JP2019504853A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019504853A5 JP2019504853A5 JP2018541604A JP2018541604A JP2019504853A5 JP 2019504853 A5 JP2019504853 A5 JP 2019504853A5 JP 2018541604 A JP2018541604 A JP 2018541604A JP 2018541604 A JP2018541604 A JP 2018541604A JP 2019504853 A5 JP2019504853 A5 JP 2019504853A5
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- cross
- delivery system
- moisturizing composition
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims description 18
- 229920001661 Chitosan Polymers 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 21
- 150000004804 polysaccharides Chemical class 0.000 claims 20
- 230000003020 moisturizing effect Effects 0.000 claims 19
- 229920001184 polypeptide Polymers 0.000 claims 19
- 229920001282 polysaccharide Polymers 0.000 claims 19
- 239000005017 polysaccharide Substances 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 9
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 8
- 235000002639 sodium chloride Nutrition 0.000 claims 8
- 230000002209 hydrophobic effect Effects 0.000 claims 7
- 238000012986 modification Methods 0.000 claims 7
- 230000004048 modification Effects 0.000 claims 7
- 229920002148 Gellan gum Polymers 0.000 claims 5
- 238000004132 cross linking Methods 0.000 claims 5
- 235000010492 gellan gum Nutrition 0.000 claims 5
- 239000000216 gellan gum Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 4
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims 4
- 239000011575 calcium Substances 0.000 claims 4
- 229910052791 calcium Inorganic materials 0.000 claims 4
- 235000010418 carrageenan Nutrition 0.000 claims 4
- 239000000679 carrageenan Substances 0.000 claims 4
- 229920001525 carrageenan Polymers 0.000 claims 4
- 229940113118 carrageenan Drugs 0.000 claims 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 4
- 229910017053 inorganic salt Inorganic materials 0.000 claims 4
- 235000014655 lactic acid Nutrition 0.000 claims 4
- 239000004310 lactic acid Substances 0.000 claims 4
- YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Chemical compound [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 claims 4
- 239000011734 sodium Substances 0.000 claims 4
- 229910052708 sodium Inorganic materials 0.000 claims 4
- 229920001285 xanthan gum Polymers 0.000 claims 4
- 235000010493 xanthan gum Nutrition 0.000 claims 4
- 239000000230 xanthan gum Substances 0.000 claims 4
- 229940082509 xanthan gum Drugs 0.000 claims 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 4
- 108010020346 Polyglutamic Acid Proteins 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 3
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims 3
- JQAACYUZYRBHGG-QHTZZOMLSA-L magnesium;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Mg+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 JQAACYUZYRBHGG-QHTZZOMLSA-L 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 229940010747 sodium hyaluronate Drugs 0.000 claims 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 3
- 239000000080 wetting agent Substances 0.000 claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- ODHCTXKNWHHXJC-UHFFFAOYSA-N 5-oxoproline Chemical compound OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 claims 2
- 244000215068 Acacia senegal Species 0.000 claims 2
- OPSXJNAGCGVGOG-DKWTVANSSA-L Calcium L-aspartate Chemical compound [Ca+2].[O-]C(=O)[C@@H](N)CC([O-])=O OPSXJNAGCGVGOG-DKWTVANSSA-L 0.000 claims 2
- 229920002101 Chitin Polymers 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical class OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- 229920002907 Guar gum Polymers 0.000 claims 2
- 229920000084 Gum arabic Polymers 0.000 claims 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 2
- 229920001100 Polydextrose Polymers 0.000 claims 2
- 239000004373 Pullulan Substances 0.000 claims 2
