JP2018529321A5 - - Google Patents
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- Publication number
- JP2018529321A5 JP2018529321A5 JP2018506297A JP2018506297A JP2018529321A5 JP 2018529321 A5 JP2018529321 A5 JP 2018529321A5 JP 2018506297 A JP2018506297 A JP 2018506297A JP 2018506297 A JP2018506297 A JP 2018506297A JP 2018529321 A5 JP2018529321 A5 JP 2018529321A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- seq
- amino acid
- amino
- donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15180278 | 2015-08-07 | ||
| EP15180278.2 | 2015-08-07 | ||
| PCT/EP2016/001344 WO2017025179A1 (en) | 2015-08-07 | 2016-08-04 | A transglutamine tag for efficient site-specific bioconjugation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529321A JP2018529321A (ja) | 2018-10-11 |
| JP2018529321A5 true JP2018529321A5 (https=) | 2019-09-12 |
| JP7008014B2 JP7008014B2 (ja) | 2022-02-10 |
Family
ID=53785570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506297A Expired - Fee Related JP7008014B2 (ja) | 2015-08-07 | 2016-08-04 | 有効な部位特異的バイオコンジュゲーションのためのトランスグルタミンタグ |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11130818B2 (https=) |
| EP (1) | EP3331904B1 (https=) |
| JP (1) | JP7008014B2 (https=) |
| CN (1) | CN107922479A (https=) |
| AU (1) | AU2016306907A1 (https=) |
| CA (1) | CA2994741A1 (https=) |
| ES (1) | ES2855998T3 (https=) |
| IL (1) | IL256810B (https=) |
| WO (1) | WO2017025179A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017147542A2 (en) * | 2016-02-26 | 2017-08-31 | Regeneron Pharmaceuticals, Inc. | Optimized transglutaminase site-specific antibody conjugation |
| EP3272864A1 (en) * | 2016-07-20 | 2018-01-24 | Paul Scherrer Institut | Solid-phase immobilization of microbial transglutaminase mtg on microbeads for protein conjugation |
| WO2019057772A1 (en) | 2017-09-19 | 2019-03-28 | Paul Scherrer Institut | METHOD FOR CONJUGATING TRANSGLUTAMINASE AND BINDING SEQUENCE |
| ES2943474T3 (es) * | 2018-11-30 | 2023-06-13 | Bristol Myers Squibb Co | Anticuerpo que comprende una extensión carboxiterminal de una cadena ligera que contiene glutamina, conjugados del mismo, y métodos y usos |
| JP7629902B2 (ja) | 2019-03-19 | 2025-02-14 | パウル・シェラー・インスティトゥート | グリシンベースリンカーを用いたトランスグルタミナーゼコンジュゲーション法 |
| FI3865155T3 (fi) * | 2020-02-13 | 2023-01-13 | Menetelmä vasta-aineen kohdespesifiseksi modifioimiseksi | |
| KR20230069211A (ko) | 2020-09-18 | 2023-05-18 | 아라리스 바이오테크 아게 | 아미노산-기반 링커를 사용한 트란스글루타미나제 접합 방법 |
| CA3196218A1 (en) | 2020-10-25 | 2022-04-28 | Philipp SPYCHER | Means and methods for producing antibody-linker conjugates |
| CN118159298A (zh) | 2021-10-25 | 2024-06-07 | 阿拉里斯生物技术股份公司 | 生产抗体-接头偶联物的方法 |
| JP2025506650A (ja) * | 2022-02-17 | 2025-03-13 | レボロ バイオセラピューティクス リミテッド | シャペロニン６０．１由来のペプチドを作製する方法 |
| KR20240150807A (ko) | 2022-02-22 | 2024-10-16 | 아라리스 바이오테크 아게 | 2개 이상의 페이로드를 포함하는 펩티드 링커 |
| WO2024211135A2 (en) * | 2023-04-07 | 2024-10-10 | Regeneron Pharmaceuticals, Inc. | Characterization of crosslinking sites in antibody-drug conjugates |
| WO2025026338A1 (zh) * | 2023-07-31 | 2025-02-06 | 石药集团巨石生物制药有限公司 | 具有高药物负载的抗体-药物缀合物及其用途 |
| WO2025082990A1 (en) | 2023-10-15 | 2025-04-24 | Araris Biotech Ag | Antibody-drug conjugates using two different types of topoisomerase i inhibitors |
| WO2026013234A1 (en) | 2024-07-10 | 2026-01-15 | Araris Biotech Ag | Triple-payload antibody-drug conjugates (adcs) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| AU701578B2 (en) | 1992-08-21 | 1999-02-04 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| US6004528A (en) | 1997-09-18 | 1999-12-21 | Bergstein; Ivan | Methods of cancer diagnosis and therapy targeted against the cancer stemline |
| BRPI0209933B8 (pt) | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| KR20060032140A (ko) * | 2003-05-30 | 2006-04-14 | 센토코 인코포레이티드 | 트랜스글루타미나아제를 이용한 신규 에리트로포이에틴접합체의 형성 |
| EP2033662B1 (en) * | 2004-01-21 | 2012-10-17 | Novo Nordisk Health Care AG | Transglutaminase mediated conjugation of peptides |
| US9676871B2 (en) | 2010-11-05 | 2017-06-13 | Pfizer Inc. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| US9764038B2 (en) | 2011-12-23 | 2017-09-19 | Innate Pharma | Enzymatic conjugation of antibodies |
| JP6865584B2 (ja) | 2013-12-23 | 2021-04-28 | コヴァラブ | 化合物の共有結合性コンジュゲーションのためのｍＴＧ基質 |
| US11135304B2 (en) * | 2015-12-18 | 2021-10-05 | Eisai R&D Management Co., Ltd. | C-terminal lysine conjugated immunoglobulins |
-
2016
- 2016-08-04 CA CA2994741A patent/CA2994741A1/en not_active Abandoned
- 2016-08-04 US US15/750,725 patent/US11130818B2/en not_active Expired - Fee Related
- 2016-08-04 EP EP16753248.0A patent/EP3331904B1/en active Active
- 2016-08-04 ES ES16753248T patent/ES2855998T3/es active Active
- 2016-08-04 WO PCT/EP2016/001344 patent/WO2017025179A1/en not_active Ceased
- 2016-08-04 JP JP2018506297A patent/JP7008014B2/ja not_active Expired - Fee Related
- 2016-08-04 AU AU2016306907A patent/AU2016306907A1/en not_active Abandoned
- 2016-08-04 CN CN201680046587.7A patent/CN107922479A/zh active Pending
-
2018
- 2018-01-09 IL IL256810A patent/IL256810B/en unknown
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