JP2018529359A5 - - Google Patents
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- JP2018529359A5 JP2018529359A5 JP2018516765A JP2018516765A JP2018529359A5 JP 2018529359 A5 JP2018529359 A5 JP 2018529359A5 JP 2018516765 A JP2018516765 A JP 2018516765A JP 2018516765 A JP2018516765 A JP 2018516765A JP 2018529359 A5 JP2018529359 A5 JP 2018529359A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 149
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 125000000539 amino acid group Chemical group 0.000 claims 13
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 12
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 102000048362 human PDCD1 Human genes 0.000 claims 3
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 2
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 229940034982 antineoplastic agent Drugs 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 2
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 238000012575 bio-layer interferometry Methods 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 210000000777 hematopoietic system Anatomy 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000021039 metastatic melanoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000007799 mixed lymphocyte reaction assay Methods 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 230000008520 organization Effects 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 238000013389 whole blood assay Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562236341P | 2015-10-02 | 2015-10-02 | |
| US62/236,341 | 2015-10-02 | ||
| PCT/EP2016/073421 WO2017055547A1 (en) | 2015-10-02 | 2016-09-30 | Anti-pd-1 antibodies and compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529359A JP2018529359A (ja) | 2018-10-11 |
| JP2018529359A5 true JP2018529359A5 (enExample) | 2019-11-07 |
| JP6875385B2 JP6875385B2 (ja) | 2021-05-26 |
Family
ID=57042898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516765A Active JP6875385B2 (ja) | 2015-10-02 | 2016-09-30 | 抗ｐｄ−１抗体および組成物 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US11034765B2 (enExample) |
| EP (2) | EP3368572B9 (enExample) |
| JP (1) | JP6875385B2 (enExample) |
| KR (1) | KR102897330B1 (enExample) |
| CN (1) | CN108290953B (enExample) |
| AU (1) | AU2016333517B2 (enExample) |
| CA (1) | CA3000564A1 (enExample) |
| CO (1) | CO2018003500A2 (enExample) |
| CY (1) | CY1125327T1 (enExample) |
| DK (1) | DK3368572T3 (enExample) |
| ES (1) | ES2924402T3 (enExample) |
| HR (1) | HRP20221041T1 (enExample) |
| HU (1) | HUE059788T2 (enExample) |
| IL (1) | IL258214B2 (enExample) |
| LT (1) | LT3368572T (enExample) |
| MX (1) | MX2018003936A (enExample) |
| MY (1) | MY190324A (enExample) |
| PE (1) | PE20181044A1 (enExample) |
| PL (1) | PL3368572T3 (enExample) |
| PT (1) | PT3368572T (enExample) |
| RS (1) | RS63490B1 (enExample) |
| RU (1) | RU2750675C1 (enExample) |
| SA (1) | SA518391262B1 (enExample) |
| SG (1) | SG10201912943RA (enExample) |
| SI (1) | SI3368572T1 (enExample) |
| TW (1) | TWI751981B (enExample) |
| WO (1) | WO2017055547A1 (enExample) |
| ZA (1) | ZA201801852B (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240046641A (ko) | 2015-04-17 | 2024-04-09 | 알파인 이뮨 사이언시즈, 인코포레이티드 | 조율가능한 친화성을 갖는 면역조절 단백질 |
| AU2016294440B2 (en) | 2015-07-13 | 2022-10-13 | Cytomx Therapeutics, Inc | Anti-PD-1 antibodies, activatable anti-PD-1 antibodies, and methods of use thereof |
| PL3334763T3 (pl) | 2015-08-11 | 2024-12-02 | WuXi Biologics Ireland Limited | Nowe przeciwciała anty-pd-1 |
