CN108349900A - 雄激素受体拮抗剂 - Google Patents

雄激素受体拮抗剂 Download PDF

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Publication number
CN108349900A
CN108349900A CN201680064061.1A CN201680064061A CN108349900A CN 108349900 A CN108349900 A CN 108349900A CN 201680064061 A CN201680064061 A CN 201680064061A CN 108349900 A CN108349900 A CN 108349900A
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CN
China
Prior art keywords
unsubstituted
substituted
nhc
independently
alkyl
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Pending
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CN201680064061.1A
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English (en)
Chinese (zh)
Inventor
J·琼斯
S·K·帕尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
City of Hope
Original Assignee
City of Hope
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Application filed by City of Hope filed Critical City of Hope
Publication of CN108349900A publication Critical patent/CN108349900A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
CN201680064061.1A 2015-09-04 2016-09-02 雄激素受体拮抗剂 Pending CN108349900A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562214613P 2015-09-04 2015-09-04
US62/214,613 2015-09-04
PCT/US2016/050270 WO2017041040A1 (en) 2015-09-04 2016-09-02 Androgen receptor antagonists

Publications (1)

Publication Number Publication Date
CN108349900A true CN108349900A (zh) 2018-07-31

Family

ID=58188655

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680064061.1A Pending CN108349900A (zh) 2015-09-04 2016-09-02 雄激素受体拮抗剂

Country Status (5)

Country Link
US (1) US10428048B2 (enExample)
EP (1) EP3350167A4 (enExample)
JP (1) JP6933644B2 (enExample)
CN (1) CN108349900A (enExample)
WO (1) WO2017041040A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10865184B2 (en) 2015-04-21 2020-12-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10654809B2 (en) 2016-06-10 2020-05-19 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
WO2019023651A2 (en) 2017-07-28 2019-01-31 Massachusetts Institute Of Technology MODULATORS OF THE SMALL MOLECULE ANDROGEN RECEPTOR
US20200197416A1 (en) * 2017-08-09 2020-06-25 Nangenex Nanotechnology Incorporated Pharmaceutical composition comprising abiraterone acetate and darulotamide
MX2022012329A (es) * 2020-04-02 2022-12-13 Univ Tennessee Res Found Compuestos de pirazolilpropanamida y usos de los mismos para el tratamiento de cáncer de próstata.
US12152035B2 (en) 2020-12-30 2024-11-26 Industrial Technology Research Institute Androgen receptor binding molecule and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101106992A (zh) * 2005-01-18 2008-01-16 伊姆索公司 新颖的喹啉鎓盐和衍生物
WO2008128100A1 (en) * 2007-04-13 2008-10-23 The Regents Of The University Of California Small-molecule inhibitors of the androgen receptor
KR20150123006A (ko) * 2014-04-24 2015-11-03 동아에스티 주식회사 퀴놀린계 화합물 및 이를 포함하는 선택적 안드로겐 수용체 효능제

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH509382A (it) 1967-06-23 1971-06-30 Crc Ricerca Chim Metodo per l'ottenimento dei colori pirolchinolici e dei loro sali derivati
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
JP2594486B2 (ja) 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
JP2008527047A (ja) * 2005-01-18 2008-07-24 イミューソル インコーポレイテッド 新規キノリニウム塩及び誘導体
WO2009132307A1 (en) 2008-04-24 2009-10-29 The Regents Of The University Of California Small-molecule inhibitors of the androgen receptor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101106992A (zh) * 2005-01-18 2008-01-16 伊姆索公司 新颖的喹啉鎓盐和衍生物
WO2008128100A1 (en) * 2007-04-13 2008-10-23 The Regents Of The University Of California Small-molecule inhibitors of the androgen receptor
KR20150123006A (ko) * 2014-04-24 2015-11-03 동아에스티 주식회사 퀴놀린계 화합물 및 이를 포함하는 선택적 안드로겐 수용체 효능제

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FENGTIAN XUE ET AL.: "Concise Route to the Chiral Pyrrolidine Core of Selective Inhibitors of Neuronal Nitric Oxide", 《ORGANIC LETTERS》 *
王润玲主编: "《药物化学 第三版》", 31 October 2014, 中国医药科技出版社 *
贾娴主编: "《药物化学课堂笔记》", 31 January 2011, 人民出版社 *

Also Published As

Publication number Publication date
EP3350167A4 (en) 2019-04-03
WO2017041040A1 (en) 2017-03-09
US10428048B2 (en) 2019-10-01
JP6933644B2 (ja) 2021-09-08
US20180244650A1 (en) 2018-08-30
EP3350167A1 (en) 2018-07-25
JP2018534243A (ja) 2018-11-22

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