JP2018531583A5 - - Google Patents
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- Publication number
- JP2018531583A5 JP2018531583A5 JP2018506601A JP2018506601A JP2018531583A5 JP 2018531583 A5 JP2018531583 A5 JP 2018531583A5 JP 2018506601 A JP2018506601 A JP 2018506601A JP 2018506601 A JP2018506601 A JP 2018506601A JP 2018531583 A5 JP2018531583 A5 JP 2018531583A5
- Authority
- JP
- Japan
- Prior art keywords
- free dna
- dna fragments
- cell
- sequence
- subsequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 78
- 108020004414 DNA Proteins 0.000 claims 74
- 238000000034 method Methods 0.000 claims 40
- 210000004027 cell Anatomy 0.000 claims 23
- 108091028732 Concatemer Proteins 0.000 claims 14
- 239000012472 biological sample Substances 0.000 claims 9
- 238000012163 sequencing technique Methods 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 210000001124 body fluid Anatomy 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 210000000349 chromosome Anatomy 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 230000002759 chromosomal effect Effects 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021060027A JP7506408B2 (ja) | 2015-08-12 | 2021-03-31 | 血漿ｄｎａの単分子配列決定 |
| JP2024092950A JP2024113130A (ja) | 2015-08-12 | 2024-06-07 | 血漿ｄｎａの単分子配列決定 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562204396P | 2015-08-12 | 2015-08-12 | |
| US62/204,396 | 2015-08-12 | ||
| PCT/CN2016/094802 WO2017025059A1 (en) | 2015-08-12 | 2016-08-12 | Single-molecule sequencing of plasma dna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021060027A Division JP7506408B2 (ja) | 2015-08-12 | 2021-03-31 | 血漿ｄｎａの単分子配列決定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018531583A JP2018531583A (ja) | 2018-11-01 |
| JP2018531583A5 true JP2018531583A5 (cg-RX-API-DMAC7.html) | 2019-09-05 |
| JP6867045B2 JP6867045B2 (ja) | 2021-04-28 |
Family
ID=57983895
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506601A Active JP6867045B2 (ja) | 2015-08-12 | 2016-08-12 | 血漿ｄｎａの単分子配列決定 |
| JP2021060027A Active JP7506408B2 (ja) | 2015-08-12 | 2021-03-31 | 血漿ｄｎａの単分子配列決定 |
| JP2024092950A Pending JP2024113130A (ja) | 2015-08-12 | 2024-06-07 | 血漿ｄｎａの単分子配列決定 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021060027A Active JP7506408B2 (ja) | 2015-08-12 | 2021-03-31 | 血漿ｄｎａの単分子配列決定 |
| JP2024092950A Pending JP2024113130A (ja) | 2015-08-12 | 2024-06-07 | 血漿ｄｎａの単分子配列決定 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11319586B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3334843A4 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6867045B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN115433769A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2016305103C1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2995422A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1248286A1 (cg-RX-API-DMAC7.html) |
| IL (3) | IL285795B (cg-RX-API-DMAC7.html) |
| MY (1) | MY188348A (cg-RX-API-DMAC7.html) |
| SA (1) | SA518390907B1 (cg-RX-API-DMAC7.html) |
| TW (2) | TWI793586B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017025059A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111356772B (zh) | 2017-08-23 | 2023-10-03 | 豪夫迈·罗氏有限公司 | 酶筛选方法 |
| WO2019051244A1 (en) * | 2017-09-07 | 2019-03-14 | Coopersurgical, Inc. | SYSTEMS AND METHODS FOR NON-EFFRACTIVE PREIMPLANTATORY GENETIC DIAGNOSIS |
| WO2019084158A1 (en) | 2017-10-26 | 2019-05-02 | Ultima Genomics, Inc. | METHODS AND SYSTEMS FOR SEQUENCE CALL |
| EP3731959B1 (en) | 2017-12-29 | 2025-10-08 | Clear Labs, Inc. | Automated priming and library loading device |