- 229920001218 Pullulan Polymers 0.000 claims 2
- 241001558929 Sclerotium <basidiomycota> Species 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- 235000010489 acacia gum Nutrition 0.000 claims 2
- 239000000205 acacia gum Substances 0.000 claims 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 2
- 235000010443 alginic acid Nutrition 0.000 claims 2
- 239000000783 alginic acid Substances 0.000 claims 2
- 229920000615 alginic acid Polymers 0.000 claims 2
- 229960001126 alginic acid Drugs 0.000 claims 2
- 150000004781 alginic acids Chemical class 0.000 claims 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
- 229960003237 betaine Drugs 0.000 claims 2
- 235000010376 calcium ascorbate Nutrition 0.000 claims 2
- 229940047036 calcium ascorbate Drugs 0.000 claims 2
- 239000011692 calcium ascorbate Substances 0.000 claims 2
- 229940034055 calcium aspartate Drugs 0.000 claims 2
- 235000010237 calcium benzoate Nutrition 0.000 claims 2
- 239000004301 calcium benzoate Substances 0.000 claims 2
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims 2
- 239000000292 calcium oxide Substances 0.000 claims 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims 2
- 229940087373 calcium oxide Drugs 0.000 claims 2
- 235000012255 calcium oxide Nutrition 0.000 claims 2
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 claims 2
- HZQXCUSDXIKLGS-UHFFFAOYSA-L calcium;dibenzoate;trihydrate Chemical compound O.O.O.[Ca+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 HZQXCUSDXIKLGS-UHFFFAOYSA-L 0.000 claims 2
- 229920006037 cross link polymer Polymers 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 235000010417 guar gum Nutrition 0.000 claims 2
- 239000000665 guar gum Substances 0.000 claims 2
- 229960002154 guar gum Drugs 0.000 claims 2
- 229920000591 gum Polymers 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 2
- 229960000448 lactic acid Drugs 0.000 claims 2
- 229940074358 magnesium ascorbate Drugs 0.000 claims 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims 2
- 239000001095 magnesium carbonate Substances 0.000 claims 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims 2
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 2
- AIOKQVJVNPDJKA-ZZMNMWMASA-L magnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-olate Chemical compound [Mg+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] AIOKQVJVNPDJKA-ZZMNMWMASA-L 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- 239000001814 pectin Substances 0.000 claims 2
- 235000010987 pectin Nutrition 0.000 claims 2
- 229920001277 pectin Polymers 0.000 claims 2
- 235000013856 polydextrose Nutrition 0.000 claims 2
- 239000001259 polydextrose Substances 0.000 claims 2
- 229940035035 polydextrose Drugs 0.000 claims 2
- 235000019423 pullulan Nutrition 0.000 claims 2
- -1 serum Substances 0.000 claims 2
- CRPCXAMJWCDHFM-UHFFFAOYSA-M sodium;5-oxopyrrolidine-2-carboxylate Chemical compound [Na+].[O-]C(=O)C1CCC(=O)N1 CRPCXAMJWCDHFM-UHFFFAOYSA-M 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- OWVLYQRCCIEOPF-QHTZZOMLSA-L zinc;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Zn+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 OWVLYQRCCIEOPF-QHTZZOMLSA-L 0.000 claims 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims 1
- 229940015975 1,2-hexanediol Drugs 0.000 claims 1
- 229940043375 1,5-pentanediol Drugs 0.000 claims 1
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical class C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 claims 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- 125000000070 5-oxo-L-proline group Chemical group [H]N1[C@@](C(=O)[*])([H])C([H])([H])C([H])([H])C1=O 0.000 claims 1
- 229920002567 Chondroitin Polymers 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- WQXNXVUDBPYKBA-UHFFFAOYSA-N Ectoine Chemical class CC1=NCCC(C(O)=O)N1 WQXNXVUDBPYKBA-UHFFFAOYSA-N 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- 239000004368 Modified starch Substances 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 1
