 2005-07-14 | Activbiotics, Inc | Rifamycin analogs and uses thereof |
| US7265107B2 (en) | 2004-03-10 | 2007-09-04 | Cumbre Pharmaceuticals Inc. | Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| CN101395259A (zh) | 2005-12-14 | 2009-03-25 | 活跃生物药物学有限公司 | 利福霉素类似物及其应用 |
| WO2008008480A2 (en) | 2006-07-12 | 2008-01-17 | Cumbre Pharmaceuticals Inc. | Nitroheteroaryl-containing rifamycin derivatives |
| JP5669397B2 (ja) | 2007-03-01 | 2015-02-12 | シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ | 同族抗体をクローニングするための方法 |
| TW200902554A (en) | 2007-05-08 | 2009-01-16 | Genentech Inc | Cysteine engineered anti-MUC16 antibodies and antibody drug conjugates |
| AU2008312457B2 (en) | 2007-10-19 | 2014-04-17 | Genentech, Inc. | Cysteine engineered anti-TENB2 antibodies and antibody drug conjugates |
| WO2009064792A1 (en) | 2007-11-16 | 2009-05-22 | Cumbre Pharmaceuticals Inc. | Quinolone carboxylic acid-substituted rifamycin derivatives |
| RU2527177C2 (ru) * | 2007-12-20 | 2014-08-27 | Энвиво Фармасьютикалз, Инк. | Четырехзамещенные бензолы |
| US8524691B2 (en) | 2008-08-13 | 2013-09-03 | The Medicines Company | Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections |
| SG185428A1 (en) | 2010-06-08 | 2012-12-28 | Genentech Inc | Cysteine engineered antibodies and conjugates |
| WO2013168965A2 (ko) | 2012-05-07 | 2013-11-14 | 목암생명공학연구소 | 포도상구균 감염 예방용 백신 조성물 |
| WO2014142117A1 (ja) | 2013-03-12 | 2014-09-18 | 全薬工業株式会社 | 抗ブドウ球菌抗体、その製造方法並びにその使用 |
| MA38686A1 (fr) * | 2013-05-31 | 2017-10-31 | Genentech Inc | Anticorps anti-acide téichoïque de la paroi cellulaire et conjugués associés |
| TWI692483B (zh) * | 2013-05-31 | 2020-05-01 | 美商建南德克公司 | 抗壁磷壁酸抗體（ａｎｔｉ-ｗａｌｌ ｔｅｉｃｈｏｉｃ ａｃｉｄ ａｎｔｉｂｏｄｉｅｓ）及結合物 |
| BR112015029754A2 (pt) | 2013-05-31 | 2017-09-26 | Genentech Inc | anticorpos anti-teicoico da parede e conjugados |
| KR20170086536A (ko) * | 2014-12-03 | 2017-07-26 | 제넨테크, 인크. | 항-스타필로코커스 아우레우스 항체 리파마이신 접합체 및 이의 용도 |
| JP6751393B2 (ja) * | 2014-12-03 | 2020-09-02 | ジェネンテック， インコーポレイテッド | 抗ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ抗体リファマイシン抱合体及びその使用 |
| CN108713020A (zh) | 2016-03-04 | 2018-10-26 | 豪夫迈·罗氏有限公司 | 制备抗体-利福霉素缀合物的方法 |
-
2017
- 2017-03-03 CN CN201780014867.4A patent/CN108713020A/zh active Pending
- 2017-03-03 SG SG11201807537RA patent/SG11201807537RA/en unknown
- 2017-03-03 KR KR1020187027989A patent/KR102204805B1/ko not_active Expired - Fee Related
- 2017-03-03 BR BR112018014355-3A patent/BR112018014355A2/pt not_active Application Discontinuation
- 2017-03-03 EP EP17712298.3A patent/EP3423457B1/en not_active Not-in-force
- 2017-03-03 AR ARP170100538A patent/AR107800A1/es unknown
- 2017-03-03 WO PCT/US2017/020711 patent/WO2017152083A1/en not_active Ceased
- 2017-03-03 US US15/448,894 patent/US10336683B2/en not_active Expired - Fee Related
- 2017-03-03 JP JP2018540460A patent/JP6705904B2/ja not_active Expired - Fee Related
- 2017-03-03 CA CA3012046A patent/CA3012046C/en not_active Expired - Fee Related
- 2017-03-03 MX MX2018010491A patent/MX2018010491A/es unknown
- 2017-03-03 AU AU2017228468A patent/AU2017228468B2/en not_active Ceased
-
2018
- 2018-07-08 IL IL260465A patent/IL260465B/en active IP Right Grant
-
2019
- 2019-05-17 US US16/415,612 patent/US10689325B2/en not_active Expired - Fee Related
-
2020
- 2020-01-07 JP JP2020000874A patent/JP2020090506A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6705904B2 (ja) | 抗体−リファマイシン複合体の製造プロセス | |
| US20260125363A1 (en) | Processes for making modulators of cystic fibrosis transmembrane conductance regulator | |
| JP7280929B2 (ja) | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体 | |
| CN103298809B (zh) | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 | |
| CN106029653A (zh) | 二氨基嘧啶苯砜衍生物及其用途 | |
| CN105939607A (zh) | 二氢蝶啶酮衍生物及其用途 | |
| CN105940005A (zh) | 二氮杂环庚烷衍生物及其用途 | |
| KR20220052918A (ko) | 치료제로서의 사이토톡신의 펩티드 접합체 | |
| US9650359B2 (en) | Modulators of resistant androgen receptor | |
| CN108472295A (zh) | 二价溴结构域抑制剂及其用途 | |
| CN106573956A (zh) | 澳瑞他汀衍生物及其缀合物 | |
| CN109311886B (zh) | [1,2,3]三唑并[4,5-d]嘧啶衍生物 | |
| JP6797923B2 (ja) | Ａｌｋおよびｓｒｐｋ阻害剤ならびに使用方法 | |
| WO2015172732A1 (zh) | 作为二肽基肽酶-iv抑制剂的氨基四氢吡喃衍生物 | |
| JP2024056819A (ja) | 細胞傷害性ベンゾジアゼピン誘導体の調製方法 | |
| CN105164138A (zh) | 新吗啉基蒽环类抗生素衍生物 | |
| NZ526399A (en) | Antitumoral carbazoles | |
| KR101656238B1 (ko) | 광역학 치료용 광민감제로 유용한 양이온성 클로린계 및 퍼퓨린이마이드계 화합물과 이들의 클로린계- 및 퍼퓨린이마이드계-다중금속산화물의 착화합물 | |
| HK1262552A1 (en) | Process for the preparation of an antibody-rifamycin conjugate | |
| Mironov et al. | Synthesis of cationic bacteriochlorins | |
| Preux | Studies on Proximity-Induced Cycloaddition for Bioconjugation | |
| CN119923396A (zh) | 芳香乙炔类衍生物及其制备方法和其医药上的用途 | |
| HK40003147A (en) | Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives | |
| HK40009310B (en) | Synthesis of polycyclic-carbamoylpyridone compounds | |
| TW201211043A (en) | Tetrahydro-imidazo[1,5-a]pyrazine derivatives salts, preparation process and pharmaceutical use thereof |