JP2019011316A - 肌改善用組成物 - Google Patents
肌改善用組成物 Download PDFInfo
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- JP2019011316A JP2019011316A JP2018123899A JP2018123899A JP2019011316A JP 2019011316 A JP2019011316 A JP 2019011316A JP 2018123899 A JP2018123899 A JP 2018123899A JP 2018123899 A JP2018123899 A JP 2018123899A JP 2019011316 A JP2019011316 A JP 2019011316A
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- JP
- Japan
- Prior art keywords
- skin
- composition
- improving
- proteoglycan
- lactic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
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Abstract
Description
項1.
プロテオグリカン、及び/又は
イチジクの乳酸菌醗酵物
を含有する、肌改善用組成物。
項2.
肌保湿用、又は肌バリア向上若しくは改善用である、項1に記載の肌改善用組成物。
項3.
皮膚水分蒸発量(TEWL)抑制用、及び/又は
角質水分量向上用である、
項1又は2に記載の肌改善用組成物。
項4.
イチジクの乳酸菌醗酵物が、イチジクのラクトバチルス・ペントサス醗酵物である、項1〜3のいずれかに記載の肌改善用組成物。
項5.
経口組成物である、項1〜4のいずれかに記載の肌改善用組成物。
項6.
プロテオグリカン、及び
イチジクの乳酸菌醗酵物
を含有する、項1〜5のいずれかに記載の肌改善用組成物。
国際公開第12/099216号の実施例における、凍結サケ鼻軟骨小片からプロテオグリカンを抽出する方法に準じてプロテオグリカンを調製した。具体的には、凍結サケ鼻軟骨を破砕機で2mm程度サイズに粗粉砕し、水および温水による洗浄後、2.5倍量の蒸留水を加えて95℃で3.5時間加熱し、加熱後、ろ過及び16000rpmの遠心分離により不要物(残渣)を除き、得られた上清を減圧濃縮により濃縮し、濃縮液を得た。下記のヒト試験には、当該濃縮液を凍結乾燥して得た凍結乾燥物を用いた。また、下記の大腸炎モデルマウスの検討には、当該濃縮液を水で希釈して用いた。
桝井ドーフィンのイチジクの花軸部分を除去し、水で洗浄した。水分を除去した後に、フードプロセッサーを用いて粉砕し、イチジクの全果破砕物を得た。当該イチジクの全果破砕物200gに対して、乳酸菌菌液を10g加え、均一になるように軽く混合した後、嫌気的条件下にて、30℃、24時間静置にて醗酵した。乳酸菌としては、ラクトバチルス・ペントサス(Lactobacillus pentosus)を使用した。醗酵処理においては、醗酵処理物のpH及び酸度を測定することにより醗酵処理の終点の確認を行った。得られた醗酵処理物を凍結乾燥させ、イチジクの乳酸菌醗酵物として用いた。
下記成分を含有する3種類のハードカプセルを調製した。
カプセル1(PG):上記プロテオグリカン(乾燥物)200mg及びデキストリン472.5mg/6粒あたり
カプセル2(イチジク):上記イチジクの乳酸菌醗酵物(乾燥物)472.5mg及びデキストリン472.5mg/6粒あたり
カプセル3(プラセボ):デキストリン472.5mg/3粒あたり
摂取開始時、摂取開始4週間目、及び摂取開始6週目に腕の皮膚の水分蒸散量(TEWL)及び角質水分量を測定した。
腸炎は、本来体内へ吸収すべきではない物質を吸収することにつながり、これによって体内での炎症が起こりやすくなり、結果として肌への悪影響を及ぼすと予測した。当該予測のもと、大腸炎誘発モデルヘアレスマウスに対する、プロテオグリカン及びイチジクの乳酸菌醗酵物の皮膚水分蒸散量(TEWL)増加抑制効果を検討した。
病態惹起物質:デキストラン硫酸(DSS)(分子量36000〜50000;MP Biomedicals)
試験群:4群(投与物質により群分け)
蒸留水群(陰性対照群)、
1.5%DSS群(陽性対照群)、
1.5%DSS+イチジクの乳酸菌醗酵物群(被験物質A投与群)、
1.5%DSS+プロテオグリカン群(被験物質B投与群)
測定項目:皮膚水分蒸散量(TEWL)
下記成分を含有する2種類のハードカプセルを調製した。
カプセル1(PG):上記プロテオグリカン(乾燥物)200mg及びデキストリン472.5mg/3粒あたり
カプセル3(プラセボ):デキストリン472.5mg/3粒あたり
Claims (6)
- プロテオグリカン、及び/又は
イチジクの乳酸菌醗酵物
を含有する、肌改善用組成物。 - 肌保湿用、又は肌バリア向上若しくは改善用である、請求項1に記載の肌改善用組成物。
- 皮膚水分蒸発量(TEWL)抑制用、及び/又は
角質水分量向上用である、
請求項1又は2に記載の肌改善用組成物。 - イチジクの乳酸菌醗酵物が、イチジクのラクトバチルス・ペントサス醗酵物である、請求項1〜3のいずれかに記載の肌改善用組成物。
- 経口組成物である、請求項1〜4のいずれかに記載の肌改善用組成物。
- プロテオグリカン、及び
イチジクの乳酸菌醗酵物
を含有する、請求項1〜5のいずれかに記載の肌改善用組成物。
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Citations (4)
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KR20070096163A (ko) * | 2006-03-21 | 2007-10-02 | 강종우 | 아토피 피부용 조성물 |
WO2012099224A1 (ja) * | 2011-01-19 | 2012-07-26 | 国立大学法人弘前大学 | 水棲動物軟骨抽出物 |
CN103798374A (zh) * | 2012-11-15 | 2014-05-21 | 邹金娥 | 一种无花果酸奶 |
JP2019011315A (ja) * | 2017-06-30 | 2019-01-24 | サンスター株式会社 | 腸バリア改善用組成物 |
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2018
- 2018-06-29 JP JP2018123899A patent/JP7182917B2/ja active Active
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KR20070096163A (ko) * | 2006-03-21 | 2007-10-02 | 강종우 | 아토피 피부용 조성물 |
WO2012099224A1 (ja) * | 2011-01-19 | 2012-07-26 | 国立大学法人弘前大学 | 水棲動物軟骨抽出物 |
CN103798374A (zh) * | 2012-11-15 | 2014-05-21 | 邹金娥 | 一种无花果酸奶 |
JP2019011315A (ja) * | 2017-06-30 | 2019-01-24 | サンスター株式会社 | 腸バリア改善用組成物 |
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FOOD STYLE 21, 2011, VOL.15, NO.5, PP.65-67, JPN6022020974, ISSN: 0004785817 * |
FRAGRANCE JOURNAL, 2014, VOL.42, NO.1, PP.38-43, JPN6022020977, ISSN: 0004785816 * |
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