JP2024507996A5 - - Google Patents

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Publication number
JP2024507996A5
JP2024507996A5 JP2023552220A JP2023552220A JP2024507996A5 JP 2024507996 A5 JP2024507996 A5 JP 2024507996A5 JP 2023552220 A JP2023552220 A JP 2023552220A JP 2023552220 A JP2023552220 A JP 2023552220A JP 2024507996 A5 JP2024507996 A5 JP 2024507996A5
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JP
Japan
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protein
plasmid
seq
cells
domain
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Pending
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JP2023552220A
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English (en)
Japanese (ja)
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JP2024507996A (ja
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Priority claimed from PCT/US2022/018027 external-priority patent/WO2022183072A1/en
Publication of JP2024507996A publication Critical patent/JP2024507996A/ja
Publication of JP2024507996A5 publication Critical patent/JP2024507996A5/ja
Pending legal-status Critical Current

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JP2023552220A 2021-02-26 2022-02-25 リンパ球を標的とするレンチウイルスベクター Pending JP2024507996A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163154639P 2021-02-26 2021-02-26
US63/154,639 2021-02-26
PCT/US2022/018027 WO2022183072A1 (en) 2021-02-26 2022-02-25 Lymphocyte targeted lentiviral vectors

Publications (2)

Publication Number Publication Date
JP2024507996A JP2024507996A (ja) 2024-02-21
JP2024507996A5 true JP2024507996A5 (https=) 2025-03-03

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ID=80780729

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JP2023552220A Pending JP2024507996A (ja) 2021-02-26 2022-02-25 リンパ球を標的とするレンチウイルスベクター

Country Status (11)

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US (3) US20240218390A1 (https=)
EP (1) EP4298114A1 (https=)
JP (1) JP2024507996A (https=)
KR (1) KR20230160242A (https=)
CN (1) CN117203223A (https=)
AU (1) AU2022227021A1 (https=)
BR (1) BR112023017213A2 (https=)
CA (1) CA3212006A1 (https=)
IL (1) IL305411A (https=)
MX (1) MX2023009910A (https=)
WO (1) WO2022183072A1 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022227021A1 (en) 2021-02-26 2023-09-21 Kelonia Therapeutics, Inc. Lymphocyte targeted lentiviral vectors
US12565647B2 (en) 2021-05-28 2026-03-03 The Regents Of The University Of California Compositions and methods for targeted delivery of CRISPR-Cas effector polypeptides and transgenes
IL313473A (en) 2021-12-15 2024-08-01 Interius Biotherapeutics Inc Pseudotyped viral particles, compositions comprising the same, and uses thereof
KR20250057777A (ko) 2022-07-25 2025-04-29 인테리우스 바이오테라퓨틱스, 인코포레이티드 돌연변이된 폴리펩티드, 이를 포함하는 조성물, 및 그 용도(mutated polypeptides, compositions comprising the same, and uses thereof)
