JP2018530538A5 - - Google Patents
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- Publication number
- JP2018530538A5 JP2018530538A5 JP2018513528A JP2018513528A JP2018530538A5 JP 2018530538 A5 JP2018530538 A5 JP 2018530538A5 JP 2018513528 A JP2018513528 A JP 2018513528A JP 2018513528 A JP2018513528 A JP 2018513528A JP 2018530538 A5 JP2018530538 A5 JP 2018530538A5
- Authority
- JP
- Japan
- Prior art keywords
- active ingredient
- composition
- range
- polyvinyl alcohol
- hardness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 50
- 239000004480 active ingredient Substances 0.000 claims description 42
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims description 17
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 14
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 238000013268 sustained release Methods 0.000 claims description 13
- 239000012730 sustained-release form Substances 0.000 claims description 13
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 10
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N Theophylline Natural products O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims description 10
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 10
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 10
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 10
- 238000007906 compression Methods 0.000 claims description 9
- 230000006835 compression Effects 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 229960003712 propranolol Drugs 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 7
- 229960000278 theophylline Drugs 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000000377 silicon dioxide Substances 0.000 claims description 4
- 235000012239 silicon dioxide Nutrition 0.000 claims description 4
- 239000012453 solvate Substances 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- 230000003276 anti-hypertensive effect Effects 0.000 claims description 2
- 239000002876 beta blocker Substances 0.000 claims description 2
- 229940097320 beta blocking agent Drugs 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims 5
- -1 theophylline anhydride Chemical class 0.000 claims 2
- MEAPRSDUXBHXGD-UHFFFAOYSA-N 3-chloro-n-(4-propan-2-ylphenyl)propanamide Chemical compound CC(C)C1=CC=C(NC(=O)CCCl)C=C1 MEAPRSDUXBHXGD-UHFFFAOYSA-N 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 238000005282 brightening Methods 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 230000003628 erosive effect Effects 0.000 claims 1
- 210000005095 gastrointestinal system Anatomy 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 150000004682 monohydrates Chemical class 0.000 claims 1
- 229960004604 propranolol hydrochloride Drugs 0.000 claims 1
- 239000003826 tablet Substances 0.000 description 6
- 238000009472 formulation Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000007939 sustained release tablet Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15185028.6 | 2015-09-14 | ||
| EP15185028 | 2015-09-14 | ||
| EP15189045 | 2015-10-09 | ||
| EP15189045.6 | 2015-10-09 | ||
| PCT/EP2016/001430 WO2017045742A1 (de) | 2015-09-14 | 2016-08-25 | Formulierung mit kontrollierter, verzögerter wirkstoffreisetzung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018530538A JP2018530538A (ja) | 2018-10-18 |
| JP2018530538A5 true JP2018530538A5 (enExample) | 2020-12-10 |
| JP6841819B2 JP6841819B2 (ja) | 2021-03-10 |
Family
ID=56855404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513528A Expired - Fee Related JP6841819B2 (ja) | 2015-09-14 | 2016-08-25 | 制御され、遅延された活性成分の放出を有する製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10874615B2 (enExample) |
| EP (1) | EP3349733A1 (enExample) |
| JP (1) | JP6841819B2 (enExample) |
