JP6841819B2 - 制御され、遅延された活性成分の放出を有する製剤 - Google Patents
制御され、遅延された活性成分の放出を有する製剤 Download PDFInfo
- Publication number
- JP6841819B2 JP6841819B2 JP2018513528A JP2018513528A JP6841819B2 JP 6841819 B2 JP6841819 B2 JP 6841819B2 JP 2018513528 A JP2018513528 A JP 2018513528A JP 2018513528 A JP2018513528 A JP 2018513528A JP 6841819 B2 JP6841819 B2 JP 6841819B2
- Authority
- JP
- Japan
- Prior art keywords
- active ingredient
- release
- composition
- range
- propranolol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 229960003712 propranolol Drugs 0.000 claims description 56
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- KQXKVJAGOJTNJS-HNNXBMFYSA-N penbutolol Chemical compound CC(C)(C)NC[C@H](O)COC1=CC=CC=C1C1CCCC1 KQXKVJAGOJTNJS-HNNXBMFYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15185028.6 | 2015-09-14 | ||
| EP15185028 | 2015-09-14 | ||
| EP15189045 | 2015-10-09 | ||
| EP15189045.6 | 2015-10-09 | ||
| PCT/EP2016/001430 WO2017045742A1 (de) | 2015-09-14 | 2016-08-25 | Formulierung mit kontrollierter, verzögerter wirkstoffreisetzung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018530538A JP2018530538A (ja) | 2018-10-18 |
| JP2018530538A5 JP2018530538A5 (enExample) | 2020-12-10 |
| JP6841819B2 true JP6841819B2 (ja) | 2021-03-10 |
Family
ID=56855404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513528A Expired - Fee Related JP6841819B2 (ja) | 2015-09-14 | 2016-08-25 | 制御され、遅延された活性成分の放出を有する製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10874615B2 (enExample) |
| EP (1) | EP3349733A1 (enExample) |
| JP (1) | JP6841819B2 (enExample) |
| KR (1) | KR20180052126A (enExample) |
| CN (1) | CN108024966A (enExample) |
| AU (1) | AU2016321659A1 (enExample) |
| CA (1) | CA2998422A1 (enExample) |
| WO (1) | WO2017045742A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160235709A1 (en) | 2012-08-31 | 2016-08-18 | Molecular product management LLC | Limited release lingual thioctic acid delivery systems |
| JP7238509B2 (ja) * | 2019-03-19 | 2023-03-14 | 三菱ケミカル株式会社 | 医薬錠剤 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58502097A (ja) * | 1981-12-18 | 1983-12-08 | キイ・フア−マシユ−テイカルズ・インコ−ポレイテツド | ポリビニルアルコ−ルおよびポリエチレングリコ−ルの拡張性格子 |
| EP0359746B1 (en) * | 1987-03-25 | 1992-06-03 | E.I. Du Pont De Nemours And Company | Use of vinyl alcohol homopolymers and copolymers for tableting active materials |
| US6495656B1 (en) * | 1990-11-30 | 2002-12-17 | Eastman Chemical Company | Copolyesters and fibrous materials formed therefrom |
| ES2079327B1 (es) * | 1994-12-13 | 1996-08-01 | Lilly Sa | Formulaciones farmaceuticas de cefaclor. |
| US5838571A (en) * | 1996-01-29 | 1998-11-17 | Alza Corporation | Tablet press monitoring and controlling method and apparatus |
| AU2001273231A1 (en) * | 2000-07-06 | 2002-01-21 | Delsys Pharmaceutical Corporation | Method for formulating healthcare products with enhanced stability |
| GB0113841D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
| US7022342B2 (en) * | 2002-03-28 | 2006-04-04 | Andrx Corporation, Inc. | Controlled release oral dosage form of beta-adrenergic blocking agents |
| US20060099256A1 (en) * | 2002-11-27 | 2006-05-11 | Price James C | Microspheres and related processes and pharmaceutical compositions |
| US7241838B2 (en) * | 2003-12-19 | 2007-07-10 | Eastman Chemical Company | Blends of aliphatic-aromatic copolyesters with ethylene-vinyl acetate copolymers |
| US7368503B2 (en) * | 2003-12-22 | 2008-05-06 | Eastman Chemical Company | Compatibilized blends of biodegradable polymers with improved rheology |
| US20080152595A1 (en) * | 2004-11-24 | 2008-06-26 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
| WO2007090883A1 (en) * | 2006-02-10 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Extended release formulation |
| US9238073B2 (en) * | 2006-04-12 | 2016-01-19 | Wyeth Llc | Pharmaceutical composition containing sympathomimetic amine salt and co-distillable additive |
| NZ584521A (en) * | 2007-10-10 | 2011-03-31 | Avantor Performance Mat Inc | Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof |
| PT2177213E (pt) * | 2008-09-17 | 2013-02-21 | Siegfried Ltd | Granulado contendo nicotina |
| EP2498764B1 (en) * | 2009-11-09 | 2017-09-06 | Spotlight Technology Partners LLC | Fragmented hydrogels |
| JP2013241341A (ja) * | 2012-05-17 | 2013-12-05 | Nisshin Kasei Kk | マトリックス製剤用基剤、及び該基剤を用いた徐放性製剤 |
| GB201412413D0 (en) * | 2014-07-11 | 2014-08-27 | Revolymer Uk Ltd | Encapsulated benefit agent particles |
| AU2015295847B2 (en) * | 2014-07-30 | 2020-06-18 | Merck Patent Gmbh | Pulverulent, directly compressible types of polyvinyl alcohol |
-
2016
- 2016-08-25 AU AU2016321659A patent/AU2016321659A1/en not_active Abandoned
- 2016-08-25 WO PCT/EP2016/001430 patent/WO2017045742A1/de not_active Ceased
- 2016-08-25 KR KR1020187010365A patent/KR20180052126A/ko not_active Withdrawn
- 2016-08-25 JP JP2018513528A patent/JP6841819B2/ja not_active Expired - Fee Related
- 2016-08-25 CA CA2998422A patent/CA2998422A1/en not_active Abandoned
- 2016-08-25 US US15/759,674 patent/US10874615B2/en active Active
- 2016-08-25 EP EP16760385.1A patent/EP3349733A1/de not_active Withdrawn
- 2016-08-25 CN CN201680053419.0A patent/CN108024966A/zh active Pending
-
2020
- 2020-04-21 US US16/854,516 patent/US20200246270A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3349733A1 (de) | 2018-07-25 |
| KR20180052126A (ko) | 2018-05-17 |
| WO2017045742A1 (de) | 2017-03-23 |
| CA2998422A1 (en) | 2017-03-23 |
| AU2016321659A1 (en) | 2018-05-10 |
| CN108024966A (zh) | 2018-05-11 |
| JP2018530538A (ja) | 2018-10-18 |
| US20190038562A1 (en) | 2019-02-07 |
| US10874615B2 (en) | 2020-12-29 |
| US20200246270A1 (en) | 2020-08-06 |
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