JP2018538335A5 - - Google Patents
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- JP2018538335A5 JP2018538335A5 JP2018532639A JP2018532639A JP2018538335A5 JP 2018538335 A5 JP2018538335 A5 JP 2018538335A5 JP 2018532639 A JP2018532639 A JP 2018532639A JP 2018532639 A JP2018532639 A JP 2018532639A JP 2018538335 A5 JP2018538335 A5 JP 2018538335A5
- Authority
- JP
- Japan
- Prior art keywords
- gdf15
- therapeutic agent
- seq
- conjugate
- hgdf15
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562270967P | 2015-12-22 | 2015-12-22 | |
| US62/270,967 | 2015-12-22 | ||
| PCT/IB2016/057839 WO2017109706A1 (en) | 2015-12-22 | 2016-12-20 | Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018538335A JP2018538335A (ja) | 2018-12-27 |
| JP2018538335A5 true JP2018538335A5 (enExample) | 2020-01-30 |
| JP6946304B2 JP6946304B2 (ja) | 2021-10-06 |
Family
ID=57796765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532639A Expired - Fee Related JP6946304B2 (ja) | 2015-12-22 | 2016-12-20 | 増殖分化因子１５（ｇｄｆ−１５）を使用して代謝障害を処置するまたは軽快させる方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20190000923A1 (enExample) |
| EP (1) | EP3393494A1 (enExample) |
| JP (1) | JP6946304B2 (enExample) |
| CN (1) | CN108367053A (enExample) |
| WO (1) | WO2017109706A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2694092B1 (en) | 2011-04-08 | 2017-01-04 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
| WO2013148117A1 (en) | 2012-03-27 | 2013-10-03 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| WO2015017710A1 (en) | 2013-07-31 | 2015-02-05 | Amgen Inc. | Growth differentiation factor 15 (gdf-15) constructs |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| ES2883158T3 (es) | 2014-07-30 | 2021-12-07 | Ngm Biopharmaceuticals Inc | Composiciones y procedimientos de uso para el tratamiento de trastornos metabólicos |
| US10004596B2 (en) | 2014-07-31 | 2018-06-26 | Lensgen, Inc. | Accommodating intraocular lens device |
| AP2017009828A0 (en) | 2014-10-31 | 2017-03-31 | Ngm Biopharmaceuticals Inc | Compositions and methods of use for treating metabolic disorders |
| SG11201803359VA (en) * | 2015-10-23 | 2018-05-30 | Merus Nv | Binding molecules that inhibit cancer growth |
| BR112018072034A2 (pt) | 2016-05-24 | 2019-02-12 | Novo Nordisk A/S | compostos mic-1 e usos dos mesmos |
| MX2019005466A (es) * | 2016-11-13 | 2019-10-02 | Imagine Pharma | Composiciones y metodos para tratar diabetes, hipertension e hipercolesterolemia. |
| TWI710377B (zh) * | 2017-05-23 | 2020-11-21 | 丹麥商諾佛 儂迪克股份有限公司 | Ｍｉｃ－１化合物及其用途 |
| CN111163795A (zh) | 2017-09-10 | 2020-05-15 | 诺沃挪第克公司 | 用于治疗肥胖症的mic-1和glp-1 |
| TWI724392B (zh) * | 2018-04-06 | 2021-04-11 | 美商美國禮來大藥廠 | 生長分化因子15促效劑化合物及其使用方法 |
| AU2019253462B2 (en) | 2018-04-09 | 2025-04-24 | Amgen Inc. | Growth differentiation factor 15 fusion proteins |
| WO2020009740A2 (en) * | 2018-04-25 | 2020-01-09 | Washington University | Compositions and methods of use thereof for treatment of metabolic diseases and related disorders |
| AU2019317813A1 (en) | 2018-08-10 | 2021-02-11 | Novartis Ag | GFRAL extracellular domains and methods of use |
| CR20210193A (es) | 2018-10-22 | 2021-06-15 | Janssen Pharmaceutica Nv | Proteínas de fusión de péptido similar al glucagón 1 (glp1)-factor de diferenciación de crecimiento 15 (gdf15) y usos de estas |
