JP2018533963A5 - - Google Patents
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- Publication number
- JP2018533963A5 JP2018533963A5 JP2018526188A JP2018526188A JP2018533963A5 JP 2018533963 A5 JP2018533963 A5 JP 2018533963A5 JP 2018526188 A JP2018526188 A JP 2018526188A JP 2018526188 A JP2018526188 A JP 2018526188A JP 2018533963 A5 JP2018533963 A5 JP 2018533963A5
- Authority
- JP
- Japan
- Prior art keywords
- lag
- rodent
- polypeptide
- humanized
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562258181P | 2015-11-20 | 2015-11-20 | |
| US62/258,181 | 2015-11-20 | ||
| US201662370430P | 2016-08-03 | 2016-08-03 | |
| US62/370,430 | 2016-08-03 | ||
| PCT/US2016/062733 WO2017087780A1 (en) | 2015-11-20 | 2016-11-18 | Non-human animals having a humanized lymphocyte-activation gene 3 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533963A JP2018533963A (ja) | 2018-11-22 |
| JP2018533963A5 true JP2018533963A5 (https=) | 2019-12-12 |
| JP6997708B2 JP6997708B2 (ja) | 2022-02-04 |
Family
ID=57543170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526188A Active JP6997708B2 (ja) | 2015-11-20 | 2016-11-18 | ヒト化されたｌｙｍｐｈｏｃｙｔｅ－ａｃｔｉｖａｔｉｏｎ ｇｅｎｅ ３遺伝子を有する非ヒト動物 |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US10306874B2 (https=) |
| EP (1) | EP3376857B1 (https=) |
| JP (1) | JP6997708B2 (https=) |
| KR (1) | KR102454546B1 (https=) |
| CN (1) | CN108366548B (https=) |
| AU (1) | AU2016358101B2 (https=) |
| BR (1) | BR112018010158A2 (https=) |
| CA (1) | CA3003786C (https=) |
| CY (1) | CY1124171T1 (https=) |
| DK (1) | DK3376857T3 (https=) |
| ES (1) | ES2872799T3 (https=) |
| HR (1) | HRP20210824T1 (https=) |
| HU (1) | HUE054612T2 (https=) |
| IL (1) | IL258841B (https=) |
| LT (1) | LT3376857T (https=) |
| MX (1) | MX2018005389A (https=) |
| NZ (1) | NZ742447A (https=) |
| PL (1) | PL3376857T3 (https=) |
| PT (1) | PT3376857T (https=) |
| RS (1) | RS61866B1 (https=) |
| RU (1) | RU2745403C2 (https=) |
| SG (1) | SG11201803409UA (https=) |
| SI (1) | SI3376857T1 (https=) |
| SM (1) | SMT202100299T1 (https=) |
| WO (1) | WO2017087780A1 (https=) |
| ZA (1) | ZA201802717B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113412818B (zh) | 2014-12-09 | 2022-11-04 | 瑞泽恩制药公司 | 具有人源化分化簇274基因的非人动物 |
| WO2017087780A1 (en) | 2015-11-20 | 2017-05-26 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized lymphocyte-activation gene 3 |
| DK3422845T3 (da) | 2016-02-29 | 2021-08-30 | Regeneron Pharma | Gnavere med et humaniseret tmprss-gen |
| WO2018001241A1 (zh) | 2016-06-28 | 2018-01-04 | 北京百奥赛图基因生物技术有限公司 | 一种pd-1基因修饰人源化动物模型的构建方法及其应用 |
| CN107815468B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018086583A1 (en) * | 2016-11-11 | 2018-05-17 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric lag-3 |
| CN108070613B (zh) | 2016-11-11 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| ES2996886T3 (en) * | 2017-06-27 | 2025-02-13 | Regeneron Pharma | Rodents comprising a humanized asgr1 locus |
| CN110891420B (zh) | 2017-07-31 | 2022-06-03 | 瑞泽恩制药公司 | Cas转基因小鼠胚胎干细胞和小鼠及其应用 |
| KR20200033259A (ko) | 2017-07-31 | 2020-03-27 | 리제너론 파마슈티칼스 인코포레이티드 | 생체내에서 CRISPR/Cas-매개된 파괴 또는 삭제 및 외인성 도너 핵산과의 CRISPR/Cas-유도된 재조합을 평가하기 위한 방법 및 조성물 |
| US20190098879A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use |
| WO2019072241A1 (en) * | 2017-10-13 | 2019-04-18 | Beijing Biocytogen Co., Ltd | NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC |
| CN109666701B (zh) * | 2017-10-13 | 2021-08-24 | 百奥赛图(北京)医药科技股份有限公司 | 一种pd-1基因修饰人源化动物模型的构建方法及其应用 |
| JP7361031B2 (ja) * | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| EP3592140A1 (en) | 2018-03-19 | 2020-01-15 | Regeneron Pharmaceuticals, Inc. | Transcription modulation in animals using crispr/cas systems |
