JP2019501948A5 - - Google Patents
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- Publication number
- JP2019501948A5 JP2019501948A5 JP2018537469A JP2018537469A JP2019501948A5 JP 2019501948 A5 JP2019501948 A5 JP 2019501948A5 JP 2018537469 A JP2018537469 A JP 2018537469A JP 2018537469 A JP2018537469 A JP 2018537469A JP 2019501948 A5 JP2019501948 A5 JP 2019501948A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutical composition
- inhibitor
- composition according
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 C 1 to C 4 acyloxy Chemical group 0.000 claims description 22
- 229910052739 hydrogen Inorganic materials 0.000 claims description 21
- 239000001257 hydrogen Substances 0.000 claims description 21
- 150000001875 compounds Chemical class 0.000 claims description 12
- 125000005843 halogen group Chemical group 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 6
- 125000005842 heteroatom Chemical group 0.000 claims description 5
- 150000002431 hydrogen Chemical class 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 5
- 229910052717 sulfur Inorganic materials 0.000 claims description 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 102000004890 Interleukin-8 Human genes 0.000 claims 13
- 108090001007 Interleukin-8 Proteins 0.000 claims 13
- 239000003112 inhibitor Substances 0.000 claims 13
- 238000002512 chemotherapy Methods 0.000 claims 4
- 208000033808 peripheral neuropathy Diseases 0.000 claims 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 3
- 159000000000 sodium salts Chemical class 0.000 claims 3
- 108010018976 Interleukin-8A Receptors Proteins 0.000 claims 2
- 229940123237 Taxane Drugs 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- YPGCWEMNNLXISK-UHFFFAOYSA-N hydratropic acid Chemical group OC(=O)C(C)C1=CC=CC=C1 YPGCWEMNNLXISK-UHFFFAOYSA-N 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 229910052697 platinum Inorganic materials 0.000 claims 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
- 125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 claims 2
- OUGCUPYREMACGK-ZETCQYMHSA-N (2s)-2-[4-[[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino]phenyl]propanoic acid Chemical group C1=CC([C@@H](C(O)=O)C)=CC=C1NC1=NC(C(F)(F)F)=CS1 OUGCUPYREMACGK-ZETCQYMHSA-N 0.000 claims 1
- TVKXUJXIOMUVFS-UHFFFAOYSA-N 2-methyl-2-[4-[[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino]phenyl]propanoic acid Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1NC1=NC(C(F)(F)F)=CS1 TVKXUJXIOMUVFS-UHFFFAOYSA-N 0.000 claims 1
- 208000004454 Hyperalgesia Diseases 0.000 claims 1
- 108010018951 Interleukin-8B Receptors Proteins 0.000 claims 1
- 102000002791 Interleukin-8B Receptors Human genes 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 206010053552 allodynia Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000000973 chemotherapeutic effect Effects 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 208000020911 optic nerve disease Diseases 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical group O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 0 CC(*)(C(*)*)C(CC1)=CC=C1N(*)C1=NC(**)=C*1 Chemical compound CC(*)(C(*)*)C(CC1)=CC=C1N(*)C1=NC(**)=C*1 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16151618.2A EP3192504A1 (en) | 2016-01-15 | 2016-01-15 | Il-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy |
| EP16151618.2 | 2016-01-15 | ||
| EP16190871 | 2016-09-27 | ||
| EP16190871.0 | 2016-09-27 | ||
| PCT/EP2017/050637 WO2017121838A1 (en) | 2016-01-15 | 2017-01-13 | Il-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501948A JP2019501948A (ja) | 2019-01-24 |
| JP2019501948A5 true JP2019501948A5 (OSRAM) | 2021-12-02 |
| JP7049254B2 JP7049254B2 (ja) | 2022-04-06 |
Family
ID=57906595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018537469A Active JP7049254B2 (ja) | 2016-01-15 | 2017-01-13 | 化学療法で誘導される末梢神経障害の治療に使用するためのｉｌ－８阻害剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US12268671B2 (OSRAM) |
| EP (1) | EP3402474B1 (OSRAM) |
| JP (1) | JP7049254B2 (OSRAM) |
| KR (1) | KR102737378B1 (OSRAM) |
