JP2018527014A5 - - Google Patents
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- JP2018527014A5 JP2018527014A5 JP2018515108A JP2018515108A JP2018527014A5 JP 2018527014 A5 JP2018527014 A5 JP 2018527014A5 JP 2018515108 A JP2018515108 A JP 2018515108A JP 2018515108 A JP2018515108 A JP 2018515108A JP 2018527014 A5 JP2018527014 A5 JP 2018527014A5
- Authority
- JP
- Japan
- Prior art keywords
- acid sequence
- cell
- hiv
- nucleic acid
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222132P | 2015-09-22 | 2015-09-22 | |
| US62/222,132 | 2015-09-22 | ||
| US201562253790P | 2015-11-11 | 2015-11-11 | |
| US62/253,790 | 2015-11-11 | ||
| PCT/US2016/053097 WO2017053556A1 (en) | 2015-09-22 | 2016-09-22 | Method of redirecting t cells to treat hiv infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527014A JP2018527014A (ja) | 2018-09-20 |
| JP2018527014A5 true JP2018527014A5 (https=) | 2019-10-31 |
| JP6991131B2 JP6991131B2 (ja) | 2022-02-03 |
Family
ID=58387210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018515108A Active JP6991131B2 (ja) | 2015-09-22 | 2016-09-22 | Ｈｉｖ感染症を処置するためにｔ細胞を再度方向付ける方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10738099B2 (https=) |
| EP (1) | EP3353197A4 (https=) |
| JP (1) | JP6991131B2 (https=) |
| KR (1) | KR20180050413A (https=) |
| CN (1) | CN108779161A (https=) |
| AU (1) | AU2016326500A1 (https=) |
| BR (1) | BR112018005741A2 (https=) |
| CA (1) | CA2999496A1 (https=) |
| CL (1) | CL2018000750A1 (https=) |
| EA (1) | EA201890782A1 (https=) |
| IL (1) | IL258191A (https=) |
| MA (1) | MA42951A (https=) |
| MX (1) | MX2018003463A (https=) |
| PH (1) | PH12018500609A1 (https=) |
| WO (1) | WO2017053556A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10434153B1 (en) | 2015-05-20 | 2019-10-08 | Kim Leslie O'Neill | Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors |
| WO2017053556A1 (en) * | 2015-09-22 | 2017-03-30 | The Trustees Of The University Of Pennsylvania | Method of redirecting t cells to treat hiv infection |
| HRP20211528T1 (hr) | 2015-10-25 | 2021-12-24 | Sanofi | Trispecifični i/ili trovalentni vezujući proteini za prevenciju ili liječenje hiv infekcije |
| US10888613B2 (en) | 2016-02-08 | 2021-01-12 | American Gene Technologies International Inc. | Method of producing cells resistant to HIV infection |
| IL262241B2 (en) | 2016-04-13 | 2024-05-01 | Sanofi Sa | Trispecific and/or trivalent binding proteins with a crossover dual variable domain arm and a traditional antibody fab arm, pharmaceutical composition comprising said binding proteins and their uses in preventing and/or treating cancer or inflammatory diseases |
| HRP20231188T1 (hr) | 2016-04-13 | 2024-02-02 | Sanofi | Trispecifični i/ili trovalentni vezujući proteini |
| IL284348B2 (en) | 2016-07-08 | 2025-06-01 | American Gene Tech Int Inc | Hiv pre-immunization and immunotherapy |
| US20200061117A1 (en) * | 2017-05-08 | 2020-02-27 | The Regents Of The University Of California | Protective Chimeric Antigen Receptor Stem Cell Gene Therapy for Viral Infection |
| US10415017B2 (en) | 2017-05-17 | 2019-09-17 | Thunder Biotech, Inc. | Transgenic macrophages, chimeric antigen receptors, and associated methods |
| JP7164598B2 (ja) * | 2017-05-17 | 2022-11-01 | サンダー・バイオテック・インコーポレイテッド | トランスジェニックマクロファージ、キメラ抗原受容体、及び関連する方法 |
| WO2019084018A1 (en) * | 2017-10-23 | 2019-05-02 | City Of Hope | CAR FOR THE TREATMENT OF HIV INFECTION |
| CN108059675B (zh) * | 2017-12-12 | 2021-09-10 | 武汉波睿达生物科技有限公司 | 重组pg9-car分子的构建及其在清除hiv-1感染细胞中的应用 |
| US20210275589A1 (en) | 2018-07-13 | 2021-09-09 | Nanjing Legend Biotech Co. Ltd. | Co-receptor systems for treating infectious diseases |
| WO2020159941A1 (en) * | 2019-01-28 | 2020-08-06 | Xyphos Biosciences Inc. | Modified non-natural nkg2d ligands that selectively deliver attached heterologous molecules to non-natural nkg2d receptors on car-cells |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| CN110358793A (zh) * | 2019-05-30 | 2019-10-22 | 南京艾德免疫治疗研究院有限公司 | 一种用于car-t制备的慢病毒载体制备方法 |
