JP2018519804A5 - - Google Patents
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- JP2018519804A5 JP2018519804A5 JP2017560539A JP2017560539A JP2018519804A5 JP 2018519804 A5 JP2018519804 A5 JP 2018519804A5 JP 2017560539 A JP2017560539 A JP 2017560539A JP 2017560539 A JP2017560539 A JP 2017560539A JP 2018519804 A5 JP2018519804 A5 JP 2018519804A5
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- 239000000427 antigen Substances 0.000 claims description 26
- 102000036639 antigens Human genes 0.000 claims description 24
- 108091007433 antigens Proteins 0.000 claims description 24
- 208000037262 Hepatitis delta Diseases 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 8
- 239000013604 expression vector Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 230000008485 antagonism Effects 0.000 claims description 2
- 210000004748 cultured cell Anatomy 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims 176
- 239000012634 fragment Substances 0.000 claims 14
- 241000700721 Hepatitis B virus Species 0.000 claims 8
- 241000724709 Hepatitis delta virus Species 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 5
- 230000009227 antibody-mediated cytotoxicity Effects 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 208000029570 hepatitis D virus infection Diseases 0.000 description 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020116317A JP7304320B2 (ja) | 2015-05-22 | 2020-07-06 | 抗Ｐｒｅ－Ｓ１ ＨＢＶ抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2015079534 | 2015-05-22 | ||
| CNPCT/CN2015/079534 | 2015-05-22 | ||
| PCT/CN2016/082985 WO2016188386A1 (en) | 2015-05-22 | 2016-05-23 | Anti-Pre-S1 HBV Antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116317A Division JP7304320B2 (ja) | 2015-05-22 | 2020-07-06 | 抗Ｐｒｅ－Ｓ１ ＨＢＶ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018519804A JP2018519804A (ja) | 2018-07-26 |
| JP2018519804A5 true JP2018519804A5 (cg-RX-API-DMAC7.html) | 2019-06-27 |
| JP6820278B2 JP6820278B2 (ja) | 2021-01-27 |
Family
ID=57392535
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560539A Active JP6820278B2 (ja) | 2015-05-22 | 2016-05-23 | 抗Ｐｒｅ−Ｓ１ ＨＢＶ抗体 |
| JP2020116317A Active JP7304320B2 (ja) | 2015-05-22 | 2020-07-06 | 抗Ｐｒｅ－Ｓ１ ＨＢＶ抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116317A Active JP7304320B2 (ja) | 2015-05-22 | 2020-07-06 | 抗Ｐｒｅ－Ｓ１ ＨＢＶ抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20180094047A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3978521A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6820278B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102770671B1 (cg-RX-API-DMAC7.html) |
| CN (3) | CN113527470B (cg-RX-API-DMAC7.html) |
| ES (1) | ES2896275T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1243429A1 (cg-RX-API-DMAC7.html) |
| MA (1) | MA42137A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2739955C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016188386A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102770671B1 (ko) | 2015-05-22 | 2025-02-24 | 화후이 헬스 리미티드 | 항-Pre-S1 HBV 항체 |
| WO2019204462A2 (en) | 2018-04-17 | 2019-10-24 | Celldex Therapeutics, Inc. | Anti-cd27 and anti-pd-l1 antibodies and bispecific constructs |
| JP7454855B2 (ja) * | 2018-12-21 | 2024-03-25 | 国立大学法人広島大学 | 抗ｐｒｅＳ１抗体およびその用途 |
