JP2018516875A5 - - Google Patents
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- Publication number
- JP2018516875A5 JP2018516875A5 JP2017555812A JP2017555812A JP2018516875A5 JP 2018516875 A5 JP2018516875 A5 JP 2018516875A5 JP 2017555812 A JP2017555812 A JP 2017555812A JP 2017555812 A JP2017555812 A JP 2017555812A JP 2018516875 A5 JP2018516875 A5 JP 2018516875A5
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- JP
- Japan
- Prior art keywords
- salt
- ring
- substituted
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 7
- 206010063837 Reperfusion injury Diseases 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 claims 4
- LPIQUOYDBNQMRZ-UHFFFAOYSA-N cyclopentene Chemical compound C1CC=CC1 LPIQUOYDBNQMRZ-UHFFFAOYSA-N 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 102100036988 Cyclin-dependent kinase 2-interacting protein Human genes 0.000 claims 3
- 101000737869 Homo sapiens Cyclin-dependent kinase 2-interacting protein Proteins 0.000 claims 3
- 206010067125 Liver injury Diseases 0.000 claims 3
- 231100000753 hepatic injury Toxicity 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 208000021722 neuropathic pain Diseases 0.000 claims 3
- 208000033808 peripheral neuropathy Diseases 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 230000003449 preventive effect Effects 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 229940041181 antineoplastic drug Drugs 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- ZSSBBJDUDZIRTI-UHFFFAOYSA-N 1,4-dioxaspiro[4.5]dec-6-ene-7-carboxylic acid Chemical compound C1CC(=CC2(C1)OCCO2)C(=O)O ZSSBBJDUDZIRTI-UHFFFAOYSA-N 0.000 claims 1
- 102000008233 Toll-Like Receptor 4 Human genes 0.000 claims 1
- 108010060804 Toll-Like Receptor 4 Proteins 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- CBUQKMCLJLPQDO-MKXGPGLRSA-N ethyl (2R,3R,8R)-8-[[(1S)-7-chloro-2,3-dihydro-1H-inden-1-yl]sulfonyl]-2,3-bis(hydroxymethyl)-1,4-dioxaspiro[4.5]dec-6-ene-7-carboxylate Chemical compound CCOC(=O)C1=CC2(CC[C@H]1S(=O)(=O)[C@H]1CCC3=C1C(Cl)=CC=C3)O[C@H](CO)[C@@H](CO)O2 CBUQKMCLJLPQDO-MKXGPGLRSA-N 0.000 claims 1
- UZPIQLPSQIYBTH-NCYKPQTJSA-N ethyl (2R,3R,8R)-8-[[(1S)-7-chloro-2,3-dihydro-1H-inden-1-yl]sulfonyl]-2,3-bis(methoxymethyl)-1,4-dioxaspiro[4.5]dec-6-ene-7-carboxylate Chemical compound ClC=1C=CC=C2CC[C@@H](C=12)S(=O)(=O)[C@H]1C(=CC2(O[C@@H]([C@H](O2)COC)COC)CC1)C(=O)OCC UZPIQLPSQIYBTH-NCYKPQTJSA-N 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- UJLCQFMVTCPZLZ-UHFFFAOYSA-N hydroxymethyl 1,4-dioxaspiro[4.5]dec-6-ene-7-carboxylate Chemical compound OCOC(=O)C1=CC2(OCCO2)CCC1 UJLCQFMVTCPZLZ-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015095817 | 2015-05-08 | ||
| JP2015095817 | 2015-05-08 | ||
| PCT/JP2016/064204 WO2016182036A1 (en) | 2015-05-08 | 2016-05-06 | Cyclic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516875A JP2018516875A (ja) | 2018-06-28 |
| JP2018516875A5 true JP2018516875A5 (https=) | 2019-05-23 |
| JP6718884B2 JP6718884B2 (ja) | 2020-07-08 |
