IL256810B - "A transglutamine tag for efficient site-specific bio-attachment". - Google Patents
"A transglutamine tag for efficient site-specific bio-attachment".Info
- Publication number
- IL256810B IL256810B IL256810A IL25681018A IL256810B IL 256810 B IL256810 B IL 256810B IL 256810 A IL256810 A IL 256810A IL 25681018 A IL25681018 A IL 25681018A IL 256810 B IL256810 B IL 256810B
- Authority
- IL
- Israel
- Prior art keywords
- transglutamine
- tag
- efficient site
- specific bioconjugation
- bioconjugation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15180278 | 2015-08-07 | ||
| PCT/EP2016/001344 WO2017025179A1 (en) | 2015-08-07 | 2016-08-04 | A transglutamine tag for efficient site-specific bioconjugation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL256810A IL256810A (en) | 2018-03-29 |
| IL256810B true IL256810B (en) | 2021-10-31 |
Family
ID=53785570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL256810A IL256810B (en) | 2015-08-07 | 2018-01-09 | "A transglutamine tag for efficient site-specific bio-attachment". |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11130818B2 (https=) |
| EP (1) | EP3331904B1 (https=) |
| JP (1) | JP7008014B2 (https=) |
| CN (1) | CN107922479A (https=) |
| AU (1) | AU2016306907A1 (https=) |
| CA (1) | CA2994741A1 (https=) |
| ES (1) | ES2855998T3 (https=) |
| IL (1) | IL256810B (https=) |
| WO (1) | WO2017025179A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017147542A2 (en) * | 2016-02-26 | 2017-08-31 | Regeneron Pharmaceuticals, Inc. | Optimized transglutaminase site-specific antibody conjugation |
| EP3272864A1 (en) * | 2016-07-20 | 2018-01-24 | Paul Scherrer Institut | Solid-phase immobilization of microbial transglutaminase mtg on microbeads for protein conjugation |
| WO2019057772A1 (en) | 2017-09-19 | 2019-03-28 | Paul Scherrer Institut | METHOD FOR CONJUGATING TRANSGLUTAMINASE AND BINDING SEQUENCE |
| ES2943474T3 (es) * | 2018-11-30 | 2023-06-13 | Bristol Myers Squibb Co | Anticuerpo que comprende una extensión carboxiterminal de una cadena ligera que contiene glutamina, conjugados del mismo, y métodos y usos |
| JP7629902B2 (ja) | 2019-03-19 | 2025-02-14 | パウル・シェラー・インスティトゥート | グリシンベースリンカーを用いたトランスグルタミナーゼコンジュゲーション法 |
| FI3865155T3 (fi) * | 2020-02-13 | 2023-01-13 | Menetelmä vasta-aineen kohdespesifiseksi modifioimiseksi | |
| KR20230069211A (ko) | 2020-09-18 | 2023-05-18 | 아라리스 바이오테크 아게 | 아미노산-기반 링커를 사용한 트란스글루타미나제 접합 방법 |
| CA3196218A1 (en) | 2020-10-25 | 2022-04-28 | Philipp SPYCHER | Means and methods for producing antibody-linker conjugates |
| CN118159298A (zh) | 2021-10-25 | 2024-06-07 | 阿拉里斯生物技术股份公司 | 生产抗体-接头偶联物的方法 |
| JP2025506650A (ja) * | 2022-02-17 | 2025-03-13 | レボロ バイオセラピューティクス リミテッド | シャペロニン６０．１由来のペプチドを作製する方法 |
| KR20240150807A (ko) | 2022-02-22 | 2024-10-16 | 아라리스 바이오테크 아게 | 2개 이상의 페이로드를 포함하는 펩티드 링커 |
| WO2024211135A2 (en) * | 2023-04-07 | 2024-10-10 | Regeneron Pharmaceuticals, Inc. | Characterization of crosslinking sites in antibody-drug conjugates |
| WO2025026338A1 (zh) * | 2023-07-31 | 2025-02-06 | 石药集团巨石生物制药有限公司 | 具有高药物负载的抗体-药物缀合物及其用途 |
| WO2025082990A1 (en) | 2023-10-15 | 2025-04-24 | Araris Biotech Ag | Antibody-drug conjugates using two different types of topoisomerase i inhibitors |
