JP2018518172A5 - - Google Patents
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- JP2018518172A5 JP2018518172A5 JP2017563914A JP2017563914A JP2018518172A5 JP 2018518172 A5 JP2018518172 A5 JP 2018518172A5 JP 2017563914 A JP2017563914 A JP 2017563914A JP 2017563914 A JP2017563914 A JP 2017563914A JP 2018518172 A5 JP2018518172 A5 JP 2018518172A5
- Authority
- JP
- Japan
- Prior art keywords
- segment
- arenavirus
- virus vector
- configuration
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 241000712891 Arenavirus Species 0.000 claims description 408
- 239000013598 vector Substances 0.000 claims description 235
- 239000000427 antigen Substances 0.000 claims description 182
- 102000036639 antigens Human genes 0.000 claims description 182
- 108091007433 antigens Proteins 0.000 claims description 182
- 241000701806 Human papillomavirus Species 0.000 claims description 137
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 120
- 239000013603 viral vector Substances 0.000 claims description 115
- 239000012634 fragment Substances 0.000 claims description 106
- 238000000034 method Methods 0.000 claims description 93
- 230000000890 antigenic effect Effects 0.000 claims description 87
- 108090000623 proteins and genes Proteins 0.000 claims description 61
- 102000004169 proteins and genes Human genes 0.000 claims description 59
- 241000700605 Viruses Species 0.000 claims description 51
- 229960005486 vaccine Drugs 0.000 claims description 50
- 229920001184 polypeptide Polymers 0.000 claims description 49
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 49
- 239000008194 pharmaceutical composition Substances 0.000 claims description 42
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- 125000003729 nucleotide group Chemical group 0.000 claims description 36
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- 210000004027 cell Anatomy 0.000 claims description 33
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- 101000767631 Human papillomavirus type 16 Protein E7 Proteins 0.000 claims description 32
- 101710132595 Protein E7 Proteins 0.000 claims description 29
- 108020005345 3' Untranslated Regions Proteins 0.000 claims description 28
- 101710132594 Protein E6 Proteins 0.000 claims description 25
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- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 description 3
- 101000606090 Homo sapiens Tyrosinase Proteins 0.000 description 3
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- 101100335081 Mus musculus Flt3 gene Proteins 0.000 description 3
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022104300A JP2022160401A (ja) | 2015-06-10 | 2022-06-29 | Ｈｐｖワクチン |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562173805P | 2015-06-10 | 2015-06-10 | |
| US62/173,805 | 2015-06-10 | ||
| US201562254410P | 2015-11-12 | 2015-11-12 | |
| US62/254,410 | 2015-11-12 | ||
| US201662331158P | 2016-05-03 | 2016-05-03 | |
| US62/331,158 | 2016-05-03 | ||
| PCT/EP2016/063182 WO2016198531A2 (en) | 2015-06-10 | 2016-06-09 | Hpv vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022104300A Division JP2022160401A (ja) | 2015-06-10 | 2022-06-29 | Ｈｐｖワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518172A JP2018518172A (ja) | 2018-07-12 |
| JP2018518172A5 true JP2018518172A5 (enExample) | 2020-04-02 |
| JP7098330B2 JP7098330B2 (ja) | 2022-07-11 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017563914A Active JP7098330B2 (ja) | 2015-06-10 | 2016-06-09 | Ｈｐｖワクチン |