| AU2019383019A1 (en) * | 2018-11-20 | 2021-06-03 | Janssen Pharmaceutica Nv | GDF15 analogs and methods for use in decreasing body weight and/or reducing food intake |
| WO2020152367A1 (en) | 2019-01-25 | 2020-07-30 | Ospedale San Raffaele S.R.L. | Inhibitor of dux4 and uses thereof |
| CA3136969A1 (en) * | 2019-04-23 | 2020-10-29 | Lg Chem, Ltd. | Fusion polypeptide comprising fc region of immunoglobulin and gdf15 |
| WO2021067655A1 (en) | 2019-10-04 | 2021-04-08 | Amgen Inc. | Use of gdf15 for treating cardiometabolic syndrome and other conditions |
| WO2021136223A1 (en) * | 2019-12-31 | 2021-07-08 | Beijing Ql Biopharmaceutical Co., Ltd. | Fusion proteins of glp-1 and gdf15 and conjugates thereof |
| WO2021139763A1 (zh) * | 2020-01-08 | 2021-07-15 | 上海翰森生物医药科技有限公司 | Fgf21突变体蛋白及其融合蛋白 |
| CN111333505B (zh) * | 2020-03-31 | 2022-07-26 | 东莞市东阳光生物药研发有限公司 | 制备长链脂肪二酸单苄酯的方法及其应用 |
| EP4237438A4 (en) * | 2020-10-27 | 2024-11-27 | Beijing QL Biopharmaceutical Co., Ltd. | GDF15 FUSION PROTEINS AND THEIR USE |
| KR102569644B1 (ko) * | 2020-10-30 | 2023-08-23 | 가톨릭대학교 산학협력단 | Gdf15를 유효성분으로 함유하는 면역질환의 예방 및 치료용 조성물 |
| WO2022219495A1 (en) | 2021-04-12 | 2022-10-20 | Novartis Ag | 2-((4-((s)-2-(4-chloro-2-fluorophenyl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((s)-oxetan-2-yl)methyl)-1h-imidazole derivatives as activators of the glp1 receptor for the treatment of obesity |
| JP2024519950A (ja) * | 2021-05-21 | 2024-05-21 | ユハン コーポレーション | Ｇｄｆ１５変異体及びｇｌｐ－１受容体作動薬を含む併用投与用組成物 |
| WO2022245183A1 (en) * | 2021-05-21 | 2022-11-24 | Yuhan Corporation | Composition for preventing or treating non-alcoholic fatty liver disease or non-alcoholic steatohepatitis comprising growth differentiation factor-15 variant |
| TW202342014A (zh) | 2022-02-10 | 2023-11-01 | 瑞士商諾華公司 | １，３－苯并二氧戊環衍生物 |
| WO2023154953A1 (en) | 2022-02-14 | 2023-08-17 | Ngm Biopharmaceuticals, Inc. | Gdf15 polypeptides for treating and preventing autoimmune diseases |
| EP4389762A1 (en) | 2022-12-23 | 2024-06-26 | Ospedale San Raffaele S.r.l. | Inhibitors of dux4 activity and their use in therapy. |
| CN118995820A (zh) * | 2024-10-22 | 2024-11-22 | 江苏凯基生物技术股份有限公司 | 一种生长分化因子-15及其制备方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
| ATE92107T1 (de) | 1989-04-29 | 1993-08-15 | Delta Biotechnology Ltd | N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen. |
| US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
| ATE423788T1 (de) | 1995-06-22 | 2009-03-15 | St Vincents Hosp Sydney | Neues tgf-beta-ahnliches cytokin |
| WO1998019523A1 (fr) * | 1996-11-01 | 1998-05-14 | Shionogi & Co., Ltd. | Souris modele pour maladies affectant l'homme |
| GB9912350D0 (en) * | 1999-05-26 | 1999-07-28 | European Molecular Biology Lab Embl | Modified cytokine |
| AU2001266557A1 (en) | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| DK2322631T3 (en) | 2001-04-19 | 2015-01-12 | Scripps Research Inst | Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA syntetasepar |
| FI117667B (fi) * | 2001-07-05 | 2007-01-15 | Univ Zuerich | Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä |
| EP1441589B1 (en) | 2001-11-08 | 2012-05-09 | Abbott Biotherapeutics Corp. | Stable liquid pharmaceutical formulation of igg antibodies |
