JP2019038829A5 - - Google Patents
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- Publication number
- JP2019038829A5 JP2019038829A5 JP2018202024A JP2018202024A JP2019038829A5 JP 2019038829 A5 JP2019038829 A5 JP 2019038829A5 JP 2018202024 A JP2018202024 A JP 2018202024A JP 2018202024 A JP2018202024 A JP 2018202024A JP 2019038829 A5 JP2019038829 A5 JP 2019038829A5
- Authority
- JP
- Japan
- Prior art keywords
- represented
- formula
- compound
- disease
- neurodegenerative disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 14
- 230000004770 neurodegeneration Effects 0.000 claims 8
- 208000015122 neurodegenerative disease Diseases 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 4
- 208000027747 Kennedy disease Diseases 0.000 claims 4
- 208000029402 Bulbospinal muscular atrophy Diseases 0.000 claims 2
- 206010068597 Bulbospinal muscular atrophy congenital Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 239000003098 androgen Substances 0.000 claims 2
- -1 purine skeleton compound Chemical class 0.000 claims 2
- 208000002320 spinal muscular atrophy Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- UYODNJZBUUEXPC-UHFFFAOYSA-N 9-[2-(2,2-dimethylpropylamino)ethyl]-8-[(6-iodo-1,3-benzodioxol-5-yl)sulfanyl]purin-6-amine Chemical compound N1=CN=C2N(CCNCC(C)(C)C)C(SC=3C(=CC=4OCOC=4C=3)I)=NC2=C1N UYODNJZBUUEXPC-UHFFFAOYSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000027089 Parkinsonian disease Diseases 0.000 claims 1
- 206010034010 Parkinsonism Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80642706P | 2006-06-30 | 2006-06-30 | |
| US60/806,427 | 2006-06-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017110721A Division JP6427227B2 (ja) | 2006-06-30 | 2017-06-05 | Ｈｓｐ９０の阻害による神経変性疾患の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019038829A JP2019038829A (ja) | 2019-03-14 |
| JP2019038829A5 true JP2019038829A5 (https=) | 2019-05-09 |
| JP6585266B2 JP6585266B2 (ja) | 2019-10-02 |
Family
ID=38895418
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009518602A Expired - Fee Related JP5599610B2 (ja) | 2006-06-30 | 2007-07-02 | Ｈｓｐ９０の阻害による神経変性疾患の処置 |
| JP2013058040A Expired - Fee Related JP5824698B2 (ja) | 2006-06-30 | 2013-03-21 | Ｈｓｐ９０の阻害による神経変性疾患の処置 |
| JP2015174609A Pending JP2016028063A (ja) | 2006-06-30 | 2015-09-04 | Ｈｓｐ９０の阻害による神経変性疾患の処置 |
| JP2017110721A Expired - Fee Related JP6427227B2 (ja) | 2006-06-30 | 2017-06-05 | Ｈｓｐ９０の阻害による神経変性疾患の処置 |
| JP2018202024A Expired - Fee Related JP6585266B2 (ja) | 2006-06-30 | 2018-10-26 | Ｈｓｐ９０の阻害による神経変性疾患の処置 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009518602A Expired - Fee Related JP5599610B2 (ja) | 2006-06-30 | 2007-07-02 | Ｈｓｐ９０の阻害による神経変性疾患の処置 |
| JP2013058040A Expired - Fee Related JP5824698B2 (ja) | 2006-06-30 | 2013-03-21 | Ｈｓｐ９０の阻害による神経変性疾患の処置 |
| JP2015174609A Pending JP2016028063A (ja) | 2006-06-30 | 2015-09-04 | Ｈｓｐ９０の阻害による神経変性疾患の処置 |
| JP2017110721A Expired - Fee Related JP6427227B2 (ja) | 2006-06-30 | 2017-06-05 | Ｈｓｐ９０の阻害による神経変性疾患の処置 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US10336757B2 (https=) |
| EP (2) | EP3305297A1 (https=) |
| JP (5) | JP5599610B2 (https=) |
| AU (1) | AU2007269144B2 (https=) |
| CA (1) | CA2656202C (https=) |
| DK (1) | DK2034839T3 (https=) |
| ES (1) | ES2645095T3 (https=) |