| JP2022104300A Pending JP2022160401A (ja) | 2015-06-10 | 2022-06-29 | Ｈｐｖワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022104300A Pending JP2022160401A (ja) | 2015-06-10 | 2022-06-29 | Ｈｐｖワクチン |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10669315B2 (enExample) |
| EP (1) | EP3307308A2 (enExample) |
| JP (2) | JP7098330B2 (enExample) |
| CN (2) | CN107921117B (enExample) |
| AU (2) | AU2016274655B2 (enExample) |
| CA (1) | CA2987155A1 (enExample) |
| HK (1) | HK1246183A1 (enExample) |
| WO (1) | WO2016198531A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20221475T3 (hr) | 2007-12-27 | 2023-01-06 | Universität Zürich | Replikacijski defektni vektori arenavirusa |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| LT3077519T (lt) | 2013-12-03 | 2021-04-26 | Hookipa Biotech Gmbh | Cmv vakcinos |
| RS60937B1 (sr) | 2014-11-13 | 2020-11-30 | Univ Geneve | Tri-segmentirani arenavirusi kao vektori za vakcinu |
| JP7098330B2 (ja) | 2015-06-10 | 2022-07-11 | ホオキパ バイオテック ジーエムビーエイチ | Ｈｐｖワクチン |
| MA45209A (fr) | 2015-10-22 | 2019-04-17 | Modernatx Inc | Vaccins contre les maladies sexuellement transmissibles |
| ES2934698T3 (es) | 2015-11-04 | 2023-02-24 | Hookipa Biotech Gmbh | Vacunas contra el virus de la hepatitis B |
| CA3003548A1 (en) | 2015-11-12 | 2017-05-18 | Hookipa Biotech Ag | Arenavirus particles as cancer vaccines |
| WO2018060288A1 (en) | 2016-09-29 | 2018-04-05 | Glaxosmithkline Biologicals S.A. | Compositions and methods of treatment of persistent hpv infection |
| EP3534943A2 (en) * | 2016-11-04 | 2019-09-11 | Hookipa Biotech GmbH | Replication-deficient arenavirus particles and tri-segmented arenavirus particles as cancer vaccines |
| WO2018185307A1 (en) * | 2017-04-07 | 2018-10-11 | Hookipa Biotech Ag | Arenavirus particles to treat solid tumors |
| EP3652325A4 (en) * | 2017-07-14 | 2021-09-15 | Oncorus, Inc. | ENCAPSULATED POLYNUCLEOTIDES AND METHODS OF USE |
| EP3461497A1 (en) | 2017-09-27 | 2019-04-03 | GlaxoSmithKline Biologicals S.A. | Viral antigens |
| US11021692B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Hepatitis B virus (HBV) vaccines and uses thereof |
| KR102222582B1 (ko) * | 2018-02-02 | 2021-03-04 | 주식회사 에스엘백시젠 | 신규 다가 hpv 백신 조성물 |
| CN109706144A (zh) * | 2018-03-07 | 2019-05-03 | 江苏润洁生物科技有限公司 | 一种治疗性hpv核酸疫苗 |
| EP3880812A4 (en) * | 2018-11-13 | 2022-09-07 | Oncorus, Inc. | ENCAPSULATED POLYNUCLEOTIDES AND METHODS OF USE |
| JP7688576B6 (ja) * | 2018-11-28 | 2025-07-04 | ザ ジェネラル ホスピタル コーポレイション | 共生ウイルスに対するｔ細胞指向性抗がんワクチン |
| JP7125760B2 (ja) * | 2019-06-14 | 2022-08-25 | 国立研究開発法人理化学研究所 | 免疫系を賦活化する細胞および当該細胞を含む医薬組成物 |
| AU2020297011A1 (en) * | 2019-06-18 | 2022-02-10 | Janssen Sciences Ireland Unlimited Company | Arenavirus vectors for hepatitis B virus (HBV) vaccines and uses thereof |
| US20220380805A1 (en) * | 2019-11-07 | 2022-12-01 | Universität Basel | Arenaviruses as vectors |
| JPWO2021095838A1 (enExample) * | 2019-11-15 | 2021-05-20 | ||
| KR20230011335A (ko) * | 2020-05-14 | 2023-01-20 | 이노비오 파마수티컬즈, 인크. | 재발성 호흡기 유두종증에 대한 백신 및 이의 사용 방법 |
| AU2021282287A1 (en) | 2020-05-29 | 2023-01-05 | Hookipa Biotech Gmbh | Cancer treatment strategies using arenavirus vectors |
| US20240174724A1 (en) | 2021-03-23 | 2024-05-30 | Hookipa Biotech Gmbh | Arenaviruses used in treatments of prostate cancer |
| CN115820696A (zh) * | 2022-07-28 | 2023-03-21 | 怡道生物科技(苏州)有限公司 | 治疗性多价HPV mRNA疫苗及其制备方法 |
| WO2025056782A1 (en) | 2023-09-15 | 2025-03-20 | Hookipa Biotech Gmbh | Arenavirus formulations, methods and uses thereof |
| WO2025155938A1 (en) * | 2024-01-18 | 2025-07-24 | Aov Biopharma, Inc. | Vaccine for prevention and treatment of human papilloma virus related cancer |
