JP2019507890A5 - - Google Patents
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- JP2019507890A5 JP2019507890A5 JP2018557296A JP2018557296A JP2019507890A5 JP 2019507890 A5 JP2019507890 A5 JP 2019507890A5 JP 2018557296 A JP2018557296 A JP 2018557296A JP 2018557296 A JP2018557296 A JP 2018557296A JP 2019507890 A5 JP2019507890 A5 JP 2019507890A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- biological sample
- group
- test device
- molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229930003316 Vitamin D Natural products 0.000 claims description 56
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 56
- 235000019166 vitamin D Nutrition 0.000 claims description 56
- 239000011710 vitamin D Substances 0.000 claims description 56
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 56
- 229940046008 vitamin d Drugs 0.000 claims description 56
- 238000001514 detection method Methods 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 35
- 239000012472 biological sample Substances 0.000 claims description 28
- 239000011230 binding agent Substances 0.000 claims description 18
- 238000007689 inspection Methods 0.000 claims description 17
- 239000000523 sample Substances 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- 239000003153 chemical reaction reagent Substances 0.000 claims description 10
- JWUBBDSIWDLEOM-NQZHSCJISA-N 25-hydroxy-3 epi cholecalciferol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@H](O)CCC1=C JWUBBDSIWDLEOM-NQZHSCJISA-N 0.000 claims description 9
- KJKIIUAXZGLUND-ICCVIKJNSA-N 25-hydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C KJKIIUAXZGLUND-ICCVIKJNSA-N 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 7
- 238000000159 protein binding assay Methods 0.000 claims description 5
- JWUBBDSIWDLEOM-XHQRYOPUSA-N (3e)-3-[(2e)-2-[1-(6-hydroxy-6-methylheptan-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol Chemical compound C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2\C1=C\C=C1/CC(O)CCC1=C JWUBBDSIWDLEOM-XHQRYOPUSA-N 0.000 claims description 4
- 102000050760 Vitamin D-binding protein Human genes 0.000 claims description 4
- 101710179590 Vitamin D-binding protein Proteins 0.000 claims description 4
- 210000001742 aqueous humor Anatomy 0.000 claims description 4
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 4
- 230000000536 complexating effect Effects 0.000 claims description 4
- 230000007812 deficiency Effects 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 239000010931 gold Substances 0.000 claims description 4
- 238000003384 imaging method Methods 0.000 claims description 4
- 239000004816 latex Substances 0.000 claims description 4
- 229920000126 latex Polymers 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 210000003296 saliva Anatomy 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 210000004243 sweat Anatomy 0.000 claims description 4
- 210000002700 urine Anatomy 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 2
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 2
- 125000003158 alcohol group Chemical group 0.000 claims description 2
- 239000011852 carbon nanoparticle Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 230000002950 deficient Effects 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 239000002502 liposome Substances 0.000 claims description 2
- 238000001294 liquid chromatography-tandem mass spectrometry Methods 0.000 claims description 2
- 239000002105 nanoparticle Substances 0.000 claims description 2
- 239000002096 quantum dot Substances 0.000 claims description 2
- 239000011541 reaction mixture Substances 0.000 claims description 2
- 239000011669 selenium Substances 0.000 claims description 2
- 229910052711 selenium Inorganic materials 0.000 claims description 2
- 230000035945 sensitivity Effects 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 238000003556 assay Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 description 2
- JWUBBDSIWDLEOM-UHFFFAOYSA-N 25-Hydroxycholecalciferol Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CCC1=C JWUBBDSIWDLEOM-UHFFFAOYSA-N 0.000 description 1
- JWUBBDSIWDLEOM-DCHLRESJSA-N 25-Hydroxyvitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C/C=C1\C[C@@H](O)CCC1=C JWUBBDSIWDLEOM-DCHLRESJSA-N 0.000 description 1
- -1 hydroxy vitamin D 3 Chemical compound 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662286297P | 2016-01-22 | 2016-01-22 | |
| US62/286,297 | 2016-01-22 | ||
| PCT/US2017/014620 WO2017127833A1 (en) | 2016-01-22 | 2017-01-23 | Device for detection of vitamin d metabolites |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019507890A JP2019507890A (ja) | 2019-03-22 |
| JP2019507890A5 true JP2019507890A5 (enExample) | 2020-02-06 |
Family
