JP2018526407A5 - - Google Patents
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- JP2018526407A5 JP2018526407A5 JP2018512564A JP2018512564A JP2018526407A5 JP 2018526407 A5 JP2018526407 A5 JP 2018526407A5 JP 2018512564 A JP2018512564 A JP 2018512564A JP 2018512564 A JP2018512564 A JP 2018512564A JP 2018526407 A5 JP2018526407 A5 JP 2018526407A5
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- JP
- Japan
- Prior art keywords
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- pharmaceutical composition
- valyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 23
- 208000024827 Alzheimer disease Diseases 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 4
- 230000006996 mental state Effects 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 229940100691 oral capsule Drugs 0.000 claims description 3
- 229940096978 oral tablet Drugs 0.000 claims description 3
- 239000007935 oral tablet Substances 0.000 claims description 3
- SNKZJIOFVMKAOJ-UHFFFAOYSA-N 3-Aminopropanesulfonate Chemical compound NCCCS(O)(=O)=O SNKZJIOFVMKAOJ-UHFFFAOYSA-N 0.000 claims description 2
- 230000006999 cognitive decline Effects 0.000 claims description 2
- 208000010877 cognitive disease Diseases 0.000 claims description 2
- 229960003570 tramiprosate Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 description 1
- 239000008203 oral pharmaceutical composition Substances 0.000 description 1
- KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562216404P | 2015-09-10 | 2015-09-10 | |
| US62/216,404 | 2015-09-10 | ||
| US201662290287P | 2016-02-02 | 2016-02-02 | |
| US62/290,287 | 2016-02-02 | ||
| US201662302027P | 2016-03-01 | 2016-03-01 | |
| US62/302,027 | 2016-03-01 | ||
| US201662365809P | 2016-07-22 | 2016-07-22 | |
| US62/365,809 | 2016-07-22 | ||
| PCT/US2016/051091 WO2017044840A1 (en) | 2015-09-10 | 2016-09-09 | Methods of treating neurodegenerative disorders in a particular patient population |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020161995A Division JP7128536B2 (ja) | 2015-09-10 | 2020-09-28 | 特定の患者集団において神経変性障害を処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018526407A JP2018526407A (ja) | 2018-09-13 |
| JP2018526407A5 true JP2018526407A5 (https=) | 2019-10-24 |
| JP6789579B2 JP6789579B2 (ja) | 2020-11-25 |
Family
ID=58240195
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018512564A Active JP6789579B2 (ja) | 2015-09-10 | 2016-09-09 | 特定の患者集団において神経変性障害を処置する方法 |
| JP2020161995A Active JP7128536B2 (ja) | 2015-09-10 | 2020-09-28 | 特定の患者集団において神経変性障害を処置する方法 |
| JP2022128786A Pending JP2022145949A (ja) | 2015-09-10 | 2022-08-12 | 特定の患者集団において神経変性障害を処置する方法 |
| JP2025023627A Pending JP2025065545A (ja) | 2015-09-10 | 2025-02-17 | 特定の患者集団において神経変性障害を処置する方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020161995A Active JP7128536B2 (ja) | 2015-09-10 | 2020-09-28 | 特定の患者集団において神経変性障害を処置する方法 |
| JP2022128786A Pending JP2022145949A (ja) | 2015-09-10 | 2022-08-12 | 特定の患者集団において神経変性障害を処置する方法 |
| JP2025023627A Pending JP2025065545A (ja) | 2015-09-10 | 2025-02-17 | 特定の患者集団において神経変性障害を処置する方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US11191742B2 (https=) |
