JP2018518172A5 - - Google Patents
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- JP2018518172A5 JP2018518172A5 JP2017563914A JP2017563914A JP2018518172A5 JP 2018518172 A5 JP2018518172 A5 JP 2018518172A5 JP 2017563914 A JP2017563914 A JP 2017563914A JP 2017563914 A JP2017563914 A JP 2017563914A JP 2018518172 A5 JP2018518172 A5 JP 2018518172A5
- Authority
- JP
- Japan
- Prior art keywords
- segment
- arenavirus
- virus vector
- configuration
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 241000712891 Arenavirus Species 0.000 claims description 408
- 239000013598 vector Substances 0.000 claims description 235
- 239000000427 antigen Substances 0.000 claims description 182
- 102000036639 antigens Human genes 0.000 claims description 182
- 108091007433 antigens Proteins 0.000 claims description 182
- 241000701806 Human papillomavirus Species 0.000 claims description 137
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 120
- 239000013603 viral vector Substances 0.000 claims description 115
- 239000012634 fragment Substances 0.000 claims description 106
- 238000000034 method Methods 0.000 claims description 93
- 230000000890 antigenic effect Effects 0.000 claims description 87
- 108090000623 proteins and genes Proteins 0.000 claims description 61
- 102000004169 proteins and genes Human genes 0.000 claims description 59
- 241000700605 Viruses Species 0.000 claims description 51
- 229960005486 vaccine Drugs 0.000 claims description 50
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- 210000004027 cell Anatomy 0.000 claims description 33
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- 101000767631 Human papillomavirus type 16 Protein E7 Proteins 0.000 claims description 32
- 101710132595 Protein E7 Proteins 0.000 claims description 29
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- 241000598436 Human T-cell lymphotropic virus Species 0.000 claims description 3
- 108010086140 Interferon alpha-beta Receptor Proteins 0.000 claims description 3
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- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 description 3
- 101000606090 Homo sapiens Tyrosinase Proteins 0.000 description 3
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- 101100335081 Mus musculus Flt3 gene Proteins 0.000 description 3
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022104300A JP2022160401A (ja) | 2015-06-10 | 2022-06-29 | Ｈｐｖワクチン |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562173805P | 2015-06-10 | 2015-06-10 | |
| US62/173,805 | 2015-06-10 | ||
| US201562254410P | 2015-11-12 | 2015-11-12 | |
| US62/254,410 | 2015-11-12 | ||
| US201662331158P | 2016-05-03 | 2016-05-03 | |
| US62/331,158 | 2016-05-03 | ||
| PCT/EP2016/063182 WO2016198531A2 (en) | 2015-06-10 | 2016-06-09 | Hpv vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022104300A Division JP2022160401A (ja) | 2015-06-10 | 2022-06-29 | Ｈｐｖワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518172A JP2018518172A (ja) | 2018-07-12 |
| JP2018518172A5 true JP2018518172A5 (enExample) | 2020-04-02 |
| JP7098330B2 JP7098330B2 (ja) | 2022-07-11 |
Family
ID=56137292
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017563914A Active JP7098330B2 (ja) | 2015-06-10 | 2016-06-09 | Ｈｐｖワクチン |
| JP2022104300A Pending JP2022160401A (ja) | 2015-06-10 | 2022-06-29 | Ｈｐｖワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022104300A Pending JP2022160401A (ja) | 2015-06-10 | 2022-06-29 | Ｈｐｖワクチン |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10669315B2 (enExample) |
| EP (1) | EP3307308A2 (enExample) |
| JP (2) | JP7098330B2 (enExample) |
| CN (2) | CN115197965A (enExample) |
| AU (2) | AU2016274655B2 (enExample) |
| CA (1) | CA2987155A1 (enExample) |
| HK (1) | HK1246183A1 (enExample) |
| WO (1) | WO2016198531A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2604695T (lt) | 2007-12-27 | 2022-12-12 | Universität Zürich | Replikacijos defektų turintys arenaviruso vektoriai |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| AU2014359276B2 (en) | 2013-12-03 | 2021-01-28 | Hookipa Biotech Gmbh | CMV vaccines |
