JP2018516572A5 - - Google Patents
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- Publication number
- JP2018516572A5 JP2018516572A5 JP2017562290A JP2017562290A JP2018516572A5 JP 2018516572 A5 JP2018516572 A5 JP 2018516572A5 JP 2017562290 A JP2017562290 A JP 2017562290A JP 2017562290 A JP2017562290 A JP 2017562290A JP 2018516572 A5 JP2018516572 A5 JP 2018516572A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid sequence
- grna
- hiv
- complementary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 52
- 108020005004 Guide RNA Proteins 0.000 claims 44
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 38
- 241000725303 Human immunodeficiency virus Species 0.000 claims 37
- 108020004414 DNA Proteins 0.000 claims 24
- 230000000295 complement effect Effects 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 14
- 230000001177 retroviral effect Effects 0.000 claims 14
- 241001430294 unidentified retrovirus Species 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 102100034343 Integrase Human genes 0.000 claims 9
- 108010042407 Endonucleases Proteins 0.000 claims 8
- 102100031780 Endonuclease Human genes 0.000 claims 7
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000000415 inactivating effect Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000001566 pro-viral effect Effects 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108091033409 CRISPR Proteins 0.000 claims 3
- 238000010354 CRISPR gene editing Methods 0.000 claims 3
- 208000031886 HIV Infections Diseases 0.000 claims 3
- 208000037357 HIV infectious disease Diseases 0.000 claims 3
- 108010061833 Integrases Proteins 0.000 claims 3
- 108091092195 Intron Proteins 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- 108010027225 gag-pol Fusion Proteins Proteins 0.000 claims 3
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 108091029795 Intergenic region Proteins 0.000 claims 2
- 101710172711 Structural protein Proteins 0.000 claims 2
- 102000034356 gene-regulatory proteins Human genes 0.000 claims 2
- 108091006104 gene-regulatory proteins Proteins 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 102000004533 Endonucleases Human genes 0.000 claims 1
- -1 Nef Proteins 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562169384P | 2015-06-01 | 2015-06-01 | |
| US62/169,384 | 2015-06-01 | ||
| US201562169633P | 2015-06-02 | 2015-06-02 | |
| US62/169,633 | 2015-06-02 | ||
| US201662308320P | 2016-03-15 | 2016-03-15 | |
| US62/308,320 | 2016-03-15 | ||
| PCT/US2016/035141 WO2016196539A2 (en) | 2015-06-01 | 2016-06-01 | Methods and compositions for rna-guided treatment of hiv infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516572A JP2018516572A (ja) | 2018-06-28 |
| JP2018516572A5 true JP2018516572A5 (https=) | 2019-07-04 |
| JP6968416B2 JP6968416B2 (ja) | 2021-11-17 |
Family
ID=57442165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562290A Active JP6968416B2 (ja) | 2015-06-01 | 2016-06-01 | Ｒｎａ誘導性の、ｈｉｖ感染の処置のための、方法および組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11298410B2 (https=) |
| EP (2) | EP3302709B1 (https=) |
| JP (1) | JP6968416B2 (https=) |
| KR (2) | KR102553518B1 (https=) |
| CN (1) | CN108025188A (https=) |
| AU (3) | AU2016270702B2 (https=) |
| CA (1) | CA2987927C (https=) |
| DK (1) | DK3302709T3 (https=) |
| EA (1) | EA037359B1 (https=) |
| ES (1) | ES2886480T3 (https=) |
| MX (1) | MX2017015582A (https=) |
| PL (1) | PL3302709T3 (https=) |
| SG (1) | SG10201914137YA (https=) |
| WO (1) | WO2016196539A2 (https=) |
| ZA (1) | ZA201708236B (https=) |
Families Citing this family (44)
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| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| JP7118588B2 (ja) | 2013-08-29 | 2022-08-16 | テンプル ユニヴァーシティ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | Ｈｉｖ感染のｒｎａガイド処置のための方法および組成物 |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| CN108025188A (zh) | 2015-06-01 | 2018-05-11 | 天普大学-联邦高等教育系统 | 用于hiv感染的rna导向治疗的方法和组合物 |
| JP2018527943A (ja) * | 2015-09-28 | 2018-09-27 | テンプル ユニバーシティー オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | Ｒｎａ誘導性の、ｈｉｖ感染の処置のための、方法および組成物 |
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| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US20200140865A1 (en) * | 2017-04-17 | 2020-05-07 | Temple University - Of The Commonwealth System Of Higher Education | An hiv-1 eradication strategy employing nanoformulated anti-retroviral drugs and gene editing agents |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| US12415000B2 (en) * | 2017-07-07 | 2025-09-16 | The Broad Institute, Inc. | CRISPR system based antiviral therapy |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| EP3688159A4 (en) * | 2017-09-26 | 2021-10-20 | The Board of Trustees of the University of Illinois | CRISPR / CAS SYSTEM AND PROCESS FOR GENOME EDITING AND TRANSCRIPT MODULATION |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
