CN108699129A - 单链light受体激动剂蛋白 - Google Patents

单链light受体激动剂蛋白 Download PDF

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Publication number
CN108699129A
CN108699129A CN201680073585.7A CN201680073585A CN108699129A CN 108699129 A CN108699129 A CN 108699129A CN 201680073585 A CN201680073585 A CN 201680073585A CN 108699129 A CN108699129 A CN 108699129A
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CN
China
Prior art keywords
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gly
ser
val
thr
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Pending
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CN201680073585.7A
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English (en)
Chinese (zh)
Inventor
克里斯汀·吉费斯
奥利弗·希尔
迈诺尔夫·蒂曼
蒂姆·施尼德
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Apo Gio Keiji Nikos Joint-Stock Co
Original Assignee
Apo Gio Keiji Nikos Joint-Stock Co
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Application filed by Apo Gio Keiji Nikos Joint-Stock Co filed Critical Apo Gio Keiji Nikos Joint-Stock Co
Publication of CN108699129A publication Critical patent/CN108699129A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201680073585.7A 2015-10-23 2016-10-24 单链light受体激动剂蛋白 Pending CN108699129A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562245943P 2015-10-23 2015-10-23
US62/245,943 2015-10-23
PCT/EP2016/075536 WO2017068180A1 (en) 2015-10-23 2016-10-24 Single-chain light receptor agonist proteins

Publications (1)

Publication Number Publication Date
CN108699129A true CN108699129A (zh) 2018-10-23

Family

ID=57206257

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680073585.7A Pending CN108699129A (zh) 2015-10-23 2016-10-24 单链light受体激动剂蛋白

Country Status (7)

Country Link
US (2) US10683332B2 (enExample)
EP (1) EP3365361A1 (enExample)
JP (1) JP6873119B2 (enExample)
CN (1) CN108699129A (enExample)
AU (1) AU2016342420B2 (enExample)
CA (1) CA3002587A1 (enExample)
WO (1) WO2017068180A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114632156A (zh) * 2022-05-17 2022-06-17 中国人民解放军军事科学院军事医学研究院 Tim-3在预防、治疗或减轻疼痛中的应用
WO2023237051A1 (en) * 2022-06-08 2023-12-14 Analytical Biosciences Shanghai Limited Light muteins and uses thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3365448A1 (en) * 2015-10-23 2018-08-29 Apogenix AG Single-chain cd137-receptor agonist proteins
CN112955175A (zh) * 2018-10-17 2021-06-11 阿尔伯特爱因斯坦医学院 增强抗体依赖性细胞介导的细胞毒性（adcc）的方法
WO2021229103A2 (en) 2020-05-15 2021-11-18 Apogenix Ag Multi-specific immune modulators
KR20230129229A (ko) * 2020-12-03 2023-09-07 샤턱 랩스 인코포레이티드 Tigit- 및 light-기반 키메라 단백질을 이용한 암 치료방법
WO2023088876A1 (en) 2021-11-16 2023-05-25 Apogenix Ag Multi-specific immune modulators

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101160322A (zh) * 2005-01-28 2008-04-09 阿波罗生命科学有限公司 分子及其嵌合分子
WO2010010051A1 (en) * 2008-07-21 2010-01-28 Apogenix Gmbh Tnfsf single chain molecules
WO2016146818A1 (en) * 2015-03-18 2016-09-22 Universität Stuttgart Single-chain tnf ligand family molecules and fusion proteins and derivatives thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025277A1 (en) 1999-10-07 2001-04-12 Maxygen Aps Single-chain antagonist polypeptides
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
CA2314199A1 (en) 2000-07-21 2002-01-21 Robert Simoneau C-chip
PL1606318T3 (pl) 2003-03-26 2010-01-29 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts Ulepszone białka fuzyjne FC
DE102004014983A1 (de) 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
WO2006079176A1 (en) * 2005-01-28 2006-08-03 Apollo Life Sciences Limited Molecules and chimeric molecules thereof
JP2008537941A (ja) * 2005-03-31 2008-10-02 ゼンコー・インコーポレイテッド 最適化特性を有するＦｃ変異体
WO2014202773A1 (en) * 2013-06-20 2014-12-24 Innate Pharma Enzymatic conjugation of polypeptides
NO2776305T3 (enExample) * 2014-04-23 2018-01-27

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101160322A (zh) * 2005-01-28 2008-04-09 阿波罗生命科学有限公司 分子及其嵌合分子
WO2010010051A1 (en) * 2008-07-21 2010-01-28 Apogenix Gmbh Tnfsf single chain molecules
WO2016146818A1 (en) * 2015-03-18 2016-09-22 Universität Stuttgart Single-chain tnf ligand family molecules and fusion proteins and derivatives thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JUNG-HWAN LEE等: "Biochemical characterization of a new recombinant TNF receptor-hyFc fusion protein expressed in CHO cells", 《PROTEIN EXPRESSION AND PURIFICATION》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114632156A (zh) * 2022-05-17 2022-06-17 中国人民解放军军事科学院军事医学研究院 Tim-3在预防、治疗或减轻疼痛中的应用
WO2023237051A1 (en) * 2022-06-08 2023-12-14 Analytical Biosciences Shanghai Limited Light muteins and uses thereof

Also Published As

Publication number Publication date
AU2016342420A1 (en) 2018-04-26
EP3365361A1 (en) 2018-08-29
JP6873119B2 (ja) 2021-05-19
US20180251509A1 (en) 2018-09-06
US20200331979A1 (en) 2020-10-22
CA3002587A1 (en) 2017-04-27
US10683332B2 (en) 2020-06-16
JP2018533948A (ja) 2018-11-22
WO2017068180A1 (en) 2017-04-27
AU2016342420B2 (en) 2020-10-01

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WD01 Invention patent application deemed withdrawn after publication
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Application publication date: 20181023