JP2018527932A - CD8+CD45RClow Tregの新しい亜集団およびその使用 - Google Patents
CD8+CD45RClow Tregの新しい亜集団およびその使用 Download PDFInfo
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- JP2018527932A JP2018527932A JP2018511706A JP2018511706A JP2018527932A JP 2018527932 A JP2018527932 A JP 2018527932A JP 2018511706 A JP2018511706 A JP 2018511706A JP 2018511706 A JP2018511706 A JP 2018511706A JP 2018527932 A JP2018527932 A JP 2018527932A
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
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- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- A—HUMAN NECESSITIES
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- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/20—Cytokines; Chemokines
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/515—CD3, T-cell receptor complex
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/72—Transferases [EC 2.]
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- C12N2501/999—Small molecules not provided for elsewhere
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
- G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
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- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
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- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021133065A JP7254128B2 (ja) | 2015-09-07 | 2021-08-18 | CD8+CD45RClow Tregの新しい亜集団およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15306366.4 | 2015-09-07 | ||
| EP15306366 | 2015-09-07 | ||
| PCT/EP2016/070991 WO2017042170A1 (en) | 2015-09-07 | 2016-09-06 | A new subpopulation of cd8+cd45rclow tregs and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021133065A Division JP7254128B2 (ja) | 2015-09-07 | 2021-08-18 | CD8+CD45RClow Tregの新しい亜集団およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018527932A true JP2018527932A (ja) | 2018-09-27 |
| JP2018527932A5 JP2018527932A5 (enExample) | 2019-09-26 |
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ID=54196910
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511706A Pending JP2018527932A (ja) | 2015-09-07 | 2016-09-06 | CD8+CD45RClow Tregの新しい亜集団およびその使用 |
| JP2021133065A Active JP7254128B2 (ja) | 2015-09-07 | 2021-08-18 | CD8+CD45RClow Tregの新しい亜集団およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021133065A Active JP7254128B2 (ja) | 2015-09-07 | 2021-08-18 | CD8+CD45RClow Tregの新しい亜集団およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20180251731A1 (enExample) |
| EP (1) | EP3347452B1 (enExample) |
| JP (2) | JP2018527932A (enExample) |
| KR (1) | KR102768442B1 (enExample) |
| CN (1) | CN108291203A (enExample) |
| AU (1) | AU2016318762B2 (enExample) |
| BR (1) | BR112018004454A2 (enExample) |
| CA (1) | CA2997646C (enExample) |
| ES (1) | ES2890818T3 (enExample) |
| IL (1) | IL257891B (enExample) |
| MX (1) | MX390494B (enExample) |
| WO (1) | WO2017042170A1 (enExample) |
| ZA (1) | ZA201801265B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022516408A (ja) * | 2018-12-14 | 2022-02-28 | インセルム(インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル) | 単離されたMHC由来ヒトペプチドおよびCD8+CD45RClowTregの抑制機能を刺激し、かつ活性化するためのその使用 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018234827B2 (en) | 2017-03-15 | 2024-04-04 | Orca Biosystems Inc. | Compositions and methods for hematopoietic stem cell transplants |
| WO2019012024A1 (en) | 2017-07-13 | 2019-01-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS FOR INCREASING EXPANSION AND IMMUNOSUPPRESSIVE CAPACITY OF A CD8 + CD45RCBAS TREGS POPULATION / - |
| KR102795692B1 (ko) | 2018-01-19 | 2025-04-16 | 밀테니 비오텍 비.브이. & 씨오. 케이지 | 키메라 항원 수용체를 발현하는 조절 t 세포 |
| EP3749334B1 (en) | 2018-02-08 | 2024-12-11 | The Board of Trustees of the Leland Stanford Junior University | Allogenic hematopoietic stem cell transplantation |
| EP3765121A4 (en) * | 2018-03-14 | 2021-12-22 | Thermogenesis Corp. | ACTIVATION / TRANSDUCTION SYSTEMS AND METHODS COMPATIBLE WITH CELL SORTING ACTIVATED BY BUOYANCY |
| US20230043255A1 (en) | 2018-11-14 | 2023-02-09 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for t cell delivery |
| BR112021021528A2 (pt) * | 2019-04-30 | 2022-04-19 | Univ California | Expansão ex vivo livre de contas de células t reguladoras humanas |
| EP4013780A4 (en) * | 2019-08-14 | 2024-04-10 | The Regents Of The University Of California | CAR T CELLS SPECIFIC FOR MODIFIED PROTEINS IN EXTRACELLULAR SPACES |
