JP2019507116A5 - - Google Patents
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- Publication number
- JP2019507116A5 JP2019507116A5 JP2018536179A JP2018536179A JP2019507116A5 JP 2019507116 A5 JP2019507116 A5 JP 2019507116A5 JP 2018536179 A JP2018536179 A JP 2018536179A JP 2018536179 A JP2018536179 A JP 2018536179A JP 2019507116 A5 JP2019507116 A5 JP 2019507116A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- pharmaceutically acceptable
- alkoxy
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 17
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 125000005843 halogen group Chemical group 0.000 claims 12
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 12
- 125000004043 oxo group Chemical group O=* 0.000 claims 5
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- -1 cyano, amino, hydroxy Chemical group 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 208000020084 Bone disease Diseases 0.000 claims 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 claims 1
- 208000033830 Hot Flashes Diseases 0.000 claims 1
- 206010060800 Hot flush Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000006999 cognitive decline Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 230000001457 vasomotor Effects 0.000 claims 1
- 0 CCC(C(*)(CC1)C(C)(*)CC1c1cc(*)c(*)c(*)c1)=* Chemical compound CCC(C(*)(CC1)C(C)(*)CC1c1cc(*)c(*)c(*)c1)=* 0.000 description 1
- UCXWFKNKSWDWCD-MRXNPFEDSA-N Cc1cc(-c2ccc([C@@H](CC3)O)c3c2)cc(C)c1O Chemical compound Cc1cc(-c2ccc([C@@H](CC3)O)c3c2)cc(C)c1O UCXWFKNKSWDWCD-MRXNPFEDSA-N 0.000 description 1
- UCXWFKNKSWDWCD-INIZCTEOSA-N Cc1cc(-c2ccc([C@H](CC3)O)c3c2)cc(C)c1O Chemical compound Cc1cc(-c2ccc([C@H](CC3)O)c3c2)cc(C)c1O UCXWFKNKSWDWCD-INIZCTEOSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662275416P | 2016-01-06 | 2016-01-06 | |
| US62/275,416 | 2016-01-06 | ||
| PCT/US2017/012586 WO2017120507A1 (en) | 2016-01-06 | 2017-01-06 | Novel compounds which activate estrogen receptors and compositions and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019507116A JP2019507116A (ja) | 2019-03-14 |
| JP2019507116A5 true JP2019507116A5 (enExample) | 2020-02-13 |
Family
ID=59274443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536179A Pending JP2019507116A (ja) | 2016-01-06 | 2017-01-06 | エストロゲン受容体を活性化する新規化合物ならびにその組成物および使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10703698B2 (enExample) |
| EP (1) | EP3400071A4 (enExample) |
| JP (1) | JP2019507116A (enExample) |
| AU (1) | AU2017206060A1 (enExample) |
| CA (1) | CA3010506A1 (enExample) |
| WO (1) | WO2017120507A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11462943B2 (en) | 2018-01-30 | 2022-10-04 | Wireless Advanced Vehicle Electrification, Llc | DC link charging of capacitor in a wireless power transfer pad |
| CN110872213A (zh) * | 2018-08-31 | 2020-03-10 | 西安力邦肇新生物科技有限公司 | Gabaa受体变构增强化合物及其制备和用途 |
| US20220081653A1 (en) * | 2019-05-21 | 2022-03-17 | Firmenich Sa | Poly(ester urea) microcapsules |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2949080A1 (de) * | 1979-12-06 | 1981-06-11 | Merck Patent Gmbh, 6100 Darmstadt | Naphthalinderivate, diese enthaltende dielektrika und elektrooptisches anzeigeelement |
| US5583267B1 (en) * | 1995-01-27 | 1998-11-24 | Enzymol International | Biocatalytic process for preparing tetraalkylbiphenols |
| DE10225048B4 (de) * | 2001-06-07 | 2015-03-12 | Merck Patent Gmbh | Fluorierte (Dihydro)phenanthrenderivate und deren Verwendung in flüssigkristallinen Medien |
| DE10251017A1 (de) * | 2001-11-27 | 2003-05-28 | Merck Patent Gmbh | Verfahren zur Herstellung von Naphthalin-Derivaten |
| US6914074B2 (en) * | 2001-12-13 | 2005-07-05 | Wyeth | Substituted phenyl naphthalenes as estrogenic agents |
| JP4246958B2 (ja) * | 2002-04-25 | 2009-04-02 | 株式会社キノファーマ | 発光触媒活性を有する触媒抗体 |
| JP2008515407A (ja) | 2004-10-08 | 2008-05-15 | ガムリンク エー／エス | 菓子製品 |
| US20070066628A1 (en) * | 2005-09-19 | 2007-03-22 | Wyeth | 5-Aryl-indan-1-ol and analogs useful as progesterone receptor modulators |
| EP2013176A2 (en) * | 2006-02-27 | 2009-01-14 | Sterix Limited | Diaryl compounds as non-steroidal inhibitors of 17-beta hydroxysteroid dehydrogenase and/or steroid sulphatase for the treatment of oestrogen-related diseases such as hormone dependent breast cancer |
| CL2008000793A1 (es) * | 2007-03-23 | 2008-05-30 | Xenon Pharmaceuticals Inc | Compuestos derivados de dihidroindazol; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno del hierro. |
| GB0822486D0 (en) * | 2008-12-10 | 2009-01-14 | Univ Liverpool | Compounds for use in the treatment of pain |
| AR078173A1 (es) * | 2009-09-15 | 2011-10-19 | Sanofi Aventis | Bifeniloximetil dihidro oxazolopirimidinonas sustituidas, su preparacion y su uso |
-
2017
- 2017-01-06 US US16/067,676 patent/US10703698B2/en active Active
- 2017-01-06 CA CA3010506A patent/CA3010506A1/en not_active Abandoned
- 2017-01-06 AU AU2017206060A patent/AU2017206060A1/en not_active Abandoned
- 2017-01-06 JP JP2018536179A patent/JP2019507116A/ja active Pending
- 2017-01-06 EP EP17736458.5A patent/EP3400071A4/en not_active Withdrawn
- 2017-01-06 WO PCT/US2017/012586 patent/WO2017120507A1/en not_active Ceased
-
2020
- 2020-07-02 US US16/919,466 patent/US20200331828A1/en not_active Abandoned
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