| IL314733A (en) | 2018-03-26 | 2024-10-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| HRP20240999T1 (hr) | 2018-07-16 | 2024-10-25 | Regeneron Pharmaceuticals, Inc. | Glodavački modeli bolesti ditra i njihova upotreba |
| WO2020125763A1 (en) | 2018-12-20 | 2020-06-25 | Biocytogen Jiangsu Co., Ltd. | Genetically modified non-human animal with human or chimeric lag3 |
| CN109929875B (zh) * | 2019-03-12 | 2021-02-19 | 江苏集萃药康生物科技股份有限公司 | 一种lag3基因人源化动物模型的构建方法及其应用 |
| KR102661779B1 (ko) | 2019-04-04 | 2024-04-30 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 응고 인자 12 좌위를 포함하는 비-인간 동물 |
| US11891618B2 (en) | 2019-06-04 | 2024-02-06 | Regeneron Pharmaceuticals, Inc. | Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use |
| MX2021015122A (es) | 2019-06-07 | 2022-04-06 | Regeneron Pharma | Animales no humanos que comprenden un locus de albumina humanizado. |
| WO2021154791A1 (en) | 2020-01-28 | 2021-08-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized pnpla3 locus and methods of use |
| JP7765403B2 (ja) * | 2020-04-21 | 2025-11-06 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｃｘｃｌ１３遺伝子を有する非ヒト動物 |
| KR20240117571A (ko) | 2021-12-08 | 2024-08-01 | 리제너론 파마슈티칼스 인코포레이티드 | 돌연변이 마이오실린 질환 모델 및 이의 용도 |
| WO2025163140A1 (en) * | 2024-02-02 | 2025-08-07 | Vacara Ab | Physiologic humanized mice for studies of mhc class ii function |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2189657C (fr) * | 1994-05-06 | 2002-03-12 | Florence Faure | Fractions polypeptidiques solubles de la proteine lag-3; procede de production; composition therapeutique; anticorps anti-idiotype |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| US6586251B2 (en) * | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| PL1897548T5 (pl) * | 2003-02-28 | 2025-03-17 | The Johns Hopkins University | Regulacja komórek T |
| ES2463476T3 (es) | 2004-10-19 | 2014-05-28 | Regeneron Pharmaceuticals, Inc. | Método para generar un ratón homocigótico para una modificación genética |
| AR072999A1 (es) * | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| US8518392B2 (en) | 2009-08-14 | 2013-08-27 | Regeneron Pharmaceuticals, Inc. | Promoter-regulated differentiation-dependent self-deleting cassette |
| EP4502152A3 (en) | 2009-10-06 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| US20130061340A1 (en) * | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc. | Identification and Enrichment of Cell Subpopulations |
| SG10202008003VA (en) | 2011-02-15 | 2020-10-29 | Regeneron Pharma | Humanized m-csf mice |
| CN107858333B (zh) | 2011-10-28 | 2022-05-27 | 瑞泽恩制药公司 | T细胞受体基因修饰小鼠 |
| CN108866101A (zh) | 2011-10-28 | 2018-11-23 | 瑞泽恩制药公司 | 人源化il-6和il-6受体 |
| SMT202200205T1 (it) | 2011-10-28 | 2022-07-21 | Regeneron Pharma | Topi geneticamente modificati che esprimono molecole chimeriche del complesso maggiore di istocompatibilità (mhc) ii |
| SMT201900478T1 (it) | 2011-10-28 | 2019-09-09 | Regeneron Pharma | Topi con complesso maggiore di istocompatibilita' geneticamente modificati |
| UY34887A (es) * | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| FI2892330T3 (fi) | 2012-09-07 | 2023-03-25 | Univ Yale | Geneettisesti muokattuja hiiriä ja menetelmiä niiden käyttämiseksi |
| AU2013315019B2 (en) * | 2012-09-17 | 2017-06-01 | Galectin Therapeutics, Inc. | Method for enhancing specific immunotherapies in cancer treatment |
| MX377561B (es) | 2012-11-05 | 2025-03-10 | Regeneron Pharma | Animales no humanos genéticamente modificados y métodos de uso de los mismos. |
