JP2019502682A5 - - Google Patents
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- Publication number
- JP2019502682A5 JP2019502682A5 JP2018531107A JP2018531107A JP2019502682A5 JP 2019502682 A5 JP2019502682 A5 JP 2019502682A5 JP 2018531107 A JP2018531107 A JP 2018531107A JP 2018531107 A JP2018531107 A JP 2018531107A JP 2019502682 A5 JP2019502682 A5 JP 2019502682A5
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- nanoemulsion
- pressure vessel
- fluorocarbon
- bypass valve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 34
- 239000007908 nanoemulsion Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 17
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 15
- 150000003904 phospholipids Chemical class 0.000 claims 8
- NJCBUSHGCBERSK-UHFFFAOYSA-N perfluoropentane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F NJCBUSHGCBERSK-UHFFFAOYSA-N 0.000 claims 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 4
- 229930006000 Sucrose Natural products 0.000 claims 4
- 239000000337 buffer salt Substances 0.000 claims 4
- 239000000839 emulsion Substances 0.000 claims 4
- 239000005720 sucrose Substances 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 238000000265 homogenisation Methods 0.000 claims 3
- 230000003641 microbiacidal effect Effects 0.000 claims 3
- 229940124561 microbicide Drugs 0.000 claims 3
- -1 perfluoro -n- hexyl Chemical group 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- 230000001954 sterilising effect Effects 0.000 claims 3
- 238000004659 sterilization and disinfection Methods 0.000 claims 3
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 2
- 229950010592 dodecafluoropentane Drugs 0.000 claims 2
- 229960004624 perflexane Drugs 0.000 claims 2
- ZJIJAJXFLBMLCK-UHFFFAOYSA-N perfluorohexane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F ZJIJAJXFLBMLCK-UHFFFAOYSA-N 0.000 claims 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000011345 viscous material Substances 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 229940075564 anhydrous dibasic sodium phosphate Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000003139 biocide Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000002855 microbicide agent Substances 0.000 claims 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 claims 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims 1
- 235000019799 monosodium phosphate Nutrition 0.000 claims 1
- 229960004692 perflenapent Drugs 0.000 claims 1
- KAVGMUDTWQVPDF-UHFFFAOYSA-N perflubutane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)F KAVGMUDTWQVPDF-UHFFFAOYSA-N 0.000 claims 1
- 229950003332 perflubutane Drugs 0.000 claims 1
- LGUZHRODIJCVOC-UHFFFAOYSA-N perfluoroheptane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F LGUZHRODIJCVOC-UHFFFAOYSA-N 0.000 claims 1
- YVBBRRALBYAZBM-UHFFFAOYSA-N perfluorooctane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F YVBBRRALBYAZBM-UHFFFAOYSA-N 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 1
- 238000003260 vortexing Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562270226P | 2015-12-21 | 2015-12-21 | |
| US62/270,226 | 2015-12-21 | ||
| PCT/US2016/067650 WO2017112614A1 (en) | 2015-12-21 | 2016-12-20 | Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019502682A JP2019502682A (ja) | 2019-01-31 |
| JP2019502682A5 true JP2019502682A5 (https=) | 2020-01-16 |
| JP6936226B2 JP6936226B2 (ja) | 2021-09-15 |
Family
