JP2018522579A - アクチビンＩＩ型受容体リガンドトラップを使用するβ−サラセミアのインビトロ細胞培養法 - Google Patents

アクチビンＩＩ型受容体リガンドトラップを使用するβ−サラセミアのインビトロ細胞培養法 Download PDF

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JP2018522579A
JP2018522579A JP2018512825A JP2018512825A JP2018522579A JP 2018522579 A JP2018522579 A JP 2018522579A JP 2018512825 A JP2018512825 A JP 2018512825A JP 2018512825 A JP2018512825 A JP 2018512825A JP 2018522579 A JP2018522579 A JP 2018522579A
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カッペリーニ マリア
カッペリーニ マリア
サング ヴィクトリア
サング ヴィクトリア
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Celgene Corp
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K2039/515—Animal cells
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance

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JP2018512825A 2015-05-20 2016-05-19 アクチビンＩＩ型受容体リガンドトラップを使用するβ−サラセミアのインビトロ細胞培養法 Pending JP2018522579A (ja)

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JP2021158571A JP2022023072A (ja) 2015-05-20 2021-09-29 アクチビンＩＩ型受容体リガンドトラップを使用するβ－サラセミアのインビトロ細胞培養法

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US201562164367P 2015-05-20 2015-05-20
US62/164,367 2015-05-20
US201662320032P 2016-04-08 2016-04-08
US62/320,032 2016-04-08
PCT/US2016/033187 WO2016187378A1 (en) 2015-05-20 2016-05-19 In vitro cell culture methods for beta-thalassemia using activin type ii receptor ligand traps

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JP2021158571A Division JP2022023072A (ja) 2015-05-20 2021-09-29 アクチビンＩＩ型受容体リガンドトラップを使用するβ－サラセミアのインビトロ細胞培養法

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JP2018522579A true JP2018522579A (ja) 2018-08-16
JP2018522579A5 JP2018522579A5 (https=) 2019-06-27

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JP2021158571A Pending JP2022023072A (ja) 2015-05-20 2021-09-29 アクチビンＩＩ型受容体リガンドトラップを使用するβ－サラセミアのインビトロ細胞培養法

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US (2) US10548976B2 (https=)
EP (2) EP3298034A4 (https=)
JP (2) JP2018522579A (https=)
CN (1) CN108350057A (https=)
CA (1) CA2986432A1 (https=)
HK (1) HK1252174A1 (https=)
MA (1) MA42160A (https=)
WO (1) WO2016187378A1 (https=)

Cited By (5)

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JP2020193857A (ja) * 2019-05-28 2020-12-03 学校法人 東洋大学 熱中症マーカー及びその利用
JP2023518260A (ja) * 2020-03-20 2023-04-28 ケロス セラピューティクス インコーポレイテッド アクチビン受容体ｉｉ型キメラ及びその使用方法
JP2023529278A (ja) * 2020-04-28 2023-07-10 アクセルロン ファーマ インコーポレイテッド Ａｃｔｒｉｉタンパク質および後毛細管性肺高血圧症の処置における使用
JP2023534143A (ja) * 2020-06-23 2023-08-08 アクセルロン ファーマ インコーポレイテッド 肺動脈性肺高血圧症（ｐａｈ）の処置のためのａｃｔｒｉｉタンパク質
JP7851259B2 (ja) 2020-04-28 2026-04-24 アクセルロン ファーマ インコーポレイテッド Ａｃｔｒｉｉタンパク質および後毛細管性肺高血圧症の処置における使用

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JP2018501307A (ja) 2014-12-03 2018-01-18 セルジーン コーポレイション アクチビン−ＡｃｔＲＩＩアンタゴニスト及び貧血を治療するための使用
MA42160A (fr) 2015-05-20 2018-03-28 Maria Cappellini Procédés de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type ii
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JP7405772B2 (ja) * 2018-05-09 2023-12-26 ケロス セラピューティクス インコーポレイテッド アクチビンｉｉａ型受容体変異体および同変異体を含む医薬組成物
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US12186370B1 (en) 2020-11-05 2025-01-07 Celgene Corporation ACTRIIB ligand trap compositions and uses thereof
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020193857A (ja) * 2019-05-28 2020-12-03 学校法人 東洋大学 熱中症マーカー及びその利用
JP7388679B2 (ja) 2019-05-28 2023-11-29 学校法人 東洋大学 熱中症マーカー及びその利用
JP2023518260A (ja) * 2020-03-20 2023-04-28 ケロス セラピューティクス インコーポレイテッド アクチビン受容体ｉｉ型キメラ及びその使用方法
JP2023529278A (ja) * 2020-04-28 2023-07-10 アクセルロン ファーマ インコーポレイテッド Ａｃｔｒｉｉタンパク質および後毛細管性肺高血圧症の処置における使用
JP7851259B2 (ja) 2020-04-28 2026-04-24 アクセルロン ファーマ インコーポレイテッド Ａｃｔｒｉｉタンパク質および後毛細管性肺高血圧症の処置における使用
JP2023534143A (ja) * 2020-06-23 2023-08-08 アクセルロン ファーマ インコーポレイテッド 肺動脈性肺高血圧症（ｐａｈ）の処置のためのａｃｔｒｉｉタンパク質
JP7854402B2 (ja) 2020-06-23 2026-05-01 アクセルロン ファーマ インコーポレイテッド 肺動脈性肺高血圧症（ｐａｈ）の処置のためのａｃｔｒｉｉタンパク質

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