AU2017238392A1 - Mannose-derived antagonists of FimH useful for treating disease - Google Patents
Mannose-derived antagonists of FimH useful for treating disease Download PDFInfo
- Publication number
- AU2017238392A1 AU2017238392A1 AU2017238392A AU2017238392A AU2017238392A1 AU 2017238392 A1 AU2017238392 A1 AU 2017238392A1 AU 2017238392 A AU2017238392 A AU 2017238392A AU 2017238392 A AU2017238392 A AU 2017238392A AU 2017238392 A1 AU2017238392 A1 AU 2017238392A1
- Authority
- AU
- Australia
- Prior art keywords
- mannopyranosyloxy
- methyl
- methylphenyl
- compound
- recited
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 55
- 201000010099 disease Diseases 0.000 title claims description 43
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 title description 10
- 239000005557 antagonist Substances 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 194
- 238000000034 method Methods 0.000 claims abstract description 85
- 238000011282 treatment Methods 0.000 claims abstract description 35
- 208000019206 urinary tract infection Diseases 0.000 claims abstract description 32
- 230000002265 prevention Effects 0.000 claims abstract description 10
- -1 3- methyl-3'-(morpholin-4-ylcarbonyl)biphenyl-4-yl Chemical group 0.000 claims description 109
- 150000003839 salts Chemical class 0.000 claims description 72
- 239000000203 mixture Substances 0.000 claims description 61
- 125000003118 aryl group Chemical group 0.000 claims description 55
- 125000000217 alkyl group Chemical group 0.000 claims description 52
- 125000001072 heteroaryl group Chemical group 0.000 claims description 50
- 229910052736 halogen Inorganic materials 0.000 claims description 38
- 150000002367 halogens Chemical class 0.000 claims description 29
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 28
- 239000003814 drug Substances 0.000 claims description 27
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 26
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- 230000001404 mediated effect Effects 0.000 claims description 16
- 229940124597 therapeutic agent Drugs 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 11
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 11
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 10
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims description 10
- IYZIARNSXPGYSC-UHFFFAOYSA-N 3-phenylbenzamide Chemical compound NC(=O)C1=CC=CC(C=2C=CC=CC=2)=C1 IYZIARNSXPGYSC-UHFFFAOYSA-N 0.000 claims description 9
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- 208000022362 bacterial infectious disease Diseases 0.000 claims description 7
- METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 claims description 6
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- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 4
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- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 4
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 claims description 4
- VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical compound C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
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- XNLWJFYYOIRPIO-UHFFFAOYSA-N 3-phenylbenzoic acid Chemical compound OC(=O)C1=CC=CC(C=2C=CC=CC=2)=C1 XNLWJFYYOIRPIO-UHFFFAOYSA-N 0.000 claims description 2
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- NEZJDVYDSZTRFS-GCHJQGSQSA-N (2r,3s,4s,5s,6r)-2-(hydroxymethyl)-6-phenoxyoxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC1=CC=CC=C1 NEZJDVYDSZTRFS-GCHJQGSQSA-N 0.000 claims 3
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- 239000000243 solution Substances 0.000 description 17
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 16
- 239000004480 active ingredient Substances 0.000 description 16
- 125000000623 heterocyclic group Chemical group 0.000 description 16
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 16
- 125000004432 carbon atom Chemical group C* 0.000 description 15
- 125000005843 halogen group Chemical group 0.000 description 15
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 14
