|
US10323236B2
(en)
|
2011-07-22 |
2019-06-18 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
US10704021B2
(en)
|
2012-03-15 |
2020-07-07 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
WO2015105955A1
(en)
|
2014-01-08 |
2015-07-16 |
Flodesign Sonics, Inc. |
Acoustophoresis device with dual acoustophoretic chamber
|
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
|
US11708572B2
(en)
|
2015-04-29 |
2023-07-25 |
Flodesign Sonics, Inc. |
Acoustic cell separation techniques and processes
|
|
US11377651B2
(en)
|
2016-10-19 |
2022-07-05 |
Flodesign Sonics, Inc. |
Cell therapy processes utilizing acoustophoresis
|
|
IL310721B2
(en)
|
2015-10-23 |
2025-11-01 |
Harvard College |
Nucleobase editors and uses thereof
|
|
US11214789B2
(en)
|
2016-05-03 |
2022-01-04 |
Flodesign Sonics, Inc. |
Concentration and washing of particles with acoustics
|
|
CN110214183A
(zh)
|
2016-08-03 |
2019-09-06 |
哈佛大学的校长及成员们 |
腺苷核碱基编辑器及其用途
|
|
WO2018031683A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
IL308824A
(en)
*
|
2016-08-17 |
2024-01-01 |
Factor Bioscience Inc |
Nucleic acid products and methods of administration thereof
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
KR102622411B1
(ko)
|
2016-10-14 |
2024-01-10 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
US12390514B2
(en)
|
2017-03-09 |
2025-08-19 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
US11542496B2
(en)
|
2017-03-10 |
2023-01-03 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
|
KR20240116572A
(ko)
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
CN108690845B
(zh)
|
2017-04-10 |
2021-04-27 |
中国科学院动物研究所 |
基因组编辑系统和方法
|
|
JP2020517247A
(ja)
|
2017-04-18 |
2020-06-18 |
イエール ユニバーシティ |
Tリンパ球ゲノム操作のためのプラットフォームおよびそのインビボハイスループットスクリーニング法
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
EP3686275A4
(en)
*
|
2017-09-18 |
2021-09-29 |
Edigene Inc. |
GENE EDITING LYMPHOCYTE T AND RELATED USE
|
|
KR20250107288A
(ko)
|
2017-10-16 |
2025-07-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
EP3707258A1
(en)
*
|
2017-11-06 |
2020-09-16 |
Editas Medicine, Inc. |
Methods, compositions and components for crispr-cas9 editing of cblb in t cells for immunotherapy
|
|
MX2020005235A
(es)
*
|
2017-11-16 |
2020-08-24 |
Mogam Inst Biomedical Res |
Celula humana transformada y uso de la misma.
|
|
EP3724326A1
(en)
*
|
2017-12-11 |
2020-10-21 |
Editas Medicine, Inc. |
Cpf1-related methods and compositions for gene editing
|
|
KR102439221B1
(ko)
|
2017-12-14 |
2022-09-01 |
프로디자인 소닉스, 인크. |
음향 트랜스듀서 구동기 및 제어기
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
CN111788307A
(zh)
*
|
2018-03-12 |
2020-10-16 |
南京北恒生物科技有限公司 |
工程化的嵌合向导rna及其用途
|
|
WO2019178225A2
(en)
|
2018-03-13 |
2019-09-19 |
Regents Of The University Of Minnesota |
Lymphohematopoietic engineering using cas9 base editors
|
|
JP2021522188A
(ja)
*
|
2018-04-18 |
2021-08-30 |
イエール ユニバーシティ |
内因性遺伝子活性化を用いる多重腫瘍ワクチン接種のための組成物および方法
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
US20210363206A1
(en)
*
|
2018-06-18 |
2021-11-25 |
The Regents Of The University Of California |
Proteins that inhibit cas12a (cpf1), a cripr-cas nuclease
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
US20210322473A1
(en)
*
|
2018-07-18 |
2021-10-21 |
The General Hospital Corporation |
