JP2018527288A5 - - Google Patents

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JP2018527288A5
JP2018527288A5 JP2017562721A JP2017562721A JP2018527288A5 JP 2018527288 A5 JP2018527288 A5 JP 2018527288A5 JP 2017562721 A JP2017562721 A JP 2017562721A JP 2017562721 A JP2017562721 A JP 2017562721A JP 2018527288 A5 JP2018527288 A5 JP 2018527288A5
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JP
Japan
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human insulin
desb30 human
insulin
desb30
extended
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JP2017562721A
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English (en)
Japanese (ja)
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JP2018527288A (ja
JP6983075B2 (ja
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Priority claimed from PCT/EP2016/062514 external-priority patent/WO2016193380A1/en
Publication of JP2018527288A publication Critical patent/JP2018527288A/ja
Publication of JP2018527288A5 publication Critical patent/JP2018527288A5/ja
Priority to JP2021070977A priority Critical patent/JP2021119156A/ja
Application granted granted Critical
Publication of JP6983075B2 publication Critical patent/JP6983075B2/ja
Expired - Fee Related legal-status Critical Current
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JP2017562721A 2015-06-02 2016-06-02 極性の組換え延長部を有するインスリン Expired - Fee Related JP6983075B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021070977A JP2021119156A (ja) 2015-06-02 2021-04-20 極性の組換え延長部を有するインスリン

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15170337.8 2015-06-02
EP15170337 2015-06-02
EP15176207 2015-07-10
EP15176207.7 2015-07-10
PCT/EP2016/062514 WO2016193380A1 (en) 2015-06-02 2016-06-02 Insulins with polar recombinant extensions

Related Child Applications (1)

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JP2021070977A Division JP2021119156A (ja) 2015-06-02 2021-04-20 極性の組換え延長部を有するインスリン

Publications (3)

Publication Number Publication Date
JP2018527288A JP2018527288A (ja) 2018-09-20
JP2018527288A5 true JP2018527288A5 (OSRAM) 2019-05-09
JP6983075B2 JP6983075B2 (ja) 2021-12-17

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ID=56098249

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JP2017562721A Expired - Fee Related JP6983075B2 (ja) 2015-06-02 2016-06-02 極性の組換え延長部を有するインスリン
JP2021070977A Withdrawn JP2021119156A (ja) 2015-06-02 2021-04-20 極性の組換え延長部を有するインスリン

Family Applications After (1)

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JP2021070977A Withdrawn JP2021119156A (ja) 2015-06-02 2021-04-20 極性の組換え延長部を有するインスリン

Country Status (6)

Country Link
US (1) US11208452B2 (OSRAM)
EP (1) EP3303380B1 (OSRAM)
JP (2) JP6983075B2 (OSRAM)
CN (1) CN107743494B (OSRAM)
ES (1) ES2784603T3 (OSRAM)
WO (1) WO2016193380A1 (OSRAM)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107743494B (zh) 2015-06-02 2022-04-29 诺和诺德股份有限公司 具有极性重组延伸体的胰岛素
MA43348A (fr) 2015-10-01 2018-08-08 Novo Nordisk As Conjugués de protéines
DK3551209T3 (da) 2016-12-09 2021-08-23 Akston Biosciences Corp Insulin-fc-fusioner og fremgangsmåder til anvendelse
JP2020513019A (ja) * 2017-04-05 2020-04-30 ノヴォ ノルディスク アー/エス オリゴマー伸長インスリン−Fcコンジュゲート
CN112312922B (zh) * 2018-06-21 2025-04-11 诺和诺德股份有限公司 用于治疗肥胖症的新型化合物
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
EP3655006B1 (en) 2018-06-29 2021-11-17 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
JP2022502467A (ja) 2018-10-10 2022-01-11 ノヴォ ノルディスク アー/エス オリゴマー伸長インスリン−fcコンジュゲートおよびそれらの医学的使用
HUE064376T2 (hu) 2019-12-19 2024-03-28 Akston Biosciences Corp Ultra-hosszú hatású inzulin-FC fúziós fehérjék és felhasználási eljárások
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
CN116925237A (zh) 2019-12-31 2023-10-24 北京质肽生物医药科技有限公司 Glp-1和gdf15的融合蛋白以及其缀合物
CN116096733A (zh) 2020-04-10 2023-05-09 阿卡斯通生物科学公司 Covid-19融合蛋白的抗原特异性免疫疗法和使用方法
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
US11198719B2 (en) 2020-04-29 2021-12-14 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
EP3915571A1 (en) * 2020-05-29 2021-12-01 Adocia Pharmaceutical composition in the form of an injectable aqueous solution including at least a rapid acting insulin analog and a glucagon suppressor with prandial action
CN115925994B (zh) * 2020-09-30 2023-09-22 北京质肽生物医药科技有限公司 多肽缀合物和使用方法
US11667689B2 (en) 2021-07-23 2023-06-06 Akston Biosciences Corporation Insulin-Fc fusion proteins and methods of use to treat cancer
JP2025512832A (ja) 2022-03-30 2025-04-22 ベイジン キューエル バイオファーマシューティカル カンパニー,リミテッド ポリペプチドコンジュゲートの液体医薬組成物およびその使用の方法
CN115716877B (zh) * 2022-07-04 2023-09-01 北京惠之衡生物科技有限公司 一种表达glp-1和胰岛素缀合物多肽的重组工程菌
CN115947822B (zh) * 2022-07-04 2023-08-18 北京惠之衡生物科技有限公司 一种长效酰化胰岛素衍生物及其药物组合物和应用
WO2024051787A1 (zh) * 2022-09-09 2024-03-14 北京惠之衡生物科技有限公司 一种长效酰化胰岛素衍生物及其应用

