JP2019509315A - 疾患の処置に有用なＦｉｍＨのマンノース由来アンタゴニスト - Google Patents

疾患の処置に有用なＦｉｍＨのマンノース由来アンタゴニスト Download PDF

Info

Publication number
JP2019509315A
JP2019509315A JP2018549836A JP2018549836A JP2019509315A JP 2019509315 A JP2019509315 A JP 2019509315A JP 2018549836 A JP2018549836 A JP 2018549836A JP 2018549836 A JP2018549836 A JP 2018549836A JP 2019509315 A JP2019509315 A JP 2019509315A
Authority
JP
Japan
Prior art keywords
methyl
mannopyranosyloxy
methylphenyl
disease
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018549836A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019509315A5 (enExample
Inventor
ダブリュー ジャネトカ ジェイムス
ダブリュー ジャネトカ ジェイムス
マイドック−マクグレーン ローレル
マイドック−マクグレーン ローレル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fimbrion Therapeutics Inc
Original Assignee
Fimbrion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fimbrion Therapeutics Inc filed Critical Fimbrion Therapeutics Inc
Publication of JP2019509315A publication Critical patent/JP2019509315A/ja
Publication of JP2019509315A5 publication Critical patent/JP2019509315A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Composite Materials (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018549836A 2016-03-23 2017-03-23 疾患の処置に有用なＦｉｍＨのマンノース由来アンタゴニスト Pending JP2019509315A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662312017P 2016-03-23 2016-03-23
US62/312,017 2016-03-23
PCT/US2017/023764 WO2017165619A1 (en) 2016-03-23 2017-03-23 Mannose-derived antagonists of fimh useful for treating disease

Publications (2)

Publication Number Publication Date
JP2019509315A true JP2019509315A (ja) 2019-04-04
JP2019509315A5 JP2019509315A5 (enExample) 2020-04-23

Family

ID=59900869

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018549836A Pending JP2019509315A (ja) 2016-03-23 2017-03-23 疾患の処置に有用なＦｉｍＨのマンノース由来アンタゴニスト

Country Status (10)

Country Link
US (3) US10738070B2 (enExample)
EP (1) EP3432892A4 (enExample)
JP (1) JP2019509315A (enExample)
KR (1) KR20180128937A (enExample)
CN (1) CN108778288A (enExample)
AU (1) AU2017238392A1 (enExample)
BR (1) BR112018069147A2 (enExample)
CA (1) CA3018345A1 (enExample)
RU (1) RU2018131440A (enExample)
WO (1) WO2017165619A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180128937A (ko) 2016-03-23 2018-12-04 핌브리온 세러퓨틱스 인코포레이티드 질환을 치료하는데 유용한 fimh의 만노스-유래 길항제
US10385087B1 (en) * 2018-04-26 2019-08-20 National Taipei University Of Technology Xylose derivatives and process for preparation thereof
DK3820856T3 (da) 2018-07-10 2022-10-24 Glaxosmithkline Ip Dev Ltd C-Mannosid-forbindelser, der kan anvendes til behandling af urinvejsinfektioner
BR112021022281A2 (pt) * 2019-05-07 2021-12-28 Fimbrion Therapeutics Inc Novos compostos
WO2020254369A1 (en) * 2019-06-19 2020-12-24 Glaxosmithkline Intellectual Property Development Limited Substituted biphenyl or phenylheteroaryl-mannosides as antagonists of fimh
CN111205344B (zh) * 2020-01-14 2023-03-14 华东理工大学 一种用于甲醇溶剂识别的纯有机磷光小分子材料及其制备方法
CN113461753B (zh) * 2020-03-31 2023-05-23 郑计岳 2-炔基甘露糖衍生物及其应用
CN111518738B (zh) * 2020-05-08 2022-02-08 徐州海润生物科技有限公司 重组卡介苗及其制备方法和应用
CN113797212B (zh) * 2020-06-11 2023-12-22 兰州大学 一组含有甘露糖结构的抗菌药物的合成方法及活性研究
CN116621891B (zh) * 2023-05-25 2023-10-31 齐齐哈尔医学院 白鲜酚苷c及其制备方法和其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120309701A1 (en) * 2009-10-22 2012-12-06 The Washington University Compounds and methods for treating bacterial infections
JP2013513637A (ja) * 2009-12-14 2013-04-22 ユニバーシティ・オブ・バーゼル 細菌接着のアンタゴニストとしてのマンノース誘導体
WO2014194270A1 (en) * 2013-05-30 2014-12-04 Washington University Compounds and methods for treating bacterial infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122602A (en) 1989-02-13 1992-06-16 Miles Inc. Chromogenic merocyanine enzyme substrates
DE69433901T2 (de) 1993-11-18 2005-07-28 Siga Technologies, Inc. Verbindungen und pharmazeutische zusammensetzungen zur behandlung und prophylaxe bakterieller infektionen
US6420127B1 (en) 1994-11-18 2002-07-16 Washington University Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections
WO2001010386A2 (en) 1999-08-11 2001-02-15 Washington University Anti-bacterial compounds directed against pilus biogenesis, adhesion and activity; co-crystals of pilus subunits and methods of use thereof
CA2411944C (en) 2000-06-09 2010-12-14 Baylor College Of Medicine The combination of antimicrobial agents and bacterial interference to coat medical devices
WO2005033059A1 (es) 2003-10-08 2005-04-14 Innovaprotean, S.L. Compuestos útiles para el tratamiento de enfermedades asociadas a la formación de fibrilas amiloides
EP1755619A2 (en) 2004-03-23 2007-02-28 VIB vzw Anti-adhesive compounds to prevent and treat bacterial infections
SE528382C2 (sv) 2004-10-05 2006-10-31 Probi Ab Probiotiska lactobacillusstammar för förbättrad vaginal hälsa
FR2876798A1 (fr) 2004-10-14 2006-04-21 Univ Clermont Auvergne Diagnostic et traitement de la maladie de crohn
EP2490530A4 (en) 2009-10-22 2014-01-22 Univ Washington COMPOUNDS AND METHOD FOR THE TREATMENT OF BACTERIAL INFECTIONS
WO2012164074A1 (en) 2011-06-03 2012-12-06 University Of Basel Mannose phosphate derivatives as antagonists of bacterial adhesion
US9890176B2 (en) 2013-03-12 2018-02-13 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
US20200002303A1 (en) 2016-03-11 2020-01-02 Fimbrion Therapeutics, Inc. C-glycoside compounds useful for treating disease
KR20180128937A (ko) 2016-03-23 2018-12-04 핌브리온 세러퓨틱스 인코포레이티드 질환을 치료하는데 유용한 fimh의 만노스-유래 길항제

