JP2018510864A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018510864A5 JP2018510864A5 JP2017547459A JP2017547459A JP2018510864A5 JP 2018510864 A5 JP2018510864 A5 JP 2018510864A5 JP 2017547459 A JP2017547459 A JP 2017547459A JP 2017547459 A JP2017547459 A JP 2017547459A JP 2018510864 A5 JP2018510864 A5 JP 2018510864A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acids
- antibody
- terminal extension
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562130673P | 2015-03-10 | 2015-03-10 | |
| US62/130,673 | 2015-03-10 | ||
| PCT/US2016/020192 WO2016144608A1 (en) | 2015-03-10 | 2016-03-01 | Antibodies conjugatable by transglutaminase and conjugates made therefrom |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510864A JP2018510864A (ja) | 2018-04-19 |
| JP2018510864A5 true JP2018510864A5 (https=) | 2019-04-11 |
Family
ID=55538626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547459A Pending JP2018510864A (ja) | 2015-03-10 | 2016-03-01 | トランスグルタミナーゼによって結合可能な抗体およびそれによって製造される結合体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10676773B2 (https=) |
| EP (1) | EP3268048B1 (https=) |
| JP (1) | JP2018510864A (https=) |
| CN (1) | CN107406496A (https=) |
| ES (1) | ES2736106T3 (https=) |
| WO (1) | WO2016144608A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017147542A2 (en) * | 2016-02-26 | 2017-08-31 | Regeneron Pharmaceuticals, Inc. | Optimized transglutaminase site-specific antibody conjugation |
| EP3272864A1 (en) | 2016-07-20 | 2018-01-24 | Paul Scherrer Institut | Solid-phase immobilization of microbial transglutaminase mtg on microbeads for protein conjugation |
| US10398783B2 (en) | 2016-10-20 | 2019-09-03 | Bristol-Myers Squibb Company | Antiproliferative compounds and conjugates made therefrom |
| US10457681B2 (en) | 2017-08-16 | 2019-10-29 | Bristol_Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor |
| US10508115B2 (en) | 2017-08-16 | 2019-12-17 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor |
| US10472361B2 (en) | 2017-08-16 | 2019-11-12 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor |
| US10494370B2 (en) | 2017-08-16 | 2019-12-03 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor |
| US10487084B2 (en) | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
| WO2019057772A1 (en) | 2017-09-19 | 2019-03-28 | Paul Scherrer Institut | METHOD FOR CONJUGATING TRANSGLUTAMINASE AND BINDING SEQUENCE |
| WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
| CN112188902A (zh) | 2018-05-29 | 2021-01-05 | 百时美施贵宝公司 | 用于前药和缀合物的经修饰的自消灭部分以及使用和制造方法 |
| US11554120B2 (en) | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
| ES2943474T3 (es) * | 2018-11-30 | 2023-06-13 | Bristol Myers Squibb Co | Anticuerpo que comprende una extensión carboxiterminal de una cadena ligera que contiene glutamina, conjugados del mismo, y métodos y usos |
| KR20210102334A (ko) | 2018-12-12 | 2021-08-19 | 브리스톨-마이어스 스큅 컴퍼니 | 트랜스글루타미나제 접합을 위해 변형된 항체, 그의 접합체, 및 방법 및 용도 |
| JP7629902B2 (ja) | 2019-03-19 | 2025-02-14 | パウル・シェラー・インスティトゥート | グリシンベースリンカーを用いたトランスグルタミナーゼコンジュゲーション法 |
| KR20230012592A (ko) | 2020-05-19 | 2023-01-26 | 르 라보레또레 쎄르비에르 | 파라-아미노-벤질 링커, 이의 제조 방법 및 컨쥬게이트에서의 이의 용도 |
