JP2018517394A - 記憶力、学習力、認知力向上用組成物 - Google Patents
記憶力、学習力、認知力向上用組成物 Download PDFInfo
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Abstract
Description
合成されたペプチドは、Genscript(New Jersey、USA)から得た。ペプチドは、Flexpeptide technology方法で合成され、高速液体クロマトグラフィー及び質量分析計を用いて確認した。合成されたペプチドのアミノ酸配列は、以下の表1の通りである。
SGGAG(配列番号8)、
GAGGAGGAG(配列番号9)
スコポラミン(Scopolamine)は、Sigma-Aldrich(St. Louis、MO、USA)から購入した。4週齢の雄ICRマウスをKorean BioLink Co. (Chungbuk、Korea)から購入した。 1週間の適応期間の後、試験に使用し、すべての試薬は、腹腔内投与した。記憶障害は、検査30分前のスコポラミンの注入によって誘導され、合成されたペプチドは、スコポラミンの注入30分前に注入した。
受動回避反応検査は、同一の明るい部屋及び暗い部屋で行った。各部屋の床は、2-mmのステンレス棒が1-cm間隔で離れている形になっている。明るい部屋(20×20×20cm)は、100-Wの電球を備えている。これらの部屋は、ギロチンドア(guillotine door)で連結されている。
マウスを一方の枝の長さが30cm、幅5cm、高さ13cmからなるY迷路の片端に置いて各枝に入る順番を記録した。変更(alternation)は、3つの他の枝に順次入った場合、成功したものと判断した。変更行動力(spontaneous alternation)は、次の数式で定義した。
Claims (17)
- C末端部位が、GAGのアミノ酸配列を含む、ペプチド。
- 前記ペプチドは、人工的に合成されたことを特徴とする、請求項1に記載のペプチド。
- 前記ペプチドは、アミノ酸残基の数が4〜6であることを特徴とする、請求項1に記載のペプチド。
- 前記ペプチドは、アミノ酸配列がGGAGであることを特徴とする、請求項1に記載のペプチド。
- 前記ペプチドは、アミノ酸配列がAGAGであることを特徴とする、請求項1に記載のペプチド。
- 前記ペプチドは、アミノ酸配列がQGAGであることを特徴とする、請求項1に記載のペプチド。
- 前記ペプチドは、アミノ酸配列がSGAGAGであることを特徴とする、請求項1に記載のペプチド。
- 前記ペプチドは、アミノ酸残基の数が5〜9であることを特徴とする、請求項1に記載のペプチド。
- 前記アミノ酸配列が、QAGAG、SGGAG、またはGAGGAGGAGであることを特徴とする、請求項1に記載のペプチド。
- 第1項〜第9項のいずれかのペプチドを有効成分として含む、記憶、認知、または学習障害の予防または治療用薬学的組成物。
- 前記記憶、認知、または学習障害は、老化、アルツハイマー病、精神分裂症、パーキンソン病、ハンチントン病、ピック病、クロイツフェルト-ヤコブ病、うつ病、老化、頭部外傷、脳卒中、 CNS低酸素症、脳虚血症、脳炎、健忘症、外傷性脳損傷、低血糖症 、ウェルニッケ・コルサコフ症候群、薬物中毒、雷電症、癲癇、海馬硬化症、頭痛、脳老衰症、痴呆、前頭側頭葉変性、腫瘍、正常圧水頭症、HIV、脳血管性疾患、脳神経疾患、心血管系疾患、記憶喪失、被曝、代謝性疾患、甲状腺機能低下症、軽度認知障害、認知欠乏及び注意力欠陥による記憶、認知、または学習障害を特徴とする、請求項10に記載の薬学的組成物。
- 第1項〜第9項のいずれかのペプチドを有効成分として含む、頭脳または認知機能の増進のための食品組成物。
- 前記頭脳または認知機能は、学習能力、記憶能力または集中力であることを特徴とする、請求項12に記載の食品組成物。
- 第1項〜第9項のいずれかのペプチドをコードするポリヌクレオチド。
- 請求項14のポリヌクレオチドを含む組換えベクター。
- 請求項15の組み換えベクターで形質転換された宿主細胞。
- 請求項16の宿主細胞を培養するステップを含むペプチドの製造方法。
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KR10-2016-0026600 | 2016-03-04 | ||
PCT/KR2016/004650 WO2017111215A1 (ko) | 2015-12-21 | 2016-05-03 | 기억력, 학습력, 인지력 향상용 조성물 |
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MY197348A (en) | 2023-06-14 |
TR201807610T1 (tr) | 2018-06-21 |
EP3255055B1 (en) | 2024-06-05 |
RU2694064C1 (ru) | 2019-07-09 |
EP3255055A1 (en) | 2017-12-13 |
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EP3255055C0 (en) | 2024-06-05 |
US10435436B2 (en) | 2019-10-08 |
SG11201804902UA (en) | 2018-07-30 |
MX2018006823A (es) | 2018-11-29 |
CN110279845A (zh) | 2019-09-27 |
US20180327452A1 (en) | 2018-11-15 |
JP6463499B2 (ja) | 2019-02-06 |
US20180327451A1 (en) | 2018-11-15 |
CA2965840A1 (en) | 2017-06-29 |
PH12017550079A1 (en) | 2018-02-12 |
AU2016376059B2 (en) | 2019-02-14 |
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US20220296673A1 (en) | 2022-09-22 |
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