EP4587580A2 (en) * 2022-09-12 2025-07-23 The Board of Trustees of the Leland Stanford Junior University Composition and method of universal pseudotyped retroviruses
CN117802163A (zh) * 2022-09-30 2024-04-02 深圳市济因生物科技有限公司 靶向载体及其制备方法与用途
KR20250121163A (ko) * 2022-11-04 2025-08-11 우모자 바이오파마 인코포레이티드 융합 분자를 디스플레이하는 렌티바이러스 입자 및 이의 용도
TW202434735A (zh) * 2022-11-04 2024-09-01 美商烏莫賈生物製藥股份有限公司 展示黏著分子融合的顆粒
WO2024145593A1 (en) * 2022-12-29 2024-07-04 Kelonia Therapeutics, Inc. Recombinant retrovirus, compositions, and methods of use
WO2024145605A1 (en) * 2022-12-29 2024-07-04 Kelonia Therapeutics, Inc. Recombinant retroviruses, compositions, and methods of use
WO2024145599A1 (en) * 2022-12-29 2024-07-04 Kelonia Therapeutics, Inc. Recombinant retrovirus, compositions, and methods of use
WO2024145622A1 (en) * 2022-12-29 2024-07-04 Kelonia Therapeutics, Inc. Recombinant retroviruses, compositions, and methods of use
EP4680753A2 (en) * 2023-03-17 2026-01-21 Kelonia Therapeutics, Inc. Dual targeted gene therapy
WO2024207008A2 (en) * 2023-03-30 2024-10-03 Kelonia Therapeutics, Inc. In vivo lentivirus animal models
JP2026512079A (ja) * 2023-04-10 2026-04-14 深▲せん▼市済因生物科技有限公司 突然変異型の水疱性口内炎ウイルスg糖タンパク及びターゲティングベクター
EP4694916A1 (en) 2023-04-14 2026-02-18 SOTIO Biotech Inc. Engineered immune cells for treating cancer in combination with il-2/il-15 receptor ?? agonists
WO2024215987A1 (en) 2023-04-14 2024-10-17 Sotio Biotech Inc. IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES
EP4713467A1 (en) * 2023-05-15 2026-03-25 Umoja Biopharma, Inc. Lentiviral delivery of anti-cd20 chimeric antigen receptors
ES3055997T3 (en) * 2023-06-30 2026-02-17 Esobiotec Sa Viral vector and producer cell
WO2025011662A1 (zh) * 2023-07-12 2025-01-16 深圳市济因生物科技有限公司 一种载体和体外转染非激活t细胞的方法
CN121443745A (zh) * 2023-07-25 2026-01-30 深圳市济因生物科技有限公司 一种病毒载体及tcr亚基的应用
CN121844055A (zh) * 2023-08-16 2026-04-10 深圳市济因生物科技有限公司 一种病毒载体及其在感染b细胞中的应用
WO2025072257A1 (en) * 2023-09-25 2025-04-03 Kelonia Therapeutics, Inc. Compositions for treating cancer
AU2024353718A1 (en) 2023-09-25 2026-04-09 Kelonia Therapeutics, Inc. Compositions for treating cancer
AU2024353243A1 (en) 2023-09-25 2026-04-09 Kelonia Therapeutics, Inc. Antigen binding polypeptides
CN116987157B (zh) * 2023-09-27 2023-11-28 深圳华大生命科学研究院 一种弹状病毒包膜蛋白、含其的靶向慢病毒载体及其应用
WO2025149068A1 (zh) * 2024-01-10 2025-07-17 深圳市济因生物科技有限公司 一种病毒颗粒及其制备方法与应用
WO2025178803A1 (en) * 2024-02-21 2025-08-28 The Regents Of The University Of California Compositions and methods for targeted delivery of nucleic acid-binding effector polypeptides
WO2025203091A2 (en) * 2024-03-26 2025-10-02 Micro Crispr Pvt. Ltd. Surface modification of lentiviral particle and producer cell thereof
CN119174831A (zh) * 2024-11-26 2024-12-24 中国医学科学院医学实验动物研究所 基于冠状病毒Spike与hACE2互作介导的细胞特异性基因递送系统

