JP2019502682A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019502682A5 JP2019502682A5 JP2018531107A JP2018531107A JP2019502682A5 JP 2019502682 A5 JP2019502682 A5 JP 2019502682A5 JP 2018531107 A JP2018531107 A JP 2018531107A JP 2018531107 A JP2018531107 A JP 2018531107A JP 2019502682 A5 JP2019502682 A5 JP 2019502682A5
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- nanoemulsion
- pressure vessel
- fluorocarbon
- bypass valve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 34
- 239000007908 nanoemulsion Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 17
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 15
- 150000003904 phospholipids Chemical class 0.000 claims 8
- NJCBUSHGCBERSK-UHFFFAOYSA-N perfluoropentane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F NJCBUSHGCBERSK-UHFFFAOYSA-N 0.000 claims 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 4
- 229930006000 Sucrose Natural products 0.000 claims 4
- 239000000337 buffer salt Substances 0.000 claims 4
- 239000000839 emulsion Substances 0.000 claims 4
- 239000005720 sucrose Substances 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 238000000265 homogenisation Methods 0.000 claims 3
- 230000003641 microbiacidal effect Effects 0.000 claims 3
- 229940124561 microbicide Drugs 0.000 claims 3
- -1 perfluoro -n- hexyl Chemical group 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- 230000001954 sterilising effect Effects 0.000 claims 3
- 238000004659 sterilization and disinfection Methods 0.000 claims 3
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 2
- 229950010592 dodecafluoropentane Drugs 0.000 claims 2
- 229960004624 perflexane Drugs 0.000 claims 2
- ZJIJAJXFLBMLCK-UHFFFAOYSA-N perfluorohexane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F ZJIJAJXFLBMLCK-UHFFFAOYSA-N 0.000 claims 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000011345 viscous material Substances 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 229940075564 anhydrous dibasic sodium phosphate Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000003139 biocide Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000002855 microbicide agent Substances 0.000 claims 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 claims 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims 1
- 235000019799 monosodium phosphate Nutrition 0.000 claims 1
- 229960004692 perflenapent Drugs 0.000 claims 1
- KAVGMUDTWQVPDF-UHFFFAOYSA-N perflubutane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)F KAVGMUDTWQVPDF-UHFFFAOYSA-N 0.000 claims 1
- 229950003332 perflubutane Drugs 0.000 claims 1
- LGUZHRODIJCVOC-UHFFFAOYSA-N perfluoroheptane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F LGUZHRODIJCVOC-UHFFFAOYSA-N 0.000 claims 1
- YVBBRRALBYAZBM-UHFFFAOYSA-N perfluorooctane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F YVBBRRALBYAZBM-UHFFFAOYSA-N 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 1
- 238000003260 vortexing Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562270226P | 2015-12-21 | 2015-12-21 | |
| US62/270,226 | 2015-12-21 | ||
| PCT/US2016/067650 WO2017112614A1 (en) | 2015-12-21 | 2016-12-20 | Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019502682A JP2019502682A (ja) | 2019-01-31 |
| JP2019502682A5 true JP2019502682A5 (enExample) | 2020-01-16 |
| JP6936226B2 JP6936226B2 (ja) | 2021-09-15 |
Family
ID=59089857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531107A Active JP6936226B2 (ja) | 2015-12-21 | 2016-12-20 | フルオロカーボンナノエマルジョンの組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11304899B2 (enExample) |
| EP (1) | EP3393459A4 (enExample) |
| JP (1) | JP6936226B2 (enExample) |
| KR (2) | KR20240100472A (enExample) |
| CN (2) | CN108697664A (enExample) |
| AU (2) | AU2016377361B2 (enExample) |
| BR (1) | BR112018012618A2 (enExample) |
| CA (1) | CA3009404C (enExample) |
| EA (1) | EA201891296A1 (enExample) |
| IL (2) | IL260206B2 (enExample) |
| WO (1) | WO2017112614A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102342326B1 (ko) * | 2020-12-11 | 2021-12-23 | 애경케미칼주식회사 | 계면장력이 우수한 불소계 계면활성제 조성물 |
| KR102342324B1 (ko) | 2020-12-11 | 2021-12-23 | 애경케미칼주식회사 | 불소계 계면활성제 조성물 |
| AU2024260092A1 (en) * | 2023-04-26 | 2025-10-23 | Swaza Inc. | Nanoparticle composition for oxygen delivery |
| CN116622338A (zh) * | 2023-06-05 | 2023-08-22 | 西安科技大学 | 井下复合型降尘防爆一体化处理材料及其制备方法和应用 |
