JP2018536163A5 - - Google Patents
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- JP2018536163A5 JP2018536163A5 JP2018526566A JP2018526566A JP2018536163A5 JP 2018536163 A5 JP2018536163 A5 JP 2018536163A5 JP 2018526566 A JP2018526566 A JP 2018526566A JP 2018526566 A JP2018526566 A JP 2018526566A JP 2018536163 A5 JP2018536163 A5 JP 2018536163A5
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- JP
- Japan
- Prior art keywords
- dye
- primary antibody
- enzyme
- tissue sample
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000523 sample Substances 0.000 claims 21
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 16
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 16
- 102000004190 Enzymes Human genes 0.000 claims 14
- 108090000790 Enzymes Proteins 0.000 claims 14
- 210000002865 immune cell Anatomy 0.000 claims 14
- 238000000034 method Methods 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 239000002771 cell marker Substances 0.000 claims 8
- 238000001514 detection method Methods 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 7
- 238000000151 deposition Methods 0.000 claims 6
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 4
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 2
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 2
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims 2
- 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 claims 2
- 101710120843 Indoleamine 2,3-dioxygenase 1 Proteins 0.000 claims 2
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 2
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims 2
- 230000008021 deposition Effects 0.000 claims 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000002626 targeted therapy Methods 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 239000000439 tumor marker Substances 0.000 claims 2
- -1 FoxP3 Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562258493P | 2015-11-22 | 2015-11-22 | |
| US62/258,493 | 2015-11-22 | ||
| PCT/EP2016/078237 WO2017085307A1 (en) | 2015-11-22 | 2016-11-21 | Methods of identifying immune cells in pd-l1 positive tumor tissue |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018536163A JP2018536163A (ja) | 2018-12-06 |
| JP2018536163A5 true JP2018536163A5 (https=) | 2019-11-07 |
| JP6832930B2 JP6832930B2 (ja) | 2021-02-24 |
Family
ID=57391956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526566A Active JP6832930B2 (ja) | 2015-11-22 | 2016-11-21 | Ｐｄ−ｌ１陽性腫瘍組織における免疫細胞を同定する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11899016B2 (https=) |
| EP (1) | EP3377530B1 (https=) |
| JP (1) | JP6832930B2 (https=) |
| AU (1) | AU2016357478B2 (https=) |
| CA (1) | CA3005804C (https=) |
| ES (1) | ES2886600T3 (https=) |
| WO (1) | WO2017085307A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102389677B1 (ko) | 2013-03-15 | 2022-04-21 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
| ES2916923T3 (es) * | 2014-07-11 | 2022-07-06 | Ventana Med Syst Inc | Anticuerpos anti-PD-L1 y usos diagnósticos de los mismos |
| EP3596114A2 (en) | 2017-03-16 | 2020-01-22 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
| US12065476B2 (en) | 2018-06-15 | 2024-08-20 | Alpine Immune Sciences, Inc. | PD-1 variant immunomodulatory proteins and uses thereof |
| AU2019345151B2 (en) | 2018-09-19 | 2025-04-17 | Alpine Immune Sciences, Inc. | Methods and uses of variant CD80 fusion proteins and related constructs |
| JP7259019B2 (ja) | 2018-09-20 | 2023-04-17 | ヴェンタナ メディカル システムズ， インク． | フローサイトメトリデータを分析するためのサイズに基づくゲーティング |
| CN112789684B (zh) | 2018-10-01 | 2025-05-09 | 文塔纳医疗系统公司 | 用于预测对pd-1轴导向疗法的应答的方法和系统 |
| CN113383089A (zh) | 2018-11-29 | 2021-09-10 | 文塔纳医疗系统公司 | 经由代表性DNA测序进行个性化ctDNA疾病监测 |
| WO2021224293A1 (en) * | 2020-05-07 | 2021-11-11 | Ventana Medical Systems, Inc. | Histochemical systems and methods for evaluating egfr and egfr ligand expression in tumor samples |
| CN111830256A (zh) * | 2020-07-01 | 2020-10-27 | 北京基谱生物科技有限公司 | 一种石蜡切片免疫荧光多重染色试剂盒及使用方法 |
| JPWO2022059601A1 (https=) * | 2020-09-16 | 2022-03-24 | ||
| CN118786346A (zh) * | 2022-03-07 | 2024-10-15 | 阿斯利康(瑞典)有限公司 | 用于预测患者对免疫疗法的应答的方法 |
| WO2023172883A1 (en) | 2022-03-07 | 2023-09-14 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins of variant cd80 polypeptides, cell therapies thereof and related methods and uses |
| JP2025526652A (ja) * | 2022-08-08 | 2025-08-15 | ヴェンタナ メディカル システムズ， インク． | デジタル化された病理スライドの定量化のためのシステムおよび方法 |
| CN121368715A (zh) | 2023-04-13 | 2026-01-20 | 文塔纳医疗系统公司 | 用于固定的实体瘤的增殖测定 |
| WO2025193604A1 (en) | 2024-03-11 | 2025-09-18 | Ventana Medical Systems, Inc. | Non-enzymatic dissociation of ffpe tissue and generation of single cells with intact cell surface markers |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01004287A (es) * | 1998-10-26 | 2002-06-04 | Ventana Med Syst Inc | Deteccion del virus del papiloma humano en frotis de papanicolau (pap). |
| US6544798B1 (en) | 1999-02-26 | 2003-04-08 | Ventana Medical Systems, Inc. | Removal of embedding media from biological samples and cell conditioning on automated staining instruments |
| US6195451B1 (en) * | 1999-05-13 | 2001-02-27 | Advanced Pathology Ststems, Inc. | Transformation of digital images |
| US8071322B2 (en) * | 2002-11-12 | 2011-12-06 | Epitomics, Inc. | Method for identifying differentially expressed proteins |
| WO2012003476A2 (en) * | 2010-07-02 | 2012-01-05 | Ventana Medical Systems, Inc. | Hapten conjugates for target detection |
| EP2831587B1 (en) * | 2012-03-27 | 2018-05-16 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
| CN113967253A (zh) * | 2012-05-15 | 2022-01-25 | 百时美施贵宝公司 | 通过破坏pd-1/pd-l1信号传输的免疫治疗 |
| WO2014194293A1 (en) * | 2013-05-30 | 2014-12-04 | Amplimmune, Inc. | Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof |
| AU2014293154A1 (en) * | 2013-07-24 | 2016-02-18 | Dana-Farber Cancer Institute, Inc. | Anti-galectin-1 monoclonal antibodies and fragments thereof |
| EP3079772B1 (en) * | 2013-12-10 | 2020-02-05 | Merck Sharp & Dohme Corp. | Immunohistochemical proximity assay for pd-1 positive cells and pd-ligand positive cells in tumor tissue |
| WO2015124703A1 (en) * | 2014-02-24 | 2015-08-27 | Ventana Medical Systems, Inc. | Quinone methide analog signal amplification |
-
2016
- 2016-11-21 WO PCT/EP2016/078237 patent/WO2017085307A1/en not_active Ceased
- 2016-11-21 ES ES16800915T patent/ES2886600T3/es active Active
- 2016-11-21 CA CA3005804A patent/CA3005804C/en active Active
- 2016-11-21 AU AU2016357478A patent/AU2016357478B2/en active Active
- 2016-11-21 JP JP2018526566A patent/JP6832930B2/ja active Active
- 2016-11-21 EP EP16800915.7A patent/EP3377530B1/en active Active
-
2018
- 2018-05-21 US US15/985,638 patent/US11899016B2/en active Active
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