JP2019507116A - エストロゲン受容体を活性化する新規化合物ならびにその組成物および使用方法 - Google Patents

エストロゲン受容体を活性化する新規化合物ならびにその組成物および使用方法 Download PDF

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JP2019507116A
JP2019507116A JP2018536179A JP2018536179A JP2019507116A JP 2019507116 A JP2019507116 A JP 2019507116A JP 2018536179 A JP2018536179 A JP 2018536179A JP 2018536179 A JP2018536179 A JP 2018536179A JP 2019507116 A JP2019507116 A JP 2019507116A
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alkyl
compound
compound according
pape
hydroxy
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JP2019507116A5 (enExample
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ジョン カッツェンエレンボーゲン
ジョン カッツェンエレンボーゲン
ベニータ カッツェンエレンボーゲン
ベニータ カッツェンエレンボーゲン
ソンフン キム
ソンフン キム
ゼイネプ マダク−エルドガン
ゼイネプ マダク−エルドガン
フィリップ シャウル
フィリップ シャウル
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University of Illinois System
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University of Illinois System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/06—Alkylated phenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/42—Halogenated derivatives containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/733—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2018536179A 2016-01-06 2017-01-06 エストロゲン受容体を活性化する新規化合物ならびにその組成物および使用方法 Pending JP2019507116A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662275416P 2016-01-06 2016-01-06
US62/275,416 2016-01-06
PCT/US2017/012586 WO2017120507A1 (en) 2016-01-06 2017-01-06 Novel compounds which activate estrogen receptors and compositions and methods of using the same

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JP2019507116A true JP2019507116A (ja) 2019-03-14
JP2019507116A5 JP2019507116A5 (enExample) 2020-02-13

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JP2018536179A Pending JP2019507116A (ja) 2016-01-06 2017-01-06 エストロゲン受容体を活性化する新規化合物ならびにその組成物および使用方法

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US (2) US10703698B2 (enExample)
EP (1) EP3400071A4 (enExample)
JP (1) JP2019507116A (enExample)
AU (1) AU2017206060A1 (enExample)
CA (1) CA3010506A1 (enExample)
WO (1) WO2017120507A1 (enExample)

Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
US11462943B2 (en) 2018-01-30 2022-10-04 Wireless Advanced Vehicle Electrification, Llc DC link charging of capacitor in a wireless power transfer pad
CN110872213A (zh) * 2018-08-31 2020-03-10 西安力邦肇新生物科技有限公司 Gabaa受体变构增强化合物及其制备和用途
US20220081653A1 (en) * 2019-05-21 2022-03-17 Firmenich Sa Poly(ester urea) microcapsules

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692223A (en) * 1979-12-06 1981-07-25 Merck Patent Gmbh Naphthalene derivatives* dielectric body containing them and electrooptical display element
JP2003096003A (ja) * 2001-06-07 2003-04-03 Merck Patent Gmbh フッ素化（ジヒドロ）フェナントレン誘導体および液晶媒体におけるそれらの使用
DE10251017A1 (de) * 2001-11-27 2003-05-28 Merck Patent Gmbh Verfahren zur Herstellung von Naphthalin-Derivaten
JP2004002212A (ja) * 2002-04-25 2004-01-08 Ikuo Fujii 発光触媒活性を有する触媒抗体
US20080234327A1 (en) * 2007-03-23 2008-09-25 Xenon Pharmaceuticals Inc. Dihydroindazole compounds useful in treating iron disorders
WO2011034828A1 (en) * 2009-09-15 2011-03-24 Sanofi-Aventis Substituted para-biphenyloxymethyl dihydro oxazolopyrimidinones, preparation and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583267B1 (en) * 1995-01-27 1998-11-24 Enzymol International Biocatalytic process for preparing tetraalkylbiphenols
TWI306450B (en) * 2001-12-13 2009-02-21 Wyeth Corp Substituted phenyl naphthalenes as estrogenic agents
ES2369501T5 (es) 2004-10-08 2019-10-21 Fertin Pharma As Producto de confitería
US20070066628A1 (en) 2005-09-19 2007-03-22 Wyeth 5-Aryl-indan-1-ol and analogs useful as progesterone receptor modulators
CA2643670A1 (en) * 2006-02-27 2007-08-30 Sterix Limited Diaryl compounds as non-steroidal inhibitors of 17-beta hydroxysteroid dehydrogenase and/or steroid sulphatase for the treatment of oestrogen-related diseases such as hormone dependent breast cancer
GB0822486D0 (en) * 2008-12-10 2009-01-14 Univ Liverpool Compounds for use in the treatment of pain

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692223A (en) * 1979-12-06 1981-07-25 Merck Patent Gmbh Naphthalene derivatives* dielectric body containing them and electrooptical display element
JP2003096003A (ja) * 2001-06-07 2003-04-03 Merck Patent Gmbh フッ素化（ジヒドロ）フェナントレン誘導体および液晶媒体におけるそれらの使用
DE10251017A1 (de) * 2001-11-27 2003-05-28 Merck Patent Gmbh Verfahren zur Herstellung von Naphthalin-Derivaten
JP2004002212A (ja) * 2002-04-25 2004-01-08 Ikuo Fujii 発光触媒活性を有する触媒抗体
US20080234327A1 (en) * 2007-03-23 2008-09-25 Xenon Pharmaceuticals Inc. Dihydroindazole compounds useful in treating iron disorders
WO2011034828A1 (en) * 2009-09-15 2011-03-24 Sanofi-Aventis Substituted para-biphenyloxymethyl dihydro oxazolopyrimidinones, preparation and use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, JPN6021000553, 2008, pages 4438 - 4456, ISSN: 0004424362 *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, JPN6021000552, 2008, pages 2158 - 2169, ISSN: 0004424361 *
SCIENCE SIGNALING, vol. 9, no. 429, JPN6021000551, 24 May 2016 (2016-05-24), pages 53 - 1, ISSN: 0004424360 *

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AU2017206060A1 (en) 2018-07-19
US20190002380A1 (en) 2019-01-03
EP3400071A4 (en) 2019-10-30
WO2017120507A1 (en) 2017-07-13
US20200331828A1 (en) 2020-10-22
CA3010506A1 (en) 2017-07-13
US10703698B2 (en) 2020-07-07
EP3400071A1 (en) 2018-11-14

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