| WO2024028486A1 (en) * | 2022-08-04 | 2024-02-08 | Nantes Universite | In vitro method for obtaining clinical-grade cd8+ cd45rclow/- regulatory t cells |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003530101A (ja) * | 2000-04-11 | 2003-10-14 | ユニバーシティ・オブ・サザン・カリフォルニア | 抑制性T細胞を誘導するためにTGF−βを用いる移植拒絶反応を防止する方法 |
| US20100135974A1 (en) * | 2007-01-31 | 2010-06-03 | Yeda Research And Development Co. Ltd. | Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015150492A2 (en) * | 2014-04-01 | 2015-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An isolated donor mhc-derived peptide and uses thereof |
| EP3169350B1 (en) * | 2014-07-17 | 2019-01-09 | INSERM - Institut National de la Santé et de la Recherche Médicale | An isolated interleukin-34 polypeptide for use in preventing transplant rejection and treating autoimmune diseases |
-
2016
- 2016-09-06 AU AU2016318762A patent/AU2016318762B2/en active Active
- 2016-09-06 MX MX2018002849A patent/MX390494B/es unknown
- 2016-09-06 EP EP16769882.8A patent/EP3347452B1/en active Active
- 2016-09-06 KR KR1020187009677A patent/KR102768442B1/ko active Active
- 2016-09-06 CN CN201680064881.0A patent/CN108291203A/zh active Pending
- 2016-09-06 WO PCT/EP2016/070991 patent/WO2017042170A1/en not_active Ceased
- 2016-09-06 BR BR112018004454A patent/BR112018004454A2/pt not_active Application Discontinuation
- 2016-09-06 ES ES16769882T patent/ES2890818T3/es active Active
- 2016-09-06 US US15/758,139 patent/US20180251731A1/en not_active Abandoned
- 2016-09-06 JP JP2018511706A patent/JP2018527932A/ja active Pending
- 2016-09-06 CA CA2997646A patent/CA2997646C/en active Active
-
2018
- 2018-02-23 ZA ZA2018/01265A patent/ZA201801265B/en unknown
- 2018-03-05 IL IL257891A patent/IL257891B/en active IP Right Grant
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2021
- 2021-08-18 JP JP2021133065A patent/JP7254128B2/ja active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003530101A (ja) * | 2000-04-11 | 2003-10-14 | ユニバーシティ・オブ・サザン・カリフォルニア | 抑制性T細胞を誘導するためにTGF−βを用いる移植拒絶反応を防止する方法 |
| US20100135974A1 (en) * | 2007-01-31 | 2010-06-03 | Yeda Research And Development Co. Ltd. | Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease |
Non-Patent Citations (4)
| Title |
|---|
| GUILLONNEAU C. ET AL.: "CD40Ig treatment results in allograft acceptance mediated by CD8+CD45RClow T cells, IFN-γ, and indo", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 117, no. 4, JPN6020020438, April 2007 (2007-04-01), pages 1096 - 1106, ISSN: 0004487134 * |
| LI X. L. ET AL.: "Mechanism and localization of CD8 regulatory T cells in a heart transplant model of tolerance.' , ,", THE JOURNAL OF IMMUNOLOGY, vol. 185, no. 2, JPN6020020439, 15 July 2010 (2010-07-15), pages 823 - 833, ISSN: 0004286706 * |
| ORDONEZ L. ET AL.: "A higher risk of acute rejection of human kidney allografts can be predicted from the level of CD45R", PLOS ONE, vol. 8, no. 7, JPN6020020441, July 2013 (2013-07-01), pages 69791, ISSN: 0004286707 * |
| XYSTRAKIS E. ET AL.: "Functional and genetic analysis of two CD8 T cell subsets defined by the level of CD45RC expression", THE JOURNAL OF IMMUNOLOGY, vol. 173, no. 5, JPN6020020443, 2004, pages 3140 - 3147, ISSN: 0004286708 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022516408A (ja) * | 2018-12-14 | 2022-02-28 | インセルム(インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル) | 単離されたMHC由来ヒトペプチドおよびCD8+CD45RClowTregの抑制機能を刺激し、かつ活性化するためのその使用 |
| JP7609775B2 (ja) | 2018-12-14 | 2025-01-07 | インセルム(インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル) | 単離されたMHC由来ヒトペプチドおよびCD8+CD45RClowTregの抑制機能を刺激し、かつ活性化するためのその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR102768442B1 (ko) | 2025-02-17 |
| RU2018107363A3 (enExample) | 2020-02-27 |
| RU2766691C2 (ru) | 2022-03-15 |
| IL257891B (en) | 2020-09-30 |
| US20180251731A1 (en) | 2018-09-06 |
| IL257891A (en) | 2018-05-31 |
| CA2997646C (en) | 2024-04-23 |
| JP2021183631A (ja) | 2021-12-02 |
| AU2016318762B2 (en) | 2022-03-31 |
| EP3347452A1 (en) | 2018-07-18 |
| EP3347452B1 (en) | 2021-06-23 |
| KR20180054663A (ko) | 2018-05-24 |
| MX390494B (es) | 2025-03-20 |
| JP7254128B2 (ja) | 2023-04-07 |
| CN108291203A (zh) | 2018-07-17 |
| AU2016318762A1 (en) | 2018-03-22 |
| ES2890818T3 (es) | 2022-01-24 |
| MX2018002849A (es) | 2018-09-05 |
| WO2017042170A1 (en) | 2017-03-16 |
| NZ740225A (en) | 2025-05-30 |
| RU2018107363A (ru) | 2019-10-09 |
| BR112018004454A2 (pt) | 2018-09-25 |
| ZA201801265B (en) | 2022-08-31 |
| CA2997646A1 (en) | 2017-03-16 |
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