| KR (1) | KR20180052126A (enExample) |
| CN (1) | CN108024966A (enExample) |
| AU (1) | AU2016321659A1 (enExample) |
| CA (1) | CA2998422A1 (enExample) |
| WO (1) | WO2017045742A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160235709A1 (en) | 2012-08-31 | 2016-08-18 | Molecular product management LLC | Limited release lingual thioctic acid delivery systems |
| JP7238509B2 (ja) * | 2019-03-19 | 2023-03-14 | 三菱ケミカル株式会社 | 医薬錠剤 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58502097A (ja) * | 1981-12-18 | 1983-12-08 | キイ・フア−マシユ−テイカルズ・インコ−ポレイテツド | ポリビニルアルコ−ルおよびポリエチレングリコ−ルの拡張性格子 |
| EP0359746B1 (en) * | 1987-03-25 | 1992-06-03 | E.I. Du Pont De Nemours And Company | Use of vinyl alcohol homopolymers and copolymers for tableting active materials |
| US6495656B1 (en) * | 1990-11-30 | 2002-12-17 | Eastman Chemical Company | Copolyesters and fibrous materials formed therefrom |
| ES2079327B1 (es) * | 1994-12-13 | 1996-08-01 | Lilly Sa | Formulaciones farmaceuticas de cefaclor. |
| US5838571A (en) * | 1996-01-29 | 1998-11-17 | Alza Corporation | Tablet press monitoring and controlling method and apparatus |
| AU2001273231A1 (en) * | 2000-07-06 | 2002-01-21 | Delsys Pharmaceutical Corporation | Method for formulating healthcare products with enhanced stability |
| GB0113841D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
| US7022342B2 (en) * | 2002-03-28 | 2006-04-04 | Andrx Corporation, Inc. | Controlled release oral dosage form of beta-adrenergic blocking agents |
| US20060099256A1 (en) * | 2002-11-27 | 2006-05-11 | Price James C | Microspheres and related processes and pharmaceutical compositions |
| US7241838B2 (en) * | 2003-12-19 | 2007-07-10 | Eastman Chemical Company | Blends of aliphatic-aromatic copolyesters with ethylene-vinyl acetate copolymers |
| US7368503B2 (en) * | 2003-12-22 | 2008-05-06 | Eastman Chemical Company | Compatibilized blends of biodegradable polymers with improved rheology |
| US20080152595A1 (en) * | 2004-11-24 | 2008-06-26 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
| WO2007090883A1 (en) * | 2006-02-10 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Extended release formulation |
| US9238073B2 (en) * | 2006-04-12 | 2016-01-19 | Wyeth Llc | Pharmaceutical composition containing sympathomimetic amine salt and co-distillable additive |
| NZ584521A (en) * | 2007-10-10 | 2011-03-31 | Avantor Performance Mat Inc | Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof |
| PT2177213E (pt) * | 2008-09-17 | 2013-02-21 | Siegfried Ltd | Granulado contendo nicotina |
| EP2498764B1 (en) * | 2009-11-09 | 2017-09-06 | Spotlight Technology Partners LLC | Fragmented hydrogels |
| JP2013241341A (ja) * | 2012-05-17 | 2013-12-05 | Nisshin Kasei Kk | マトリックス製剤用基剤、及び該基剤を用いた徐放性製剤 |
| GB201412413D0 (en) * | 2014-07-11 | 2014-08-27 | Revolymer Uk Ltd | Encapsulated benefit agent particles |
| AU2015295847B2 (en) * | 2014-07-30 | 2020-06-18 | Merck Patent Gmbh | Pulverulent, directly compressible types of polyvinyl alcohol |
-
2016
- 2016-08-25 AU AU2016321659A patent/AU2016321659A1/en not_active Abandoned
- 2016-08-25 WO PCT/EP2016/001430 patent/WO2017045742A1/de not_active Ceased
- 2016-08-25 KR KR1020187010365A patent/KR20180052126A/ko not_active Withdrawn
- 2016-08-25 JP JP2018513528A patent/JP6841819B2/ja not_active Expired - Fee Related
- 2016-08-25 CA CA2998422A patent/CA2998422A1/en not_active Abandoned
- 2016-08-25 US US15/759,674 patent/US10874615B2/en active Active
- 2016-08-25 EP EP16760385.1A patent/EP3349733A1/de not_active Withdrawn
- 2016-08-25 CN CN201680053419.0A patent/CN108024966A/zh active Pending
-
2020
- 2020-04-21 US US16/854,516 patent/US20200246270A1/en not_active Abandoned
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