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120309701A1 (en) * 2009-10-22 2012-12-06 The Washington University Compounds and methods for treating bacterial infections
JP2013513637A (ja) * 2009-12-14 2013-04-22 ユニバーシティ・オブ・バーゼル 細菌接着のアンタゴニストとしてのマンノース誘導体
WO2014194270A1 (en) * 2013-05-30 2014-12-04 Washington University Compounds and methods for treating bacterial infections

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JARVIS,C. ET AL: "Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding A", CHEMMEDCHEM, vol. 11, no. 4, JPN6021013352, 2016, pages 367 - 373, ISSN: 0004630828 *

Also Published As

Publication number Publication date
CA3018345A1 (en) 2017-09-28
CN108778288A (zh) 2018-11-09
RU2018131440A (ru) 2020-04-23
EP3432892A4 (en) 2019-10-30
US10738070B2 (en) 2020-08-11
RU2018131440A3 (enExample) 2020-05-18
BR112018069147A2 (pt) 2019-01-22
AU2017238392A1 (en) 2018-09-27
US20190106451A1 (en) 2019-04-11
WO2017165619A1 (en) 2017-09-28
US20250009723A1 (en) 2025-01-09
US20200407390A1 (en) 2020-12-31
KR20180128937A (ko) 2018-12-04
EP3432892A1 (en) 2019-01-30

Similar Documents

Publication Publication Date Title
US20220235087A1 (en) Mannose-derived antagonists of fimh useful for treating disease
US20250009723A1 (en) Mannose-derived antagonists of fimh useful for treating disease
ES2895257T3 (es) Inhibidores de biciclo[1.1.1]pentano de cremallera de leucina doble cinasa (DLK) para el tratamiento de una enfermedad
CN103570630B (zh) 氮杂环衍生物及其在药物中的应用
CN107074805B (zh) 用于治疗疾病的gls1抑制剂
JP2019508504A (ja) 疾病の処置に有用なｃ−グリコシド化合物
CN104606194A (zh) Pde4的双环杂芳基抑制剂
CN107921044B (zh) 用于治疗疾病的gls1抑制剂
JP2021519308A (ja) 転写活性化タンパク質のイミダゾピペラジン阻害剤
TW202128642A (zh) 用於疾病治療之雙白胺酸拉鍊（dlk）激酶的雙環[1.1.1]戊烷抑制劑
US11046649B2 (en) Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
CN107759602A (zh) 含有共轭联烯结构的化合物、其药物组合物和用途
WO2023133284A2 (en) Compounds and methods for treating friedreich's ataxia
JP5142730B2 (ja) 抗感染薬としての新規なイソチアゾロキノロンおよび関連化合物
JP6856550B2 (ja) 細菌感染症の処置のためのマンノース誘導体
JP7628506B2 (ja) 新規化合物
WO2014195697A1 (en) Novel pyrrole derivative
WO2021136326A1 (zh) 芳香酰胺类化合物及其在药物中的应用
HK40037519B (zh) Ptpn11的取代的杂环抑制剂
CN101528228A (zh) Pde4的双环杂芳基抑制剂

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200316

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200316

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210413

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20211102