JP2017505811A5 - - Google Patents
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- Publication number
- JP2017505811A5 JP2017505811A5 JP2016565117A JP2016565117A JP2017505811A5 JP 2017505811 A5 JP2017505811 A5 JP 2017505811A5 JP 2016565117 A JP2016565117 A JP 2016565117A JP 2016565117 A JP2016565117 A JP 2016565117A JP 2017505811 A5 JP2017505811 A5 JP 2017505811A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- glyceryl
- patient
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- HIZCTWCPHWUPFU-UHFFFAOYSA-N Glycerol tribenzoate Chemical compound C=1C=CC=CC=1C(=O)OCC(OC(=O)C=1C=CC=CC=1)COC(=O)C1=CC=CC=C1 HIZCTWCPHWUPFU-UHFFFAOYSA-N 0.000 claims 6
- 208000028547 Inborn Urea Cycle disease Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- -1 glyceryl dibenzoate compound Chemical class 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 208000030954 urea cycle disease Diseases 0.000 claims 4
- ITRIWXSLDIKBHK-UHFFFAOYSA-N (3-benzoyloxy-2-hydroxypropyl) benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC(O)COC(=O)C1=CC=CC=C1 ITRIWXSLDIKBHK-UHFFFAOYSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 102000007610 Amino-acid N-acetyltransferase Human genes 0.000 claims 2
- 108010032178 Amino-acid N-acetyltransferase Proteins 0.000 claims 2
- 101710191958 Amino-acid acetyltransferase Proteins 0.000 claims 2
- 208000000044 Amnesia Diseases 0.000 claims 2
- 102100021723 Arginase-1 Human genes 0.000 claims 2
- 101710129000 Arginase-1 Proteins 0.000 claims 2
- 102000009042 Argininosuccinate Lyase Human genes 0.000 claims 2
- 102000053640 Argininosuccinate synthases Human genes 0.000 claims 2
- 108700024106 Argininosuccinate synthases Proteins 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 2
- 208000026139 Memory disease Diseases 0.000 claims 2
- 101000859568 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) Carbamoyl-phosphate synthase Proteins 0.000 claims 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000006984 memory degeneration Effects 0.000 claims 2
- 208000023060 memory loss Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 229960003104 ornithine Drugs 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461928622P | 2014-01-17 | 2014-01-17 | |
| US61/928,622 | 2014-01-17 | ||
| PCT/US2015/011798 WO2015109215A1 (en) | 2014-01-17 | 2015-01-16 | The use of a benzoate containing composition in urea cycle disorders and neurodegenerativre disordrs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019191224A Division JP2020037558A (ja) | 2014-01-17 | 2019-10-18 | 尿素サイクル障害及び神経変性障害におけるベンゾエート含有組成物の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505811A JP2017505811A (ja) | 2017-02-23 |
| JP2017505811A5 true JP2017505811A5 (https=) | 2018-02-22 |
| JP6836905B2 JP6836905B2 (ja) | 2021-03-03 |
Family
ID=53543490
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565117A Active JP6836905B2 (ja) | 2014-01-17 | 2015-01-16 | 尿素サイクル障害及び神経変性障害におけるベンゾエート含有組成物の使用 |
| JP2019191224A Pending JP2020037558A (ja) | 2014-01-17 | 2019-10-18 | 尿素サイクル障害及び神経変性障害におけるベンゾエート含有組成物の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019191224A Pending JP2020037558A (ja) | 2014-01-17 | 2019-10-18 | 尿素サイクル障害及び神経変性障害におけるベンゾエート含有組成物の使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9968582B2 (https=) |
| EP (1) | EP3094616B1 (https=) |
| JP (2) | JP6836905B2 (https=) |
| CA (1) | CA2936548C (https=) |
| CY (1) | CY1124115T1 (https=) |
| DK (1) | DK3094616T3 (https=) |
| ES (1) | ES2853974T3 (https=) |
| HR (1) | HRP20210361T1 (https=) |
| HU (1) | HUE053671T2 (https=) |
| LT (1) | LT3094616T (https=) |
| PL (1) | PL3094616T3 (https=) |
| PT (1) | PT3094616T (https=) |
| RS (1) | RS61611B1 (https=) |
| SI (1) | SI3094616T1 (https=) |
| SM (1) | SMT202100074T1 (https=) |
| WO (1) | WO2015109215A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3691630A4 (en) * | 2017-10-06 | 2021-10-27 | Rush University Medical Center | USE OF A COMPOSITION CONTAINING BENZOATE TO TREAT GLYCINE ENCEPHALOPATHY |
| TWI752282B (zh) * | 2017-11-22 | 2022-01-11 | 林潔欣 | 苯甲酸或其鹽及衍生物用於預防或治療憂鬱症之用途 |
| WO2020176432A1 (en) * | 2019-02-25 | 2020-09-03 | Rush University Medical Center | Compositions including cinnamic acid and methods of use thereof |
| AU2020315331A1 (en) * | 2019-07-16 | 2022-02-03 | Rush University Medical Center | Use of a benzoate containing composition to treat neurodegenerative disorders |
| CN116390761A (zh) * | 2020-10-28 | 2023-07-04 | 拉什大学医学中心 | 肉桂酸苄酯组合物在治疗甘氨酸脑病和尿素循环障碍中的应用 |
| CA3205005A1 (en) * | 2020-12-16 | 2022-06-23 | Rush University Medical Center | Administration of glycerol tribenzoate and glycerol phenylbutyrate for treatment of neurodegenerative and urea cycle disorders |
| CA3241282A1 (en) * | 2021-12-16 | 2023-06-22 | Kalipada PAHAN | Benzoic acid salts for treatment of nervous system injuries and disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4284647A (en) * | 1980-03-31 | 1981-08-18 | The Johns Hopkins University | Process for waste nitrogen removal |
| US20080171792A1 (en) | 2006-12-28 | 2008-07-17 | Jobdevairakkam Christopher New | Use of highly concentrated formulations of 4-phenylbutyrate for treatment of certain disorders |
-
2015
- 2015-01-16 JP JP2016565117A patent/JP6836905B2/ja active Active
- 2015-01-16 LT LTEP15737329.1T patent/LT3094616T/lt unknown
- 2015-01-16 PT PT157373291T patent/PT3094616T/pt unknown
- 2015-01-16 RS RS20210230A patent/RS61611B1/sr unknown
- 2015-01-16 WO PCT/US2015/011798 patent/WO2015109215A1/en not_active Ceased
- 2015-01-16 SM SM20210074T patent/SMT202100074T1/it unknown
- 2015-01-16 ES ES15737329T patent/ES2853974T3/es active Active
- 2015-01-16 PL PL15737329T patent/PL3094616T3/pl unknown
- 2015-01-16 HU HUE15737329A patent/HUE053671T2/hu unknown
- 2015-01-16 HR HRP20210361TT patent/HRP20210361T1/hr unknown
- 2015-01-16 DK DK15737329.1T patent/DK3094616T3/da active
- 2015-01-16 EP EP15737329.1A patent/EP3094616B1/en active Active
- 2015-01-16 US US15/110,702 patent/US9968582B2/en active Active
- 2015-01-16 CA CA2936548A patent/CA2936548C/en active Active
- 2015-01-16 SI SI201531511T patent/SI3094616T1/sl unknown
-
2019
- 2019-10-18 JP JP2019191224A patent/JP2020037558A/ja active Pending
-
2021
- 2021-03-09 CY CY20211100204T patent/CY1124115T1/el unknown
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