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| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020150499A1 (en) * | 2019-01-16 | 2020-07-23 | Fred Hutchinson Cancer Research Center | Methods to tag and isolate cells infected with the human immunodeficiency virus |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
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| AU2020369599A1 (en) * | 2019-10-23 | 2022-05-12 | Monsanto Technology Llc | Compositions and methods for RNA-templated editing in plants |
| EP4114952A4 (en) * | 2020-03-05 | 2024-05-08 | Board of Regents of the University of Nebraska | Crispr/cas9 system for multistrain hiv-1 treatment |
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| EP4179120A4 (en) * | 2020-07-13 | 2024-08-21 | The United States Government as represented by the Department of Veterans Affairs | Methods and compositions for crispr/cas9 guide rna efficiency and specificity against genetically diverse hiv-1 isolates |
| CN112322587A (zh) * | 2020-09-17 | 2021-02-05 | 杭州市第一人民医院 | 一种带Cas9基因的人源可诱导多能干细胞系、构建方法、鉴定方法及应用 |
| EP4308087A4 (en) * | 2021-03-17 | 2025-06-18 | Board of Regents of the University of Nebraska | LIPID NANOPARTICLE FORMULATIONS AND METHODS OF USE THEREOF |
| WO2024103049A1 (en) * | 2022-11-11 | 2024-05-16 | The United States Government As Represented By The Department Of Veterans Affairs | Cd33 specific exosomes and uses thereof |
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| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9074199B1 (en) | 2013-11-19 | 2015-07-07 | President And Fellows Of Harvard College | Mutant Cas9 proteins |
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| US20190093092A1 (en) | 2016-05-05 | 2019-03-28 | Temple University - Of The Commonwealth System Of Higher Education | Rna guided eradication of varicella zoster virus |
| US20190256844A1 (en) | 2016-06-07 | 2019-08-22 | Temple University - Of The Commonwealth System Of Higher Education | Rna guided compositions for preventing and treating hepatitis b virus infections |
| US20190085326A1 (en) | 2016-09-14 | 2019-03-21 | Temple University - Of The Commonwealth System Of Higher Education | Negative feedback regulation of HIV-1 by gene editing strategy |
| MX2019003674A (es) | 2016-09-30 | 2021-01-08 | Univ California | Enzimas modificadoras de ácido nucleico guiadas por arn y métodos de uso de estas. |
| WO2018071623A2 (en) | 2016-10-12 | 2018-04-19 | Temple University - Of The Commonwealth System Of Higher Education | Combination therapies for eradicating flavivirus infections in subjects |
| US10737984B2 (en) | 2016-11-30 | 2020-08-11 | Hrl Laboratories, Llc | Formulations and methods for 3D printing of ceramic matrix composites |
| CN110431230A (zh) | 2017-01-26 | 2019-11-08 | 切除生物治疗公司 | 慢病毒和非整合型慢病毒作为病毒载体实施crispr治疗 |
| US20190367924A1 (en) | 2017-02-17 | 2019-12-05 | Temple University - Of The Commonwealth System Of Higher Education | Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5 |
| US20200140865A1 (en) | 2017-04-17 | 2020-05-07 | Temple University - Of The Commonwealth System Of Higher Education | An hiv-1 eradication strategy employing nanoformulated anti-retroviral drugs and gene editing agents |
-
2016
- 2016-06-01 CN CN201680045342.2A patent/CN108025188A/zh active Pending
- 2016-06-01 AU AU2016270702A patent/AU2016270702B2/en active Active
- 2016-06-01 CA CA2987927A patent/CA2987927C/en active Active
- 2016-06-01 WO PCT/US2016/035141 patent/WO2016196539A2/en not_active Ceased
- 2016-06-01 DK DK16804274.5T patent/DK3302709T3/da active
- 2016-06-01 EP EP16804274.5A patent/EP3302709B1/en active Active
- 2016-06-01 MX MX2017015582A patent/MX2017015582A/es unknown
- 2016-06-01 PL PL16804274T patent/PL3302709T3/pl unknown
- 2016-06-01 US US15/578,372 patent/US11298410B2/en active Active
- 2016-06-01 SG SG10201914137YA patent/SG10201914137YA/en unknown
- 2016-06-01 ES ES16804274T patent/ES2886480T3/es active Active
- 2016-06-01 JP JP2017562290A patent/JP6968416B2/ja active Active
- 2016-06-01 KR KR1020177037584A patent/KR102553518B1/ko active Active
- 2016-06-01 EA EA201890012A patent/EA037359B1/ru unknown
- 2016-06-01 EP EP21172750.8A patent/EP3919622A1/en active Pending
- 2016-06-01 KR KR1020237022586A patent/KR20230110368A/ko not_active Withdrawn
-
2017
- 2017-12-04 ZA ZA2017/08236A patent/ZA201708236B/en unknown
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2020
- 2020-05-15 US US16/875,271 patent/US11273209B2/en active Active
- 2020-09-10 US US17/017,037 patent/US12251429B2/en active Active
-
2022
- 2022-03-17 AU AU2022201875A patent/AU2022201875A1/en not_active Abandoned
-
2025
- 2025-06-05 AU AU2025204187A patent/AU2025204187A1/en active Pending
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