JP2019500850A5 - - Google Patents

Download PDF

Info

Publication number
JP2019500850A5
JP2019500850A5 JP2018521279A JP2018521279A JP2019500850A5 JP 2019500850 A5 JP2019500850 A5 JP 2019500850A5 JP 2018521279 A JP2018521279 A JP 2018521279A JP 2018521279 A JP2018521279 A JP 2018521279A JP 2019500850 A5 JP2019500850 A5 JP 2019500850A5
Authority
JP
Japan
Prior art keywords
seq
receptor agonist
cd137l
agonist protein
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018521279A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019500850A (ja
JP7033062B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2016/075543 external-priority patent/WO2017068183A1/en
Publication of JP2019500850A publication Critical patent/JP2019500850A/ja
Publication of JP2019500850A5 publication Critical patent/JP2019500850A5/ja
Application granted granted Critical
Publication of JP7033062B2 publication Critical patent/JP7033062B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018521279A 2015-10-23 2016-10-24 一本鎖ｃｄ１３７受容体アゴニストタンパク質 Expired - Fee Related JP7033062B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562245838P 2015-10-23 2015-10-23
US62/245,838 2015-10-23
PCT/EP2016/075543 WO2017068183A1 (en) 2015-10-23 2016-10-24 Single-chain cd137-receptor agonist proteins

Publications (3)

Publication Number Publication Date
JP2019500850A JP2019500850A (ja) 2019-01-17
JP2019500850A5 true JP2019500850A5 (enExample) 2019-12-05
JP7033062B2 JP7033062B2 (ja) 2022-03-09

Family

ID=57208274

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018521279A Expired - Fee Related JP7033062B2 (ja) 2015-10-23 2016-10-24 一本鎖ｃｄ１３７受容体アゴニストタンパク質

Country Status (7)

Country Link
US (2) US10870688B2 (enExample)
EP (1) EP3365448A1 (enExample)
JP (1) JP7033062B2 (enExample)
CN (1) CN108368511B (enExample)
AU (2) AU2016341400B2 (enExample)
CA (1) CA3002588C (enExample)
WO (1) WO2017068183A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL268058B2 (en) 2017-01-20 2023-09-01 Magenta Therapeutics Inc Compositions and methods for depleting cd137 plus cells
WO2019109238A1 (en) 2017-12-05 2019-06-13 Lyvgen Biopharma Co., Ltd. Anti-cd137 antibodies and uses thereof
CN113039201A (zh) * 2018-09-28 2021-06-25 礼进生物医药科技（上海）有限公司 具有经过工程化的Fc结构域的抗CD137结合分子及其治疗用途
WO2020231809A1 (en) 2019-05-10 2020-11-19 Lyvgen Biopharma Co., Ltd. Humanized anti-cd137 antibodies and uses thereof
CN115836084A (zh) 2020-05-15 2023-03-21 阿珀吉尼科斯股份公司 多特异性免疫调节剂
KR102251580B1 (ko) * 2020-08-14 2021-05-13 최상호 이중 보온관 접속용 레듀사 및 이를 이용한 시공방법
WO2023088889A1 (en) 2021-11-16 2023-05-25 Apogenix Ag CD137 ligands
WO2023088876A1 (en) 2021-11-16 2023-05-25 Apogenix Ag Multi-specific immune modulators
WO2024088404A1 (en) * 2022-10-28 2024-05-02 Fbd Biologics Limited Engineered 4-1bbl variants and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE462725T1 (de) * 1998-08-25 2010-04-15 Merck Patent Gmbh Expression und export von angiostatin und endostatin als immunofusins
US20030223989A1 (en) * 2002-04-18 2003-12-04 Pluenneke John D. CD137 agonists to treat patients with IgE-mediated conditions
JP2008537941A (ja) * 2005-03-31 2008-10-02 ゼンコー・インコーポレイテッド 最適化特性を有するＦｃ変異体
EP3103875A1 (en) * 2008-07-21 2016-12-14 Apogenix AG Tnfsf single chain molecules
CA2822366A1 (en) * 2010-12-23 2012-06-28 Janssen Biotech, Inc. Active protease-resistant antibody fc mutants
AU2012237456B2 (en) * 2011-04-01 2017-06-29 Universitat Stuttgart Recombinant TNF ligand family member polypeptides with antibody binding domain and uses thereof
AU2012356894B2 (en) * 2011-12-23 2018-01-18 Araris Biotech Ltd. Enzymatic conjugation of polypeptides
JP6873119B2 (ja) * 2015-10-23 2021-05-19 アポジェニックス アーゲー 一本鎖ｌｉｇｈｔ受容体アゴニストタンパク質
EP3364995B1 (en) * 2015-10-23 2021-08-04 Apogenix AG Single-chain cd27-receptor agonist proteins

Similar Documents

Publication Publication Date Title
JP2018533947A5 (enExample)
RU2017141727A (ru) Одноцепочечные белки-агонисты рецептора cd40
US11919931B2 (en) Anti-cancer fusion polypeptide capable of binding both CD137 and glypican-3 (GPC3)
JP2018533948A5 (enExample)
JP6272907B2 (ja) 代謝障害の処置における組成物及び使用方法
US8927693B2 (en) Fibronectin based scaffold domain proteins that bind IL-23
US9260496B2 (en) Fibronectin based scaffold domain proteins that bind IL-23
DK2855509T3 (en) NON-NATURAL CONSENSUS ALBUMIN BINDING DOMAINS
HRP20150425T1 (hr) Tnf sf jednolanäśane molekule
RU2015110250A (ru) ВАРИАНТЫ FcγRIIB-СПЕЦИФИЧЕСКОЙ Fc-ОБЛАСТИ
RS55609B1 (sr) Fc fuzioni proteini koji sadrže nove linkere ili aranžmane
RU2017135596A (ru) Слитый полипептид с противораковой активностью
US20220048981A1 (en) Modified product of fc domain of antibody
CA2831820A1 (en) Recombinant tnf ligand family member polypeptides with antibody binding domain and uses thereof
US20250195673A1 (en) Compositions and methods for selective depletion of target molecules
JP7225116B2 (ja) Ｌａｇ－３に対する結合親和性を有するリポカリンムテイン
JP2019501631A5 (enExample)
AU2016242905A1 (en) Protoxin-II variants and methods of use
US20230100941A1 (en) Molecules targeting mutant ras protein
EP2597102A1 (en) A novel fusion protein comprising an antibody light chain and a polypeptide binding to IL-17
KR20230030649A (ko) 인간 il23 수용체에 결합하는 폴리펩타이드
CN115702169A (zh) 包含促红细胞生成素多肽的融合蛋白
US20220289824A1 (en) TGF-beta TRAP
US20220135649A1 (en) Dominant negative cd40l polypeptides
WO2025257333A1 (en) Receptor agonists