| WO (1) | WO2008005937A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7834181B2 (en) | 2005-02-01 | 2010-11-16 | Slaon-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| US9403828B2 (en) | 2005-02-01 | 2016-08-02 | Sloan-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| WO2007134298A2 (en) * | 2006-05-12 | 2007-11-22 | Myriad Genetics, Inc. | Therapeutic compounds and their use in cancer |
| WO2008005937A2 (en) * | 2006-06-30 | 2008-01-10 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases through inhibiton of hsp90 |
| KR101313804B1 (ko) | 2007-03-20 | 2013-10-01 | 쿠리스 인코퍼레이션 | Ｈｓｐ９０ 억제제로서의 융합된 아미노 피리딘 |
| NZ586129A (en) * | 2007-11-14 | 2012-06-29 | Myrexis Inc | Therapeutic compounds and their use in treating diseases and disorders |
| US20090258869A1 (en) * | 2008-02-08 | 2009-10-15 | The Regents Of The University Of California | Methods and compounds for treatment or prevention of substance-related disorders |
| US8540985B2 (en) | 2008-06-26 | 2013-09-24 | Orphazyme Aps | Use of Hsp70 as a regulator of enzymatic activity |
| EP2440204B1 (en) | 2009-06-12 | 2013-12-18 | Bristol-Myers Squibb Company | Nicotinamide compounds useful as kinase modulators |
| JP5941407B2 (ja) | 2009-10-07 | 2016-06-29 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | Ｈｓｐ９０阻害剤 |
| AU2013204109B2 (en) * | 2009-10-07 | 2016-05-05 | Sloan-Kettering Institute For Cancer Research | Purine derivatives useful as hsp90 inhibitors |
| RU2013125923A (ru) | 2010-11-30 | 2015-01-10 | Орфазиме Апс | СПОСОБЫ УВЕЛИЧЕНИЯ ВНУТРИКЛЕТОЧНОЙ АКТИВНОСТИ Hsp70 |
| JP6266506B2 (ja) | 2011-04-05 | 2018-01-24 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | Ｈｓｐ９０阻害物質 |
| CN103596955B (zh) | 2011-04-05 | 2016-11-16 | 索隆-基特林癌症研究协会 | Hsp90抑制剂 |
| EA201490230A1 (ru) | 2011-07-08 | 2014-06-30 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисерч | Применение меченых ингибиторов hsp90 |
| US20140079636A1 (en) | 2012-04-16 | 2014-03-20 | Dinesh U. Chimmanamada | Targeted therapeutics |
| WO2014025395A1 (en) | 2012-08-06 | 2014-02-13 | Duke University | Compounds and methods for targeting hsp90 |
| CA2897279C (en) | 2013-01-23 | 2020-12-29 | Astrazeneca Ab | Aminopyrazine derivatives and pharmaceutical compositions thereof for use in the treatment of cancer |
| EP2972394A4 (en) | 2013-03-15 | 2016-11-02 | Sloan Kettering Inst Cancer | HSP90-DESIGNING AND THERAPY |
| SG11201601542SA (en) | 2013-08-16 | 2016-04-28 | Sloan Kettering Inst Cancer | Selective grp94 inhibitors and uses thereof |
| EP3738594A1 (en) | 2013-09-10 | 2020-11-18 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics having an hsp90 ligand as binding moiety |
| WO2015066053A2 (en) | 2013-10-28 | 2015-05-07 | Synta Pharmaceuticals Corp. | Targeted therapeutics |
| WO2015138039A1 (en) | 2013-12-23 | 2015-09-17 | Memorial Sloan-Kettering Cancer Center | Methods and reagents for radiolabeling |
| EP3099332A4 (en) | 2014-01-29 | 2017-06-21 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics |
| JP6576942B6 (ja) | 2014-03-03 | 2019-11-27 | マドリガル ファーマシューティカルズ インコーポレイテッド | 標的治療薬 |
| MA39483A (fr) | 2014-03-18 | 2015-09-24 | Synta Pharmaceuticals Corp | Agents thérapeutiques cibles |
| US10709700B2 (en) | 2014-09-15 | 2020-07-14 | Orphazyme A/S | Arimoclomol formulation |
| MX387627B (es) | 2014-09-17 | 2025-03-18 | Memorial Sloan Kettering Cancer Center | Formación de imágenes de inflamación e infección dirigida a hsp90 y terapia |
| US20180280397A1 (en) | 2015-10-05 | 2018-10-04 | Memorial Sloan Kettering Cancer Center | Rational combination therapy for the treatment of cancer |