| US12378603B2 (en) | 2018-04-20 | 2025-08-05 | The Regents Of The University Of California | Nucleic acid sequencing methods and computer-readable media for practicing same |
| EP3939047B1 (en) | 2019-03-10 | 2025-09-17 | Ultima Genomics, Inc. | Methods and systems for sequence calling |
| EP3987525A1 (en) | 2019-06-21 | 2022-04-27 | CooperSurgical, Inc. | System and method for determining genetic relationships between a sperm provider, oocyte provider, and the respective conceptus |
| US20220411863A1 (en) * | 2019-11-25 | 2022-12-29 | William Marsh Rice University | Linear dna assembly for nanopore sequencing |
| WO2022008641A1 (en) | 2020-07-08 | 2022-01-13 | Roche Sequencing Solutions, Inc. | Split-pool synthesis apparatus and methods of performing split-pool synthesis |
| JP2023545478A (ja) | 2020-10-15 | 2023-10-30 | カパ バイオシステムズ，インコーポレイティド | 次世代配列決定ライブラリ調製のための電気泳動デバイスおよび方法 |
| CN114507708A (zh) * | 2020-11-16 | 2022-05-17 | 唐纳德·李 | 一种制备长分子测序dna的方法 |
| EP4308723B1 (en) | 2021-03-15 | 2025-04-23 | F. Hoffmann-La Roche AG | Targeted next-generation sequencing via anchored primer extension |
| JP7657961B2 (ja) | 2021-03-26 | 2025-04-07 | エフ． ホフマン－ラ ロシュ アーゲー | ハイブリダイゼーション緩衝調合物 |
| EP4314337A1 (en) | 2021-04-01 | 2024-02-07 | F. Hoffmann-La Roche AG | Immune cell counting of sars-cov-2 patients based on immune repertoire sequencing |
| CN117545855A (zh) * | 2021-04-12 | 2024-02-09 | 香港中文大学 | 使用电信号的碱基修饰分析 |
| WO2023023561A1 (en) * | 2021-08-17 | 2023-02-23 | Quantapore, Inc. | Multiplex binding assays with optical nanopore readout |
| US20250243536A1 (en) * | 2021-10-18 | 2025-07-31 | Belgian Volition Srl | Use of nanopore sequencing for determining the origin of circulating dna |
| US20250368983A1 (en) | 2022-06-30 | 2025-12-04 | Kapa Biosystems, Inc. | Controlling for tagmentation sequencing library insert size using archaeal histone-like proteins |
| CN114898802B (zh) * | 2022-07-14 | 2022-09-30 | 臻和(北京)生物科技有限公司 | 基于血浆游离dna甲基化测序数据的末端序列频率分布特征确定方法、评价方法及装置 |
| CN119895049A (zh) | 2022-09-02 | 2025-04-25 | 豪夫迈·罗氏有限公司 | 对下一代靶标富集性能的改进 |
| WO2024215528A1 (en) | 2023-04-13 | 2024-10-17 | Ventana Medical Systems, Inc. | Proliferation assay for fixed solid tumors |
| WO2024256358A2 (en) | 2023-06-14 | 2024-12-19 | F. Hoffmann-La Roche Ag | Accelerated marking of 5-formyl cytosine and use in nucleic acid methylation sequencing |
| WO2025193604A1 (en) | 2024-03-11 | 2025-09-18 | Ventana Medical Systems, Inc. | Non-enzymatic dissociation of ffpe tissue and generation of single cells with intact cell surface markers |
| WO2025210056A1 (en) | 2024-04-03 | 2025-10-09 | Roche Sequencing Solutions, Inc. | In vitro amplification of dna methylation patterns |
| WO2025247632A1 (en) | 2024-05-27 | 2025-12-04 | European Molecular Biology Laboratory | Preparation of cell-free fragmented nucleic acids for genetic analysis sequencing |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020197618A1 (en) | 2001-01-20 | 2002-12-26 | Sampson Jeffrey R. | Synthesis and amplification of unstructured nucleic acids for rapid sequencing |
| GB0504774D0 (en) * | 2005-03-08 | 2005-04-13 | Lingvitae As | Method |
| JP2008161056A (ja) * | 2005-04-08 | 2008-07-17 | Hiroaki Mita | Ｄｎａ配列解析装置、ｄｎａ配列解析方法およびプログラム |
| KR102561664B1 (ko) | 2007-07-23 | 2023-07-28 | 더 차이니즈 유니버시티 오브 홍콩 | 대규모 병렬 게놈 서열분석을 이용한 태아 염색체 이수성의 진단 방법 |
| US9175341B2 (en) | 2008-12-11 | 2015-11-03 | Pacific Biosciences Of California, Inc. | Methods for identifying nucleic acid modifications |