Family
ID=56132991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555812A Active JP6718884B2 (ja) | 2015-05-08 | 2016-05-06 | 環状化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9611244B2 (https=) |
| EP (1) | EP3294706B1 (https=) |
| JP (1) | JP6718884B2 (https=) |
| CN (1) | CN107835800B (https=) |
| AR (1) | AR104539A1 (https=) |
| CA (1) | CA2985325C (https=) |
| EA (1) | EA033083B1 (https=) |
| ES (1) | ES2772703T3 (https=) |
| TW (1) | TW201704206A (https=) |
| UY (1) | UY36675A (https=) |
| WO (1) | WO2016182036A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107835800B (zh) * | 2015-05-08 | 2019-11-26 | 武田药品工业株式会社 | 环状化合物 |
| WO2018047888A1 (ja) | 2016-09-09 | 2018-03-15 | 武田薬品工業株式会社 | 環状化合物 |
| FR3095755A1 (fr) * | 2019-05-10 | 2020-11-13 | Balmes Transplantation | Nouveaux médicaments cytoprotecteurs |
| CN114425054A (zh) * | 2022-01-20 | 2022-05-03 | 中国人民解放军军事科学院军事医学研究院 | 一种蛋白酶体抑制剂Bortezomib在抗辐射损伤中的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2214398C2 (ru) | 1998-03-09 | 2003-10-20 | Такеда Кемикал Индастриз, Лтд. | Производное циклоалкена, способ его получения (варианты), фармацевтическая композиция, способ ингибирования, способ профилактики или лечения |
| DE60045033D1 (de) | 1999-08-06 | 2010-11-11 | Takeda Pharmaceutical | Substituierte aromatische ringverbindungen, verfahren zu ihrer herstellung und ihre anwendung |
| JP2004002370A (ja) * | 2002-04-08 | 2004-01-08 | Takeda Chem Ind Ltd | 重症セプシス予防治療剤 |
| US20060058288A1 (en) | 2002-04-08 | 2006-03-16 | Masayuki Ii | Severe sepsis preventive therapeutic agent |
| KR101327610B1 (ko) | 2005-09-14 | 2013-11-12 | 다이이찌 산쿄 가부시키가이샤 | 치환 시클로알켄 유도체 |
| JP2008260760A (ja) | 2007-03-12 | 2008-10-30 | Daiichi Sankyo Co Ltd | 置換シクロアルケン誘導体を含有する医薬組成物 |
| US20100137787A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Delivery devices for modulating inflammation |
| TWI481401B (zh) | 2010-01-27 | 2015-04-21 | Takeda Pharmaceutical | 藥劑 |
| CN107835800B (zh) * | 2015-05-08 | 2019-11-26 | 武田药品工业株式会社 | 环状化合物 |
-
2016
- 2016-05-06 CN CN201680040064.1A patent/CN107835800B/zh active Active
- 2016-05-06 WO PCT/JP2016/064204 patent/WO2016182036A1/en not_active Ceased
- 2016-05-06 EP EP16729646.6A patent/EP3294706B1/en active Active
- 2016-05-06 EA EA201792469A patent/EA033083B1/ru not_active IP Right Cessation
- 2016-05-06 US US15/148,210 patent/US9611244B2/en active Active
- 2016-05-06 AR ARP160101293A patent/AR104539A1/es unknown
- 2016-05-06 UY UY0001036675A patent/UY36675A/es not_active Application Discontinuation
- 2016-05-06 JP JP2017555812A patent/JP6718884B2/ja active Active
- 2016-05-06 CA CA2985325A patent/CA2985325C/en active Active
- 2016-05-06 ES ES16729646T patent/ES2772703T3/es active Active
- 2016-05-06 TW TW105114092A patent/TW201704206A/zh unknown
- 2016-06-07 US US15/175,292 patent/US9533966B2/en active Active
- 2016-11-21 US US15/356,906 patent/US9828357B2/en active Active
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