JP2019014754A5 - - Google Patents

Info

Publication number

JP2019014754A5

JP2019014754A5 JP2018204916A JP2018204916A JP2019014754A5 JP 2019014754 A5 JP2019014754 A5 JP 2019014754A5 JP 2018204916 A JP2018204916 A JP 2018204916A JP 2018204916 A JP2018204916 A JP 2018204916A JP 2019014754 A5 JP2019014754 A5 JP 2019014754A5

Authority

JP

Japan

Prior art keywords

biomedical device

hydrogel

biomedical

capsule

layer

Prior art date

2018-10-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000017 hydrogel Substances 0.000 claims 15
• 239000002775 capsule Substances 0.000 claims 10
• 210000004027 cell Anatomy 0.000 claims 8
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 5
• 229940072056 alginate Drugs 0.000 claims 5
• 235000010443 alginic acid Nutrition 0.000 claims 5
• 229920000615 alginic acid Polymers 0.000 claims 5
• 239000000560 biocompatible material Substances 0.000 claims 5
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 230000001225 therapeutic effect Effects 0.000 claims 4
• 229920000447 polyanionic polymer Polymers 0.000 claims 3
• 229920000642 polymer Polymers 0.000 claims 3
• 239000002260 anti-inflammatory agent Substances 0.000 claims 2
• 238000002513 implantation Methods 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• 102000004877 Insulin Human genes 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• 102000000588 Interleukin-2 Human genes 0.000 claims 1
• 108010002350 Interleukin-2 Proteins 0.000 claims 1
• 108010039918 Polylysine Proteins 0.000 claims 1
• 239000004793 Polystyrene Substances 0.000 claims 1
• QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
• 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
• 230000003110 anti-inflammatory effect Effects 0.000 claims 1
• 230000001028 anti-proliverative effect Effects 0.000 claims 1
• 230000004888 barrier function Effects 0.000 claims 1
• 239000004621 biodegradable polymer Substances 0.000 claims 1
• 229920002988 biodegradable polymer Polymers 0.000 claims 1
• 239000012620 biological material Substances 0.000 claims 1
• 239000011258 core-shell material Substances 0.000 claims 1
• 238000004132 cross linking Methods 0.000 claims 1
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
• 229960003957 dexamethasone Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 230000003176 fibrotic effect Effects 0.000 claims 1
• 239000011521 glass Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 230000006698 induction Effects 0.000 claims 1
• 229940125396 insulin Drugs 0.000 claims 1
• 210000004153 islets of langerhan Anatomy 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 230000007935 neutral effect Effects 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 239000004033 plastic Substances 0.000 claims 1
• 229920003023 plastic Polymers 0.000 claims 1
• 229920001610 polycaprolactone Polymers 0.000 claims 1
• 239000004632 polycaprolactone Substances 0.000 claims 1
• 229920000656 polylysine Polymers 0.000 claims 1
• 229920002223 polystyrene Polymers 0.000 claims 1
• 239000011148 porous material Substances 0.000 claims 1
• 239000004065 semiconductor Substances 0.000 claims 1
• 230000003637 steroidlike Effects 0.000 claims 1
• 229960001967 tacrolimus Drugs 0.000 claims 1
• QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
• 230000017423 tissue regeneration Effects 0.000 claims 1