- 235000014121 butter Nutrition 0.000 claims 1
- MCFVRESNTICQSJ-RJNTXXOISA-L calcium sorbate Chemical compound [Ca+2].C\C=C\C=C\C([O-])=O.C\C=C\C=C\C([O-])=O MCFVRESNTICQSJ-RJNTXXOISA-L 0.000 claims 1
- 235000010244 calcium sorbate Nutrition 0.000 claims 1
- 239000004303 calcium sorbate Substances 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940045110 chitosan Drugs 0.000 claims 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- 229940105990 diglycerin Drugs 0.000 claims 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims 1
- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical class CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 150000004676 glycans Polymers 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 229960004275 glycolic acid Drugs 0.000 claims 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims 1
- 229940014041 hyaluronate Drugs 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical class OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 235000015110 jellies Nutrition 0.000 claims 1
- 239000008274 jelly Substances 0.000 claims 1
- BJHIKXHVCXFQLS-OTWZMJIISA-N keto-L-sorbose Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-OTWZMJIISA-N 0.000 claims 1
- 229940099563 lactobionic acid Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 229960001708 magnesium carbonate Drugs 0.000 claims 1
- 229960002337 magnesium chloride Drugs 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- 235000013923 monosodium glutamate Nutrition 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000002453 shampoo Substances 0.000 claims 1
- 229940083542 sodium Drugs 0.000 claims 1
- 229940073490 sodium glutamate Drugs 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 description 4
- 239000000017 hydrogel Substances 0.000 description 4
- FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 description 2
- 229920002305 Schizophyllan Polymers 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- BXCRLBBIZJSWNS-UHFFFAOYSA-N 2-hydroxyethyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCO BXCRLBBIZJSWNS-UHFFFAOYSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229940042040 innovative drug Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022004732A JP2022062065A (ja) | 2016-02-12 | 2022-01-15 | 保湿性組成物及びその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662294706P | 2016-02-12 | 2016-02-12 | |
| US62/294,706 | 2016-02-12 | ||
| US201662394540P | 2016-09-14 | 2016-09-14 | |
| US62/394,540 | 2016-09-14 | ||
| PCT/US2017/017671 WO2017139765A1 (en) | 2016-02-12 | 2017-02-13 | Moisturizing compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022004732A Division JP2022062065A (ja) | 2016-02-12 | 2022-01-15 | 保湿性組成物及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504853A JP2019504853A (ja) | 2019-02-21 |
| JP2019504853A5 true JP2019504853A5 (https=) | 2020-03-19 |
| JP7013377B2 JP7013377B2 (ja) | 2022-02-15 |
Family
ID=59563455
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541604A Active JP7013377B2 (ja) | 2016-02-12 | 2017-02-13 | 保湿性組成物及びその使用 |
| JP2022004732A Pending JP2022062065A (ja) | 2016-02-12 | 2022-01-15 | 保湿性組成物及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022004732A Pending JP2022062065A (ja) | 2016-02-12 | 2022-01-15 | 保湿性組成物及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11234921B2 (https=) |
| EP (1) | EP3413816A4 (https=) |
| JP (2) | JP7013377B2 (https=) |
| KR (1) | KR102821397B1 (https=) |
| CN (2) | CN114129470A (https=) |
| AU (1) | AU2017218138B2 (https=) |
| CA (1) | CA3013477A1 (https=) |
| SG (1) | SG11201806845VA (https=) |