| KR20250101952A (ko) * | 2023-12-27 | 2025-07-04 | (주)아이엠디팜 | 과불화탄소와 카제인을 함유한 산소운반체 약학조성물 및 그의 제조방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
| US5846517A (en) * | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
| US20060003012A9 (en) * | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| JP6431671B2 (ja) * | 2011-03-04 | 2018-11-28 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | 発作および虚血療法としてのドデカフルオロペンタンエマルション |
| US10279053B2 (en) * | 2011-07-19 | 2019-05-07 | Nuvox Pharma Llc | Microbubble compositions, method of making same, and method using same |
| WO2013043236A1 (en) * | 2011-09-22 | 2013-03-28 | Rockland Technimed, Ltd. | Compositions and methods useful for realtime in situ physiological molecular imaging of oxygen metabolism |
| US8822549B2 (en) * | 2011-10-13 | 2014-09-02 | Jennifer L. Johnson | Buffered oxygen therapeutic |
| JP6728050B2 (ja) * | 2014-03-05 | 2020-07-22 | アンガー， エヴァン， シー．ＵＮＧＥＲ， Ｅｖａｎ， Ｃ． | 分割放射線療法および化学療法と併用する酸素療法剤、その使用方法、およびそれを含む薬剤 |
| AU2015274259B2 (en) * | 2014-06-12 | 2019-04-18 | Evan C. Unger | Phospholipid composition and microbubbles and emulsions formed using same |
| HUE043680T2 (hu) * | 2014-12-18 | 2019-09-30 | Bracco Suisse Sa | Célbajuttató gázzal töltött mikrorészecske készítmény |
-
2016
- 2016-12-20 IL IL260206A patent/IL260206B2/en unknown
- 2016-12-20 KR KR1020247020626A patent/KR20240100472A/ko not_active Ceased
- 2016-12-20 AU AU2016377361A patent/AU2016377361B2/en active Active
- 2016-12-20 CN CN201680081126.3A patent/CN108697664A/zh active Pending
- 2016-12-20 JP JP2018531107A patent/JP6936226B2/ja active Active
- 2016-12-20 IL IL298236A patent/IL298236B2/en unknown
- 2016-12-20 WO PCT/US2016/067650 patent/WO2017112614A1/en not_active Ceased
- 2016-12-20 CN CN202410295358.5A patent/CN118662440A/zh active Pending
- 2016-12-20 CA CA3009404A patent/CA3009404C/en active Active
- 2016-12-20 US US16/060,950 patent/US11304899B2/en active Active
- 2016-12-20 EA EA201891296A patent/EA201891296A1/ru unknown
- 2016-12-20 KR KR1020187020326A patent/KR102679118B1/ko active Active
- 2016-12-20 BR BR112018012618A patent/BR112018012618A2/pt not_active Application Discontinuation
- 2016-12-20 EP EP16879945.0A patent/EP3393459A4/en active Pending
-
2022
- 2022-04-15 US US17/721,445 patent/US20220401364A1/en not_active Abandoned
- 2022-09-21 AU AU2022235555A patent/AU2022235555B2/en active Active
-
2024
- 2024-12-29 US US19/004,382 patent/US20250248937A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019502682A5 (enExample) | ||
| JP2022164892A (ja) | 眼科用水性組成物 | |
| JP6410889B2 (ja) | 注射用徐放性製剤 | |
| HRP20110271T1 (hr) | Farmaceutska kombinacija koja sadrži 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol i nsaid (nesteroidni antiinflamatorni lijek) | |
| AR077338A1 (es) | Formulacion farmaceutica. procedimiento de preparacion. disolucion para perfusion. | |
| KR20190122255A (ko) | 고양이 코로나바이러스 감염의 치료 방법 | |
| RU2013121788A (ru) | Ингибиторы репликации вич | |
| JP2012519694A5 (enExample) | ||
| HRP20110076T1 (hr) | Farmaceutske kombinacije koje sadrže 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol i paracetamol | |
| JP2023052927A (ja) | 水性眼科組成物 | |
| JP2015530382A5 (enExample) | ||
| IL298899A (en) | A compound for the treatment of corona virus infections | |
| ES2685469T3 (es) | Suspensión y composición de torta que contienen derivado de carboestirilo y aceite de silicona y/o derivado de aceite de silicona | |
| Nakahara et al. | Fluorocarbon-hybrid pulmonary surfactants for replacement therapy-a Langmuir monolayer study | |
| DK168322B1 (da) | Ethanoliske opløsninger af oxazaphosphoriner med forbedret stabilitet | |
| CN102655859A (zh) | 病毒感染的组合疗法治疗 | |
| JP2017519568A5 (enExample) | ||
| UY29085A1 (es) | Derivados de pirimidina 4-sulfonamido sustituidos, compuestos intermedios para su preparación, procedimientos de preparación, composiciones medicinales conteniéndolos y aplicaci0nes | |
| TWI376240B (en) | Pyrazolone derivative emulsion formulations | |
| HRP20191044T1 (hr) | Oftalmološki pripravci i njihova uporaba | |
| JP2023126908A (ja) | 眼科組成物 | |
| MX2021003030A (es) | Composiciones farmaceuticas adecuadas para suministro articular y su uso en tratamiento de dolor de articulacion. | |
| JP7179154B2 (ja) | ウイルス送達用ポリマーナノ粒子組成物及びその製造方法 | |
| JP5369389B2 (ja) | 痔疾治療用組成物 | |
| Orizondo et al. | Characterization of a reverse-phase perfluorocarbon emulsion for the pulmonary delivery of tobramycin |