JP2018516572A5 - - Google Patents
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- Publication number
- JP2018516572A5 JP2018516572A5 JP2017562290A JP2017562290A JP2018516572A5 JP 2018516572 A5 JP2018516572 A5 JP 2018516572A5 JP 2017562290 A JP2017562290 A JP 2017562290A JP 2017562290 A JP2017562290 A JP 2017562290A JP 2018516572 A5 JP2018516572 A5 JP 2018516572A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid sequence
- grna
- hiv
- complementary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 52
- 108020005004 Guide RNA Proteins 0.000 claims 44
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 38
- 241000725303 Human immunodeficiency virus Species 0.000 claims 37
- 108020004414 DNA Proteins 0.000 claims 24
- 230000000295 complement effect Effects 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 14
- 230000001177 retroviral effect Effects 0.000 claims 14
- 241001430294 unidentified retrovirus Species 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 102100034343 Integrase Human genes 0.000 claims 9
- 108010042407 Endonucleases Proteins 0.000 claims 8
- 102100031780 Endonuclease Human genes 0.000 claims 7
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000000415 inactivating effect Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000001566 pro-viral effect Effects 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108091033409 CRISPR Proteins 0.000 claims 3
- 238000010354 CRISPR gene editing Methods 0.000 claims 3
- 208000031886 HIV Infections Diseases 0.000 claims 3
- 208000037357 HIV infectious disease Diseases 0.000 claims 3
- 108010061833 Integrases Proteins 0.000 claims 3
- 108091092195 Intron Proteins 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- 108010027225 gag-pol Fusion Proteins Proteins 0.000 claims 3
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 108091029795 Intergenic region Proteins 0.000 claims 2
- 101710172711 Structural protein Proteins 0.000 claims 2
- 102000034356 gene-regulatory proteins Human genes 0.000 claims 2
- 108091006104 gene-regulatory proteins Proteins 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 102000004533 Endonucleases Human genes 0.000 claims 1
- -1 Nef Proteins 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562169384P | 2015-06-01 | 2015-06-01 | |
| US62/169,384 | 2015-06-01 | ||
| US201562169633P | 2015-06-02 | 2015-06-02 | |
| US62/169,633 | 2015-06-02 | ||
| US201662308320P | 2016-03-15 | 2016-03-15 | |
| US62/308,320 | 2016-03-15 | ||
| PCT/US2016/035141 WO2016196539A2 (en) | 2015-06-01 | 2016-06-01 | Methods and compositions for rna-guided treatment of hiv infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516572A JP2018516572A (ja) | 2018-06-28 |
| JP2018516572A5 true JP2018516572A5 (https=) | 2019-07-04 |
| JP6968416B2 JP6968416B2 (ja) | 2021-11-17 |
Family
ID=57442165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562290A Active JP6968416B2 (ja) | 2015-06-01 | 2016-06-01 | Ｒｎａ誘導性の、ｈｉｖ感染の処置のための、方法および組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11298410B2 (https=) |
| EP (2) | EP3919622A1 (https=) |
| JP (1) | JP6968416B2 (https=) |
| KR (2) | KR102553518B1 (https=) |
| CN (1) | CN108025188A (https=) |
| AU (3) | AU2016270702B2 (https=) |
| CA (1) | CA2987927C (https=) |
| DK (1) | DK3302709T3 (https=) |
| EA (1) | EA037359B1 (https=) |
| ES (1) | ES2886480T3 (https=) |
| MX (1) | MX2017015582A (https=) |
| PL (1) | PL3302709T3 (https=) |
| SG (1) | SG10201914137YA (https=) |
| WO (1) | WO2016196539A2 (https=) |
| ZA (1) | ZA201708236B (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9925248B2 (en) | 2013-08-29 | 2018-03-27 | Temple University Of The Commonwealth System Of Higher Education | Methods and compositions for RNA-guided treatment of HIV infection |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EA037359B1 (ru) | 2015-06-01 | 2021-03-17 | Тэмпл Юниверсити - Оф Зе Коммонвэлс Систем Оф Хайе Эдьюкейшн | Способы и композиции для рнк-направляемого лечения инфекции, вызываемой вич |