| AU2020286471B2 (en) * | 2019-06-07 | 2025-07-31 | The Trustees Of The University Of Pennsylvania | Dual CAR expressing T cells individually linked to CD28 and 4-1BB |
| CN110343175B (zh) * | 2019-06-26 | 2021-02-26 | 深圳市再生之城生物医药技术有限公司 | 抑制HIV-1病毒感染的scFv序列及其应用 |
| JP2023516685A (ja) * | 2020-03-03 | 2023-04-20 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Ｈｉｖを処置するためのリンパ球における外因性因子のオンデマンド発現 |
| AU2022425312A1 (en) * | 2021-12-31 | 2024-07-18 | Beijing Solobio Genetechnology Co., Ltd. | Chimeric antigen receptor t cells targeting hiv-infected cells |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5851828A (en) | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
| US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
| AU2752892A (en) * | 1991-09-26 | 1993-04-27 | Oklahoma Medical Research Foundation | Fusion proteins targeted to lysosomes, for the treatment of aids |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| WO1996003883A1 (en) * | 1994-08-02 | 1996-02-15 | The General Hospital Corporation | Cells bearing cd4 decoy receptors and related molecules and methods |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US9708384B2 (en) * | 2011-09-22 | 2017-07-18 | The Trustees Of The University Of Pennsylvania | Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens |
| JP6850528B2 (ja) | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| AU2013289979A1 (en) | 2012-07-13 | 2015-01-22 | The Trustees Of The University Of Pennsylvania | Methods of assessing the suitability of transduced T cells for administration |
| TW201446794A (zh) * | 2013-02-20 | 2014-12-16 | Novartis Ag | 利用抗－ｃｄ１２３嵌合抗原受體工程化ｔ細胞之初級人類白血病有效靶向 |
| UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| CA2954168C (en) | 2013-08-02 | 2023-09-19 | The Regents Of The University Of California | Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| US10246505B2 (en) | 2013-11-25 | 2019-04-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors to control HIV infection |
| US10934346B2 (en) | 2014-02-14 | 2021-03-02 | Bellicum Pharmaceuticals, Inc. | Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12 |
| DK3166968T3 (da) * | 2014-05-02 | 2021-12-06 | Univ Pennsylvania | Sammensætninger og fremgangsmåder til kimæriske autoantistofreceptor-T-celler |
| WO2017053556A1 (en) * | 2015-09-22 | 2017-03-30 | The Trustees Of The University Of Pennsylvania | Method of redirecting t cells to treat hiv infection |
-
2016
- 2016-09-22 WO PCT/US2016/053097 patent/WO2017053556A1/en not_active Ceased
- 2016-09-22 CA CA2999496A patent/CA2999496A1/en active Pending
- 2016-09-22 KR KR1020187011293A patent/KR20180050413A/ko not_active Withdrawn
- 2016-09-22 US US15/761,563 patent/US10738099B2/en active Active
- 2016-09-22 MA MA042951A patent/MA42951A/fr unknown
- 2016-09-22 CN CN201680066602.4A patent/CN108779161A/zh active Pending
- 2016-09-22 BR BR112018005741A patent/BR112018005741A2/pt not_active Application Discontinuation
- 2016-09-22 EP EP16849585.1A patent/EP3353197A4/en active Pending
- 2016-09-22 JP JP2018515108A patent/JP6991131B2/ja active Active
- 2016-09-22 MX MX2018003463A patent/MX2018003463A/es unknown
- 2016-09-22 AU AU2016326500A patent/AU2016326500A1/en not_active Abandoned
- 2016-09-22 EA EA201890782A patent/EA201890782A1/ru unknown
-
2018
- 2018-03-18 IL IL258191A patent/IL258191A/en unknown
- 2018-03-21 PH PH12018500609A patent/PH12018500609A1/en unknown
- 2018-03-21 CL CL2018000750A patent/CL2018000750A1/es unknown
-
2020
- 2020-08-07 US US16/988,415 patent/US12122820B2/en active Active
-
2024
- 2024-09-13 US US18/885,127 patent/US20250084147A1/en active Pending
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