EA201891296A1 - Композиции фторуглеродных наноэмульсий, способы их получения и применения - Google Patents
Композиции фторуглеродных наноэмульсий, способы их получения и примененияInfo
- Publication number
- EA201891296A1 EA201891296A1 EA201891296A EA201891296A EA201891296A1 EA 201891296 A1 EA201891296 A1 EA 201891296A1 EA 201891296 A EA201891296 A EA 201891296A EA 201891296 A EA201891296 A EA 201891296A EA 201891296 A1 EA201891296 A1 EA 201891296A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- compositions
- emulsions
- fluoro
- production
- Prior art date
Links
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical group FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000007908 nanoemulsion Substances 0.000 title abstract 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L27/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
- C08L27/02—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L27/12—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment containing fluorine atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562270226P | 2015-12-21 | 2015-12-21 | |
| PCT/US2016/067650 WO2017112614A1 (en) | 2015-12-21 | 2016-12-20 | Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201891296A1 true EA201891296A1 (ru) | 2019-01-31 |
Family
ID=59089857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201891296A EA201891296A1 (ru) | 2015-12-21 | 2016-12-20 | Композиции фторуглеродных наноэмульсий, способы их получения и применения |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11304899B2 (enExample) |
| EP (1) | EP3393459A4 (enExample) |
| JP (1) | JP6936226B2 (enExample) |
| KR (2) | KR20240100472A (enExample) |
| CN (2) | CN108697664A (enExample) |
| AU (2) | AU2016377361B2 (enExample) |
| BR (1) | BR112018012618A2 (enExample) |
| CA (1) | CA3009404C (enExample) |
| EA (1) | EA201891296A1 (enExample) |
| IL (2) | IL260206B2 (enExample) |
| WO (1) | WO2017112614A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102342326B1 (ko) * | 2020-12-11 | 2021-12-23 | 애경케미칼주식회사 | 계면장력이 우수한 불소계 계면활성제 조성물 |
| KR102342324B1 (ko) | 2020-12-11 | 2021-12-23 | 애경케미칼주식회사 | 불소계 계면활성제 조성물 |
| AU2024260092A1 (en) * | 2023-04-26 | 2025-10-23 | Swaza Inc. | Nanoparticle composition for oxygen delivery |
| CN116622338A (zh) * | 2023-06-05 | 2023-08-22 | 西安科技大学 | 井下复合型降尘防爆一体化处理材料及其制备方法和应用 |
| KR20250101952A (ko) * | 2023-12-27 | 2025-07-04 | (주)아이엠디팜 | 과불화탄소와 카제인을 함유한 산소운반체 약학조성물 및 그의 제조방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
| US5846517A (en) * | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
| US20060003012A9 (en) * | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| JP6431671B2 (ja) * | 2011-03-04 | 2018-11-28 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | 発作および虚血療法としてのドデカフルオロペンタンエマルション |
| US10279053B2 (en) * | 2011-07-19 | 2019-05-07 | Nuvox Pharma Llc | Microbubble compositions, method of making same, and method using same |
| WO2013043236A1 (en) * | 2011-09-22 | 2013-03-28 | Rockland Technimed, Ltd. | Compositions and methods useful for realtime in situ physiological molecular imaging of oxygen metabolism |
| US8822549B2 (en) * | 2011-10-13 | 2014-09-02 | Jennifer L. Johnson | Buffered oxygen therapeutic |
| JP6728050B2 (ja) * | 2014-03-05 | 2020-07-22 | アンガー, エヴァン, シー.UNGER, Evan, C. | 分割放射線療法および化学療法と併用する酸素療法剤、その使用方法、およびそれを含む薬剤 |
| AU2015274259B2 (en) * | 2014-06-12 | 2019-04-18 | Evan C. Unger | Phospholipid composition and microbubbles and emulsions formed using same |
| HUE043680T2 (hu) * | 2014-12-18 | 2019-09-30 | Bracco Suisse Sa | Célbajuttató gázzal töltött mikrorészecske készítmény |
-
2016
- 2016-12-20 IL IL260206A patent/IL260206B2/en unknown
- 2016-12-20 KR KR1020247020626A patent/KR20240100472A/ko not_active Ceased
- 2016-12-20 AU AU2016377361A patent/AU2016377361B2/en active Active
- 2016-12-20 CN CN201680081126.3A patent/CN108697664A/zh active Pending
- 2016-12-20 JP JP2018531107A patent/JP6936226B2/ja active Active
- 2016-12-20 IL IL298236A patent/IL298236B2/en unknown
- 2016-12-20 WO PCT/US2016/067650 patent/WO2017112614A1/en not_active Ceased
- 2016-12-20 CN CN202410295358.5A patent/CN118662440A/zh active Pending
- 2016-12-20 CA CA3009404A patent/CA3009404C/en active Active
- 2016-12-20 US US16/060,950 patent/US11304899B2/en active Active
- 2016-12-20 EA EA201891296A patent/EA201891296A1/ru unknown
- 2016-12-20 KR KR1020187020326A patent/KR102679118B1/ko active Active
- 2016-12-20 BR BR112018012618A patent/BR112018012618A2/pt not_active Application Discontinuation
- 2016-12-20 EP EP16879945.0A patent/EP3393459A4/en active Pending
-
2022
- 2022-04-15 US US17/721,445 patent/US20220401364A1/en not_active Abandoned
- 2022-09-21 AU AU2022235555A patent/AU2022235555B2/en active Active
-
2024
- 2024-12-29 US US19/004,382 patent/US20250248937A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017112614A1 (en) | 2017-06-29 |
| US20220401364A1 (en) | 2022-12-22 |
| BR112018012618A2 (pt) | 2018-12-04 |
| CN118662440A (zh) | 2024-09-20 |
| CA3009404C (en) | 2023-12-12 |
| IL260206A (en) | 2018-07-31 |
| EP3393459A4 (en) | 2019-10-02 |
| AU2016377361A1 (en) | 2018-07-05 |
| IL298236A (en) | 2023-01-01 |
| US20180360754A1 (en) | 2018-12-20 |
| AU2016377361B2 (en) | 2022-07-07 |
| KR102679118B1 (ko) | 2024-06-26 |
| AU2022235555B2 (en) | 2024-11-14 |
| KR20240100472A (ko) | 2024-07-01 |
| KR20180132605A (ko) | 2018-12-12 |
| IL298236B1 (en) | 2024-01-01 |
| IL260206B (en) | 2022-12-01 |
| JP6936226B2 (ja) | 2021-09-15 |
| US20250248937A1 (en) | 2025-08-07 |
| IL298236B2 (en) | 2024-05-01 |
| JP2019502682A (ja) | 2019-01-31 |
| AU2022235555A1 (en) | 2022-10-13 |
| CN108697664A (zh) | 2018-10-23 |
| EP3393459A1 (en) | 2018-10-31 |
| US11304899B2 (en) | 2022-04-19 |
| CA3009404A1 (en) | 2017-06-29 |
| IL260206B2 (en) | 2023-04-01 |
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