| RS60937B1 (sr) | 2014-11-13 | 2020-11-30 | Univ Geneve | Tri-segmentirani arenavirusi kao vektori za vakcinu |
| CN115197965A (zh) | 2015-06-10 | 2022-10-18 | 霍欧奇帕生物科技有限公司 | Hpv疫苗 |
| AU2016342376A1 (en) | 2015-10-22 | 2018-06-07 | Modernatx, Inc. | Sexually transmitted disease vaccines |
| CN108779472B (zh) | 2015-11-04 | 2022-09-09 | 霍欧奇帕生物科技有限公司 | 针对乙型肝炎病毒的疫苗 |
| EP3373959B1 (en) | 2015-11-12 | 2022-06-29 | Hookipa Biotech GmbH | Arenavirus particles as cancer vaccines |
| EP3518966A1 (en) | 2016-09-29 | 2019-08-07 | GlaxoSmithKline Biologicals S.A. | Compositions and methods of treatment of persistent hpv infection |
| WO2018083220A2 (en) * | 2016-11-04 | 2018-05-11 | Hookipa Biotech Ag | Replication-deficient arenavirus particles and tri-segmented arenavirus particles as cancer vaccines |
| EP3606549A1 (en) * | 2017-04-07 | 2020-02-12 | Hookipa Biotech GmbH | Arenavirus particles to treat solid tumors |
| KR20200036873A (ko) * | 2017-07-14 | 2020-04-07 | 온코루스, 인크. | 캡슐화된 폴리뉴클레오티드 및 사용 방법 |
| EP3461497A1 (en) * | 2017-09-27 | 2019-04-03 | GlaxoSmithKline Biologicals S.A. | Viral antigens |
| EA202091513A1 (ru) | 2017-12-19 | 2020-09-09 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Вакцины против вируса гепатита b (hbv) и их применение |
| KR102222582B1 (ko) * | 2018-02-02 | 2021-03-04 | 주식회사 에스엘백시젠 | 신규 다가 hpv 백신 조성물 |
| CN109706144A (zh) * | 2018-03-07 | 2019-05-03 | 江苏润洁生物科技有限公司 | 一种治疗性hpv核酸疫苗 |
| JP2022507269A (ja) * | 2018-11-13 | 2022-01-18 | オンコラス， インコーポレイテッド | カプセル化ポリヌクレオチド及び使用方法 |
| CN113347987A (zh) * | 2018-11-28 | 2021-09-03 | 总医院公司 | 针对共生病毒的t细胞导向的抗癌疫苗 |
| JP7125760B2 (ja) * | 2019-06-14 | 2022-08-25 | 国立研究開発法人理化学研究所 | 免疫系を賦活化する細胞および当該細胞を含む医薬組成物 |
| US20220226467A1 (en) * | 2019-06-18 | 2022-07-21 | Janssen Sciences Ireland Unlimited Company | Arenavirus vectors for hepatitis b virus (hbv) vaccines and uses thereof |
| US20220380805A1 (en) * | 2019-11-07 | 2022-12-01 | Universität Basel | Arenaviruses as vectors |
| AU2020382378A1 (en) * | 2019-11-15 | 2022-06-30 | Daiichi Sankyo Company, Limited | Nucleic acid lipid particle vaccine encapsulating HPV mRNA |
| PH12022553102A1 (en) * | 2020-05-14 | 2023-11-20 | Inovio Pharmaceuticals Inc | Vaccines for recurrent respiratory papillomatosis and methods of using the same |
| IL298420A (en) | 2020-05-29 | 2023-01-01 | Hookipa Biotech Gmbh | Cancer treatment strategies using RNA virus vectors |
| CN117280027A (zh) | 2021-03-23 | 2023-12-22 | 霍欧奇帕生物科技有限公司 | 用于治疗前列腺癌的沙粒病毒 |
| CN115820696A (zh) * | 2022-07-28 | 2023-03-21 | 怡道生物科技(苏州)有限公司 | 治疗性多价HPV mRNA疫苗及其制备方法 |
| CN121866044A (zh) | 2023-09-15 | 2026-04-14 | 吉利德科学公司 | 沙粒病毒制剂、方法及其用途 |
| WO2025155938A1 (en) * | 2024-01-18 | 2025-07-24 | Aov Biopharma, Inc. | Vaccine for prevention and treatment of human papilloma virus related cancer |
| WO2025191169A1 (en) * | 2024-03-15 | 2025-09-18 | Hookipa Biotech Gmbh | Modified arenavirus particles expressing cancer testis antigens as cancer immunotherapies |
| CN118344491B (zh) * | 2024-05-03 | 2025-02-14 | 华中科技大学同济医学院附属同济医院 | 一种hpv16/18治疗性疫苗、制备方法和应用 |
| CN118599010B (zh) * | 2024-05-03 | 2025-06-27 | 武汉凯德基诺生物技术有限公司 | 一种hpv16/18/52治疗性疫苗、制备方法和应用 |
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| EP1185615B1 (en) * | 1999-04-06 | 2007-08-01 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses for vaccines and gene therapy |
| US7223408B2 (en) * | 2002-10-03 | 2007-05-29 | Wyeth Holdings Corporation | Human papillomavirus polypeptides and immunogenic compositions |
| KR20070101854A (ko) * | 2004-11-30 | 2007-10-17 | 아에라스 글로벌 티비 백신 파운데이션 | 재조합 이중 가닥 ｒｎａ 뉴클레오캡시드의 생성 및 제조에유용한 세균 패키징 균주 및 그의 용도 |
| EP2007765B1 (en) | 2006-03-23 | 2012-06-27 | Novartis AG | Immunopotentiating compounds |
| WO2007109813A1 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
| LT2604695T (lt) * | 2007-12-27 | 2022-12-12 | Universität Zürich | Replikacijos defektų turintys arenaviruso vektoriai |
| CN102002105B (zh) * | 2009-09-03 | 2013-01-23 | 中国疾病预防控制中心病毒病预防控制所 | Hpv 16型e7e6融合蛋白基因、表达载体、方法、细胞和用途 |