ID=59089857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531107A Active JP6936226B2 (ja) | 2015-12-21 | 2016-12-20 | フルオロカーボンナノエマルジョンの組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11304899B2 (https=) |
| EP (1) | EP3393459A4 (https=) |
| JP (1) | JP6936226B2 (https=) |
| KR (2) | KR20240100472A (https=) |
| CN (2) | CN118662440A (https=) |
| AU (2) | AU2016377361B2 (https=) |
| BR (1) | BR112018012618A2 (https=) |
| CA (1) | CA3009404C (https=) |
| EA (1) | EA201891296A1 (https=) |
| IL (2) | IL298236B2 (https=) |
| WO (1) | WO2017112614A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102342324B1 (ko) * | 2020-12-11 | 2021-12-23 | 애경케미칼주식회사 | 불소계 계면활성제 조성물 |
| KR102342326B1 (ko) * | 2020-12-11 | 2021-12-23 | 애경케미칼주식회사 | 계면장력이 우수한 불소계 계면활성제 조성물 |
| WO2024227100A1 (en) * | 2023-04-26 | 2024-10-31 | Swaza Inc. | Nanoparticle composition for oxygen delivery |
| CN116622338A (zh) * | 2023-06-05 | 2023-08-22 | 西安科技大学 | 井下复合型降尘防爆一体化处理材料及其制备方法和应用 |
| WO2025143844A1 (ko) * | 2023-12-27 | 2025-07-03 | (주)아이엠디팜 | 과불화탄소와 카제인을 함유한 산소운반체 약학조성물 및 그의 제조방법 |
| KR20260008977A (ko) | 2024-07-10 | 2026-01-19 | 강원대학교산학협력단 | 키토산-운데칸산 나노에멀젼 및 그 제조방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
| US5846517A (en) * | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
| US20060003012A9 (en) * | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| EP3616691A1 (en) * | 2011-03-04 | 2020-03-04 | The Board of Trustees of the University of Arkansas | Dodecafluoropentane emulsion as a stroke and ischemia therapy |
| US10279053B2 (en) * | 2011-07-19 | 2019-05-07 | Nuvox Pharma Llc | Microbubble compositions, method of making same, and method using same |
| WO2013043236A1 (en) * | 2011-09-22 | 2013-03-28 | Rockland Technimed, Ltd. | Compositions and methods useful for realtime in situ physiological molecular imaging of oxygen metabolism |
| US8822549B2 (en) * | 2011-10-13 | 2014-09-02 | Jennifer L. Johnson | Buffered oxygen therapeutic |
| CN113398070A (zh) * | 2014-03-05 | 2021-09-17 | 埃文·C·昂格尔 | 利用氧气疗法的分割放疗和化疗 |
| US9801959B2 (en) * | 2014-06-12 | 2017-10-31 | Microvascuar Therapeutics Llc | Phospholipid composition and microbubbles and emulsions formed using same |
| EP3233136B8 (en) * | 2014-12-18 | 2019-04-10 | Bracco Suisse SA | Targeted gas-filled microvesicles formulation |
-
2016
- 2016-12-20 BR BR112018012618A patent/BR112018012618A2/pt not_active Application Discontinuation
- 2016-12-20 KR KR1020247020626A patent/KR20240100472A/ko not_active Ceased
- 2016-12-20 WO PCT/US2016/067650 patent/WO2017112614A1/en not_active Ceased
- 2016-12-20 AU AU2016377361A patent/AU2016377361B2/en active Active
- 2016-12-20 US US16/060,950 patent/US11304899B2/en active Active
- 2016-12-20 CA CA3009404A patent/CA3009404C/en active Active
- 2016-12-20 CN CN202410295358.5A patent/CN118662440A/zh active Pending
- 2016-12-20 IL IL298236A patent/IL298236B2/en unknown
- 2016-12-20 CN CN201680081126.3A patent/CN108697664A/zh active Pending
- 2016-12-20 EP EP16879945.0A patent/EP3393459A4/en active Pending
- 2016-12-20 IL IL260206A patent/IL260206B2/en unknown
- 2016-12-20 EA EA201891296A patent/EA201891296A1/ru unknown
- 2016-12-20 JP JP2018531107A patent/JP6936226B2/ja active Active
- 2016-12-20 KR KR1020187020326A patent/KR102679118B1/ko active Active
-
2022
- 2022-04-15 US US17/721,445 patent/US20220401364A1/en not_active Abandoned
- 2022-09-21 AU AU2022235555A patent/AU2022235555B2/en active Active
-
2024
- 2024-12-29 US US19/004,382 patent/US20250248937A1/en active Pending
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