| WO2026013234A1 (en) | 2024-07-10 | 2026-01-15 | Araris Biotech Ag | Triple-payload antibody-drug conjugates (adcs) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| AU701578B2 (en) | 1992-08-21 | 1999-02-04 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| US6004528A (en) | 1997-09-18 | 1999-12-21 | Bergstein; Ivan | Methods of cancer diagnosis and therapy targeted against the cancer stemline |
| BRPI0209933B8 (pt) | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| KR20060032140A (ko) * | 2003-05-30 | 2006-04-14 | 센토코 인코포레이티드 | 트랜스글루타미나아제를 이용한 신규 에리트로포이에틴접합체의 형성 |
| EP2033662B1 (en) * | 2004-01-21 | 2012-10-17 | Novo Nordisk Health Care AG | Transglutaminase mediated conjugation of peptides |
| US9676871B2 (en) | 2010-11-05 | 2017-06-13 | Pfizer Inc. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| US9764038B2 (en) | 2011-12-23 | 2017-09-19 | Innate Pharma | Enzymatic conjugation of antibodies |
| JP6865584B2 (ja) | 2013-12-23 | 2021-04-28 | コヴァラブ | 化合物の共有結合性コンジュゲーションのためのｍＴＧ基質 |
| US11135304B2 (en) * | 2015-12-18 | 2021-10-05 | Eisai R&D Management Co., Ltd. | C-terminal lysine conjugated immunoglobulins |
-
2016
- 2016-08-04 CA CA2994741A patent/CA2994741A1/en not_active Abandoned
- 2016-08-04 US US15/750,725 patent/US11130818B2/en not_active Expired - Fee Related
- 2016-08-04 EP EP16753248.0A patent/EP3331904B1/en active Active
- 2016-08-04 ES ES16753248T patent/ES2855998T3/es active Active
- 2016-08-04 WO PCT/EP2016/001344 patent/WO2017025179A1/en not_active Ceased
- 2016-08-04 JP JP2018506297A patent/JP7008014B2/ja not_active Expired - Fee Related
- 2016-08-04 AU AU2016306907A patent/AU2016306907A1/en not_active Abandoned
- 2016-08-04 CN CN201680046587.7A patent/CN107922479A/zh active Pending
-
2018
- 2018-01-09 IL IL256810A patent/IL256810B/en unknown
Non-Patent Citations (4)
| Title |
|---|
| RACHEL, NATALIE M., AND JOELLE N. PELLETIER., BIOTECHNOLOGICAL APPLICATIONS OF TRANSGLUTAMINASES., 22 October 2013 (2013-10-22) * |
| SARAFEDDINOV, ALLA, ET AL., A NOVEL TRANSGLUTAMINASE SUBSTRATE FROM STREPTOMYCES MOBARAENSIS TRIGGERS AUTOLYSIS OF NEUTRAL METALLOPROTEASES., 7 May 2009 (2009-05-07) * |
| SIEGMUND, VANESSA, ET AL., LOCKED BY DESIGN: A CONFORMATIONALLY CONSTRAINED TRANSGLUTAMINASE TAG ENABLES EFFICIENT SITE?SPECIFIC CONJUGATION., 14 September 2015 (2015-09-14) * |
| YANG, HUILIN, ET AL., WHOLE-GENOME SHOTGUN ASSEMBLY AND ANALYSIS OF THE GENOME OF STREPTOMYCES MOBARAENSIS DSM 40847, A STRAIN FOR INDUSTRIAL PRODUCTION OF MICROBIAL TRANSGLUTAMINASE., 4 April 2013 (2013-04-04) * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3331904A1 (en) | 2018-06-13 |
| US20190194344A1 (en) | 2019-06-27 |
| AU2016306907A1 (en) | 2018-03-29 |
| ES2855998T3 (es) | 2021-09-27 |
| US11130818B2 (en) | 2021-09-28 |
| AU2016306907A9 (en) | 2019-07-25 |
| WO2017025179A8 (en) | 2018-04-19 |
| CA2994741A1 (en) | 2017-02-16 |
| CN107922479A (zh) | 2018-04-17 |
| JP7008014B2 (ja) | 2022-02-10 |
| EP3331904B1 (en) | 2020-12-23 |
| IL256810A (en) | 2018-03-29 |
| WO2017025179A1 (en) | 2017-02-16 |
| JP2018529321A (ja) | 2018-10-11 |
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