JP2018527336A - ３−インドール置換誘導体、医薬組成物、および使用方法 - Google Patents
３−インドール置換誘導体、医薬組成物、および使用方法 Download PDFInfo
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- JP2018527336A JP2018527336A JP2018506432A JP2018506432A JP2018527336A JP 2018527336 A JP2018527336 A JP 2018527336A JP 2018506432 A JP2018506432 A JP 2018506432A JP 2018506432 A JP2018506432 A JP 2018506432A JP 2018527336 A JP2018527336 A JP 2018527336A
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- fluoro
- indol
- phenyl
- sulfonyl
- benzenesulfonamide
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- 0 *c1c[n](*)c2cc(*)c(*)cc12 Chemical compound *c1c[n](*)c2cc(*)c(*)cc12 0.000 description 4
- ANYUHMHSOONIKF-UHFFFAOYSA-N CCCN(CCC=N)C(NCCNS(c(cc1)ccc1-c1c[nH]c2cc(F)ccc12)(=O)=O)=O Chemical compound CCCN(CCC=N)C(NCCNS(c(cc1)ccc1-c1c[nH]c2cc(F)ccc12)(=O)=O)=O ANYUHMHSOONIKF-UHFFFAOYSA-N 0.000 description 1
- RSZNQULXVIJVJA-UHFFFAOYSA-N CN(C(CN(C1)S(c(cc2)ccc2-c2c[nH]c3cc(F)ccc23)(=O)=O)=O)C1=O Chemical compound CN(C(CN(C1)S(c(cc2)ccc2-c2c[nH]c3cc(F)ccc23)(=O)=O)=O)C1=O RSZNQULXVIJVJA-UHFFFAOYSA-N 0.000 description 1
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- KGYVMYHZZQRVHB-UHFFFAOYSA-N CS(c(c(CN)c1)ccc1-c1c[nH]c2cc(F)ccc12)(=O)=O Chemical compound CS(c(c(CN)c1)ccc1-c1c[nH]c2cc(F)ccc12)(=O)=O KGYVMYHZZQRVHB-UHFFFAOYSA-N 0.000 description 1
- VDXFXOOVWIKTGE-OKILXGFUSA-N C[C@H](C1)N[C@@H](C)CN1S(c(cc1)ccc1-c1c[nH]c2cc(F)ccc12)(=O)=O Chemical compound C[C@H](C1)N[C@@H](C)CN1S(c(cc1)ccc1-c1c[nH]c2cc(F)ccc12)(=O)=O VDXFXOOVWIKTGE-OKILXGFUSA-N 0.000 description 1
- HAVXYUYSVFFDAF-LLVKDONJSA-N C[C@H](CNS(c(cc1)ccc1-c1c[nH]c2cc(F)ccc12)(=O)=O)O Chemical compound C[C@H](CNS(c(cc1)ccc1-c1c[nH]c2cc(F)ccc12)(=O)=O)O HAVXYUYSVFFDAF-LLVKDONJSA-N 0.000 description 1
- OJOODCWBFOKGNX-UHFFFAOYSA-N Cc([nH]c1c2ccc(F)c1)c2-c(cc1)ccc1S(NCCc1ncc[nH]1)(=O)=O Chemical compound Cc([nH]c1c2ccc(F)c1)c2-c(cc1)ccc1S(NCCc1ncc[nH]1)(=O)=O OJOODCWBFOKGNX-UHFFFAOYSA-N 0.000 description 1
- JZRZPFQQIOFCGL-UHFFFAOYSA-N Cc1nnc(CNC/[O]=S/c(cc2)ccc2C(c(c(NC)c2)ccc2F)=C)[o]1 Chemical compound Cc1nnc(CNC/[O]=S/c(cc2)ccc2C(c(c(NC)c2)ccc2F)=C)[o]1 JZRZPFQQIOFCGL-UHFFFAOYSA-N 0.000 description 1
- LXIUPELUVIEOAP-UHFFFAOYSA-N NC([n]1c(cc(cc2)F)c2c(-c(cc2)ccc2S(N2CCNCC2)(=O)=O)c1)=O Chemical compound NC([n]1c(cc(cc2)F)c2c(-c(cc2)ccc2S(N2CCNCC2)(=O)=O)c1)=O LXIUPELUVIEOAP-UHFFFAOYSA-N 0.000 description 1
- MCUULSPCLNTZND-UHFFFAOYSA-N NCCN(CCN(C1)S(c(cc2)ccc2-c2c[nH]c3c2ccc(F)c3)(=O)=O)C1=O Chemical compound NCCN(CCN(C1)S(c(cc2)ccc2-c2c[nH]c3c2ccc(F)c3)(=O)=O)C1=O MCUULSPCLNTZND-UHFFFAOYSA-N 0.000 description 1
- QLGVTEJXKWYKRA-UHFFFAOYSA-N O=C1OC(CCNS(c(cc2)ccc2-c2c[nH]c3cc(F)ccc23)(=O)=O)=NN1 Chemical compound O=C1OC(CCNS(c(cc2)ccc2-c2c[nH]c3cc(F)ccc23)(=O)=O)=NN1 QLGVTEJXKWYKRA-UHFFFAOYSA-N 0.000 description 1
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- CZKCKAFNBOJQNQ-CQSZACIVSA-N O=S(c(cc1)ccc1-c1c[nH]c2cc(F)ccc12)(N[C@H]1COCC1)=O Chemical compound O=S(c(cc1)ccc1-c1c[nH]c2cc(F)ccc12)(N[C@H]1COCC1)=O CZKCKAFNBOJQNQ-CQSZACIVSA-N 0.000 description 1
- ZBVVEAXIBGDORR-UHFFFAOYSA-N OC(CC1)NCCN1S(c(cc1)ccc1-c1c[nH]c2cc(F)ccc12)(=O)=O Chemical compound OC(CC1)NCCN1S(c(cc1)ccc1-c1c[nH]c2cc(F)ccc12)(=O)=O ZBVVEAXIBGDORR-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562203032P | 2015-08-10 | 2015-08-10 | |
| US62/203,032 | 2015-08-10 | ||
| US201662309530P | 2016-03-17 | 2016-03-17 | |
| US62/309,530 | 2016-03-17 | ||
| PCT/IB2016/054701 WO2017025868A1 (en) | 2015-08-10 | 2016-08-04 | 3-indol substituted derivatives, pharmaceutical compositions and methods for use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018527336A true JP2018527336A (ja) | 2018-09-20 |
| JP2018527336A5 JP2018527336A5 (OSRAM) | 2019-09-05 |
Family
ID=56801656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506432A Ceased JP2018527336A (ja) | 2015-08-10 | 2016-08-04 | ３−インドール置換誘導体、医薬組成物、および使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10544095B2 (OSRAM) |