| EP3442530A1 (en) | 2016-04-13 | 2019-02-20 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
| US11261187B2 (en) | 2016-04-22 | 2022-03-01 | Duke University | Compounds and methods for targeting HSP90 |
| KR20210059796A (ko) | 2016-04-29 | 2021-05-25 | 오르파짐 에이/에스 | 글루코세레브로시다제 연관 장애를 치료하기 위한 아리모클로몰 |
| LT3483164T (lt) | 2017-03-20 | 2020-05-11 | Forma Therapeutics, Inc. | Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai |
| KR20190138871A (ko) * | 2017-04-24 | 2019-12-16 | 사무스 테라퓨틱스, 인코포레이티드 | Hsp90 저해제 경구 제형 및 관련 방법 |
| CA3067572A1 (en) | 2017-06-20 | 2018-12-27 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics |
| KR20200016874A (ko) | 2017-06-20 | 2020-02-17 | 마드리갈 파마슈티칼스 인코포레이티드 | 표적화 치료제를 포함하는 병용 요법 |
| CN111683658A (zh) * | 2017-06-23 | 2020-09-18 | 萨缪斯治疗股份有限公司 | 用于创伤性脑损伤及其后遗症的多蛋白复合物抑制剂疗法 |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| EP3853206B1 (en) | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Treating sickle cell disease with a pyruvate kinase r activating compound |
| EP3852791B1 (en) | 2018-09-19 | 2024-07-03 | Novo Nordisk Health Care AG | Activating pyruvate kinase r |
| HRP20251148T1 (hr) | 2019-09-19 | 2025-11-21 | Novo Nordisk Health Care Ag | Pripravci koji aktiviraju piruvat-kinazu r (pkr) |
| KR20230128462A (ko) | 2020-11-19 | 2023-09-05 | 제브라 덴마크 에이/에스 | 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정 |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2287387C (en) | 1997-05-14 | 2010-02-16 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for destruction of selected proteins |
| JP2002541255A (ja) | 1999-04-09 | 2002-12-03 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | Ｈｅｒ族チロシンキナーゼの分解および／または阻害方法および組成物 |
| US7439359B2 (en) | 2000-11-02 | 2008-10-21 | Sloan-Kettering Institute For Cancer Research | Small molecule compositions for binding to hsp90 |
| WO2002094259A1 (en) * | 2001-05-03 | 2002-11-28 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Compounds that inhibit hsp90 and stimulate hsp70 and hsp40, useful in the prevention or treatment of diseases associated with protein aggregation and amyloid formation |
| WO2003037860A2 (en) * | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
| EP1450784A4 (en) | 2001-11-09 | 2005-02-09 | Conforma Therapeutics Corp | HSP90-INHIBITABLE ZEARALANOL COMPOUNDS AND METHOD FOR THEIR PREPARATION AND USE |
| CN1649866A (zh) | 2002-02-28 | 2005-08-03 | 阿斯特拉曾尼卡有限公司 | 3－环状基－5－(含氮5－元环)甲基－噁唑烷酮衍生物及其作为抗菌药物的用途 |
| EP1620564A4 (en) | 2003-04-18 | 2008-03-12 | Cytovia Inc | METHOD FOR TREATING DISEASES RESPONSING TO APOPTOSIS INDUCTION AND SCREENING TESTS |
| GB0315111D0 (en) | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
| US20070178537A1 (en) | 2003-06-30 | 2007-08-02 | Sloan-Kettering Institute For Cancer Research | Assays for detection of bioactive compounds that interact with heat shock protein 90 |
| MXPA06002997A (es) | 2003-09-18 | 2007-02-08 | Conforma Therapeutics Corp | Novedosos compuestos heterociclicos como inhibidores- hsp90. |
| US7834181B2 (en) | 2005-02-01 | 2010-11-16 | Slaon-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| US9403828B2 (en) | 2005-02-01 | 2016-08-02 | Sloan-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| GEP20104994B (en) | 2005-02-25 | 2010-05-25 | Serenex Inc | Tetrahydroindolone and tetrahydroindazolone derivatives |
