JP2017505811A5 - - Google Patents
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- Publication number
- JP2017505811A5 JP2017505811A5 JP2016565117A JP2016565117A JP2017505811A5 JP 2017505811 A5 JP2017505811 A5 JP 2017505811A5 JP 2016565117 A JP2016565117 A JP 2016565117A JP 2016565117 A JP2016565117 A JP 2016565117A JP 2017505811 A5 JP2017505811 A5 JP 2017505811A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- glyceryl
- patient
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- HIZCTWCPHWUPFU-UHFFFAOYSA-N Glycerol tribenzoate Chemical compound C=1C=CC=CC=1C(=O)OCC(OC(=O)C=1C=CC=CC=1)COC(=O)C1=CC=CC=C1 HIZCTWCPHWUPFU-UHFFFAOYSA-N 0.000 claims 6
- 208000028547 Inborn Urea Cycle disease Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- -1 glyceryl dibenzoate compound Chemical class 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 208000030954 urea cycle disease Diseases 0.000 claims 4
- ITRIWXSLDIKBHK-UHFFFAOYSA-N (3-benzoyloxy-2-hydroxypropyl) benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC(O)COC(=O)C1=CC=CC=C1 ITRIWXSLDIKBHK-UHFFFAOYSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 102000007610 Amino-acid N-acetyltransferase Human genes 0.000 claims 2
- 108010032178 Amino-acid N-acetyltransferase Proteins 0.000 claims 2
- 101710191958 Amino-acid acetyltransferase Proteins 0.000 claims 2
- 208000000044 Amnesia Diseases 0.000 claims 2
- 102100021723 Arginase-1 Human genes 0.000 claims 2
- 101710129000 Arginase-1 Proteins 0.000 claims 2
- 102000009042 Argininosuccinate Lyase Human genes 0.000 claims 2
- 102000053640 Argininosuccinate synthases Human genes 0.000 claims 2
- 108700024106 Argininosuccinate synthases Proteins 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 2
- 208000026139 Memory disease Diseases 0.000 claims 2
- 101000859568 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) Carbamoyl-phosphate synthase Proteins 0.000 claims 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000006984 memory degeneration Effects 0.000 claims 2
- 208000023060 memory loss Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 229960003104 ornithine Drugs 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461928622P | 2014-01-17 | 2014-01-17 | |
| US61/928,622 | 2014-01-17 | ||
| PCT/US2015/011798 WO2015109215A1 (en) | 2014-01-17 | 2015-01-16 | The use of a benzoate containing composition in urea cycle disorders and neurodegenerativre disordrs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019191224A Division JP2020037558A (ja) | 2014-01-17 | 2019-10-18 | 尿素サイクル障害及び神経変性障害におけるベンゾエート含有組成物の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505811A JP2017505811A (ja) | 2017-02-23 |
| JP2017505811A5 true JP2017505811A5 (https=) | 2018-02-22 |
| JP6836905B2 JP6836905B2 (ja) | 2021-03-03 |
Family
ID=53543490
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565117A Active JP6836905B2 (ja) | 2014-01-17 | 2015-01-16 | 尿素サイクル障害及び神経変性障害におけるベンゾエート含有組成物の使用 |
| JP2019191224A Pending JP2020037558A (ja) | 2014-01-17 | 2019-10-18 | 尿素サイクル障害及び神経変性障害におけるベンゾエート含有組成物の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019191224A Pending JP2020037558A (ja) | 2014-01-17 | 2019-10-18 | 尿素サイクル障害及び神経変性障害におけるベンゾエート含有組成物の使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9968582B2 (https=) |
| EP (1) | EP3094616B1 (https=) |
| JP (2) | JP6836905B2 (https=) |
| CA (1) | CA2936548C (https=) |
| CY (1) | CY1124115T1 (https=) |
| DK (1) | DK3094616T3 (https=) |
| ES (1) | ES2853974T3 (https=) |
| HR (1) | HRP20210361T1 (https=) |
| HU (1) | HUE053671T2 (https=) |
| LT (1) | LT3094616T (https=) |
| PL (1) | PL3094616T3 (https=) |
| PT (1) | PT3094616T (https=) |
| RS (1) | RS61611B1 (https=) |
| SI (1) | SI3094616T1 (https=) |
| SM (1) | SMT202100074T1 (https=) |
| WO (1) | WO2015109215A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA202090666A1 (ru) * | 2017-10-06 | 2020-08-05 | Раш Юниверсити Медикал Сентер | Применение содержащей бензоат композиции для лечения глициновой энцефалопатии |
| JP7034314B2 (ja) * | 2017-11-22 | 2022-03-11 | 潔欣 林 | うつ病を予防または治療するための安息香酸またはその塩および誘導体 |
| US12478598B2 (en) | 2019-02-25 | 2025-11-25 | Rush University Medical Center | Compositions including cinnamic acid and methods of use thereof |
| CN114502154A (zh) * | 2019-07-16 | 2022-05-13 | 拉什大学医学中心 | 含苯甲酸酯的组合物治疗神经退行性疾病的用途 |
| CN116390761A (zh) * | 2020-10-28 | 2023-07-04 | 拉什大学医学中心 | 肉桂酸苄酯组合物在治疗甘氨酸脑病和尿素循环障碍中的应用 |
| CA3205005A1 (en) * | 2020-12-16 | 2022-06-23 | Rush University Medical Center | Administration of glycerol tribenzoate and glycerol phenylbutyrate for treatment of neurodegenerative and urea cycle disorders |
| JP2025503457A (ja) * | 2021-12-16 | 2025-02-04 | ザ ユナイテッド ステイツ ガバメント アズ リプレゼンティド バイ ザ デパートメント オブ ヴェテランズ アフェアーズ | 神経系損傷及び障害の治療のための安息香酸塩 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4284647A (en) * | 1980-03-31 | 1981-08-18 | The Johns Hopkins University | Process for waste nitrogen removal |
| WO2008083226A2 (en) | 2006-12-28 | 2008-07-10 | Navinta Llc | Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate |
-
2015
- 2015-01-16 WO PCT/US2015/011798 patent/WO2015109215A1/en not_active Ceased
- 2015-01-16 CA CA2936548A patent/CA2936548C/en active Active
- 2015-01-16 PL PL15737329T patent/PL3094616T3/pl unknown
- 2015-01-16 DK DK15737329.1T patent/DK3094616T3/da active
- 2015-01-16 US US15/110,702 patent/US9968582B2/en active Active
- 2015-01-16 HR HRP20210361TT patent/HRP20210361T1/hr unknown
- 2015-01-16 SI SI201531511T patent/SI3094616T1/sl unknown
- 2015-01-16 EP EP15737329.1A patent/EP3094616B1/en active Active
- 2015-01-16 RS RS20210230A patent/RS61611B1/sr unknown
- 2015-01-16 SM SM20210074T patent/SMT202100074T1/it unknown
- 2015-01-16 ES ES15737329T patent/ES2853974T3/es active Active
- 2015-01-16 JP JP2016565117A patent/JP6836905B2/ja active Active
- 2015-01-16 PT PT157373291T patent/PT3094616T/pt unknown
- 2015-01-16 HU HUE15737329A patent/HUE053671T2/hu unknown
- 2015-01-16 LT LTEP15737329.1T patent/LT3094616T/lt unknown
-
2019
- 2019-10-18 JP JP2019191224A patent/JP2020037558A/ja active Pending
-
2021
- 2021-03-09 CY CY20211100204T patent/CY1124115T1/el unknown
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