| EP3356521A4 (en) * | 2015-09-28 | 2019-03-13 | Temple University - Of The Commonwealth System of Higher Education | METHOD AND COMPOSITIONS FOR RNA-TREATED TREATMENT OF HIV INFECTIONS |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したＣａｓ９蛋白質 |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| US20200140865A1 (en) * | 2017-04-17 | 2020-05-07 | Temple University - Of The Commonwealth System Of Higher Education | An hiv-1 eradication strategy employing nanoformulated anti-retroviral drugs and gene editing agents |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| WO2019010422A1 (en) * | 2017-07-07 | 2019-01-10 | The Broad Institute, Inc. | ANTIVIRAL THERAPY BASED ON THE CRISPR SYSTEM |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| CN111373041B (zh) * | 2017-09-26 | 2024-10-11 | 伊利诺伊大学理事会 | 用于基因组编辑和调节转录的crispr/cas系统和方法 |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020150499A1 (en) * | 2019-01-16 | 2020-07-23 | Fred Hutchinson Cancer Research Center | Methods to tag and isolate cells infected with the human immunodeficiency virus |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN115279898A (zh) * | 2019-10-23 | 2022-11-01 | 成对植物服务股份有限公司 | 用于植物中rna模板化编辑的组合物和方法 |
| EP4114952A4 (en) * | 2020-03-05 | 2024-05-08 | Board of Regents of the University of Nebraska | Crispr/cas9 system for multistrain hiv-1 treatment |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| EP4179120A4 (en) * | 2020-07-13 | 2024-08-21 | The United States Government as represented by the Department of Veterans Affairs | Methods and compositions for crispr/cas9 guide rna efficiency and specificity against genetically diverse hiv-1 isolates |
| CN112322587A (zh) * | 2020-09-17 | 2021-02-05 | 杭州市第一人民医院 | 一种带Cas9基因的人源可诱导多能干细胞系、构建方法、鉴定方法及应用 |
| WO2022198229A1 (en) * | 2021-03-17 | 2022-09-22 | Board Of Regents Of The University Of Nebraska | Lipid nanoparticle formulations and methods of use thereof |
| WO2024103049A1 (en) * | 2022-11-11 | 2024-05-16 | The United States Government As Represented By The Department Of Veterans Affairs | Cd33 specific exosomes and uses thereof |
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| KR20250012194A (ko) | 2013-06-17 | 2025-01-23 | 더 브로드 인스티튜트, 인코퍼레이티드 | 바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용 |
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| US9925248B2 (en) | 2013-08-29 | 2018-03-27 | Temple University Of The Commonwealth System Of Higher Education | Methods and compositions for RNA-guided treatment of HIV infection |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
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| WO2017192172A1 (en) | 2016-05-05 | 2017-11-09 | Temple University - Of The Commonwealth System Of Higher Education | Rna guided eradication of varicella zoster virus |
| WO2017213898A2 (en) | 2016-06-07 | 2017-12-14 | Temple University - Of The Commonwealth System Of Higher Education | Rna guided compositions for preventing and treating hepatitis b virus infections |
| US20190085326A1 (en) | 2016-09-14 | 2019-03-21 | Temple University - Of The Commonwealth System Of Higher Education | Negative feedback regulation of HIV-1 by gene editing strategy |
| CA3038960A1 (en) | 2016-09-30 | 2018-04-05 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
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| US11299430B2 (en) | 2016-11-30 | 2022-04-12 | Hrl Laboratories, Llc | Formulations with active functional additives for 3D printing of preceramic polymers, and methods of 3D-printing the formulations |
| WO2018140269A1 (en) | 2017-01-26 | 2018-08-02 | Excision Biotherapeutics, Inc. | Lentivirus and non-integrating lentivirus as viral vector to deliver crispr therapeutic |
| WO2018152418A1 (en) | 2017-02-17 | 2018-08-23 | Temple University - Of The Commonwealth System Of Higher Education | Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5 |
| US20200140865A1 (en) | 2017-04-17 | 2020-05-07 | Temple University - Of The Commonwealth System Of Higher Education | An hiv-1 eradication strategy employing nanoformulated anti-retroviral drugs and gene editing agents |
-
2016
- 2016-06-01 EA EA201890012A patent/EA037359B1/ru unknown
- 2016-06-01 MX MX2017015582A patent/MX2017015582A/es unknown
- 2016-06-01 PL PL16804274T patent/PL3302709T3/pl unknown
- 2016-06-01 KR KR1020177037584A patent/KR102553518B1/ko active Active
- 2016-06-01 EP EP21172750.8A patent/EP3919622A1/en active Pending
- 2016-06-01 DK DK16804274.5T patent/DK3302709T3/da active
- 2016-06-01 SG SG10201914137YA patent/SG10201914137YA/en unknown
- 2016-06-01 JP JP2017562290A patent/JP6968416B2/ja active Active
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2017
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