| WO (1) | WO2017139765A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10722443B2 (en) | 2016-09-14 | 2020-07-28 | Rodan & Fields, Llc | Moisturizing compositions and uses thereof |
| EP3413816A4 (en) | 2016-02-12 | 2019-08-21 | Rodan & Fields LLC | MOISTURE-SPENDING COMPOSITIONS AND USES THEREOF |
| WO2019049723A1 (ja) * | 2017-09-07 | 2019-03-14 | 株式会社Adeka | 水系ゲル化剤を含む皮膚用又は毛髪用洗浄剤組成物、並びに該水系ゲル化剤及び該洗浄剤組成物の製造方法 |
| CN109602618A (zh) * | 2018-12-06 | 2019-04-12 | 浙江大学自贡创新中心 | 一种含矿物盐乳液的润肤凝珠及其制备方法 |
| KR102255283B1 (ko) * | 2019-05-03 | 2021-05-24 | 주식회사 에이치비엘글로벌 | 해양식물 추출혼합물을 포함하는 복합혼합물을 함유한 마스크팩 조성물 및 이를 이용한 마스크팩 |
| IT201900006884A1 (it) * | 2019-05-16 | 2020-11-16 | Areaderma S R L | Prodotto topico preferibilmente di derivazione naturale |
| CN112294707B (zh) * | 2019-07-31 | 2022-07-29 | 太和康美(北京)中医研究院有限公司 | 一种具有保湿功效的膏霜及其制备方法 |
| CN112294705B (zh) * | 2019-07-31 | 2022-07-29 | 太和康美(北京)中医研究院有限公司 | 一种保湿面膜及其制备方法 |
| CN112294702B (zh) * | 2019-07-31 | 2022-07-29 | 太和康美(北京)中医研究院有限公司 | 一种大分子载体组合物及其制备方法和应用 |
| CN112294704B (zh) * | 2019-07-31 | 2022-07-29 | 太和康美(北京)中医研究院有限公司 | 一种洗发水及其制备方法 |
| CN110638670A (zh) * | 2019-08-26 | 2020-01-03 | 广州睿新生物科技有限公司 | 一种高渗透性保湿组合物及护肤液与制备方法 |
| CN111467258A (zh) * | 2020-05-28 | 2020-07-31 | 许文斌 | 一种抗氧化抗衰老的美白凝胶及其制备方法 |
| CN113413355B (zh) * | 2021-07-08 | 2022-05-27 | 马应龙大健康有限公司 | 一种具有即时提亮淡纹功效的眼霜及其制备方法 |
| IT202100020975A1 (it) * | 2021-08-03 | 2023-02-03 | Fb Dermo S R L | Composizione per la prevenzione e/o il trattamento dell'acne. |
| CN113616561B (zh) * | 2021-09-27 | 2023-02-10 | 上海新高姿化妆品有限公司 | 一种具有保湿修护效果的组合物及化妆品 |
| CN113956095B (zh) * | 2021-11-15 | 2023-09-01 | 成都华宏生物科技有限公司 | 一种营养型生物保水剂组合物及制备方法和应用 |
| WO2023155902A1 (en) | 2022-02-18 | 2023-08-24 | Chongqing Mingdao Haoyue Biotechnology Co., Ltd. | Intranasal formulations and anti-sars-cov-2-spike protein antibodies |
| KR102690134B1 (ko) * | 2022-09-29 | 2024-08-01 | 코스맥스 주식회사 | 셀룰로오스 복합물을 포함하는 조성물 |
| CN115887317A (zh) * | 2022-11-04 | 2023-04-04 | 上海臻臣化妆品有限公司 | 用于皮肤的保湿组合物和保湿液 |
| CN115778864B (zh) * | 2022-12-12 | 2024-04-19 | 广州市美夫兰化妆品有限公司 | 一种祛斑净白抗皱冻干粉 |
| CN116115522B (zh) * | 2023-01-10 | 2023-10-13 | 山东福瑞达生物科技有限公司 | 一种γ-PGA/四氢嘧啶复合水凝胶及其制备方法、应用 |
| CN120693145A (zh) * | 2023-03-31 | 2025-09-23 | 莱雅公司 | 用于护理角蛋白材料的组合物 |
| KR102575751B1 (ko) * | 2023-05-12 | 2023-09-06 | 진홍종 | 보습 화장료 조성물 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6224893B1 (en) | 1997-04-11 | 2001-05-01 | Massachusetts Institute Of Technology | Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering |
| US6486232B1 (en) | 1997-04-18 | 2002-11-26 | Cambridge Scientific, Inc. | Bioerodible polymeric semi-interpenetrating network alloys for internal fixation devices and bone cements |
| US6077916A (en) | 1997-06-04 | 2000-06-20 | The Penn State Research Foundation | Biodegradable mixtures of polyphoshazene and other polymers |
| WO2003086291A2 (en) * | 2002-04-10 | 2003-10-23 | Yu Ruey J | Urea compositions |
| GB0329907D0 (en) * | 2003-12-23 | 2004-01-28 | Innomed Ltd | Compositions |
| UA92479C2 (ru) | 2005-01-27 | 2010-11-10 | Налко Компани | Композиция для личной гигиены, которая содержит гидрофобно модифицированные полимеры |
| DE102005026069A1 (de) | 2005-06-07 | 2006-12-14 | Goldschmidt Gmbh | Topische kosmetische Formulierungen zur Regulierung und Verbesserung des Feuchtigkeitsgehalts der Haut |
| FR2898807B1 (fr) * | 2006-03-23 | 2008-12-05 | Oreal | Composition comprenant de l'hydroxyapatite et un sel de calcium pour renforcer la fonction barriere de la peau et/ou des semi-muqueuses |
| US20080003192A1 (en) * | 2006-06-29 | 2008-01-03 | Modi Jashawant J | Functional compositions containing cationic hydrophobically modified polysaccharides for personal care, household & institutional and pet care products |
| CN101484564B (zh) * | 2006-07-06 | 2011-08-03 | 森特尼尔投资有限公司 | 对皮肤友好的广谱消毒组合物 |
| FR2924615B1 (fr) * | 2007-12-07 | 2010-01-22 | Vivacy Lab | Hydrogel cohesif biodegradable. |
