JP2019502404A5 - - Google Patents
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- Publication number
- JP2019502404A5 JP2019502404A5 JP2018548264A JP2018548264A JP2019502404A5 JP 2019502404 A5 JP2019502404 A5 JP 2019502404A5 JP 2018548264 A JP2018548264 A JP 2018548264A JP 2018548264 A JP2018548264 A JP 2018548264A JP 2019502404 A5 JP2019502404 A5 JP 2019502404A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- hpv11
- mutant
- variant
- hpv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims 25
- 102000004169 proteins and genes Human genes 0.000 claims 25
- 208000009608 Papillomavirus Infections Diseases 0.000 claims 8
- 125000000539 amino acid group Chemical group 0.000 claims 8
- 208000022361 Human papillomavirus infectious disease Diseases 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 241000588724 Escherichia coli Species 0.000 claims 4
- 108700025391 Human papillomavirus type 6 L1 Proteins 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000006166 lysate Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000006228 supernatant Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510887801.9 | 2015-12-04 | ||
| CN201510887801 | 2015-12-04 | ||
| PCT/CN2016/108349 WO2017092711A1 (zh) | 2015-12-04 | 2016-12-02 | 一种人乳头瘤病毒11型l1蛋白的突变体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019502404A JP2019502404A (ja) | 2019-01-31 |
| JP2019502404A5 true JP2019502404A5 (https=) | 2019-08-08 |
| JP6920694B2 JP6920694B2 (ja) | 2021-08-18 |
Family
ID=58796324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018548264A Active JP6920694B2 (ja) | 2015-12-04 | 2016-12-02 | ヒトパピローマウイルスタイプ１１のｌ１タンパク質の突然変異 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10513541B2 (https=) |
| EP (1) | EP3385274B1 (https=) |
| JP (1) | JP6920694B2 (https=) |
| KR (1) | KR102777995B1 (https=) |
| CN (1) | CN106831958B (https=) |
| WO (1) | WO2017092711A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114127095B (zh) * | 2019-07-19 | 2024-04-09 | 神州细胞工程有限公司 | 嵌合的人乳头瘤病毒11型l1蛋白 |
| WO2021013067A1 (zh) * | 2019-07-19 | 2021-01-28 | 神州细胞工程有限公司 | 嵌合的人乳头瘤病毒6型l1蛋白 |
| BR112022022719A2 (pt) | 2020-05-14 | 2023-02-14 | Inovio Pharmaceuticals Inc | Vacinas para papilomatose respiratória recorrente e métodos de usar a mesma |
| CN114539363B (zh) * | 2020-11-26 | 2023-12-01 | 中国医学科学院基础医学研究所 | 一种c端改造的人乳头瘤病毒11型l1蛋白及其用途 |
| KR102833970B1 (ko) | 2022-02-23 | 2025-07-17 | 충남대학교산학협력단 | 핵수송 신호 펩타이드가 접합된 핵산 전달용 2세대 폴리아미도아민 덴드리머 고분자 유도체 |
| CN116041445B (zh) * | 2023-01-06 | 2023-09-05 | 北京康乐卫士生物技术股份有限公司 | 一种人乳头瘤病毒51型l1蛋白突变体及减少重组蛋白降解的方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117591A0 (en) | 1995-03-30 | 1996-07-23 | Merck & Co Inc | Synthetic DNA encoding human papillomavirus type 11 L1 protein |
| US5795754A (en) * | 1995-07-19 | 1998-08-18 | Merck & Co., Inc. | Synthetic HPV11 virus-like particles |
| ATE258222T1 (de) * | 1995-11-15 | 2004-02-15 | Merck & Co Inc | Synthetische hpv11 virusartige partikel |
| US5738853A (en) * | 1995-11-15 | 1998-04-14 | Merck & Co., Inc. | Synthetic HPV11 virus-like particles |
| AUPP765398A0 (en) * | 1998-12-11 | 1999-01-14 | University Of Queensland, The | Treatment of papillomavirus infections |
| US6689366B1 (en) * | 1998-12-17 | 2004-02-10 | Merck & Co., Inc. | Synthetic virus like particles with heterologous epitopes |
| DK2154149T3 (da) * | 2007-05-29 | 2019-10-14 | Univ Xiamen | En trunkeret l1-protein af human papillomavirus 6 |
| BRPI0810959B1 (pt) * | 2007-05-29 | 2021-06-29 | Xiamen Innovax Biotech Co., Ltd. | Proteína l1 do hpv11, polinucleotídeo, vetor, célula, composição, partícula do tipo vírus (vlp) hpv11, método para produzir uma proteína l1 do hpv, vacina para prevenção de condiloma acuminado ou de infecções por hpv e método para produzir uma vacina para prevenção de condiloma acuminado ou infecções por hpv |
| CN101518647A (zh) * | 2008-02-29 | 2009-09-02 | 江阴艾托金生物技术有限公司 | 人乳头瘤病毒预防性疫苗、构建方法及应用 |
| NO2324113T3 (https=) * | 2008-08-08 | 2018-07-28 | ||
| CN102229660B (zh) * | 2011-05-25 | 2015-04-22 | 厦门大学 | 截短的人乳头瘤病毒33型l1蛋白 |
| CN102747047B (zh) * | 2012-02-28 | 2016-03-23 | 厦门大学 | 人乳头瘤病毒型别杂合病毒样颗粒及其制备方法 |
| CN104211782B (zh) * | 2013-06-04 | 2017-11-17 | 厦门大学 | 截短的人乳头瘤病毒45型l1蛋白 |
-
2016
- 2016-12-02 JP JP2018548264A patent/JP6920694B2/ja active Active
- 2016-12-02 US US15/781,328 patent/US10513541B2/en active Active
- 2016-12-02 WO PCT/CN2016/108349 patent/WO2017092711A1/zh not_active Ceased
- 2016-12-02 CN CN201611095116.3A patent/CN106831958B/zh active Active
- 2016-12-02 EP EP16870021.9A patent/EP3385274B1/en active Active
- 2016-12-02 KR KR1020187018923A patent/KR102777995B1/ko active Active
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