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 14
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- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
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- 238000004885 tandem mass spectrometry Methods 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
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- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
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- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 description 1
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- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
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- 239000002562 thickening agent Substances 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
- 125000000858 thiocyanato group Chemical group *SC#N 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 description 1
- 238000003354 tissue distribution assay Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
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- 239000000196 tragacanth Substances 0.000 description 1
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- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
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- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- BAVYZALUXZFZLV-FIBGUPNXSA-N trideuteriomethanamine Chemical compound [2H]C([2H])([2H])N BAVYZALUXZFZLV-FIBGUPNXSA-N 0.000 description 1
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- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
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- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A—HUMAN NECESSITIES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
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- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Composite Materials (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662312017P | 2016-03-23 | 2016-03-23 | |
| US62/312,017 | 2016-03-23 | ||
| PCT/US2017/023764 WO2017165619A1 (en) | 2016-03-23 | 2017-03-23 | Mannose-derived antagonists of fimh useful for treating disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2017238392A1 true AU2017238392A1 (en) | 2018-09-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017238392A Abandoned AU2017238392A1 (en) | 2016-03-23 | 2017-03-23 | Mannose-derived antagonists of FimH useful for treating disease |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10738070B2 (enExample) |
| EP (1) | EP3432892A4 (enExample) |
| JP (1) | JP2019509315A (enExample) |
| KR (1) | KR20180128937A (enExample) |
| CN (1) | CN108778288A (enExample) |
| AU (1) | AU2017238392A1 (enExample) |
| BR (1) | BR112018069147A2 (enExample) |
| CA (1) | CA3018345A1 (enExample) |
| RU (1) | RU2018131440A (enExample) |
| WO (1) | WO2017165619A1 (enExample) |
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| US10738070B2 (en) | 2016-03-23 | 2020-08-11 | Fimbrion Therapeutics, Inc. | Mannose-derived antagonists of FimH useful for treating disease |
| US10385087B1 (en) * | 2018-04-26 | 2019-08-20 | National Taipei University Of Technology | Xylose derivatives and process for preparation thereof |
| EP3820856B9 (en) | 2018-07-10 | 2023-07-12 | GlaxoSmithKline Intellectual Property Development Limited | C-mannoside compopunds useful for the treatment of urinary tract infections |
| US12297223B2 (en) | 2019-05-07 | 2025-05-13 | Glaxosmithkline Intellectual Property Development Limited | Compounds |
| US12351597B2 (en) * | 2019-06-19 | 2025-07-08 | Glaxosmithkline Intellectual Property Development Limited | Substituted biphenyl or phenylheteroaryl-mannosides as antagonists of FimH |
| CN111205344B (zh) * | 2020-01-14 | 2023-03-14 | 华东理工大学 | 一种用于甲醇溶剂识别的纯有机磷光小分子材料及其制备方法 |
| WO2021197363A1 (zh) * | 2020-03-31 | 2021-10-07 | 苏州大学 | 2-炔基甘露糖衍生物及其应用 |
| CN111518738B (zh) * | 2020-05-08 | 2022-02-08 | 徐州海润生物科技有限公司 | 重组卡介苗及其制备方法和应用 |
| CN113797212B (zh) * | 2020-06-11 | 2023-12-22 | 兰州大学 | 一组含有甘露糖结构的抗菌药物的合成方法及活性研究 |
| CN116621891B (zh) * | 2023-05-25 | 2023-10-31 | 齐齐哈尔医学院 | 白鲜酚苷c及其制备方法和其应用 |