| EP (2) | EP3347002B1 (https=) |
| JP (4) | JP6789579B2 (https=) |
| KR (2) | KR102547164B1 (https=) |
| CN (3) | CN116712422A (https=) |
| AU (1) | AU2016319107B2 (https=) |
| CA (1) | CA2997376C (https=) |
| DK (1) | DK3347002T3 (https=) |
| ES (1) | ES2952727T3 (https=) |
| FI (1) | FI3347002T3 (https=) |
| HR (1) | HRP20230809T1 (https=) |
| HU (1) | HUE062511T2 (https=) |
| LT (1) | LT3347002T (https=) |
| MD (1) | MD3347002T2 (https=) |
| MX (2) | MX392677B (https=) |
| PL (1) | PL3347002T3 (https=) |
| PT (1) | PT3347002T (https=) |
| RS (1) | RS64481B1 (https=) |
| SI (1) | SI3347002T1 (https=) |
| SM (1) | SMT202300250T1 (https=) |
| WO (1) | WO2017044840A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2941415A1 (en) | 2014-03-21 | 2015-09-24 | Alzheon, Inc. | Methods for treating neurological disorders |
| FI3347002T3 (fi) * | 2015-09-10 | 2023-08-10 | Alzheon Inc | Alzheimerin taudin hoitaminen tietyssä potilaspopulaatiossa |
| CN108623501B (zh) | 2017-03-21 | 2022-04-19 | 润佳（苏州）医药科技有限公司 | 同位素富集的3-氨基-1-丙磺酸衍生物及其用途 |
| CN110003058B (zh) | 2018-01-04 | 2022-01-25 | 润佳（苏州）医药科技有限公司 | 3-((l-缬氨酰基)氨基)-3,3-二氘-1-丙磺酸晶型、制备方法及用途 |
| IL316611A (en) * | 2018-08-01 | 2024-12-01 | Alzheon Inc | Sulfopropanoic acid derivatives for treating neurodegenerative disorders |
| JP7573512B2 (ja) * | 2018-08-01 | 2024-10-25 | アルツェオン・インコーポレーテッド | 神経変性障害を治療するための方法 |
| CN111170901A (zh) * | 2018-11-13 | 2020-05-19 | 润佳（苏州）医药科技有限公司 | 3-((l-缬氨酰基)氨基)-1-丙磺酸晶型、制备方法及其用途 |
| BR112021025504A2 (pt) * | 2019-06-17 | 2022-04-26 | Alzheon Inc | Métodos para tratar distúrbios neurodegenerativos |
| CN116059192B (zh) | 2019-11-13 | 2024-10-29 | 润佳（苏州）医药科技有限公司 | 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途 |
| MX2024007070A (es) * | 2021-12-09 | 2024-08-22 | Alzheon Inc | Alz-801 para uso en el tratamiento de la enfermedad de alzheimer. |
| EP4475831A1 (en) * | 2022-02-07 | 2024-12-18 | Alzheon, Inc. | Alz-801 for use in treating a covid-19 associated neurological symptom |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| JP3265577B2 (ja) | 1992-10-13 | 2002-03-11 | デューク・ユニバーシティ | アポリポ蛋白ｅの４型イソ型の測定法 |
| US20050031651A1 (en) | 2002-12-24 | 2005-02-10 | Francine Gervais | Therapeutic formulations for the treatment of beta-amyloid related diseases |
| US20050142191A1 (en) | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
| US20060079578A1 (en) | 2003-06-23 | 2006-04-13 | Julie Laurin | Pharmaceutical formulations of amyloid inhibiting compounds |
| US20070010573A1 (en) | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| WO2005060393A2 (en) | 2003-08-11 | 2005-07-07 | California Institute Of Technology | Microfluidic large scale integration |
| CA2611586A1 (en) * | 2005-04-12 | 2007-06-21 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
| PT2089417E (pt) | 2006-10-12 | 2015-04-14 | Bhi Ltd Partnership | Métodos, compostos, composições e veículos para administrar o ácido 3-amino-1-propanossulfónico |