ID=59362265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557296A Pending JP2019507890A (ja) | 2016-01-22 | 2017-01-23 | ビタミンｄ代謝産物の検出のためのデバイス |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11073524B2 (enExample) |
| EP (2) | EP3405198B1 (enExample) |
| JP (1) | JP2019507890A (enExample) |
| KR (1) | KR20180104080A (enExample) |
| AU (1) | AU2017209523A1 (enExample) |
| WO (1) | WO2017127833A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10254279B2 (en) * | 2013-03-29 | 2019-04-09 | Nima Labs, Inc. | System and method for detection of target substances |
| US10466236B2 (en) | 2013-03-29 | 2019-11-05 | Nima Labs, Inc. | System and method for detecting target substances |
| EP2979092B1 (en) | 2013-03-29 | 2018-05-30 | Nima Labs, Inc. | A portable device for detection of harmful substances |
| EP3405198B1 (en) | 2016-01-22 | 2021-08-04 | Affimedix, Inc. | Device for detection of vitamin d metabolites |
| EP3401681B1 (en) * | 2017-05-11 | 2023-03-29 | Boditech Med Inc. | Method for quick quantification assay of vitamin d based on fluorescence measurement using lateral flow cartridge |
| KR102178417B1 (ko) | 2019-08-22 | 2020-11-13 | 한국표준과학연구원 | Ldi-ms를 이용한 혈액 내 비타민 d의 검출 방법 및 이를 위한 장치 |
| JPWO2022085719A1 (enExample) * | 2020-10-21 | 2022-04-28 | ||
| CN112557675B (zh) * | 2020-12-11 | 2024-08-02 | 郑州安图生物工程股份有限公司 | 一种25-羟基维生素d及其代谢物的解离剂及其制备方法、应用 |
| CN119080938B (zh) * | 2023-06-05 | 2025-06-24 | 东莞市朋志生物科技有限公司 | 抗25羟维生素d抗体、检测25羟维生素d的试剂和试剂盒 |
| CN117229411B (zh) * | 2023-11-10 | 2024-02-02 | 南京欧凯生物科技有限公司 | 特异性结合25-羟基维生素d的单克隆抗体、其应用及检测试剂盒 |
| CN119331100B (zh) * | 2024-10-16 | 2025-07-25 | 天津大学 | 特异性结合25-羟基维生素d的单克隆抗体及其应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020036170A1 (en) | 2000-08-11 | 2002-03-28 | Harvey Michael A. | Lateral flower plasma separation device |
| GB0029729D0 (en) | 2000-12-06 | 2001-01-17 | Ids Ltd | Method for detection of vitamin D metabolites |
| US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| WO2003028582A2 (en) * | 2001-09-28 | 2003-04-10 | Aspenbio, Inc. | Bovine pregnancy test |
| FI20022048A0 (fi) * | 2002-11-18 | 2002-11-18 | Valtion Teknillinen | Ei-kompetetiivinen immunomääritys pienille analyyteille |
| US20040132104A1 (en) | 2003-01-07 | 2004-07-08 | Sackrison James L. | Vitamin D assay |
| WO2006098804A2 (en) * | 2005-03-11 | 2006-09-21 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| CA2624129C (en) | 2005-09-29 | 2011-03-29 | F. Hoffmann-La Roche Ag | Release reagent for vitamin d compounds |
| EP2047270B1 (en) | 2006-07-28 | 2013-09-04 | Beckman Coulter, Inc. | Stabilizing agents and capture ligands for use in assays measuring analyte concentrations |
| US8535617B2 (en) | 2007-11-30 | 2013-09-17 | Kimberly-Clark Worldwide, Inc. | Blood cell barrier for a lateral flow device |
| WO2012129650A1 (en) * | 2011-03-25 | 2012-10-04 | Nanospeed Diagnostics Inc. | Lateral flow immunoassay for detecting vitamins |
| US8785603B2 (en) | 2011-05-20 | 2014-07-22 | Siemens Healthcare Diagnostics Inc. | Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
| IN2014CN02113A (enExample) * | 2011-09-21 | 2015-05-29 | Fujirebio Kk | |
| US20150293085A1 (en) * | 2012-10-31 | 2015-10-15 | Astute Medical, Inc. | Quantitative lateral flow assay |
| US20140162294A1 (en) * | 2012-12-06 | 2014-06-12 | General Atomics | Methods and compositions for assaying vitamin d |
| CN105164514A (zh) * | 2013-01-21 | 2015-12-16 | 康奈尔大学 | 基于智能手机的装置和用于获取可重复的定量比色测量的方法 |
| US9787815B2 (en) * | 2013-01-21 | 2017-10-10 | Cornell University | Smartphone-based apparatus and method |
| DK2759550T3 (en) * | 2013-01-28 | 2018-11-26 | Diasorin S P A | Method and kit for detecting vitamin 1,25-dihydroxy-D and related antibodies |
| CN105229468A (zh) * | 2013-06-04 | 2016-01-06 | 普默特株式社 | 具有可变对照线的用于快速检测的条带以及使用该条带的诊断试剂盒 |
| WO2015061598A1 (en) * | 2013-10-24 | 2015-04-30 | Quidel Corporation | Systems and methods for whole blood assays |
| CN104062440B (zh) * | 2014-06-30 | 2016-05-11 | 韩雅君 | 一种快速检测维生素d的试纸条 |
| KR102425339B1 (ko) * | 2014-12-08 | 2022-07-25 | 에프. 호프만-라 로슈 아게 | 비타민 d 의 측정을 위한 방법 |
| EP3405198B1 (en) | 2016-01-22 | 2021-08-04 | Affimedix, Inc. | Device for detection of vitamin d metabolites |
-
2017
- 2017-01-23 EP EP17742126.0A patent/EP3405198B1/en active Active
- 2017-01-23 WO PCT/US2017/014620 patent/WO2017127833A1/en not_active Ceased
- 2017-01-23 EP EP21182964.3A patent/EP3954376A1/en not_active Withdrawn
- 2017-01-23 KR KR1020187024094A patent/KR20180104080A/ko not_active Withdrawn
- 2017-01-23 AU AU2017209523A patent/AU2017209523A1/en not_active Abandoned
- 2017-01-23 JP JP2018557296A patent/JP2019507890A/ja active Pending
-
2018
- 2018-07-20 US US16/041,582 patent/US11073524B2/en active Active
-
2021
- 2021-06-22 US US17/354,023 patent/US20220120767A1/en not_active Abandoned
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