| WO2025191169A1 (en) * | 2024-03-15 | 2025-09-18 | Hookipa Biotech Gmbh | Modified arenavirus particles expressing cancer testis antigens as cancer immunotherapies |
| CN118344491B (zh) * | 2024-05-03 | 2025-02-14 | 华中科技大学同济医学院附属同济医院 | 一种hpv16/18治疗性疫苗、制备方法和应用 |
| CN118599010B (zh) * | 2024-05-03 | 2025-06-27 | 武汉凯德基诺生物技术有限公司 | 一种hpv16/18/52治疗性疫苗、制备方法和应用 |
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| BR0314529A (pt) * | 2002-10-03 | 2005-08-09 | Wyeth Corp | Polipeptìdeos de papilomavìrus humano e composições imunogênicas |
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| HRP20221475T3 (hr) | 2007-12-27 | 2023-01-06 | Universität Zürich | Replikacijski defektni vektori arenavirusa |
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| DE102015207036A1 (de) | 2015-04-17 | 2016-10-20 | Karl Sebastian Lang | Arenaviren zur Anwendung bei der Behandlung und/oder Vorbeugung von Tumoren sowie Verfahren zur Herstellung von Arenaviren mit (verbesserten) tumorregressiven Eigenschaften |
| JP7098330B2 (ja) | 2015-06-10 | 2022-07-11 | ホオキパ バイオテック ジーエムビーエイチ | Ｈｐｖワクチン |
| ES3021881T3 (en) | 2015-10-23 | 2025-05-27 | Pasteur Institut | Recombinant mopeia virus and vaccine platform |
| ES2934698T3 (es) | 2015-11-04 | 2023-02-24 | Hookipa Biotech Gmbh | Vacunas contra el virus de la hepatitis B |
| CA3003548A1 (en) | 2015-11-12 | 2017-05-18 | Hookipa Biotech Ag | Arenavirus particles as cancer vaccines |
| US10980877B2 (en) | 2016-04-28 | 2021-04-20 | The University Of Chicago | Method for treating melanoma using lymphangiogenesis inducers and a melanoma-specific antigen |
| KR20240095333A (ko) | 2016-05-18 | 2024-06-25 | 유니버시타트 바셀 | 백신 벡터로서 3개의 세그먼트를 가진 피친드 바이러스 |
| EP3534943A2 (en) | 2016-11-04 | 2019-09-11 | Hookipa Biotech GmbH | Replication-deficient arenavirus particles and tri-segmented arenavirus particles as cancer vaccines |
| WO2018185307A1 (en) | 2017-04-07 | 2018-10-11 | Hookipa Biotech Ag | Arenavirus particles to treat solid tumors |
| AU2020297011A1 (en) * | 2019-06-18 | 2022-02-10 | Janssen Sciences Ireland Unlimited Company | Arenavirus vectors for hepatitis B virus (HBV) vaccines and uses thereof |
| US20220380805A1 (en) | 2019-11-07 | 2022-12-01 | Universität Basel | Arenaviruses as vectors |
| AU2021282287A1 (en) | 2020-05-29 | 2023-01-05 | Hookipa Biotech Gmbh | Cancer treatment strategies using arenavirus vectors |
-
2016
- 2016-06-09 JP JP2017563914A patent/JP7098330B2/ja active Active
- 2016-06-09 CA CA2987155A patent/CA2987155A1/en active Pending
- 2016-06-09 US US15/580,964 patent/US10669315B2/en active Active
- 2016-06-09 CN CN201680046208.4A patent/CN107921117B/zh active Active
- 2016-06-09 WO PCT/EP2016/063182 patent/WO2016198531A2/en not_active Ceased
- 2016-06-09 EP EP16730302.3A patent/EP3307308A2/en active Pending
- 2016-06-09 CN CN202210614772.9A patent/CN115197965A/zh active Pending
- 2016-06-09 AU AU2016274655A patent/AU2016274655B2/en active Active
- 2016-06-09 HK HK18105733.1A patent/HK1246183A1/zh unknown
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2020
- 2020-04-30 US US16/863,456 patent/US11407790B2/en active Active
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2021
- 2021-09-13 AU AU2021232660A patent/AU2021232660B2/en active Active
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2022
- 2022-06-29 US US17/853,783 patent/US20230086859A1/en not_active Abandoned
- 2022-06-29 JP JP2022104300A patent/JP2022160401A/ja active Pending
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