JP2018528783A5 - - Google Patents
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- JP2018528783A5 JP2018528783A5 JP2018515456A JP2018515456A JP2018528783A5 JP 2018528783 A5 JP2018528783 A5 JP 2018528783A5 JP 2018515456 A JP2018515456 A JP 2018515456A JP 2018515456 A JP2018515456 A JP 2018515456A JP 2018528783 A5 JP2018528783 A5 JP 2018528783A5
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| EA202091693A1 (ru) | 2018-01-12 | 2021-04-14 | Бристол-Маерс Сквибб Компани | Антисмысловые олигонуклеотиды, целенаправленно воздействующие на альфа-синуклеин, и их применения |
| BR112020016347A2 (pt) | 2018-02-21 | 2021-01-12 | Bristol-Myers Squibb Company | Oligonucleotídeos antisense de camk2d e seus usos |
| WO2019177061A1 (ja) | 2018-03-14 | 2019-09-19 | 国立大学法人東京医科歯科大学 | 核酸複合体 |
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| EP4208174A4 (en) * | 2020-09-04 | 2025-06-04 | The University of Chicago | Nucleic acid-derivatized therapeutics |
| CN115516092B (zh) * | 2020-09-30 | 2025-05-16 | 亿腾医药（苏州）有限公司 | 血管生成素样3(ANGPTL3)的siRNA及其用途 |
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| US20130225659A1 (en) | 2010-07-19 | 2013-08-29 | Isis Pharmaceuticals, Inc. | Modulation of nuclear-retained rna |
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| WO2013089283A1 (en) | 2011-12-16 | 2013-06-20 | National University Corporation Tokyo Medical And Dental University | Chimeric double-stranded nucleic acid |
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| PE20152002A1 (es) | 2013-05-01 | 2016-01-21 | Isis Pharmaceuticals Inc | Composiciones y metodos para modular la expresion de ttr y vhb |
| AU2014272526A1 (en) | 2013-05-30 | 2015-12-10 | National University Corporation Tokyo Medical And Dental University | Double-stranded agents for delivering therapeutic oligonucleotides |
| CA2915443A1 (en) | 2013-06-16 | 2014-12-24 | National University Corporation Tokyo Medical And Dental University | Double-stranded antisense nucleic acid with exon-skipping effect |
| TW201536329A (zh) | 2013-08-09 | 2015-10-01 | Isis Pharmaceuticals Inc | 用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法 |
| US12139542B2 (en) * | 2014-05-27 | 2024-11-12 | Trustees Of Boston University | Inhibitors of aortic carboxypeptidase-like protein (ACLP) |
| EP3686279B1 (en) * | 2014-08-17 | 2023-01-04 | The Broad Institute, Inc. | Genome editing using cas9 nickases |
| US20210052631A1 (en) | 2015-09-25 | 2021-02-25 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
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2021
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