JP2018529321A5 - - Google Patents
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- JP2018529321A5 JP2018529321A5 JP2018506297A JP2018506297A JP2018529321A5 JP 2018529321 A5 JP2018529321 A5 JP 2018529321A5 JP 2018506297 A JP2018506297 A JP 2018506297A JP 2018506297 A JP2018506297 A JP 2018506297A JP 2018529321 A5 JP2018529321 A5 JP 2018529321A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- seq
- amino acid
- amino
- donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15180278.2 | 2015-08-07 | ||
| EP15180278 | 2015-08-07 | ||
| PCT/EP2016/001344 WO2017025179A1 (en) | 2015-08-07 | 2016-08-04 | A transglutamine tag for efficient site-specific bioconjugation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529321A JP2018529321A (ja) | 2018-10-11 |
| JP2018529321A5 true JP2018529321A5 (https=) | 2019-09-12 |
| JP7008014B2 JP7008014B2 (ja) | 2022-02-10 |
Family
ID=53785570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506297A Expired - Fee Related JP7008014B2 (ja) | 2015-08-07 | 2016-08-04 | 有効な部位特異的バイオコンジュゲーションのためのトランスグルタミンタグ |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11130818B2 (https=) |
| EP (1) | EP3331904B1 (https=) |
| JP (1) | JP7008014B2 (https=) |
| CN (1) | CN107922479A (https=) |
| AU (1) | AU2016306907A1 (https=) |
| CA (1) | CA2994741A1 (https=) |
| ES (1) | ES2855998T3 (https=) |
| IL (1) | IL256810B (https=) |
| WO (1) | WO2017025179A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3419670A2 (en) * | 2016-02-26 | 2019-01-02 | Regeneron Pharmaceuticals, Inc. | Optimized transglutaminase site-specific antibody conjugation |
| EP3272864A1 (en) * | 2016-07-20 | 2018-01-24 | Paul Scherrer Institut | Solid-phase immobilization of microbial transglutaminase mtg on microbeads for protein conjugation |
| NZ762376A (en) | 2017-09-19 | 2022-08-26 | Scherrer Inst Paul | Transglutaminase conjugation method and linker |
| KR102861586B1 (ko) * | 2018-11-30 | 2025-09-17 | 브리스톨-마이어스 스큅 컴퍼니 | 글루타민-함유 경쇄 c-말단 연장부를 포함하는 항체, 그의 접합체, 및 방법 및 용도 |
| CA3128571A1 (en) | 2019-03-19 | 2020-09-24 | Paul Scherrer Institut | Transglutaminase conjugation method with a glycine based linker |
| EP3865155B1 (en) | 2020-02-13 | 2022-11-30 | Orano Med | Process for site-specific modification of an antibody |
| KR20230069211A (ko) | 2020-09-18 | 2023-05-18 | 아라리스 바이오테크 아게 | 아미노산-기반 링커를 사용한 트란스글루타미나제 접합 방법 |
| KR20230096052A (ko) | 2020-10-25 | 2023-06-29 | 아라리스 바이오테크 아게 | 항체-링커 접합체를 생성하기 위한 수단 및 방법 |
| WO2023072934A1 (en) | 2021-10-25 | 2023-05-04 | Araris Biotech Ag | Methods for producing antibody-linker conjugates |
| JP2025506650A (ja) * | 2022-02-17 | 2025-03-13 | レボロ バイオセラピューティクス リミテッド | シャペロニン６０．１由来のペプチドを作製する方法 |
| KR20240150807A (ko) | 2022-02-22 | 2024-10-16 | 아라리스 바이오테크 아게 | 2개 이상의 페이로드를 포함하는 펩티드 링커 |
| WO2024211135A2 (en) * | 2023-04-07 | 2024-10-10 | Regeneron Pharmaceuticals, Inc. | Characterization of crosslinking sites in antibody-drug conjugates |
| AU2024318241A1 (en) * | 2023-07-31 | 2026-02-19 | CSPC Megalith Biopharmaceutical Co., Ltd. | Antibody-drug conjugate having high drug load and use thereof |
| WO2025082990A1 (en) | 2023-10-15 | 2025-04-24 | Araris Biotech Ag | Antibody-drug conjugates using two different types of topoisomerase i inhibitors |
| WO2026013234A1 (en) | 2024-07-10 | 2026-01-15 | Araris Biotech Ag | Triple-payload antibody-drug conjugates (adcs) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DK1621554T4 (da) | 1992-08-21 | 2012-12-17 | Univ Bruxelles | Immunoglobuliner blottet for lette kæder |
| US6004528A (en) | 1997-09-18 | 1999-12-21 | Bergstein; Ivan | Methods of cancer diagnosis and therapy targeted against the cancer stemline |
| BRPI0209933B8 (pt) | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| CA2527665A1 (en) * | 2003-05-30 | 2004-12-16 | Centocor, Inc. | Formation of novel erythropoietin conjugates using transglutaminase |
| ES2642214T3 (es) * | 2004-01-21 | 2017-11-15 | Novo Nordisk Health Care Ag | Conjugación de péptidos mediante transglutaminasa |
| CA2813411C (en) | 2010-11-05 | 2016-08-02 | Rinat Neuroscience Corporation | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| EP2793947B1 (en) | 2011-12-23 | 2021-02-03 | Innate Pharma | Enzymatic conjugation of polypeptides |
| US11376333B2 (en) | 2013-12-23 | 2022-07-05 | Covalab | mTG substrates for covalent conjugation of compounds |
| UA124622C2 (uk) * | 2015-12-18 | 2021-10-20 | ЕЙСАЙ Ар ЕНД Ді МЕНЕДЖМЕНТ КО., ЛТД. | Кон'юговані імуноглобуліни з c-кінцевим лізином |
-
2016
- 2016-08-04 ES ES16753248T patent/ES2855998T3/es active Active
- 2016-08-04 CN CN201680046587.7A patent/CN107922479A/zh active Pending
- 2016-08-04 EP EP16753248.0A patent/EP3331904B1/en active Active
- 2016-08-04 AU AU2016306907A patent/AU2016306907A1/en not_active Abandoned
- 2016-08-04 US US15/750,725 patent/US11130818B2/en not_active Expired - Fee Related
- 2016-08-04 WO PCT/EP2016/001344 patent/WO2017025179A1/en not_active Ceased
- 2016-08-04 CA CA2994741A patent/CA2994741A1/en not_active Abandoned
- 2016-08-04 JP JP2018506297A patent/JP7008014B2/ja not_active Expired - Fee Related
-
2018
- 2018-01-09 IL IL256810A patent/IL256810B/en unknown
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