| WO2021013135A1 (en) * | 2019-07-20 | 2021-01-28 | Huahui Health Ltd. | A method of treating hbv infection by using anti-pre-s1 hbv antibodies |
| JP2024525184A (ja) * | 2021-06-15 | 2024-07-10 | アピットバイオ， インク． | Ｂ型肝炎ウイルスｐｒｅＳ１抗原の肝細胞受容体結合部位に特異的に結合するヒト抗体及びその用途 |
| WO2023039243A2 (en) * | 2021-09-13 | 2023-03-16 | Achelois Biopharma, Inc. | Hepatitis b virus antivirus (hbv-antivirus) compositions and methods of use |
| CN116568808A (zh) * | 2021-10-19 | 2023-08-08 | 北京三诺佳邑生物技术有限责任公司 | 特异性结合乙型肝炎病毒表面抗原pre-S1的抗体及其应用 |
| CN114685663B (zh) * | 2022-04-07 | 2023-09-08 | 西南大学 | 一种抗胆固醇依赖性细胞溶素的抗体及其应用 |
| CN117304308A (zh) * | 2022-06-20 | 2023-12-29 | 华辉安健（北京）生物科技有限公司 | 抗乙型肝炎病毒的抗体及其制备和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| CA2041772A1 (en) * | 1990-05-11 | 1991-11-12 | Larry T. Mimms | Monoclonal antibodies to pres2 and pres1 polypeptide of the hepatitis b viral envelope |
| ATE207119T1 (de) * | 1992-11-06 | 2001-11-15 | Sandoz Ltd | Die herstellung von menschlichen, monoklonalen antikörpern, die gegen das oberflächenantigen von hepatitis b aktiv sind |
| KR100345463B1 (ko) | 1998-11-19 | 2003-01-08 | 주)녹십자 | B형간염바이러스의표면항원프리-s1에대한인간화항체및이의제조방법 |
| CN1216914C (zh) * | 2000-05-17 | 2005-08-31 | 韩国科学技术研究院 | 对hbv表面抗原pre－s1具有特异性的人源化抗体 |
| KR100423614B1 (ko) * | 2001-05-16 | 2004-03-22 | 주식회사유한양행 | 비형간염바이러스의 에스-표면항원을 인식하는단일클론항체의 가변영역 및 이를 코딩하는 유전자 |
| EP1281761A1 (en) * | 2001-07-27 | 2003-02-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Hepatitis B virus pre-S1 derived synthetic polypeptides and their use thereof. |
| US7601351B1 (en) * | 2002-06-26 | 2009-10-13 | Human Genome Sciences, Inc. | Antibodies against protective antigen |
| CN1733798B (zh) * | 2005-08-12 | 2012-07-04 | 上海贺普生物科技有限公司 | 乙型肝炎病毒表面l蛋白相关肽 |
| WO2011045079A1 (en) * | 2009-10-15 | 2011-04-21 | Intercell Ag | Hepatitis b virus specific human antibodies |
| CN109354623B (zh) * | 2012-04-25 | 2022-06-24 | 华辉安健（北京）生物科技有限公司 | 乙肝肝炎病毒功能性受体的组成以及相关应用 |
| KR102770671B1 (ko) | 2015-05-22 | 2025-02-24 | 화후이 헬스 리미티드 | 항-Pre-S1 HBV 항체 |
-
2016
- 2016-05-23 KR KR1020177036711A patent/KR102770671B1/ko active Active
- 2016-05-23 WO PCT/CN2016/082985 patent/WO2016188386A1/en not_active Ceased
- 2016-05-23 ES ES16799274T patent/ES2896275T3/es active Active
- 2016-05-23 CN CN202110657776.0A patent/CN113527470B/zh active Active
- 2016-05-23 CN CN201680029377.7A patent/CN107614525B/zh active Active
- 2016-05-23 RU RU2017145085A patent/RU2739955C2/ru active
- 2016-05-23 HK HK18102836.4A patent/HK1243429A1/zh unknown
- 2016-05-23 JP JP2017560539A patent/JP6820278B2/ja active Active
- 2016-05-23 CN CN202310981391.9A patent/CN117247944A/zh active Pending
- 2016-05-23 EP EP21187270.0A patent/EP3978521A1/en active Pending
- 2016-05-23 EP EP16799274.2A patent/EP3298038B1/en active Active
- 2016-05-23 US US15/566,555 patent/US20180094047A1/en not_active Abandoned
- 2016-05-23 MA MA042137A patent/MA42137A/fr unknown
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2018
- 2018-01-08 US US15/864,494 patent/US10544205B2/en active Active
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2019
- 2019-12-12 US US16/711,861 patent/US11485774B2/en active Active
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2020
- 2020-07-06 JP JP2020116317A patent/JP7304320B2/ja active Active