JP2019163319A5 - - Google Patents

Info

Publication number

JP2019163319A5

JP2019163319A5 JP2019104081A JP2019104081A JP2019163319A5 JP 2019163319 A5 JP2019163319 A5 JP 2019163319A5 JP 2019104081 A JP2019104081 A JP 2019104081A JP 2019104081 A JP2019104081 A JP 2019104081A JP 2019163319 A5 JP2019163319 A5 JP 2019163319A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

acid sequence

region

sequence shown

Prior art date

2019-06-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 40
• 239000007864 aqueous solution Substances 0.000 claims 20
• 102000004965 antibodies Human genes 0.000 claims 16
• 108090001123 antibodies Proteins 0.000 claims 16
• 229920002574 CR-39 Polymers 0.000 claims 10
• 239000003814 drug Substances 0.000 claims 8
• 229940079593 drugs Drugs 0.000 claims 6
• FBPFZTCFMRRESA-KAZBKCHUSA-N D-Mannitol Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 claims 4
• CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 4
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 4
• FBPFZTCFMRRESA-KVTDHHQDSA-N Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 4
• CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 4
• 239000000594 mannitol Substances 0.000 claims 4
• 235000010355 mannitol Nutrition 0.000 claims 4
• 239000005720 sucrose Substances 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 238000006467 substitution reaction Methods 0.000 claims 2
• 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
• MFRNYXJJRJQHNW-DEMKXPNLSA-N (2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFRNYXJJRJQHNW-DEMKXPNLSA-N 0.000 claims 1
• DASWEROEPLKSEI-UIJRFTGLSA-N Monomethyl auristatin E Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1 DASWEROEPLKSEI-UIJRFTGLSA-N 0.000 claims 1
• 230000004075 alteration Effects 0.000 claims 1
• 108010044540 auristatin Proteins 0.000 claims 1
• 230000002209 hydrophobic Effects 0.000 claims 1