| WO2006130469A1 (en) | 2005-05-27 | 2006-12-07 | Oregon Health & Science University | Stimulation of neurite outgrowth by small molecules |
| US20110263693A1 (en) | 2006-03-31 | 2011-10-27 | Dana-Farber Cancer Institute, Inc. | Celastrol, gedunin, and derivatives thereof as hsp90 inhibitors |
| WO2007134298A2 (en) | 2006-05-12 | 2007-11-22 | Myriad Genetics, Inc. | Therapeutic compounds and their use in cancer |
| WO2008005937A2 (en) * | 2006-06-30 | 2008-01-10 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases through inhibiton of hsp90 |
| WO2008013985A2 (en) | 2006-07-27 | 2008-01-31 | University Of Florida | Use of heat shock activators for tissue regeneration |
| WO2008033747A2 (en) | 2006-09-11 | 2008-03-20 | Curis, Inc. | Multi-functional small molecules as anti-proliferative agents |
| CL2007002994A1 (es) | 2006-10-19 | 2008-02-08 | Wyeth Corp | Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros. |
| GB0622084D0 (en) | 2006-11-06 | 2006-12-13 | Chroma Therapeutics Ltd | Inhibitors of HSP90 |
| US8580519B2 (en) | 2006-11-27 | 2013-11-12 | University Of Maryland, Baltimore | Use of plasma HSP90 related to malignancy |
| KR101313804B1 (ko) | 2007-03-20 | 2013-10-01 | 쿠리스 인코퍼레이션 | Ｈｓｐ９０ 억제제로서의 융합된 아미노 피리딘 |
| WO2008115262A2 (en) | 2007-03-20 | 2008-09-25 | Curis, Inc. | Hsp90 inhibitors containing a zinc binding moiety |
| WO2009007399A1 (en) | 2007-07-12 | 2009-01-15 | Crystax Pharmaceuticals, S.L. | New compounds as hsp90 inhibitors |
| WO2009042646A1 (en) | 2007-09-24 | 2009-04-02 | Curis, Inc. | Anti-proliferative agents |
| NZ586129A (en) | 2007-11-14 | 2012-06-29 | Myrexis Inc | Therapeutic compounds and their use in treating diseases and disorders |
| JP5941407B2 (ja) | 2009-10-07 | 2016-06-29 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | Ｈｓｐ９０阻害剤 |
| JP6266506B2 (ja) | 2011-04-05 | 2018-01-24 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | Ｈｓｐ９０阻害物質 |
| CN103596955B (zh) | 2011-04-05 | 2016-11-16 | 索隆-基特林癌症研究协会 | Hsp90抑制剂 |
| SG11201601542SA (en) | 2013-08-16 | 2016-04-28 | Sloan Kettering Inst Cancer | Selective grp94 inhibitors and uses thereof |
-
2007
- 2007-07-02 WO PCT/US2007/072671 patent/WO2008005937A2/en not_active Ceased
- 2007-07-02 EP EP17177927.5A patent/EP3305297A1/en not_active Withdrawn
- 2007-07-02 US US12/307,063 patent/US10336757B2/en active Active
- 2007-07-02 EP EP07812557.2A patent/EP2034839B1/en active Active
- 2007-07-02 JP JP2009518602A patent/JP5599610B2/ja not_active Expired - Fee Related
- 2007-07-02 CA CA2656202A patent/CA2656202C/en active Active
- 2007-07-02 DK DK07812557.2T patent/DK2034839T3/en active
- 2007-07-02 AU AU2007269144A patent/AU2007269144B2/en not_active Ceased
- 2007-07-02 ES ES07812557.2T patent/ES2645095T3/es active Active
-
2013
- 2013-03-21 JP JP2013058040A patent/JP5824698B2/ja not_active Expired - Fee Related
-
2014
- 2014-09-10 US US14/482,628 patent/US20140378452A1/en not_active Abandoned
-
2015
- 2015-09-04 JP JP2015174609A patent/JP2016028063A/ja active Pending
-
2017
- 2017-06-05 JP JP2017110721A patent/JP6427227B2/ja not_active Expired - Fee Related
-
2018
- 2018-10-26 JP JP2018202024A patent/JP6585266B2/ja not_active Expired - Fee Related
-
2019
- 2019-04-30 US US16/398,650 patent/US20190389864A1/en not_active Abandoned
-
2021
- 2021-10-15 US US17/502,563 patent/US20230060990A1/en not_active Abandoned
-
2023
- 2023-05-26 US US18/202,704 patent/US12473288B2/en active Active
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