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
GB9300059D0 (en) 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
TW225528B (https=) 1992-04-03 1994-06-21 Ciba Geigy Ag
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
SI9620103A (sl) 1995-07-06 1998-10-31 Novartis Ag Pirolopirimidini in postopki za njihovo pripravo
GB9518220D0 (en) 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
EA001595B1 (ru) 1996-04-12 2001-06-25 Варнер-Ламберт Компани Необратимые ингибиторы тирозинкиназ
CA2258548C (en) 1996-06-24 2005-07-26 Pfizer Inc. Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
EP0954315A2 (en) 1996-09-13 1999-11-10 Sugen, Inc. Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders
EP0837063A1 (en) 1996-10-17 1998-04-22 Pfizer Inc. 4-Aminoquinazoline derivatives
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
ATE528406T1 (de) 1999-04-29 2011-10-15 Gbp Ip Llc Verfahren und mittel zur herstellung von sicheren,rekombinanten lentivirusvektoren mit hohem titer
IL148621A0 (en) 1999-09-17 2002-09-12 Pro Virus Inc Oncolytic virus
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
CA2344208A1 (en) 2001-04-30 2002-10-30 Oxford Biomedica (Uk) Limited Method
PT1478648E (pt) 2002-02-01 2014-07-15 Ariad Pharma Inc Compostos contendo fósforo e suas utilizações
DE60333487D1 (de) 2002-12-13 2010-09-02 Genetix Pharmaceuticals Inc Therapeutische retrovirus-vektoren für gentherapie
US20080227736A1 (en) 2004-06-03 2008-09-18 Regents Of The University Of California, Targeting Pseudotyped Retroviral Vectors
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
EP1885186B1 (en) 2005-06-01 2015-09-02 California Institute Of Technology Method of targeted gene delivery using viral vectors
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
US8008268B2 (en) 2006-07-25 2011-08-30 Merial Limited Vaccines against vesicular stomatitis
EP1975239A1 (en) 2006-09-27 2008-10-01 Bundesrepublik Deutschland, letztvertreten durch den Präsidenten des Paul-Ehrlich-Instituts Prof. Dr. Johannes Löwer Pseudotyping of retroviral vectors, methods for production and use thereof for targeted gene transfer and high-throughput screening
EP2019144A1 (en) 2007-07-23 2009-01-28 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vector particles for targeting CD34+ cells
EP2205242B1 (en) 2007-09-12 2015-04-15 Genentech, Inc. Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
JP5348725B2 (ja) 2007-10-25 2013-11-20 ジェネンテック, インコーポレイテッド チエノピリミジン化合物の製造方法
AU2009266924B2 (en) 2008-07-01 2015-12-10 Genocea Biosciences, Inc. Antigen screening system
CA2825370A1 (en) 2010-12-22 2012-06-28 President And Fellows Of Harvard College Continuous directed evolution
WO2014016383A2 (en) 2012-07-25 2014-01-30 Theravectys Glycoproteins for pseudotyping lentivectors
BR122020002986A8 (pt) 2012-08-20 2023-04-18 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Método e composições para imunoterapia celular
US10072273B2 (en) 2014-01-10 2018-09-11 Helmholtz Zentrum München—Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Pseudotyped lentiviral vectors
SG11201605632SA (en) 2014-01-21 2016-08-30 Einstein Coll Med Cellular platform for rapid and comprehensive t-cell immunomonitoring
JP6509884B2 (ja) 2014-01-30 2019-05-08 チルドレンズ ホスピタル メディカル センター 鎌状赤血球病の遺伝子的是正のための改善された胎児ヘモグロビン
US10816554B2 (en) 2014-04-04 2020-10-27 The Board Of Trustees Of The Leland Stanford Junior University Ligand discovery for T cell receptors
HUE049514T2 (hu) 2014-04-25 2020-09-28 Bluebird Bio Inc Javított eljárások adoptív sejtterápiák kialakítására
US9759689B2 (en) 2014-05-02 2017-09-12 The Regents Of The University Of Michigan Real-time detection and imaging of terahertz pulse radiation by using photoacoustic conversion
EP3031923A1 (en) 2014-12-11 2016-06-15 Institut Pasteur Lentiviral vector-based japanese encephalitis immunogenic composition
PL3560953T3 (pl) * 2014-12-24 2024-05-13 Autolus Limited Komórka
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
EP3235908A1 (en) 2016-04-21 2017-10-25 Ecole Normale Superieure De Lyon Methods for selectively modulating the activity of distinct subtypes of cells
CN111093715A (zh) 2017-09-18 2020-05-01 儿童医院医疗中心 强绝缘子和其在基因递送中的用途
GB201715052D0 (en) * 2017-09-19 2017-11-01 Oxford Genetics Ltd Vectors
JP7799945B2 (ja) 2017-09-22 2026-01-16 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック 変異型ウイルスタンパク質
JP7599205B2 (ja) * 2018-06-01 2024-12-13 アンヘレス セラピューティクス インコーポレイテッド 細胞療法のための多様な抗原結合ドメイン、新規プラットフォームおよびその他の強化
US20240025963A1 (en) 2018-12-14 2024-01-25 2Seventy Bio, Inc. Dimerizing agent regulated immunoreceptor complexes
CN114072418A (zh) 2019-05-20 2022-02-18 实验与技术生物学研究所(Ibet) 逆转录病毒科病毒载体伪分型的改性包膜糖蛋白及其获得方法
JP7658584B2 (ja) 2019-05-23 2025-04-08 マサチューセッツ インスティテュート オブ テクノロジー リガンドの発見およびレトロウイルス表面ディスプレーを介した遺伝子送達
AU2022227021A1 (en) 2021-02-26 2023-09-21 Kelonia Therapeutics, Inc. Lymphocyte targeted lentiviral vectors
JP2024513973A (ja) 2021-04-16 2024-03-27 マサチューセッツ インスティテュート オブ テクノロジー 造血幹細胞のウイルスによる標的化
IL313473A (en) 2021-12-15 2024-08-01 Interius Biotherapeutics Inc Pseudotyped viral particles, compositions comprising the same, and uses thereof

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