JP2018533948A5 - - Google Patents

Info

Publication number

JP2018533948A5

JP2018533948A5 JP2018521291A JP2018521291A JP2018533948A5 JP 2018533948 A5 JP2018533948 A5 JP 2018533948A5 JP 2018521291 A JP2018521291 A JP 2018521291A JP 2018521291 A JP2018521291 A JP 2018521291A JP 2018533948 A5 JP2018533948 A5 JP 2018533948A5

Authority

JP

Japan

Prior art keywords

seq

light

receptor agonist

agonist protein

soluble

Prior art date

2016-10-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 102000004127 Cytokines Human genes 0.000 claims 17
• 108090000695 Cytokines Proteins 0.000 claims 17
• 235000018102 proteins Nutrition 0.000 claims 13
• 102000004169 proteins and genes Human genes 0.000 claims 13
• 108090000623 proteins and genes Proteins 0.000 claims 13
• 239000000018 receptor agonist Substances 0.000 claims 13
• 229940044601 receptor agonist Drugs 0.000 claims 13
• 150000001413 amino acids Chemical group 0.000 claims 12
• 108090000765 processed proteins & peptides Proteins 0.000 claims 8
• 235000001014 amino acid Nutrition 0.000 claims 7
• 229940024606 amino acid Drugs 0.000 claims 7
• 210000004027 cell Anatomy 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 229920001184 polypeptide Polymers 0.000 claims 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims 4
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 3
• 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 3
• 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 101000830594 Homo sapiens Tumor necrosis factor ligand superfamily member 14 Proteins 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 2
• 210000004899 c-terminal region Anatomy 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 102000051198 human TNFSF14 Human genes 0.000 claims 2
• 208000015122 neurodegenerative disease Diseases 0.000 claims 2
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims 1
• 108010011170 Ala-Trp-Arg-His-Pro-Gln-Phe-Gly-Gly Proteins 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 241000699802 Cricetulus griseus Species 0.000 claims 1
• 239000004471 Glycine Substances 0.000 claims 1
• 230000004988 N-glycosylation Effects 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
• 206010052779 Transplant rejections Diseases 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
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• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
• 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
• 239000004333 gold (food color) Substances 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
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• 230000001926 lymphatic effect Effects 0.000 claims 1
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• 208000030159 metabolic disease Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 230000004048 modification Effects 0.000 claims 1
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• 210000001672 ovary Anatomy 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
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• 230000004481 post-translational protein modification Effects 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 210000001236 prokaryotic cell Anatomy 0.000 claims 1
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• 238000000746 purification Methods 0.000 claims 1
• 229940043131 pyroglutamate Drugs 0.000 claims 1
• 230000007017 scission Effects 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1