| CN (1) | CN108463219B (OSRAM) |
| AU (1) | AU2017207850B2 (OSRAM) |
| CA (1) | CA3009438A1 (OSRAM) |
| CY (1) | CY1125297T1 (OSRAM) |
| DK (1) | DK3402474T3 (OSRAM) |
| ES (1) | ES2893701T3 (OSRAM) |
| HR (1) | HRP20211527T1 (OSRAM) |
| HU (1) | HUE056606T2 (OSRAM) |
| IL (1) | IL260373B (OSRAM) |
| LT (1) | LT3402474T (OSRAM) |
| MA (1) | MA43861A (OSRAM) |
| MX (1) | MX388815B (OSRAM) |
| PL (1) | PL3402474T3 (OSRAM) |
| RS (1) | RS62427B1 (OSRAM) |
| SG (1) | SG11201804484YA (OSRAM) |
| SI (1) | SI3402474T1 (OSRAM) |
| SM (1) | SMT202100571T1 (OSRAM) |
| WO (1) | WO2017121838A1 (OSRAM) |
| ZA (1) | ZA201803486B (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101914358B1 (ko) * | 2017-01-18 | 2018-11-02 | 현대로템 주식회사 | 실내등 제어회로 및 이를 포함하는 철도차량 |
| EP3476390A1 (en) | 2017-10-24 | 2019-05-01 | Dompé farmaceutici S.p.A. | Il-8 inhibitors for use in the treatment of sarcomas |
| CN111343973A (zh) * | 2017-10-24 | 2020-06-26 | 多姆皮制药公司 | 用于治疗一些肉瘤的il-8抑制剂 |
| EP3498269A1 (en) * | 2017-12-12 | 2019-06-19 | Dompé farmaceutici S.p.A. | C5ar inhibitors for use in the treatment of chemotherapy-induced iatrogenic pain |
| WO2022098822A1 (en) * | 2020-11-05 | 2022-05-12 | Icahn School Of Medicine At Mount Sinai | Cxcr1/cxcr2 inhibitors for use in treating myelofibrosis |
| EP4397305A1 (en) * | 2023-01-05 | 2024-07-10 | Dompe' Farmaceutici S.P.A. | Cxcl8 inhibitors for use in the treatment of ocular mucous membrane pemphigoid and/or oral mucous membrane pemphigoid |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1303249B1 (it) | 1998-10-23 | 2000-11-06 | Dompe Spa | Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono. |
| PL1776336T3 (pl) | 2004-03-23 | 2010-06-30 | Dompe Farm Spa | Pochodne kwasu 2-fenylopropionowego i zawierające je kompozycje farmaceutyczne |
| JP2010504996A (ja) * | 2006-09-26 | 2010-02-18 | ケース ウエスタン リザーブ ユニバーシティ | サイトカインシグナリング |
| EP2166006A1 (en) | 2008-09-18 | 2010-03-24 | Dompe' S.P.A. | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them |
| CR20160557A (es) | 2014-05-29 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Compuestos derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arilsulfonil)fenil)urea como inhibidores cxcr2 |
| CA2956785A1 (en) * | 2014-07-31 | 2016-02-04 | Glaxosmithkline Intellectual Property Development Limited | Use of cxcr2 antagonists for the prevention and/or treatment of chemotherapy induced peripheral neuropathy (cipn) |
-
2017
- 2017-01-13 ES ES17701646T patent/ES2893701T3/es active Active
- 2017-01-13 SG SG11201804484YA patent/SG11201804484YA/en unknown
- 2017-01-13 AU AU2017207850A patent/AU2017207850B2/en active Active
- 2017-01-13 HU HUE17701646A patent/HUE056606T2/hu unknown
- 2017-01-13 RS RS20211209A patent/RS62427B1/sr unknown
- 2017-01-13 LT LTEPPCT/EP2017/050637T patent/LT3402474T/lt unknown
- 2017-01-13 CN CN201780005946.9A patent/CN108463219B/zh active Active
- 2017-01-13 MA MA043861A patent/MA43861A/fr unknown
- 2017-01-13 US US16/066,072 patent/US12268671B2/en active Active
- 2017-01-13 SM SM20210571T patent/SMT202100571T1/it unknown
- 2017-01-13 EP EP17701646.6A patent/EP3402474B1/en active Active
- 2017-01-13 DK DK17701646.6T patent/DK3402474T3/da active
- 2017-01-13 JP JP2018537469A patent/JP7049254B2/ja active Active
- 2017-01-13 PL PL17701646T patent/PL3402474T3/pl unknown
- 2017-01-13 HR HRP20211527TT patent/HRP20211527T1/hr unknown
- 2017-01-13 MX MX2018008614A patent/MX388815B/es unknown
- 2017-01-13 KR KR1020187019923A patent/KR102737378B1/ko active Active
- 2017-01-13 WO PCT/EP2017/050637 patent/WO2017121838A1/en not_active Ceased
- 2017-01-13 SI SI201730924T patent/SI3402474T1/sl unknown
- 2017-01-13 CA CA3009438A patent/CA3009438A1/en active Pending
-
2018
- 2018-05-25 ZA ZA2018/03486A patent/ZA201803486B/en unknown
- 2018-07-02 IL IL260373A patent/IL260373B/en active IP Right Grant
-
2021
- 2021-10-14 CY CY20211100886T patent/CY1125297T1/el unknown
-
2025
- 2025-02-27 US US19/064,835 patent/US20250195479A1/en active Pending
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