| KR20230069211A (ko) * | 2020-09-18 | 2023-05-18 | 아라리스 바이오테크 아게 | 아미노산-기반 링커를 사용한 트란스글루타미나제 접합 방법 |
| CA3196218A1 (en) | 2020-10-25 | 2022-04-28 | Philipp SPYCHER | Means and methods for producing antibody-linker conjugates |
| KR20240073035A (ko) * | 2021-09-30 | 2024-05-24 | 아지노모토 가부시키가이샤 | 항체 및 기능성 물질의 컨쥬게이트 또는 그 염, 및 그 제조에 사용되는 항체 유도체 및 화합물 또는 그 염 |
| CN118159298A (zh) | 2021-10-25 | 2024-06-07 | 阿拉里斯生物技术股份公司 | 生产抗体-接头偶联物的方法 |
| KR20240150807A (ko) | 2022-02-22 | 2024-10-16 | 아라리스 바이오테크 아게 | 2개 이상의 페이로드를 포함하는 펩티드 링커 |
| US20230408497A1 (en) * | 2022-06-20 | 2023-12-21 | Sysmex Corporation | Labeled polypeptide, modified polypeptide, production method for these polypeptides, reagent containing these polypeptides, and measurement method for target substance |
| WO2025082990A1 (en) | 2023-10-15 | 2025-04-24 | Araris Biotech Ag | Antibody-drug conjugates using two different types of topoisomerase i inhibitors |
| WO2025188693A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Bicyclic tlr7 agonists and uses thereof |
| WO2025188694A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Tricyclic tlr7 agonists and uses thereof |
| WO2026013234A1 (en) | 2024-07-10 | 2026-01-15 | Araris Biotech Ag | Triple-payload antibody-drug conjugates (adcs) |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| EP0725145A4 (en) | 1994-08-23 | 1997-06-11 | Drug Delivery System Inst Ltd | PROTEIN MODIFICATION PROCESS |
| US6548530B1 (en) | 1995-10-03 | 2003-04-15 | The Scripps Research Institute | CBI analogs of CC-1065 and the duocarmycins |
| JP2003527561A (ja) | 1999-01-22 | 2003-09-16 | スミスクライン・ビーチャム・コーポレイション | 蛋白の部位特異的標識化方法およびそのための使用 |
| JP4118462B2 (ja) | 1999-07-19 | 2008-07-16 | 株式会社リコー | 携帯電子機器 |
| KR101033196B1 (ko) * | 2002-02-14 | 2011-05-09 | 이뮤노메딕스, 인코오포레이티드 | 항-ｃｄ20 항체 및 그 융합 단백질 및 이들의 이용방법 |
| KR101424624B1 (ko) | 2003-05-14 | 2014-07-31 | 이뮤노젠 아이엔씨 | 약물 콘쥬게이트 조성물 |
| WO2004106939A2 (en) | 2003-06-03 | 2004-12-09 | Paul Scherrer Institut | Method for the linkage of bifunctional chelating agents and (radioactive) transition metal complexes to proteins and peptides |
| US7498298B2 (en) | 2003-11-06 | 2009-03-03 | Seattle Genetics, Inc. | Monomethylvaline compounds capable of conjugation to ligands |
| US7778814B2 (en) | 2004-03-30 | 2010-08-17 | Siemens Aktiengesellschaft | Method and device for simulating an automation system |
| WO2007038868A2 (en) | 2005-10-03 | 2007-04-12 | The University Of British Columbia | Novel enediyne compound and uses thereof |
| PE20080102A1 (es) | 2006-05-25 | 2008-02-11 | Bristol Myers Squibb Co | Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos |
| PE20080316A1 (es) | 2006-05-25 | 2008-04-10 | Bristol Myers Squibb Co | Compuestos de aziridinil-epotilona |
| KR20090088946A (ko) | 2006-12-14 | 2009-08-20 | 메다렉스, 인코포레이티드 | 씨디70에 결합하는 인간 항체 및 이의 용도 |
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | 梅達雷克斯有限責任公司 | 化學鏈接劑與可裂解基質以及其之綴合物 |
| EP2185188B1 (en) | 2007-08-22 | 2014-08-06 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
| CA2700860C (en) | 2007-10-01 | 2016-07-19 | Jonathan A. Terrett | Human antibodies that bind mesothelin, and uses thereof |
| WO2010002042A1 (ja) | 2008-07-04 | 2010-01-07 | 国立大学法人 九州大学 | タンパク質ラベル化用酵素基質 |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| US8697688B2 (en) | 2010-04-15 | 2014-04-15 | Seattle Genetics Inc. | Pyrrolobenzodiazepines used to treat proliferative diseases |
| MX391454B (es) | 2010-04-15 | 2025-03-05 | Seagen Inc | Compuesto de engarce-fármaco para conjugación a una unidad de ligando. |
| US9676871B2 (en) | 2010-11-05 | 2017-06-13 | Pfizer Inc. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| JP6170494B2 (ja) | 2011-09-20 | 2017-07-26 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン |
| CN104244718A (zh) * | 2011-12-05 | 2014-12-24 | 伊格尼卡生物治疗公司 | 抗体-药物缀合物以及相关化合物、组合物和方法 |
| US9764038B2 (en) | 2011-12-23 | 2017-09-19 | Innate Pharma | Enzymatic conjugation of antibodies |
| KR101660146B1 (ko) | 2012-02-13 | 2016-09-26 | 브리스톨-마이어스 스큅 컴퍼니 | 에네디인 화합물, 그의 접합체, 및 그에 대한 용도 및 방법 |
| EP2854845B1 (en) * | 2012-06-01 | 2018-03-28 | IBC Pharmaceuticals, Inc. | Multimeric complexes with improved in vivo stability, pharmacokinetics and efficacy |
| JP2015527366A (ja) * | 2012-08-20 | 2015-09-17 | グリックニック インコーポレイテッド | 抗原結合および多価ｆｃガンマ受容体結合活性を有する分子 |
| MX340090B (es) * | 2012-11-05 | 2016-06-23 | Pfizer | Analogos de spliceostatina. |
| US10036010B2 (en) | 2012-11-09 | 2018-07-31 | Innate Pharma | Recognition tags for TGase-mediated conjugation |
| RS56169B1 (sr) | 2013-02-14 | 2017-11-30 | Bristol Myers Squibb Co | Jedinjenja tubulisina, metode pripreme i primena |
| EP3010547B1 (en) | 2013-06-20 | 2021-04-21 | Innate Pharma | Enzymatic conjugation of polypeptides |
| JP6744212B2 (ja) | 2013-06-21 | 2020-08-19 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | ポリペプチドの酵素的結合 |
-
2016
- 2016-03-01 CN CN201680014722.XA patent/CN107406496A/zh active Pending
- 2016-03-01 US US15/555,594 patent/US10676773B2/en active Active
- 2016-03-01 WO PCT/US2016/020192 patent/WO2016144608A1/en not_active Ceased
- 2016-03-01 EP EP16710382.9A patent/EP3268048B1/en active Active
- 2016-03-01 JP JP2017547459A patent/JP2018510864A/ja active Pending
- 2016-03-01 ES ES16710382T patent/ES2736106T3/es active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018510864A5 (https=) | ||
| US10696676B2 (en) | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor | |
| JP2016536342A5 (https=) | ||
| JP2019520352A5 (https=) | ||
| TW201920182A (zh) | 具有吡啶或吡部分之類鐸受體7(tlr7)促效劑，其結合物及其等之方法及用途 | |
| TW201920181A (zh) | 具有經雜原子連接之芳香族部分之類鐸受體7(tlr7)促效劑，其結合物及其等之方法及用途 | |
| JP2011511773A5 (https=) | ||
| JP2011500725A5 (https=) | ||
| RU2016149433A (ru) | Конъюгат антитела и лекарственного средства, композиции на его основе и способы их получения | |
| JP2018172439A5 (https=) | ||
| JP2014129395A5 (https=) | ||
| CN109475641A (zh) | 利用固相固定的微生物转谷氨酰胺酶mtg和溶液中的mtg对抗体赖氨酸残基的位点特异性缀合 | |
| TWI455946B (zh) | 抗磷脂醯肌醇蛋白聚糖３抗體 | |
| JP2017176174A5 (https=) | ||
| KR20200041914A (ko) | 면역자극제 톨-유사 수용체 7 (tlr7) 효능제로서의 6-아미노-7,9-디히드로-8h-퓨린-8-온 유도체 | |
| RU2015100656A (ru) | Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения | |
| JP2019519490A5 (https=) | ||
| JP2017518304A5 (https=) | ||
| JP2010502207A5 (https=) | ||
| JP2021531825A5 (https=) | ||
| JP2011036254A5 (https=) | ||
| JP2018529321A5 (https=) | ||
| JP2021121590A5 (https=) | ||
| JP2018530331A5 (https=) | ||
| JP2015527366A5 (https=) |