JP2018528783A5 - - Google Patents
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- JP2018528783A5 JP2018528783A5 JP2018515456A JP2018515456A JP2018528783A5 JP 2018528783 A5 JP2018528783 A5 JP 2018528783A5 JP 2018515456 A JP2018515456 A JP 2018515456A JP 2018515456 A JP2018515456 A JP 2018515456A JP 2018528783 A5 JP2018528783 A5 JP 2018528783A5
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| US11725208B2 (en) * | 2017-12-14 | 2023-08-15 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| BR112020014011A2 (pt) | 2018-01-12 | 2020-12-08 | Bristol-Myers Squibb Company | Oligonucleotídeos antissenso dirigidos à alfa-sinucleína e usos dos mesmos |
| EP3737387A1 (en) | 2018-01-12 | 2020-11-18 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| JP7500426B2 (ja) | 2018-02-21 | 2024-06-17 | ブリストル－マイヤーズ スクイブ カンパニー | Ｃａｍｋ２ｄアンチセンスオリゴヌクレオチドおよびその使用 |
| US11597928B2 (en) | 2018-03-14 | 2023-03-07 | National University Corporation Tokyo Medical And Dental University | Nucleic acid complex |
| US11851654B2 (en) | 2018-03-19 | 2023-12-26 | National University Corporation Tokyo Medical And Dental University | Nucleic acid with reduced toxicity |
| KR20190110043A (ko) * | 2018-03-19 | 2019-09-27 | 주식회사 케이티 | 비디오 신호 처리 방법 및 장치 |
| WO2019182109A1 (ja) | 2018-03-22 | 2019-09-26 | 国立大学法人東京医科歯科大学 | ヘテロ核酸のｂｂｂ通過脂質リガンド |
| WO2020072991A1 (en) * | 2018-10-05 | 2020-04-09 | Ionis Pharmaceuticals, Inc. | Modified oligomeric compounds and uses thereof |
| CA3198199A1 (en) * | 2019-03-29 | 2020-10-08 | Mitsubishi Tanabe Pharma Corporation | Compound, method and pharmaceutical composition for modulating expression of dux4 |
| JP7687682B2 (ja) * | 2019-04-08 | 2025-06-03 | 国立大学法人東京科学大学 | 筋疾患治療用医薬組成物 |
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| US20240117346A1 (en) * | 2019-10-11 | 2024-04-11 | National University Corporation Tokyo Medical And Dental University | Modified hetero nucleic acids |
| KR20220110749A (ko) * | 2019-11-06 | 2022-08-09 | 알닐람 파마슈티칼스 인코포레이티드 | 간외 전달 |
| MX2022008533A (es) * | 2020-01-10 | 2022-08-08 | Dyne Therapeutics Inc | Complejos dirigidos al musculo y usos de los mismos para el tratamiento de la distrofia miotonica. |
| AU2021336995A1 (en) * | 2020-09-04 | 2023-03-23 | The University Of Chicago | Nucleic acid-derivatized therapeutics |
| CN115516092B (zh) * | 2020-09-30 | 2025-05-16 | 亿腾医药（苏州）有限公司 | 血管生成素样3(ANGPTL3)的siRNA及其用途 |
| WO2022106695A1 (en) | 2020-11-23 | 2022-05-27 | Alpha Anomeric Sas | Nucleic acid duplexes |
| AR124713A1 (es) * | 2021-01-28 | 2023-04-26 | Dicerna Pharmaceuticals Inc | Composiciones y métodos para inhibir la expresión de genes en el sistema nervioso central |
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| WO2023192830A2 (en) | 2022-03-28 | 2023-10-05 | Empirico Inc. | Modified oligonucleotides |
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| WO2024238385A2 (en) | 2023-05-12 | 2024-11-21 | Alnylam Pharmaceuticals, Inc. | Single-stranded loop oligonucleotides |
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| US20100222417A1 (en) | 2008-11-26 | 2010-09-02 | Alnylam Pharmaceuticals | Compostions and methods for enhancing oligonucleotide delivery across and into epithelial tissues |
| EP3009150B1 (en) | 2009-02-12 | 2019-11-13 | CuRNA, Inc. | Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf |
| AU2011282243B2 (en) | 2010-07-19 | 2016-09-22 | Ionis Pharmaceuticals, Inc. | Modulation of nuclear-retained RNA |
| WO2013040429A1 (en) * | 2011-09-14 | 2013-03-21 | Rana Therapeutics Inc. | Multimeric oligonucleotide compounds |
| CA3106312C (en) | 2011-12-16 | 2025-09-23 | National University Corporation Tokyo Medical And Dental University | CHIMERIC DOUBLE-STRANDED NUCLEIC ACID |
| AR092982A1 (es) * | 2012-10-11 | 2015-05-13 | Isis Pharmaceuticals Inc | Modulacion de la expresion de receptores androgenicos |
| AU2014222150A1 (en) * | 2013-03-01 | 2015-09-10 | National University Corporation Tokyo Medical And Dental University | Chimeric single-stranded antisense polynucleotides and double-stranded antisense agent |
| IL296543B2 (en) | 2013-05-01 | 2025-02-01 | Ionis Pharmaceuticals Inc | Compositions and methods for modulating HBV and TTR expression |
| JP6472087B2 (ja) | 2013-05-30 | 2019-02-27 | 国立大学法人 東京医科歯科大学 | 治療用オリゴヌクレオチドを送達するための二本鎖剤 |
| WO2014203518A1 (en) | 2013-06-16 | 2014-12-24 | National University Corporation Tokyo Medical And Dental University | Double-stranded antisense nucleic acid with exon-skipping effect |
| TW201536329A (zh) | 2013-08-09 | 2015-10-01 | Isis Pharmaceuticals Inc | 用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法 |
| WO2015183943A2 (en) * | 2014-05-27 | 2015-12-03 | Trustees Of Boston University | Inhibitors of fibroproliferative disorders and cancer |
| EP3180426B1 (en) * | 2014-08-17 | 2019-12-25 | The Broad Institute, Inc. | Genome editing using cas9 nickases |
| WO2017053995A1 (en) | 2015-09-25 | 2017-03-30 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
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2021
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