Modified t cells and methods of their use
|
|
US20200080056A1
(en)
*
|
2018-09-06 |
2020-03-12 |
The Trustees Of The University Of Pennsylvania |
CRISPR-Cas9 Knock-out of SHP-1/2 to Reduce T cell Exhaustion in Adoptive Cell Therapy
|
|
CN112805371B
(zh)
*
|
2018-09-21 |
2025-10-31 |
克莱格医学有限公司 |
基于CRISPR/Cas系统对细胞进行基因编辑的方法
|
|
CN113227374A
(zh)
*
|
2018-10-16 |
2021-08-06 |
因特利亚治疗公司 |
用于免疫疗法的组合物和方法
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
CN121759517A
(zh)
*
|
2019-01-04 |
2026-03-31 |
赋生元公司 |
使用单链环状dna靶向修饰基因组
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
CN120174005A
(zh)
|
2019-02-13 |
2025-06-20 |
比姆医疗股份有限公司 |
具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞
|
|
WO2021226363A1
(en)
*
|
2020-05-08 |
2021-11-11 |
Metagenomi Ip Technologies, Llc |
Enzymes with ruvc domains
|
|
PE20211959A1
(es)
|
2019-02-15 |
2021-09-30 |
Editas Medicine Inc |
Celulas asesinas naturales (nk) modificadas para inmunoterapia
|
|
EP3773918A4
(en)
|
2019-03-05 |
2022-01-05 |
Nkarta, Inc. |
CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
|
|
WO2020191233A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
AU2020288829A1
(en)
*
|
2019-06-04 |
2021-12-02 |
Nkarta, Inc. |
Combinations of engineered natural killer cells and engineered T cells for immunotherapy
|
|
WO2020264117A1
(en)
*
|
2019-06-26 |
2020-12-30 |
Integrated Dna Technologies, Inc. |
Compositions and methods for improved detection of genomic editing events
|
|
CA3145425A1
(en)
|
2019-07-03 |
2021-01-07 |
Factor Bioscience Inc. |
Cationic lipids and uses thereof
|
|
US10501404B1
(en)
|
2019-07-30 |
2019-12-10 |
Factor Bioscience Inc. |
Cationic lipids and transfection methods
|
|
CN114340656B
(zh)
*
|
2019-08-02 |
2024-07-30 |
孟山都技术公司 |
使用huh内切核酸酶促进靶向基因组修饰的方法和组合物
|
|
WO2021050565A1
(en)
*
|
2019-09-09 |
2021-03-18 |
Oregon Health & Science University |
Crispr-mediated capture of nucleic acids
|
|
US12016883B2
(en)
*
|
2019-09-26 |
2024-06-25 |
Nantbio, Inc. |
Primary T-cell expansion
|
|
EP4034138A4
(en)
|
2019-09-27 |
2024-07-31 |
Beam Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
CN110904239B
(zh)
*
|
2019-12-25 |
2020-11-10 |
武汉博杰生物医学科技有限公司 |
肺癌相关分子标志物基因突变的检测试剂盒与检测方法
|
|
AU2021216418A1
(en)
*
|
2020-02-05 |
2022-09-01 |
Danmarks Tekniske Universitet |
Compositions and methods for targeting, editing or modifying human genes
|
|
IL297761A
(en)
|
2020-05-08 |
2022-12-01 |
Broad Inst Inc |
Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence
|
|
EP4149525A4
(en)
*
|
2020-05-15 |
2024-08-28 |
Rxcell Inc. |
HYPOIMMUNOGENIC CELLS AND THEIR USES IN IMMUNE RESPONSES
|
|
BR112022023512A2
(pt)
*
|
2020-05-20 |
2022-12-20 |
The Administrators Of The Tulane Educational Fund |
Ensaio baseado em crispr para a detecção de patógenos em amostras.
|
|
AU2021286655A1
(en)
|
2020-06-12 |
2023-01-05 |
Nkarta, Inc. |
Genetically modified natural killer cells for CD70-directed cancer immunotherapy
|
|
CA3196831A1
(en)
|
2020-09-25 |
2022-03-31 |
Beam Therapeutics Inc. |
Fratricide resistant modified immune cells and methods of using the same
|
|
MX2023004505A
(es)
*
|
2020-10-19 |
2023-05-10 |
Caribou Biosciences Inc |
Polinucleotidos que contienen adn y guias para sistemas crispr de tipo v, y metodos de fabricacion y uso de los mismos.