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| US5122602A (en) | 1989-02-13 | 1992-06-16 | Miles Inc. | Chromogenic merocyanine enzyme substrates |
| US6420127B1 (en) | 1994-11-18 | 2002-07-16 | Washington University | Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections |
| CA2176808A1 (en) | 1993-11-18 | 1995-05-26 | Scott Hultgren | Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections |
| AU7470300A (en) | 1999-08-11 | 2001-03-05 | Washington University | Anti-bacterial compounds directed against pilus biogenesis, adhesion and activity; co-crystals of pilus subunits and methods of use thereof |
| ATE419880T1 (de) | 2000-06-09 | 2009-01-15 | Baylor College Medicine | Kombination von antimikrobiellen wirkstoffen und bakterieller interferenz zum überziehen medizinischer vorrichtungen |
| US7265245B2 (en) | 2003-10-08 | 2007-09-04 | Innovaprotean, S.L | Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils |
| WO2005089733A2 (en) | 2004-03-23 | 2005-09-29 | Vib Vzw | Anti-adhesive compounds to prevent and treat bacterial infections |
| SE528382C2 (sv) | 2004-10-05 | 2006-10-31 | Probi Ab | Probiotiska lactobacillusstammar för förbättrad vaginal hälsa |
| FR2876798A1 (fr) | 2004-10-14 | 2006-04-21 | Univ Clermont Auvergne | Diagnostic et traitement de la maladie de crohn |
| WO2012109263A1 (en) | 2011-02-07 | 2012-08-16 | The Washington University | Mannoside compounds and methods of use thereof |
| EP2490530A4 (en) | 2009-10-22 | 2014-01-22 | Univ Washington | COMPOUNDS AND METHOD FOR THE TREATMENT OF BACTERIAL INFECTIONS |
| AU2010333017B2 (en) * | 2009-12-14 | 2016-06-16 | University Of Basel | Mannose derivatives as antagonists of bacterial adhesion |
| WO2012164074A1 (en) | 2011-06-03 | 2012-12-06 | University Of Basel | Mannose phosphate derivatives as antagonists of bacterial adhesion |
| ES2677115T3 (es) | 2013-03-12 | 2018-07-30 | Vertex Pharmaceuticals Incorporated | Derivados de manosa para tratar las infecciones bacterianas |
| EP3003322B1 (en) | 2013-05-30 | 2023-09-13 | Washington University | Mannose derivatives and their use in the treatment of bacterial infections |
| WO2017156508A1 (en) | 2016-03-11 | 2017-09-14 | Fimbrion Therapeutics, Inc. | C-glycoside compounds useful for treating disease |
| US10738070B2 (en) | 2016-03-23 | 2020-08-11 | Fimbrion Therapeutics, Inc. | Mannose-derived antagonists of FimH useful for treating disease |
-
2017
- 2017-03-23 US US16/087,305 patent/US10738070B2/en active Active
- 2017-03-23 CA CA3018345A patent/CA3018345A1/en not_active Abandoned
- 2017-03-23 CN CN201780019049.3A patent/CN108778288A/zh active Pending
- 2017-03-23 BR BR112018069147A patent/BR112018069147A2/pt not_active Application Discontinuation
- 2017-03-23 RU RU2018131440A patent/RU2018131440A/ru not_active Application Discontinuation
- 2017-03-23 AU AU2017238392A patent/AU2017238392A1/en not_active Abandoned
- 2017-03-23 WO PCT/US2017/023764 patent/WO2017165619A1/en not_active Ceased
- 2017-03-23 JP JP2018549836A patent/JP2019509315A/ja active Pending
- 2017-03-23 KR KR1020187030240A patent/KR20180128937A/ko not_active Ceased
- 2017-03-23 EP EP17771134.8A patent/EP3432892A4/en not_active Withdrawn
-
2020
- 2020-07-10 US US16/925,977 patent/US20200407390A1/en not_active Abandoned
-
2024
- 2024-09-17 US US18/887,190 patent/US20250009723A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20190106451A1 (en) | 2019-04-11 |
| CN108778288A (zh) | 2018-11-09 |
| EP3432892A4 (en) | 2019-10-30 |
| KR20180128937A (ko) | 2018-12-04 |
| US10738070B2 (en) | 2020-08-11 |
| JP2019509315A (ja) | 2019-04-04 |
| CA3018345A1 (en) | 2017-09-28 |
| RU2018131440A (ru) | 2020-04-23 |
| EP3432892A1 (en) | 2019-01-30 |
| RU2018131440A3 (enExample) | 2020-05-18 |
| BR112018069147A2 (pt) | 2019-01-22 |
| US20200407390A1 (en) | 2020-12-31 |
| WO2017165619A1 (en) | 2017-09-28 |
| US20250009723A1 (en) | 2025-01-09 |
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| Date | Code | Title | Description |
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| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |