JP2019507599A5 - - Google Patents

Download PDF

Info

Publication number
JP2019507599A5
JP2019507599A5 JP2018546483A JP2018546483A JP2019507599A5 JP 2019507599 A5 JP2019507599 A5 JP 2019507599A5 JP 2018546483 A JP2018546483 A JP 2018546483A JP 2018546483 A JP2018546483 A JP 2018546483A JP 2019507599 A5 JP2019507599 A5 JP 2019507599A5
Authority
JP
Japan
Prior art keywords
cells
cell
group
trac
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018546483A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019507599A (ja
JP7251980B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/020598 external-priority patent/WO2017152015A1/en
Publication of JP2019507599A publication Critical patent/JP2019507599A/ja
Publication of JP2019507599A5 publication Critical patent/JP2019507599A5/ja
Priority to JP2023046534A priority Critical patent/JP2023089005A/ja
Application granted granted Critical
Publication of JP7251980B2 publication Critical patent/JP7251980B2/ja
Priority to JP2025161230A priority patent/JP2026016399A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018546483A 2016-03-04 2017-03-03 がん免疫療法のためのcrispr-cpf1関連方法、組成物および構成要素 Active JP7251980B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023046534A JP2023089005A (ja) 2016-03-04 2023-03-23 がん免疫療法のためのcrispr-cpf1関連方法、組成物および構成要素
JP2025161230A JP2026016399A (ja) 2016-03-04 2025-09-29 がん免疫療法のためのcrispr-cpf1関連方法、組成物および構成要素

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662304057P 2016-03-04 2016-03-04
US62/304,057 2016-03-04
PCT/US2017/020598 WO2017152015A1 (en) 2016-03-04 2017-03-03 Crispr-cpf1-related methods, compositions and components for cancer immunotherapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023046534A Division JP2023089005A (ja) 2016-03-04 2023-03-23 がん免疫療法のためのcrispr-cpf1関連方法、組成物および構成要素

Publications (3)

Publication Number Publication Date
JP2019507599A JP2019507599A (ja) 2019-03-22
JP2019507599A5 true JP2019507599A5 (https=) 2020-04-16
JP7251980B2 JP7251980B2 (ja) 2023-04-04

Family

ID=58358928

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018546483A Active JP7251980B2 (ja) 2016-03-04 2017-03-03 がん免疫療法のためのcrispr-cpf1関連方法、組成物および構成要素
JP2023046534A Pending JP2023089005A (ja) 2016-03-04 2023-03-23 がん免疫療法のためのcrispr-cpf1関連方法、組成物および構成要素
JP2025161230A Pending JP2026016399A (ja) 2016-03-04 2025-09-29 がん免疫療法のためのcrispr-cpf1関連方法、組成物および構成要素

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023046534A Pending JP2023089005A (ja) 2016-03-04 2023-03-23 がん免疫療法のためのcrispr-cpf1関連方法、組成物および構成要素
JP2025161230A Pending JP2026016399A (ja) 2016-03-04 2025-09-29 がん免疫療法のためのcrispr-cpf1関連方法、組成物および構成要素

Country Status (11)

Country Link
US (2) US12325854B2 (https=)
EP (1) EP3423580A1 (https=)
JP (3) JP7251980B2 (https=)
KR (4) KR102738283B1 (https=)
CN (1) CN109312340A (https=)
AU (2) AU2017226172B9 (https=)
CA (1) CA3016331A1 (https=)
IL (2) IL291971B2 (https=)
MX (2) MX2018010484A (https=)
SG (1) SG11201807538PA (https=)
WO (1) WO2017152015A1 (https=)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10323236B2 (en) 2011-07-22 2019-06-18 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9322037B2 (en) 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US10077453B2 (en) 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
IL310721B2 (en) 2015-10-23 2025-11-01 Harvard College Nucleobase editors and uses thereof
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
CN110214183A (zh) 2016-08-03 2019-09-06 哈佛大学的校长及成员们 腺苷核碱基编辑器及其用途
WO2018031683A1 (en) 2016-08-09 2018-02-15 President And Fellows Of Harvard College Programmable cas9-recombinase fusion proteins and uses thereof
IL308824A (en) * 2016-08-17 2024-01-01 Factor Bioscience Inc Nucleic acid products and methods of administration thereof
US11542509B2 (en) 2016-08-24 2023-01-03 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
KR102622411B1 (ko) 2016-10-14 2024-01-10 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵염기 에디터의 aav 전달
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
US12390514B2 (en) 2017-03-09 2025-08-19 President And Fellows Of Harvard College Cancer vaccine
EP3592853A1 (en) 2017-03-09 2020-01-15 President and Fellows of Harvard College Suppression of pain by gene editing
US11542496B2 (en) 2017-03-10 2023-01-03 President And Fellows Of Harvard College Cytosine to guanine base editor
KR20240116572A (ko) 2017-03-23 2024-07-29 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
CN108690845B (zh) 2017-04-10 2021-04-27 中国科学院动物研究所 基因组编辑系统和方法
JP2020517247A (ja) 2017-04-18 2020-06-18 イエール ユニバーシティ Tリンパ球ゲノム操作のためのプラットフォームおよびそのインビボハイスループットスクリーニング法
US11560566B2 (en) 2017-05-12 2023-01-24 President And Fellows Of Harvard College Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
CN111801345A (zh) 2017-07-28 2020-10-20 哈佛大学的校长及成员们 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
EP3676376B1 (en) 2017-08-30 2025-01-15 President and Fellows of Harvard College High efficiency base editors comprising gam
EP3686275A4 (en) * 2017-09-18 2021-09-29 Edigene Inc. GENE EDITING LYMPHOCYTE T AND RELATED USE
KR20250107288A (ko) 2017-10-16 2025-07-11 더 브로드 인스티튜트, 인코퍼레이티드 아데노신 염기 편집제의 용도
EP3707258A1 (en) * 2017-11-06 2020-09-16 Editas Medicine, Inc. Methods, compositions and components for crispr-cas9 editing of cblb in t cells for immunotherapy
MX2020005235A (es) * 2017-11-16 2020-08-24 Mogam Inst Biomedical Res Celula humana transformada y uso de la misma.
EP3724326A1 (en) * 2017-12-11 2020-10-21 Editas Medicine, Inc. Cpf1-related methods and compositions for gene editing
KR102439221B1 (ko) 2017-12-14 2022-09-01 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기
US12406749B2 (en) 2017-12-15 2025-09-02 The Broad Institute, Inc. Systems and methods for predicting repair outcomes in genetic engineering
CN111788307A (zh) * 2018-03-12 2020-10-16 南京北恒生物科技有限公司 工程化的嵌合向导rna及其用途
WO2019178225A2 (en) 2018-03-13 2019-09-19 Regents Of The University Of Minnesota Lymphohematopoietic engineering using cas9 base editors
JP2021522188A (ja) * 2018-04-18 2021-08-30 イエール ユニバーシティ 内因性遺伝子活性化を用いる多重腫瘍ワクチン接種のための組成物および方法
US12157760B2 (en) 2018-05-23 2024-12-03 The Broad Institute, Inc. Base editors and uses thereof
US20210363206A1 (en) * 2018-06-18 2021-11-25 The Regents Of The University Of California Proteins that inhibit cas12a (cpf1), a cripr-cas nuclease
US12522807B2 (en) 2018-07-09 2026-01-13 The Broad Institute, Inc. RNA programmable epigenetic RNA modifiers and uses thereof
US20210322473A1 (en) * 2018-07-18 2021-10-21 The General Hospital Corporation Modified t cells and methods of their use
US20200080056A1 (en) * 2018-09-06 2020-03-12 The Trustees Of The University Of Pennsylvania CRISPR-Cas9 Knock-out of SHP-1/2 to Reduce T cell Exhaustion in Adoptive Cell Therapy
CN112805371B (zh) * 2018-09-21 2025-10-31 克莱格医学有限公司 基于CRISPR/Cas系统对细胞进行基因编辑的方法
CN113227374A (zh) * 2018-10-16 2021-08-06 因特利亚治疗公司 用于免疫疗法的组合物和方法
WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
CN121759517A (zh) * 2019-01-04 2026-03-31 赋生元公司 使用单链环状dna靶向修饰基因组
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
CN120174005A (zh) 2019-02-13 2025-06-20 比姆医疗股份有限公司 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞
WO2021226363A1 (en) * 2020-05-08 2021-11-11 Metagenomi Ip Technologies, Llc Enzymes with ruvc domains
PE20211959A1 (es) 2019-02-15 2021-09-30 Editas Medicine Inc Celulas asesinas naturales (nk) modificadas para inmunoterapia
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
WO2020191233A1 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
US12473543B2 (en) 2019-04-17 2025-11-18 The Broad Institute, Inc. Adenine base editors with reduced off-target effects
AU2020288829A1 (en) * 2019-06-04 2021-12-02 Nkarta, Inc. Combinations of engineered natural killer cells and engineered T cells for immunotherapy
WO2020264117A1 (en) * 2019-06-26 2020-12-30 Integrated Dna Technologies, Inc. Compositions and methods for improved detection of genomic editing events
CA3145425A1 (en) 2019-07-03 2021-01-07 Factor Bioscience Inc. Cationic lipids and uses thereof
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
CN114340656B (zh) * 2019-08-02 2024-07-30 孟山都技术公司 使用huh内切核酸酶促进靶向基因组修饰的方法和组合物
WO2021050565A1 (en) * 2019-09-09 2021-03-18 Oregon Health & Science University Crispr-mediated capture of nucleic acids
US12016883B2 (en) * 2019-09-26 2024-06-25 Nantbio, Inc. Primary T-cell expansion
EP4034138A4 (en) 2019-09-27 2024-07-31 Beam Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
US12435330B2 (en) 2019-10-10 2025-10-07 The Broad Institute, Inc. Methods and compositions for prime editing RNA
CN110904239B (zh) * 2019-12-25 2020-11-10 武汉博杰生物医学科技有限公司 肺癌相关分子标志物基因突变的检测试剂盒与检测方法
AU2021216418A1 (en) * 2020-02-05 2022-09-01 Danmarks Tekniske Universitet Compositions and methods for targeting, editing or modifying human genes
IL297761A (en) 2020-05-08 2022-12-01 Broad Inst Inc Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence
EP4149525A4 (en) * 2020-05-15 2024-08-28 Rxcell Inc. HYPOIMMUNOGENIC CELLS AND THEIR USES IN IMMUNE RESPONSES
BR112022023512A2 (pt) * 2020-05-20 2022-12-20 The Administrators Of The Tulane Educational Fund Ensaio baseado em crispr para a detecção de patógenos em amostras.
AU2021286655A1 (en) 2020-06-12 2023-01-05 Nkarta, Inc. Genetically modified natural killer cells for CD70-directed cancer immunotherapy
CA3196831A1 (en) 2020-09-25 2022-03-31 Beam Therapeutics Inc. Fratricide resistant modified immune cells and methods of using the same
MX2023004505A (es) * 2020-10-19 2023-05-10 Caribou Biosciences Inc Polinucleotidos que contienen adn y guias para sistemas crispr de tipo v, y metodos de fabricacion y uso de los mismos.
EP4237559A1 (en) * 2020-10-30 2023-09-06 Arbor Biotechnologies, Inc. Compositions comprising an rna guide targeting b2m and uses thereof
US20240026351A1 (en) * 2020-10-30 2024-01-25 Arbor Biotechnologies, Inc. Compositions comprising an rna guide targeting trac and uses thereof
CN116334037A (zh) * 2020-11-11 2023-06-27 山东舜丰生物科技有限公司 新型Cas酶和系统以及应用
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
KR20230118887A (ko) 2020-12-03 2023-08-14 센츄리 쎄라퓨틱스 인코포레이티드 유전자 조작 세포 및 이의 용도
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
EP4255453A4 (en) * 2020-12-03 2025-03-26 Nkarta, Inc. Methods for manipulating immune cells for increased potency and persistence, as well as uses of engineered cells in immunotherapy
JP7850156B2 (ja) * 2020-12-17 2026-04-22 モンサント テクノロジー エルエルシー 操作されたssDNase不含CRISPRエンドヌクレアーゼ
AR124414A1 (es) 2020-12-18 2023-03-22 Century Therapeutics Inc Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
JP2024515936A (ja) * 2021-03-19 2024-04-11 メタゲノミ,インク. Cas酵素を用いたマルチプレックス編集
KR102428773B1 (ko) * 2021-04-21 2022-08-05 (주)지플러스생명과학 분리형 crRNA 및 이를 이용한 CRISPR-Cas 시스템
BR112023024983A2 (pt) * 2021-06-02 2024-04-30 Metagenomi Inc Sistemas crispr classe ii, tipo v
EP4359541A4 (en) 2021-06-23 2025-04-30 Editas Medicine, Inc. Engineered cells for therapy
US20240316102A1 (en) 2021-07-01 2024-09-26 Indapta Therapeutics, Inc. Engineered natural killer (nk) cells and related methods
AU2022335499A1 (en) 2021-08-27 2024-02-22 Metagenomi Therapeutics, Inc. Enzymes with ruvc domains
AU2022396533A1 (en) 2021-11-24 2024-05-02 Metagenomi Therapeutics, Inc. Endonuclease systems
JP2023107748A (ja) * 2022-01-24 2023-08-03 美洛生物科技股▲ふん▼有限公司 合成rna断片及びrna依存性増幅のためのその使用
TWI870769B (zh) * 2022-01-24 2025-01-21 美洛生物科技股份有限公司 合成rna片段及其用於rna依賴擴增之用途
WO2023164625A2 (en) * 2022-02-25 2023-08-31 Georgia Tech Research Corporation Modified plant virus system for delivery of nucleic acids into mammalian cells
JP2025525439A (ja) 2022-06-30 2025-08-05 インダプタ セラピューティクス インコーポレイテッド 操作されたナチュラルキラー(nk)細胞と抗体療法との組み合わせおよび関連する方法
CN120882852A (zh) * 2023-06-21 2025-10-31 隆萨科隆有限公司 多腔室电穿孔盒及其使用方法
WO2025213127A1 (en) 2024-04-05 2025-10-09 Indapta Therapeutics, Inc. Treatment of autoimmune diseases or conditions with natural killer cells
WO2025245399A1 (en) 2024-05-23 2025-11-27 Indapta Therapeutics, Inc. Method of treating cancer with natural killer cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4286517A3 (en) * 2013-04-04 2024-03-13 President and Fellows of Harvard College Therapeutic uses of genome editing with crispr/cas systems
WO2014191128A1 (en) * 2013-05-29 2014-12-04 Cellectis Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
ES2883131T3 (es) * 2013-05-29 2021-12-07 Cellectis Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
JP6681837B2 (ja) 2014-03-11 2020-04-15 セレクティスCellectis 同種移植に適合するt細胞を作製するための方法
WO2015161276A2 (en) * 2014-04-18 2015-10-22 Editas Medicine, Inc. Crispr-cas-related methods, compositions and components for cancer immunotherapy
EP3215623A4 (en) * 2014-11-06 2018-09-26 President and Fellows of Harvard College Cells lacking b2m surface expression and methods for allogeneic administration of such cells
AU2016243583B2 (en) * 2015-03-27 2022-03-10 President And Fellows Of Harvard College Modified T cells and methods of making and using the same
US9790490B2 (en) * 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
JP6816133B2 (ja) * 2015-10-05 2021-01-20 プレシジョン バイオサイエンシズ,インク. 改変ヒトt細胞受容体アルファ定常領域遺伝子を含む遺伝子改変細胞
WO2017093969A1 (en) * 2015-12-04 2017-06-08 Novartis Ag Compositions and methods for immunooncology

Similar Documents

Publication Publication Date Title
JP2019507599A5 (https=)
Hu et al. CRISPR/Cas9-engineered universal CD19/CD22 dual-targeted CAR-T cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia
JP7516617B2 (ja) マイクロrna適合shrna(shrnamir)を含む遺伝子改変免疫細胞
Vijayakumar et al. Engineering Newcastle disease virus as an oncolytic vector for intratumoral delivery of immune checkpoint inhibitors and immunocytokines
Ghaffari et al. CRISPR/Cas9 revitalizes adoptive T-cell therapy for cancer immunotherapy
AU2019236204B2 (en) Gene-regulating compositions and methods for improved immunotherapy
Zhang et al. CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells
JP7005346B2 (ja) 養子細胞免疫療法の有効性を増強させるための組成物および方法
Tang et al. Donor T cells for CAR T cell therapy
IL292512B2 (en) CRISPR-CAS-related methods, compositions and components for cancer immunotherapy
JP2020509767A (ja) 高親和性mage−a1特異的tcr及びその使用
JP2021518160A (ja) 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法
JP2021518162A (ja) 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法
JP2022531231A5 (https=)
JP2019503672A5 (https=)
JP2019517788A (ja) 遺伝子操作された細胞および同細胞を作製する方法
JP2024097924A (ja) 抗ptk7免疫細胞癌療法
JP2023105045A (ja) Braf特異的tcrおよびその使用
Alsaieedi et al. Tracing the development of CAR-T cell design: from concept to next-generation platforms
US20230233677A1 (en) Compositions and methods for enhancing immune response
CN113574174A (zh) 用于增强的淋巴细胞介导的免疫治疗的组合物和方法
BR112021008973A2 (pt) Receptores de células t específicos para mesotelina e uso dos mesmos em imunoterapia
US20250009800A1 (en) Methods for cancer immunotherapy
Nyberg et al. Genome Editing Applications in Cancer T Cell Therapy
Hopkins et al. Genome editing as a vehicle to drive successful chimeric antigen receptor T cell therapies to the clinic