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE257197C (OSRAM)
DE286509C (OSRAM)
US3914252A (en) 1971-03-15 1975-10-21 Continental Oil Co Preparation of N-iodocompounds
DD257197A1 (de) 1987-01-28 1988-06-08 Univ Dresden Tech Verfahren zur herstellung von immobilisierten, in ihrer biologischen aktivitaet stabilisierten und in ihren pharmakologischen eigenschaften modifizierten insulinpraeparationen
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DD286509A5 (de) 1989-06-30 1991-01-31 Veb Berlin-Chemie,De Verfahren zur herstellung von aktivitaetsstabilisierten, wirkungsverlaengerten rektal applizierbaren insulinpraeparationen
SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
CA2095633C (en) 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
ZA954983B (en) 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
DK0851925T3 (da) 1995-09-21 2005-11-28 Genentech Inc Humane Væksthormonvarianter
AU5065198A (en) 1996-11-15 1998-06-10 Maria Grazia Masucci Fusion proteins having increased half-lives
WO1998028429A1 (en) 1996-12-20 1998-07-02 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
IL133974A0 (en) 1997-07-14 2001-04-30 Bolder Biotechnology Inc Derivatives of growth hormone and related proteins
JP4944324B2 (ja) 1999-07-13 2012-05-30 ボルダー バイオテクノロジー, インコーポレイテッド 免疫グロブリン融合タンパク質
US20050287153A1 (en) 2002-06-28 2005-12-29 Genentech, Inc. Serum albumin binding peptides for tumor targeting
JP2003518075A (ja) 1999-12-24 2003-06-03 ジェネンテック・インコーポレーテッド 生理活性化合物の消失半減期延長のための方法及び組成物
US20060183197A1 (en) 2001-01-11 2006-08-17 Andersen Kim V Variant growth hormone molecules conjugated with macromolecules compounds
WO2002055532A2 (en) 2001-01-11 2002-07-18 Maxygen Aps Variant growth hormone molecules conjugated with macromolecular compounds
PE20020908A1 (es) 2001-03-21 2002-10-26 Cell Therapeutics Inc Produccion recombinante de polimeros polianionicos y uso de de los mismos
MXPA04004385A (es) 2001-11-12 2004-11-29 Univ Cardiff Variaciones de hormona de crecimiento en humanos y sus usos.
GB2384001B (en) 2001-12-14 2004-02-04 Asterion Ltd Chimeric growth hormone-growth hormone receptor proteins
EP2298805A3 (en) 2002-09-27 2011-04-13 Xencor, Inc. Optimized Fc variants and methods for their generation
US20040180054A1 (en) 2003-03-13 2004-09-16 Hanmi Pharm. Co., Ltd. Physiologically active polypeptide conjugate having prolonged in vivo half-life
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
JP4762904B2 (ja) 2003-11-13 2011-08-31 ハンミ ホールディングス カンパニー リミテッド 免疫グロブリン不変領域の量産方法
KR100594607B1 (ko) 2004-11-03 2006-06-30 재단법인서울대학교산학협력재단 신규한 경구투여용 재조합 인간 성장호르몬 분비미생물제제 및 그 제조방법
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
JP5735194B2 (ja) 2005-01-25 2015-06-17 セル セラピューティクス インコーポレーテッド 改善された生体内半減期を有する生物学的に活性なタンパク質
ZA200707006B (en) * 2005-01-25 2008-11-26 Cell Therapeutics Inc Conjugates of biologically active proteins having a modified in vivo half-life
WO2006079641A2 (en) 2005-01-27 2006-08-03 Novo Nordisk A/S Insulin derivatives conjugated with structurally well defined branched polymers
BRPI0607775A2 (pt) 2005-02-16 2018-06-26 Novo Nordisk As conjugado, composição farmacêutica, uso de um composto, e, método para o tratamento ou prevenção de doença
KR100754667B1 (ko) 2005-04-08 2007-09-03 한미약품 주식회사 비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물
JP5255435B2 (ja) 2005-04-26 2013-08-07 メディミューン,エルエルシー ヒンジドメイン操作による抗体エフェクター機能の調節
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2007103515A2 (en) 2006-03-06 2007-09-13 Amunix, Inc. Unstructured recombinant polymers and uses thereof
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
GB2446088B (en) 2005-12-12 2010-10-20 Innova Biosciences Ltd Production of conjugates
US8334257B2 (en) 2005-12-20 2012-12-18 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