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| JP6219849B2 (ja) | 2012-01-24 | 2017-10-25 | サンフォード ヘルス | 発癌性ウイルスポリペプチド陽性腫瘍治療用ポリヌクレオチド |
| US20150056232A1 (en) * | 2012-04-02 | 2015-02-26 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium for induction of cellular immune response |
| US8999925B2 (en) * | 2013-02-26 | 2015-04-07 | The Administrators Of The Tulane Educational Fund | Arenavirus inhibiting peptides and uses therefor |
| WO2014140301A1 (en) | 2013-03-15 | 2014-09-18 | Université De Genève | Anti-mycobacterial vaccines |
| GB201305361D0 (en) | 2013-03-25 | 2013-05-08 | Univ Edinburgh | Enhanced expression |
| AU2014359276B2 (en) | 2013-12-03 | 2021-01-28 | Hookipa Biotech Gmbh | CMV vaccines |
| WO2015183895A1 (en) | 2014-05-27 | 2015-12-03 | University Of Rochester | Novel arenavirus vaccine |
| US9943585B2 (en) | 2014-07-30 | 2018-04-17 | University Of Rochester | Methods and compositions related to reorganization of arenavirus genome for development of novel arenavirus live-attenuated vaccines (LAV) |
| PL3198008T3 (pl) | 2014-09-22 | 2020-03-31 | Regents Of The University Of Minnesota | Układ wykorzystujący odwrotną genetykę wirusa pichinde i sposoby zastosowania |
| GB201419572D0 (en) | 2014-11-03 | 2014-12-17 | Pirbright Inst The | Virus |
| RS60937B1 (sr) | 2014-11-13 | 2020-11-30 | Univ Geneve | Tri-segmentirani arenavirusi kao vektori za vakcinu |
| DE102015207036A1 (de) | 2015-04-17 | 2016-10-20 | Karl Sebastian Lang | Arenaviren zur Anwendung bei der Behandlung und/oder Vorbeugung von Tumoren sowie Verfahren zur Herstellung von Arenaviren mit (verbesserten) tumorregressiven Eigenschaften |
| CN115197965A (zh) | 2015-06-10 | 2022-10-18 | 霍欧奇帕生物科技有限公司 | Hpv疫苗 |
| US10849969B2 (en) | 2015-10-23 | 2020-12-01 | Institut Pasteur | Recombinant attenuated Mopeia virus comprising a modified nucleoprotein with reduced exonuclease activity |
| CN108779472B (zh) | 2015-11-04 | 2022-09-09 | 霍欧奇帕生物科技有限公司 | 针对乙型肝炎病毒的疫苗 |
| EP3373959B1 (en) | 2015-11-12 | 2022-06-29 | Hookipa Biotech GmbH | Arenavirus particles as cancer vaccines |
| WO2017190074A1 (en) | 2016-04-28 | 2017-11-02 | The University Of Chicago | Lymphangiogenesis for therapeutic immunomodulation |
| CN117486979A (zh) | 2016-05-18 | 2024-02-02 | 巴塞尔大学 | 作为疫苗载体的三区段pichinde病毒 |
| WO2018083220A2 (en) | 2016-11-04 | 2018-05-11 | Hookipa Biotech Ag | Replication-deficient arenavirus particles and tri-segmented arenavirus particles as cancer vaccines |
| EP3606549A1 (en) * | 2017-04-07 | 2020-02-12 | Hookipa Biotech GmbH | Arenavirus particles to treat solid tumors |
| US20220226467A1 (en) * | 2019-06-18 | 2022-07-21 | Janssen Sciences Ireland Unlimited Company | Arenavirus vectors for hepatitis b virus (hbv) vaccines and uses thereof |
| US20220380805A1 (en) | 2019-11-07 | 2022-12-01 | Universität Basel | Arenaviruses as vectors |
| IL298420A (en) | 2020-05-29 | 2023-01-01 | Hookipa Biotech Gmbh | Cancer treatment strategies using RNA virus vectors |
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2016
- 2016-06-09 CN CN202210614772.9A patent/CN115197965A/zh active Pending
- 2016-06-09 US US15/580,964 patent/US10669315B2/en active Active
- 2016-06-09 AU AU2016274655A patent/AU2016274655B2/en active Active
- 2016-06-09 HK HK18105733.1A patent/HK1246183A1/zh unknown
- 2016-06-09 JP JP2017563914A patent/JP7098330B2/ja active Active
- 2016-06-09 WO PCT/EP2016/063182 patent/WO2016198531A2/en not_active Ceased
- 2016-06-09 CA CA2987155A patent/CA2987155A1/en active Pending
- 2016-06-09 EP EP16730302.3A patent/EP3307308A2/en active Pending
- 2016-06-09 CN CN201680046208.4A patent/CN107921117B/zh active Active
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2020
- 2020-04-30 US US16/863,456 patent/US11407790B2/en active Active
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2021
- 2021-09-13 AU AU2021232660A patent/AU2021232660B2/en active Active
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2022
- 2022-06-29 JP JP2022104300A patent/JP2022160401A/ja active Pending
- 2022-06-29 US US17/853,783 patent/US20230086859A1/en not_active Abandoned
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