| MA48579A (fr) | 2015-09-01 | 2020-03-18 | Agenus Inc | Anticorps anti-pd1 et méthodes d'utilisation de ceux-ci |
| WO2017058859A1 (en) | 2015-09-29 | 2017-04-06 | Celgene Corporation | Pd-1 binding proteins and methods of use thereof |
| US12030942B2 (en) | 2015-10-02 | 2024-07-09 | Les Laboratoires Servier | Anti-PD-1 antibodies and compositions |
| DK3370768T3 (da) | 2015-11-03 | 2022-03-21 | Janssen Biotech Inc | Antistoffer som specifikt binder pd-1 og anvendelser deraf |
| MA43551A (fr) | 2016-04-15 | 2018-11-07 | Alpine Immune Sciences Inc | Protéines immunomodulatrices à variants du ligand icos et leurs utilisations |
| KR102764225B1 (ko) | 2016-04-15 | 2025-02-07 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Cd80 변이체 면역조절 단백질 및 그의 용도 |
| TW201803905A (zh) | 2016-06-20 | 2018-02-01 | 克馬伯有限公司 | 用於免疫腫瘤學之多重專一性抗體 |
| EP3515944A4 (en) | 2016-09-19 | 2020-05-06 | Celgene Corporation | METHODS OF TREATING IMMUNE DISORDERS WITH PD-1 BINDING PROTEINS |
| JP2019534859A (ja) | 2016-09-19 | 2019-12-05 | セルジーン コーポレイション | Ｐｄ−１結合タンパク質を使用して白斑を治療する方法 |
| FI3515938T3 (fi) | 2016-09-21 | 2025-03-27 | Cstone Pharmaceuticals | Monoklonaallisia vasta-aineita ohjelmoituun kuolemaan (PD-1) |
| KR20190088480A (ko) | 2016-11-02 | 2019-07-26 | 조운스 테라퓨틱스, 인크. | Pd-1에 대한 항체 및 그의 용도 |
| CA3043141A1 (en) | 2016-11-18 | 2018-05-24 | Symphogen A/S | Anti-pd-1 antibodies and compositions |
| AU2017373945B2 (en) | 2016-12-07 | 2025-01-23 | Agenus Inc. | Antibodies and methods of use thereof |
| WO2018133837A1 (en) | 2017-01-20 | 2018-07-26 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-pd-1 antibodies and uses thereof |
| IL268781B2 (en) | 2017-03-16 | 2025-09-01 | Alpine Immune Sciences Inc | Cd80 variant immunomodulatory proteins and uses thereof |
| UA129904C2 (uk) | 2017-04-05 | 2025-09-10 | Ле Лаборатуар Сервьє | Комбінація антитіла до tim-3 й антитіла до pd-1 для лікування раку |
| CN106939049B (zh) * | 2017-04-20 | 2019-10-01 | 苏州思坦维生物技术股份有限公司 | 拮抗抑制人pd-1抗原与其配体结合的单克隆抗体及其制备方法与应用 |
| US11466084B2 (en) * | 2017-06-25 | 2022-10-11 | Systimmune, Inc. | Anti-PD-1 antibodies and methods of making and using thereof |
| KR20250052490A (ko) | 2017-08-01 | 2025-04-18 | 에이비 테라퓨틱스 인코퍼레이티드 | 이중특이적 항체 및 그의 용도 |
| KR101917854B1 (ko) * | 2017-08-24 | 2018-11-12 | 한국콜마주식회사 | 세포 수용체 결합능이 있는 펩티드를 포함하는 마이크로 캡슐 및 이를 포함하는 화장료 조성물 |
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| JP7366056B2 (ja) | 2018-04-18 | 2023-10-20 | ゼンコア インコーポレイテッド | ＩＬ－１５／ＩＬ－１５ＲＡ Ｆｃ融合タンパク質およびＬＡＧ－３抗原結合ドメインを含む、ＬＡＧ－３を標的とするヘテロ二量体融合タンパク質 |
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| UA130009C2 (uk) | 2018-05-07 | 2025-10-15 | Генмаб А/С | Спосіб лікування раку за допомогою комбінації антитіла до pd-1 і кон'югата антитіла до тканинного фактора і лікарського засобу |
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2016
- 2016-09-30 MX MX2018003936A patent/MX2018003936A/es unknown
- 2016-09-30 JP JP2018516765A patent/JP6875385B2/ja active Active
- 2016-09-30 RU RU2018115979A patent/RU2750675C1/ru active
- 2016-09-30 TW TW105131644A patent/TWI751981B/zh active
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- 2016-09-30 CN CN201680069542.1A patent/CN108290953B/zh active Active
- 2016-09-30 ES ES16774691T patent/ES2924402T3/es active Active
- 2016-09-30 RS RS20220762A patent/RS63490B1/sr unknown
- 2016-09-30 HU HUE16774691A patent/HUE059788T2/hu unknown
- 2016-09-30 DK DK16774691.6T patent/DK3368572T3/da active
- 2016-09-30 LT LTEPPCT/EP2016/073421T patent/LT3368572T/lt unknown
- 2016-09-30 US US15/765,337 patent/US11034765B2/en active Active
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