| EP (1) | EP3334733A1 (OSRAM) |
| JP (1) | JP2018527336A (OSRAM) |
| CA (1) | CA2994917A1 (OSRAM) |
| WO (1) | WO2017025868A1 (OSRAM) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2017011951A (es) * | 2015-03-17 | 2018-06-15 | Pfizer | Derivados sustituidos de indol 3 novedosos, composiciones farmaceuticas y metodos para uso. |
| EP3932428A1 (en) | 2015-05-21 | 2022-01-05 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| CA3024556A1 (en) * | 2016-05-12 | 2017-11-16 | The Regents Of The University Of Michigan | Ash1l inhibitors and methods of treatment therewith |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| EP3269714A1 (en) * | 2016-07-13 | 2018-01-17 | Netherlands Translational Research Center B.V. | Inhibitors of tryptophan 2,3-dioxygenase |
| GB201705263D0 (en) | 2017-03-31 | 2017-05-17 | Probiodrug Ag | Novel inhibitors |
| KR102376863B1 (ko) | 2017-05-12 | 2022-03-21 | 하푼 테라퓨틱스, 인크. | 메소텔린 결합 단백질 |
| CN108948002A (zh) * | 2017-05-19 | 2018-12-07 | 厦门大学 | 五元并六元氮杂芳环类化合物、其制备方法、药用组合物及其应用 |
| BR112019018759A2 (pt) | 2017-05-30 | 2020-05-05 | Bristol-Myers Squibb Company | composições compreendendo uma combinação de um anticorpo anti-lag-3, um inibidor da via pd-1, e um agente imunoterápico |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| CN111630070B (zh) | 2017-10-13 | 2024-07-30 | 哈普恩治疗公司 | 三特异性蛋白质及使用方法 |
| US11110177B2 (en) | 2017-11-10 | 2021-09-07 | The Regents Of The University Of Michigan | ASH1L degraders and methods of treatment therewith |
| CN108794376B (zh) * | 2018-04-28 | 2021-01-05 | 北京施安泰医药技术开发有限公司 | 甲酰胺类衍生物、其药物组合物、制备方法与用途 |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| US10815311B2 (en) | 2018-09-25 | 2020-10-27 | Harpoon Therapeutics, Inc. | DLL3 binding proteins and methods of use |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| JP2023515190A (ja) * | 2020-02-27 | 2023-04-12 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ａｐｃ欠損がんの治療のための方法および組成物 |
| CN111825678A (zh) * | 2020-06-05 | 2020-10-27 | 连庆泉 | 一种卡马替尼的制备方法 |
| AU2021306613A1 (en) | 2020-07-07 | 2023-02-02 | BioNTech SE | Therapeutic RNA for HPV-positive cancer |
| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性ｒｎａ |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| CA3225254A1 (en) | 2021-07-13 | 2023-01-19 | BioNTech SE | Multispecific binding agents against cd40 and cd137 in combination therapy for cancer |
| TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
| KR20250004645A (ko) | 2022-03-08 | 2025-01-08 | 알렌티스 테라퓨틱스 아게 | T 세포 가용성을 증가시키기 위한 항-클라우딘-1 항체의 사용 |
| KR20250120305A (ko) | 2022-12-14 | 2025-08-08 | 아스텔라스 파마 유럽 비.브이. | Cldn18.2 및 cd3에 결합하는 2중 특이성 결합제와 면역 체크포인트 저해제를 수반한 조합 요법 |
| WO2025120867A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies |
| WO2025120866A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025121445A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010534665A (ja) * | 2007-07-25 | 2010-11-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルココルチコイドミメチックス、それらの製造方法、医薬組成物、及びこれらの使用 |
| WO2015082499A2 (en) * | 2013-12-03 | 2015-06-11 | Iomet Pharma Ltd | Pharmaceutical compound |
| WO2018011227A1 (en) * | 2016-07-13 | 2018-01-18 | Netherlands Translational Research Center B.V. | Inhibitors of tryptophan 2,3-dioxygenase |
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| SE509731C2 (sv) | 1996-05-14 | 1999-03-01 | Labwell Ab | Metod för palladium-katalyserade organiska reaktioner innefattande ett uppvärmningssteg utfört med mikrovågsenergi |
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| US20180222862A1 (en) | 2018-08-09 |
| EP3334733A1 (en) | 2018-06-20 |
| US10544095B2 (en) | 2020-01-28 |
| CA2994917A1 (en) | 2017-02-16 |
| WO2017025868A1 (en) | 2017-02-16 |
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