JP2018534243A5 - - Google Patents
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- Publication number
- JP2018534243A5 JP2018534243A5 JP2018511611A JP2018511611A JP2018534243A5 JP 2018534243 A5 JP2018534243 A5 JP 2018534243A5 JP 2018511611 A JP2018511611 A JP 2018511611A JP 2018511611 A JP2018511611 A JP 2018511611A JP 2018534243 A5 JP2018534243 A5 JP 2018534243A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrv
- refers
- isomer
- compound
- certain embodiments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 238000010992 reflux Methods 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- HIBLGLXUFLTKNR-UHFFFAOYSA-M 4-methylbenzenesulfonate N,N,1,2-tetramethylquinolin-1-ium-6-amine Chemical compound Cc1ccc(cc1)S([O-])(=O)=O.CN(C)c1ccc2[n+](C)c(C)ccc2c1 HIBLGLXUFLTKNR-UHFFFAOYSA-M 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- VUQUOGPMUUJORT-UHFFFAOYSA-N methyl 4-methylbenzenesulfonate Chemical compound COS(=O)(=O)C1=CC=C(C)C=C1 VUQUOGPMUUJORT-UHFFFAOYSA-N 0.000 description 1
- JGRWYZQONRFIFH-UHFFFAOYSA-N n,n,2-trimethylquinolin-6-amine Chemical compound N1=C(C)C=CC2=CC(N(C)C)=CC=C21 JGRWYZQONRFIFH-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562214613P | 2015-09-04 | 2015-09-04 | |
| US62/214,613 | 2015-09-04 | ||
| PCT/US2016/050270 WO2017041040A1 (en) | 2015-09-04 | 2016-09-02 | Androgen receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018534243A JP2018534243A (ja) | 2018-11-22 |
| JP2018534243A5 true JP2018534243A5 (enExample) | 2019-12-12 |
| JP6933644B2 JP6933644B2 (ja) | 2021-09-08 |
Family
ID=58188655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511611A Expired - Fee Related JP6933644B2 (ja) | 2015-09-04 | 2016-09-02 | アンドロゲン受容体拮抗薬 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10428048B2 (enExample) |
| EP (1) | EP3350167A4 (enExample) |
| JP (1) | JP6933644B2 (enExample) |
| CN (1) | CN108349900A (enExample) |
| WO (1) | WO2017041040A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10865184B2 (en) | 2015-04-21 | 2020-12-15 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
| US10654809B2 (en) | 2016-06-10 | 2020-05-19 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
| WO2019023651A2 (en) | 2017-07-28 | 2019-01-31 | Massachusetts Institute Of Technology | MODULATORS OF THE SMALL MOLECULE ANDROGEN RECEPTOR |
| EP3664783A1 (en) * | 2017-08-09 | 2020-06-17 | Nangenex Nanotechnology Incorporated | Pharmaceutical composition comprising abiraterone acetate and darulotamide |
| KR20220163435A (ko) * | 2020-04-02 | 2022-12-09 | 유니버시티 오브 테네시 리서치 파운데이션 | 피라졸릴프로판아미드 화합물 및 전립선암의 치료에서의 그 용도 |
| EP4023649A1 (en) | 2020-12-30 | 2022-07-06 | Industrial Technology Research Institute | Androgen receptor binding bifunctional molecules |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH509382A (it) | 1967-06-23 | 1971-06-30 | Crc Ricerca Chim | Metodo per l'ottenimento dei colori pirolchinolici e dei loro sali derivati |
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| EP0495421B1 (en) | 1991-01-15 | 1996-08-21 | Alcon Laboratories, Inc. | Use of carrageenans in topical ophthalmic compositions |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| WO2006078754A1 (en) * | 2005-01-18 | 2006-07-27 | Immusol Incorporated | Novel quinolinium salts and derivatives |
| CN101106992A (zh) * | 2005-01-18 | 2008-01-16 | 伊姆索公司 | 新颖的喹啉鎓盐和衍生物 |
| WO2008128100A1 (en) | 2007-04-13 | 2008-10-23 | The Regents Of The University Of California | Small-molecule inhibitors of the androgen receptor |
| JP5599385B2 (ja) | 2008-04-24 | 2014-10-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | アンドロゲンレセプターの小分子阻害剤 |
| KR102193461B1 (ko) * | 2014-04-24 | 2020-12-21 | 동아에스티 주식회사 | 퀴놀린계 화합물 및 이를 포함하는 선택적 안드로겐 수용체 효능제 |
-
2016
- 2016-09-02 CN CN201680064061.1A patent/CN108349900A/zh active Pending
- 2016-09-02 EP EP16843143.5A patent/EP3350167A4/en not_active Withdrawn
- 2016-09-02 US US15/757,238 patent/US10428048B2/en active Active
- 2016-09-02 WO PCT/US2016/050270 patent/WO2017041040A1/en not_active Ceased
- 2016-09-02 JP JP2018511611A patent/JP6933644B2/ja not_active Expired - Fee Related
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