| CN111484999B (zh) | 2013-02-20 | 2024-10-25 | 瑞泽恩制药公司 | 人源化的t细胞共受体的小鼠 |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| EP3699190B9 (en) | 2013-02-22 | 2023-10-04 | Regeneron Pharmaceuticals, Inc. | Murine cell expressing humanized major histocompatibility complex |
| DK3456831T3 (da) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| TR201901782T4 (tr) | 2013-09-23 | 2019-03-21 | Regeneron Pharma | İnsanlaştirilmiş bi̇r si̇nyal düzenleyi̇ci̇ protei̇n geni̇ne sahi̇p olan i̇nsan dişi hayvanlar. |
| CA2929846C (en) | 2013-11-19 | 2020-09-15 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| CN111690052B (zh) | 2014-04-08 | 2024-06-04 | 瑞泽恩制药公司 | 具有人源化FC-γ受体的非人动物 |
| NO2785538T3 (https=) | 2014-05-07 | 2018-08-04 | ||
| MX2016014995A (es) | 2014-05-19 | 2017-03-31 | Regeneron Pharma | Animales no humanos geneticamente modificados que expresan eritropoyetina de humano. |
| IL287519B2 (en) | 2014-06-19 | 2024-01-01 | Regeneron Pharma | Non-human animals having a humanized programmed cell death 1 gene |
| RU2726446C2 (ru) | 2014-11-24 | 2020-07-14 | Регенерон Фармасьютикалз, Инк. | Не относящиеся к человеку животные, экспрессирующие гуманизированный комплекс cd3 |
| HUE064960T2 (hu) | 2014-12-05 | 2024-04-28 | Regeneron Pharma | Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok |
| CN113412818B (zh) | 2014-12-09 | 2022-11-04 | 瑞泽恩制药公司 | 具有人源化分化簇274基因的非人动物 |
| EP4248744A3 (en) | 2015-04-06 | 2023-12-27 | Regeneron Pharmaceuticals, Inc. | Humanized t cell mediated immune responses in non-human animals |
| WO2017087780A1 (en) | 2015-11-20 | 2017-05-26 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized lymphocyte-activation gene 3 |
-
2016
- 2016-11-18 WO PCT/US2016/062733 patent/WO2017087780A1/en not_active Ceased
- 2016-11-18 CN CN201680067496.1A patent/CN108366548B/zh active Active
- 2016-11-18 DK DK16810152.5T patent/DK3376857T3/da active
- 2016-11-18 CA CA3003786A patent/CA3003786C/en active Active
- 2016-11-18 KR KR1020187016719A patent/KR102454546B1/ko active Active
- 2016-11-18 HR HRP20210824TT patent/HRP20210824T1/hr unknown
- 2016-11-18 EP EP16810152.5A patent/EP3376857B1/en active Active
- 2016-11-18 HU HUE16810152A patent/HUE054612T2/hu unknown
- 2016-11-18 PL PL16810152T patent/PL3376857T3/pl unknown
- 2016-11-18 NZ NZ742447A patent/NZ742447A/en not_active IP Right Cessation
- 2016-11-18 JP JP2018526188A patent/JP6997708B2/ja active Active
- 2016-11-18 SG SG11201803409UA patent/SG11201803409UA/en unknown
- 2016-11-18 US US15/355,392 patent/US10306874B2/en active Active
- 2016-11-18 PT PT168101525T patent/PT3376857T/pt unknown
- 2016-11-18 SM SM20210299T patent/SMT202100299T1/it unknown
- 2016-11-18 MX MX2018005389A patent/MX2018005389A/es unknown
- 2016-11-18 RS RS20210623A patent/RS61866B1/sr unknown
- 2016-11-18 BR BR112018010158A patent/BR112018010158A2/pt not_active Application Discontinuation
- 2016-11-18 LT LTEP16810152.5T patent/LT3376857T/lt unknown
- 2016-11-18 SI SI201631205T patent/SI3376857T1/sl unknown
- 2016-11-18 AU AU2016358101A patent/AU2016358101B2/en active Active
- 2016-11-18 RU RU2018117944A patent/RU2745403C2/ru active
- 2016-11-18 ES ES16810152T patent/ES2872799T3/es active Active
-
2018
- 2018-04-22 IL IL258841A patent/IL258841B/en active IP Right Grant
- 2018-04-24 ZA ZA2018/02717A patent/ZA201802717B/en unknown
-
2019
- 2019-04-18 US US16/387,664 patent/US11102961B2/en active Active
-
2021
- 2021-05-21 CY CY20211100443T patent/CY1124171T1/el unknown
- 2021-07-29 US US17/388,111 patent/US12096754B2/en active Active
-
2024
- 2024-08-13 US US18/802,201 patent/US20240397919A1/en active Pending
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