| US20110053270A1 (en) | 2009-08-26 | 2011-03-03 | Theresa Chang | Patterning Hydrogels |
| EP2726155B1 (en) * | 2011-09-29 | 2017-07-12 | Rohm and Haas Company | Personal care composition and methods containing hydrophobically-modified hydroxyalkylcellulose |
| CN103181862B (zh) * | 2011-12-29 | 2015-03-18 | 上海媚兰生物科技发展有限公司 | 一种复合保湿剂及其应用 |
| CN104004231A (zh) * | 2014-06-12 | 2014-08-27 | 东南大学 | 一种生物大分子互穿网络水凝胶及其制备方法 |
| US10722443B2 (en) | 2016-09-14 | 2020-07-28 | Rodan & Fields, Llc | Moisturizing compositions and uses thereof |
| EP3413816A4 (en) | 2016-02-12 | 2019-08-21 | Rodan & Fields LLC | MOISTURE-SPENDING COMPOSITIONS AND USES THEREOF |
-
2017
- 2017-02-13 EP EP17750964.3A patent/EP3413816A4/en active Pending
- 2017-02-13 WO PCT/US2017/017671 patent/WO2017139765A1/en not_active Ceased
- 2017-02-13 SG SG11201806845VA patent/SG11201806845VA/en unknown
- 2017-02-13 CN CN202111577224.5A patent/CN114129470A/zh active Pending
- 2017-02-13 JP JP2018541604A patent/JP7013377B2/ja active Active
- 2017-02-13 CA CA3013477A patent/CA3013477A1/en active Pending
- 2017-02-13 AU AU2017218138A patent/AU2017218138B2/en active Active
- 2017-02-13 CN CN201780011111.4A patent/CN108882951B/zh active Active
- 2017-02-13 KR KR1020187026347A patent/KR102821397B1/ko active Active
-
2020
- 2020-06-11 US US16/898,830 patent/US11234921B2/en active Active
-
2021
- 2021-12-14 US US17/644,215 patent/US20220249349A1/en not_active Abandoned
-
2022
- 2022-01-15 JP JP2022004732A patent/JP2022062065A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019504853A5 (https=) | ||
| Liu et al. | Injectable thermo-responsive hydrogel composed of xanthan gum and methylcellulose double networks with shear-thinning property | |
| Mitura et al. | Biopolymers for hydrogels in cosmetics | |
| Lochhead | The use of polymers in cosmetic products | |
| Sharma et al. | Preparation of tamarind gum based soft ion gels having thixotropic properties | |
| Cazorla-Luna et al. | Naturally occurring polyelectrolytes and their use for the development of complex-based mucoadhesive drug delivery systems: An overview | |
| Anisha et al. | Chitosan–hyaluronan/nano chondroitin sulfate ternary composite sponges for medical use | |
| Nichifor | Role of hydrophobic associations in self-healing hydrogels based on amphiphilic polysaccharides | |
| CN103613686B (zh) | 巯基化透明质酸的制备方法及其应用 | |
| Gawade et al. | Polymers in cosmetics | |
| Wang et al. | Two natural glucomannan polymers, from Konjac and Bletilla, as bioactive materials for pharmaceutical applications | |
| Morariu et al. | The behavior of chitosan in solvents with different ionic strengths | |
| Doppalapudi et al. | Biodegradable natural polymers | |
| Anurova et al. | Review of contemporary gel-forming agents in the technology of dosage forms | |
| CN112334124A (zh) | 用于护理皮肤的套盒 | |
| Majee et al. | Rheological behavior and pharmaceutical applications of bacterial exopolysaccharides | |
| JP2001520180A (ja) | 少なくとも１種のポリヒドロキシル化有機化合物と組み合わされた本質的に非晶質のセルロースナノフィブリルの、化粧品調合物中における使用 | |
| HUP0300163A2 (hu) | Hialuronsav-származékokból kialakított klatrát komplexek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| AU2010227007A1 (en) | Compositions comprising superhydrophilic amphiphilic copolymers and methods of use thereof | |
| Stanisław et al. | Biopolymers for hydrogels in cosmetics | |
| Bera et al. | Tailor-Made and Functionalized Biopolymer Systems: For Drug Delivery and Biomedical Applications | |
| Wu et al. | Development of low-molecular-weight polysaccharide-based wound dressings for full-thickness cutaneous wound healing via coacervate formation | |
| Shekh et al. | Biopolymers: an overview | |
| Jana et al. | Polysaccharide-based biomaterials: delivery of therapeutics and biomedical applications | |
| US20050124798A1 (en) | Amphoteric polysaccharide composition and use |