KR102768442B1 - CD8+CD45RClow TREGS의 신규한 아집단 및 이들의 용도 - Google Patents

CD8+CD45RClow TREGS의 신규한 아집단 및 이들의 용도 Download PDF

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KR102768442B1
KR102768442B1 KR1020187009677A KR20187009677A KR102768442B1 KR 102768442 B1 KR102768442 B1 KR 102768442B1 KR 1020187009677 A KR1020187009677 A KR 1020187009677A KR 20187009677 A KR20187009677 A KR 20187009677A KR 102768442 B1 KR102768442 B1 KR 102768442B1
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ifnγ
treg cells
cd45rc low
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KR20180054663A (ko
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캐롤 구일론뉴
이그나시오 아네곤
세브린 베지어
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인스티튜트 내셔날 드 라 싼테 에 드 라 리셰르셰 메디칼르
낭트 유니베르시테
쌍트르 하스피탈리에 유니베르시떼 드 낭뜨
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KR1020187009677A 2015-09-07 2016-09-06 CD8+CD45RClow TREGS의 신규한 아집단 및 이들의 용도 Active KR102768442B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15306366.4 2015-09-07
EP15306366 2015-09-07
PCT/EP2016/070991 WO2017042170A1 (en) 2015-09-07 2016-09-06 A new subpopulation of cd8+cd45rclow tregs and uses thereof

Publications (2)

Publication Number Publication Date
KR20180054663A KR20180054663A (ko) 2018-05-24
KR102768442B1 true KR102768442B1 (ko) 2025-02-17

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KR1020187009677A Active KR102768442B1 (ko) 2015-09-07 2016-09-06 CD8+CD45RClow TREGS의 신규한 아집단 및 이들의 용도

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US (1) US20180251731A1 (enExample)
EP (1) EP3347452B1 (enExample)
JP (2) JP2018527932A (enExample)
KR (1) KR102768442B1 (enExample)
CN (1) CN108291203A (enExample)
AU (1) AU2016318762B2 (enExample)
BR (1) BR112018004454A2 (enExample)
CA (1) CA2997646C (enExample)
ES (1) ES2890818T3 (enExample)
IL (1) IL257891B (enExample)
MX (1) MX390494B (enExample)
WO (1) WO2017042170A1 (enExample)
ZA (1) ZA201801265B (enExample)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
AU2018234827B2 (en) 2017-03-15 2024-04-04 Orca Biosystems Inc. Compositions and methods for hematopoietic stem cell transplants
WO2019012024A1 (en) 2017-07-13 2019-01-17 INSERM (Institut National de la Santé et de la Recherche Médicale) METHODS FOR INCREASING EXPANSION AND IMMUNOSUPPRESSIVE CAPACITY OF A CD8 + CD45RCBAS TREGS POPULATION / -
KR102795692B1 (ko) 2018-01-19 2025-04-16 밀테니 비오텍 비.브이. & 씨오. 케이지 키메라 항원 수용체를 발현하는 조절 t 세포
EP3749334B1 (en) 2018-02-08 2024-12-11 The Board of Trustees of the Leland Stanford Junior University Allogenic hematopoietic stem cell transplantation
EP3765121A4 (en) * 2018-03-14 2021-12-22 Thermogenesis Corp. ACTIVATION / TRANSDUCTION SYSTEMS AND METHODS COMPATIBLE WITH CELL SORTING ACTIVATED BY BUOYANCY
US20230043255A1 (en) 2018-11-14 2023-02-09 Flagship Pioneering Innovations V, Inc. Fusosome compositions for t cell delivery
WO2020120786A1 (en) 2018-12-14 2020-06-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Isolated mhc-derived human peptides and uses thereof for stimulating and activating the suppressive function of cd8+cd45rclow tregs
BR112021021528A2 (pt) * 2019-04-30 2022-04-19 Univ California Expansão ex vivo livre de contas de células t reguladoras humanas
EP4013780A4 (en) * 2019-08-14 2024-04-10 The Regents Of The University Of California CAR T CELLS SPECIFIC FOR MODIFIED PROTEINS IN EXTRACELLULAR SPACES
WO2024028486A1 (en) * 2022-08-04 2024-02-08 Nantes Universite In vitro method for obtaining clinical-grade cd8+ cd45rclow/- regulatory t cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016009041A1 (en) 2014-07-17 2016-01-21 INSERM (Institut National de la Santé et de la Recherche Médicale) An isolated interleukin-34 polypeptide for use in preventing transplant rejection and treating autoimmune diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE460475T1 (de) * 2000-04-11 2010-03-15 Univ Southern California Methode zur verhinderung der transplantatabstossung unter verwendung von tgf- beta zur induktion von t-suppressorzellen
US20100135974A1 (en) * 2007-01-31 2010-06-03 Yeda Research And Development Co. Ltd. Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease
WO2015150492A2 (en) * 2014-04-01 2015-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) An isolated donor mhc-derived peptide and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016009041A1 (en) 2014-07-17 2016-01-21 INSERM (Institut National de la Santé et de la Recherche Médicale) An isolated interleukin-34 polypeptide for use in preventing transplant rejection and treating autoimmune diseases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Carole Guillonneau et al., The Journal of Clinical Investigation (2007) pp.1096-1106
X.L. Li. et al. The Journal of Immunology (2010) 185(2):823-833

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JP2018527932A (ja) 2018-09-27
RU2018107363A3 (enExample) 2020-02-27
RU2766691C2 (ru) 2022-03-15
IL257891B (en) 2020-09-30
US20180251731A1 (en) 2018-09-06
IL257891A (en) 2018-05-31
CA2997646C (en) 2024-04-23
JP2021183631A (ja) 2021-12-02
AU2016318762B2 (en) 2022-03-31
EP3347452A1 (en) 2018-07-18
EP3347452B1 (en) 2021-06-23
KR20180054663A (ko) 2018-05-24
MX390494B (es) 2025-03-20
JP7254128B2 (ja) 2023-04-07
CN108291203A (zh) 2018-07-17
AU2016318762A1 (en) 2018-03-22
ES2890818T3 (es) 2022-01-24
MX2018002849A (es) 2018-09-05
WO2017042170A1 (en) 2017-03-16
NZ740225A (en) 2025-05-30
RU2018107363A (ru) 2019-10-09
BR112018004454A2 (pt) 2018-09-25
ZA201801265B (en) 2022-08-31
CA2997646A1 (en) 2017-03-16

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