| TW200303742A (en) | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
| AU2002364587A1 (en) | 2001-12-21 | 2003-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| WO2005077042A2 (en) | 2004-02-09 | 2005-08-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| PT1638963E (pt) | 2003-05-20 | 2009-11-18 | Novartis Ag | Heterociclos de azoto n-acilado como ligandos de receptores activados pelo proliferador peroxissomal |
| KR101241862B1 (ko) | 2003-09-19 | 2013-03-13 | 노보 노르디스크 에이/에스 | 신규 ｇｌｐ-1 유도체 |
| US8431558B2 (en) | 2004-11-01 | 2013-04-30 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| PE20071063A1 (es) | 2005-12-20 | 2007-10-24 | Bristol Myers Squibb Co | Formulaciones de proteinas estables |
| JP2011519569A (ja) * | 2008-05-06 | 2011-07-14 | エフ．ホフマン−ラ ロシュ アーゲー | 糖尿病用動物モデル |
| EA021001B1 (ru) | 2008-10-24 | 2015-03-31 | Новартис Аг | Биосинтетический пирролинкарбоксилизин и сайт-специфичные модификации белка за счет химической модификации остатков пирролинкарбоксилизина и пирролизина |
| US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| AU2012212047A1 (en) * | 2011-02-03 | 2013-08-22 | Xoma Technology Ltd. | Methods and materials for enhancing functional protein expression in bacteria |
| EP2694092B1 (en) * | 2011-04-08 | 2017-01-04 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
| US8658787B2 (en) * | 2011-09-16 | 2014-02-25 | Galectin Therapeutics Inc. | Galacto-rhamnogalacturonate compositions for the treatment of non-alcoholic steatohepatitis and non-alcoholic fatty liver disease |
| BR112014018575A2 (pt) | 2012-01-26 | 2017-07-04 | Amgen Inc | polipetídeos de fator de diferenciação de crescimento 15 (gdf-15) |
| WO2013148117A1 (en) * | 2012-03-27 | 2013-10-03 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| WO2014120619A2 (en) | 2013-01-30 | 2014-08-07 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use in treating metabolic disorders |
| WO2015017710A1 (en) | 2013-07-31 | 2015-02-05 | Amgen Inc. | Growth differentiation factor 15 (gdf-15) constructs |
| EA201790051A1 (ru) * | 2014-06-20 | 2017-04-28 | Авео Фармасьютикалз, Инк. | Лечение хронического заболевания почек и другого нарушения функции почек при помощи модулятора gdf15 |
| US20170107248A1 (en) | 2014-06-23 | 2017-04-20 | Novartis Ag | Site specific protein modifications |
| WO2015198199A1 (en) | 2014-06-23 | 2015-12-30 | Novartis Ag | Hsa-gdf-15 fusion polypeptide and use thereof. |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| EP3160496B1 (en) | 2014-06-24 | 2021-03-03 | Novo Nordisk As | Mic-1 fusion proteins and uses thereof |
| WO2016102580A1 (en) | 2014-12-22 | 2016-06-30 | Novo Nordisk A/S | Alpha-1-antitrypsin (a1at) fusion proteins and uses thereof |
-
2016
- 2016-12-20 JP JP2018532639A patent/JP6946304B2/ja not_active Expired - Fee Related
- 2016-12-20 EP EP16826174.1A patent/EP3393494A1/en not_active Withdrawn
- 2016-12-20 CN CN201680075098.4A patent/CN108367053A/zh active Pending
- 2016-12-20 WO PCT/IB2016/057839 patent/WO2017109706A1/en not_active Ceased
- 2016-12-20 US US16/064,054 patent/US20190000923A1/en not_active Abandoned
-
2022
- 2022-04-14 US US17/720,555 patent/US20220249614A1/en not_active Abandoned
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