|
|
EP4237559A1
(en)
*
|
2020-10-30 |
2023-09-06 |
Arbor Biotechnologies, Inc. |
Compositions comprising an rna guide targeting b2m and uses thereof
|
|
US20240026351A1
(en)
*
|
2020-10-30 |
2024-01-25 |
Arbor Biotechnologies, Inc. |
Compositions comprising an rna guide targeting trac and uses thereof
|
|
CN116334037A
(zh)
*
|
2020-11-11 |
2023-06-27 |
山东舜丰生物科技有限公司 |
新型Cas酶和系统以及应用
|
|
US11459372B2
(en)
|
2020-11-30 |
2022-10-04 |
Crispr Therapeutics Ag |
Gene-edited natural killer cells
|
|
KR20230118887A
(ko)
|
2020-12-03 |
2023-08-14 |
센츄리 쎄라퓨틱스 인코포레이티드 |
유전자 조작 세포 및 이의 용도
|
|
US11661459B2
(en)
|
2020-12-03 |
2023-05-30 |
Century Therapeutics, Inc. |
Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
|
|
EP4255453A4
(en)
*
|
2020-12-03 |
2025-03-26 |
Nkarta, Inc. |
Methods for manipulating immune cells for increased potency and persistence, as well as uses of engineered cells in immunotherapy
|
|
JP7850156B2
(ja)
*
|
2020-12-17 |
2026-04-22 |
モンサント テクノロジー エルエルシー |
操作されたssDNase不含CRISPRエンドヌクレアーゼ
|
|
AR124414A1
(es)
|
2020-12-18 |
2023-03-22 |
Century Therapeutics Inc |
Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable
|
|
WO2022144632A1
(en)
|
2020-12-30 |
2022-07-07 |
Crispr Therapeutics Ag |
Compositions and methods for differentiating stem cells into nk cells
|
|
JP2024515936A
(ja)
*
|
2021-03-19 |
2024-04-11 |
メタゲノミ,インク. |
Cas酵素を用いたマルチプレックス編集
|
|
KR102428773B1
(ko)
*
|
2021-04-21 |
2022-08-05 |
(주)지플러스생명과학 |
분리형 crRNA 및 이를 이용한 CRISPR-Cas 시스템
|
|
BR112023024983A2
(pt)
*
|
2021-06-02 |
2024-04-30 |
Metagenomi Inc |
Sistemas crispr classe ii, tipo v
|
|
EP4359541A4
(en)
|
2021-06-23 |
2025-04-30 |
Editas Medicine, Inc. |
Engineered cells for therapy
|
|
US20240316102A1
(en)
|
2021-07-01 |
2024-09-26 |
Indapta Therapeutics, Inc. |
Engineered natural killer (nk) cells and related methods
|
|
AU2022335499A1
(en)
|
2021-08-27 |
2024-02-22 |
Metagenomi Therapeutics, Inc. |
Enzymes with ruvc domains
|
|
AU2022396533A1
(en)
|
2021-11-24 |
2024-05-02 |
Metagenomi Therapeutics, Inc. |
Endonuclease systems
|
|
JP2023107748A
(ja)
*
|
2022-01-24 |
2023-08-03 |
美洛生物科技股▲ふん▼有限公司 |
合成rna断片及びrna依存性増幅のためのその使用
|
|
TWI870769B
(zh)
*
|
2022-01-24 |
2025-01-21 |
美洛生物科技股份有限公司 |
合成rna片段及其用於rna依賴擴增之用途
|
|
WO2023164625A2
(en)
*
|
2022-02-25 |
2023-08-31 |
Georgia Tech Research Corporation |
Modified plant virus system for delivery of nucleic acids into mammalian cells
|
|
JP2025525439A
(ja)
|
2022-06-30 |
2025-08-05 |
インダプタ セラピューティクス インコーポレイテッド |
操作されたナチュラルキラー(nk)細胞と抗体療法との組み合わせおよび関連する方法
|
|
CN120882852A
(zh)
*
|
2023-06-21 |
2025-10-31 |
隆萨科隆有限公司 |
多腔室电穿孔盒及其使用方法
|
|
WO2025213127A1
(en)
|
2024-04-05 |
2025-10-09 |
Indapta Therapeutics, Inc. |
Treatment of autoimmune diseases or conditions with natural killer cells
|
|
WO2025245399A1
(en)
|
2024-05-23 |
2025-11-27 |
Indapta Therapeutics, Inc. |
Method of treating cancer with natural killer cells
|