WO2008019368A2 (en) 2006-08-07 2008-02-14 Teva Biopharmaceuticals Usa, Inc. Albumin-insulin fusion proteins
ES2410886T3 (es) 2006-10-26 2013-07-03 Janssen Biotech, Inc. Métodos para la adaptación al ser humano de anticuerpos monoclonales
WO2008049711A1 (en) * 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
US20100303723A1 (en) 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
WO2008092117A2 (en) 2007-01-25 2008-07-31 Xencor, Inc. Immunoglobulins with modifications in the fcr binding region
KR20080095141A (ko) 2007-04-23 2008-10-28 포항공과대학교 산학협력단 인간 알부민 링커를 통하여 면역글로불린의 Fc에 결합된생리학적 활성 폴리펩티드의 융합 폴리펩티드, 및 이의제조방법
CN105198998A (zh) 2007-05-30 2015-12-30 浦项工科大学校产学协力团 免疫球蛋白融合蛋白
JP6071165B2 (ja) 2007-05-31 2017-02-01 ゲンマブ エー/エス 安定なIgG4抗体
WO2009015345A1 (en) 2007-07-25 2009-01-29 Amgen Inc. Pharmaceutical compositions comprising fc fusion proteins
BRPI0815416A2 (pt) * 2007-08-15 2014-10-21 Amunix Inc Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos
ES2400107T3 (es) 2007-10-22 2013-04-05 Merck Serono S.A. IFN-beta sencillo fusionado a un fragmento Fc de lgG mutado
MX2010014079A (es) 2008-06-20 2011-02-22 Novartis Ag Inmunoglobulinas con agregacion reducida.
WO2010001196A1 (en) 2008-07-02 2010-01-07 Koninklijke Philips Electronics N.V. V-spring configuration and end attachment assemblies therefor for use in a personal care appliance
ES2523043T3 (es) 2008-07-23 2014-11-20 Hanmi Science Co., Ltd. Un complejo polipeptídico que comprende un polímero no peptidílico que tiene tres extremos funcionales
PL2393828T3 (pl) * 2009-02-03 2017-06-30 Amunix Operating Inc. Wydłużone rekombinowane polipeptydy i zawierające je kompozycje
GB0914110D0 (en) 2009-08-12 2009-09-16 Medical Res Council Peptide libraries
SG10201406063XA (en) 2009-09-30 2014-11-27 Glaxo Group Ltd Drug fusions and conjugates with extended half life
AU2010318542B2 (en) 2009-10-29 2015-08-27 Janssen Biotech Inc. Antibody glycosylation variants
US8637637B2 (en) 2010-01-12 2014-01-28 Bill Nai-Chau Sun Fc fusion proteins of human growth hormone
AR081066A1 (es) 2010-04-02 2012-06-06 Hanmi Holdings Co Ltd Conjugado de insulina donde se usa un fragmento de inmunoglobulina
SI2571510T1 (sl) 2010-05-21 2019-02-28 Xl-Protein Gmbh Biosintetični prolin/alaninski naključno zviti polipeptidi in njihove uporabe
KR101337797B1 (ko) 2010-07-14 2013-12-06 한미사이언스 주식회사 지속형 인간 성장 호르몬 결합체 액상 제제
WO2012138920A1 (en) 2011-04-05 2012-10-11 Martin-Protean, Llc Isolation of cysteine containing peptides
UA117901C2 (uk) 2011-07-06 2018-10-25 Ґенмаб Б.В. Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
MX366864B (es) 2012-02-27 2019-07-26 Amunix Operating Inc Composiciones de conjugados de xten y métodos para realizarlas.
US9545449B2 (en) 2012-05-11 2017-01-17 Advanced Proteone Therapeutics Inc. Site-specific labeling and targeted delivery of proteins for the treatment of cancer
CN105308067B (zh) 2013-06-07 2020-07-24 诺和诺德股份有限公司 制备成熟胰岛素多肽的方法
JP6822839B2 (ja) 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
EP4053560A1 (en) 2013-11-26 2022-09-07 The Brigham and Women's Hospital, Inc. Compositions and methods for modulating an immune response
TW201619188A (zh) 2014-03-05 2016-06-01 優稀美生物醫藥公司 多聚體Fc蛋白質
EP3194447B1 (en) 2014-09-17 2021-12-01 Novo Nordisk A/S Antibodies capable of binding two epitopes on tissue factor pathway inhibitor (1-161)
CN107810202A (zh) 2015-02-17 2018-03-16 韩美药品株式会社 长效胰岛素或胰岛素类似物复合物
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
CN107743494B (zh) 2015-06-02 2022-04-29 诺和诺德股份有限公司 具有极性重组延伸体的胰岛素
WO2017031034A2 (en) 2015-08-14 2017-02-23 Rc Biotechnologies, Inc. Covalent linkers in antibody-drug conjugates and methods of making and using the same
MA43348A (fr) 2015-10-01 2018-08-08 Novo Nordisk As Conjugués de protéines
JP2020513019A (ja) 2017-04-05 2020-04-30 ノヴォ ノルディスク アー/エス オリゴマー伸長インスリン−Fcコンジュゲート

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