| DE102008061772A1 (de) * | 2008-12-11 | 2010-06-17 | Febit Holding Gmbh | Verfahren zur Untersuchung von Nukleinsäure-Populationen |
| LT3783110T (lt) | 2009-11-05 | 2023-01-25 | The Chinese University Of Hong Kong | Vaisiaus genomo analizė iš motinos biologinio mėginio |
| US8620593B2 (en) | 2009-11-06 | 2013-12-31 | The Chinese University Of Hong Kong | Size-based genomic analysis |
| US9121823B2 (en) * | 2010-02-19 | 2015-09-01 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
| KR20120045922A (ko) * | 2010-11-01 | 2012-05-09 | 엘지전자 주식회사 | 나노 포어를 포함하는 염기 서열 결정 장치 |
| EP2646579B1 (en) | 2010-11-30 | 2017-06-14 | The Chinese University Of Hong Kong | Detection of genetic or molecular aberrations associated with cancer |
| CA2843136C (en) * | 2011-07-25 | 2020-12-29 | Oxford Nanopore Technologies Limited | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
| KR101974492B1 (ko) * | 2011-07-26 | 2019-05-02 | 베리나타 헬스, 인코포레이티드 | 샘플 중 상이한 이수성의 존재 또는 부재를 결정하는 방법 |
| US20130040827A1 (en) * | 2011-08-14 | 2013-02-14 | Stephen C. Macevicz | Method and compositions for detecting and sequencing nucleic acids |
| CA2861457A1 (en) | 2012-01-20 | 2013-07-25 | Genia Technologies, Inc. | Nanopore based molecular detection and sequencing |
| US9116118B2 (en) | 2012-06-08 | 2015-08-25 | Pacific Biosciences Of California, Inc. | Modified base detection with nanopore sequencing |
| WO2013188841A1 (en) * | 2012-06-15 | 2013-12-19 | Genia Technologies, Inc. | Chip set-up and high-accuracy nucleic acid sequencing |
| US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| GB201215449D0 (en) * | 2012-08-30 | 2012-10-17 | Zoragen Biotechnologies Llp | Method of detecting chromosonal abnormalities |
| EP2898100B9 (en) | 2012-09-20 | 2023-08-02 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| EP3495506B1 (en) * | 2013-12-11 | 2023-07-12 | AccuraGen Holdings Limited | Methods for detecting rare sequence variants |
| DK3218519T3 (da) * | 2014-11-11 | 2020-12-21 | Bgi Shenzhen | Multipass-sekvensering |
| WO2017195391A1 (ja) | 2016-05-10 | 2017-11-16 | 日本電気株式会社 | 需給調整システム、制御装置、制御方法、およびプログラム |
-
2016
- 2016-08-12 MY MYPI2018000139A patent/MY188348A/en unknown
- 2016-08-12 EP EP16834683.1A patent/EP3334843A4/en active Pending
- 2016-08-12 JP JP2018506601A patent/JP6867045B2/ja active Active
- 2016-08-12 HK HK18108082.2A patent/HK1248286A1/zh unknown
- 2016-08-12 CA CA2995422A patent/CA2995422A1/en active Pending
- 2016-08-12 WO PCT/CN2016/094802 patent/WO2017025059A1/en not_active Ceased
- 2016-08-12 CN CN202211147693.8A patent/CN115433769A/zh active Pending
- 2016-08-12 TW TW110115619A patent/TWI793586B/zh active
- 2016-08-12 US US15/235,630 patent/US11319586B2/en active Active
- 2016-08-12 TW TW105125873A patent/TWI728994B/zh active
- 2016-08-12 CN CN201680046621.0A patent/CN107849607B/zh active Active
- 2016-08-12 IL IL285795A patent/IL285795B/en unknown
- 2016-08-12 AU AU2016305103A patent/AU2016305103C1/en active Active
-
2018
- 2018-01-22 IL IL257074A patent/IL257074B/en unknown
- 2018-02-12 SA SA518390907A patent/SA518390907B1/ar unknown
-
2020
- 2020-03-26 AU AU2020202153A patent/AU2020202153B2/en active Active
-
2021
- 2021-03-31 JP JP2021060027A patent/JP7506408B2/ja active Active
-
2022
- 2022-03-18 US US17/698,574 patent/US20220205038A1/en active Pending
- 2022-06-22 IL IL294192A patent/IL294192B2/en unknown
-
2023
- 2023-04-27 AU AU2023202572A patent/AU2023202572B2/en active Active
-
2024
- 2024-06-07 JP JP2024092950A patent/JP2024113130A/ja active Pending
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