| CN102838532A (zh) | 2006-11-24 | 2012-12-26 | Ac免疫有限公司 | 用于治疗与淀粉样物质或淀粉样蛋白有关的疾病的吡唑胺和噻唑胺衍生物 |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| EP2322163A1 (en) * | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| US20120009125A1 (en) | 2010-07-06 | 2012-01-12 | Lombard Jay L | Apoe4 and apoj biomarker-based prevention and treatment of dementia |
| JP6250394B2 (ja) | 2010-08-19 | 2017-12-20 | バック・インスティテュート・フォー・リサーチ・オン・エイジング | 軽度の認知障害（ｍｃｉ）および関連障害の処置方法 |
| EP2847218A4 (en) * | 2012-05-08 | 2015-12-30 | Univ Ramot | APOE4 ANTIBODY FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES |
| LT2994160T (lt) * | 2013-05-06 | 2019-08-26 | Baxalta Incorporated | Alzheimerio ligos pogrupių gydymas su iš kelių donorų sumaišytu imunoglobulinu g |
| RU2724190C2 (ru) * | 2014-02-08 | 2020-06-23 | Дженентек, Инк. | Способы лечения болезни альцгеймера |
| CA2941415A1 (en) * | 2014-03-21 | 2015-09-24 | Alzheon, Inc. | Methods for treating neurological disorders |
| FI3347002T3 (fi) * | 2015-09-10 | 2023-08-10 | Alzheon Inc | Alzheimerin taudin hoitaminen tietyssä potilaspopulaatiossa |
-
2016
- 2016-09-09 FI FIEP16845181.3T patent/FI3347002T3/fi active
- 2016-09-09 JP JP2018512564A patent/JP6789579B2/ja active Active
- 2016-09-09 MD MDE20180700T patent/MD3347002T2/ro unknown
- 2016-09-09 AU AU2016319107A patent/AU2016319107B2/en active Active
- 2016-09-09 US US15/758,405 patent/US11191742B2/en active Active
- 2016-09-09 KR KR1020227009418A patent/KR102547164B1/ko active Active
- 2016-09-09 HR HRP20230809TT patent/HRP20230809T1/hr unknown
- 2016-09-09 CN CN202310582365.9A patent/CN116712422A/zh active Pending
- 2016-09-09 KR KR1020187009381A patent/KR102412997B1/ko active Active
- 2016-09-09 EP EP16845181.3A patent/EP3347002B1/en active Active
- 2016-09-09 CN CN202310582394.5A patent/CN116712423A/zh active Pending
- 2016-09-09 PT PT168451813T patent/PT3347002T/pt unknown
- 2016-09-09 PL PL16845181.3T patent/PL3347002T3/pl unknown
- 2016-09-09 RS RS20230603A patent/RS64481B1/sr unknown
- 2016-09-09 SI SI201631729T patent/SI3347002T1/sl unknown
- 2016-09-09 CA CA2997376A patent/CA2997376C/en active Active
- 2016-09-09 DK DK16845181.3T patent/DK3347002T3/da active
- 2016-09-09 HU HUE16845181A patent/HUE062511T2/hu unknown
- 2016-09-09 LT LTEPPCT/US2016/051091T patent/LT3347002T/lt unknown
- 2016-09-09 WO PCT/US2016/051091 patent/WO2017044840A1/en not_active Ceased
- 2016-09-09 ES ES16845181T patent/ES2952727T3/es active Active
- 2016-09-09 MX MX2018003023A patent/MX392677B/es unknown
- 2016-09-09 CN CN201680052760.4A patent/CN108289870A/zh active Pending
- 2016-09-09 SM SM20230250T patent/SMT202300250T1/it unknown
- 2016-09-09 EP EP23176559.5A patent/EP4275750A3/en active Pending
-
2018
- 2018-03-09 MX MX2022003128A patent/MX2022003128A/es unknown
-
2020
- 2020-09-28 JP JP2020161995A patent/JP7128536B2/ja active Active
-
2021
- 2021-09-17 US US17/477,886 patent/US20220096406A1/en not_active Abandoned
-
2022
- 2022-08-12 JP JP2022128786A patent/JP2022145949A/ja active Pending
-
2023
- 2023-09-06 US US18/462,238 patent/US20230414541A1/en active Pending
-
2025
- 2025-02-17 JP JP2025023627A patent/JP2025065545A/ja active Pending
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