JP2019504868A5 - - Google Patents
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- JP2019504868A5 JP2019504868A5 JP2018543090A JP2018543090A JP2019504868A5 JP 2019504868 A5 JP2019504868 A5 JP 2019504868A5 JP 2018543090 A JP2018543090 A JP 2018543090A JP 2018543090 A JP2018543090 A JP 2018543090A JP 2019504868 A5 JP2019504868 A5 JP 2019504868A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- vector according
- viral vector
- sequence
- grna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000013603 viral vector Substances 0.000 claims 15
- 239000013598 vector Substances 0.000 claims 10
- 241000700605 Viruses Species 0.000 claims 9
- 108020005004 Guide RNA Proteins 0.000 claims 8
- 241000725303 Human immunodeficiency virus Species 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 241001430294 unidentified retrovirus Species 0.000 claims 3
- 108091032955 Bacterial small RNA Proteins 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 2
- 108010042407 Endonucleases Proteins 0.000 claims 2
- 102000004533 Endonucleases Human genes 0.000 claims 2
- 241000713666 Lentivirus Species 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000001177 retroviral effect Effects 0.000 claims 2
- 239000013607 AAV vector Substances 0.000 claims 1
- 241000649044 Adeno-associated virus 9 Species 0.000 claims 1
- 241000713704 Bovine immunodeficiency virus Species 0.000 claims 1
- 108091033409 CRISPR Proteins 0.000 claims 1
- 241000713730 Equine infectious anemia virus Species 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 1
- 241000713311 Simian immunodeficiency virus Species 0.000 claims 1
- 208000000389 T-cell leukemia Diseases 0.000 claims 1
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 241000713325 Visna/maedi virus Species 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 238000010362 genome editing Methods 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662295390P | 2016-02-15 | 2016-02-15 | |
| US62/295,390 | 2016-02-15 | ||
| US201662298722P | 2016-02-23 | 2016-02-23 | |
| US62/298,722 | 2016-02-23 | ||
| US201662337994P | 2016-05-18 | 2016-05-18 | |
| US62/337,994 | 2016-05-18 | ||
| US201662345520P | 2016-06-03 | 2016-06-03 | |
| US62/345,520 | 2016-06-03 | ||
| US201662363625P | 2016-07-18 | 2016-07-18 | |
| US62/363,625 | 2016-07-18 | ||
| US201662410496P | 2016-10-20 | 2016-10-20 | |
| US62/410,496 | 2016-10-20 | ||
| PCT/US2017/017652 WO2017142835A1 (en) | 2016-02-15 | 2017-02-13 | Excision of retroviral nucleic acid sequences |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504868A JP2019504868A (ja) | 2019-02-21 |
| JP2019504868A5 true JP2019504868A5 (https=) | 2020-03-26 |
| JP7176737B2 JP7176737B2 (ja) | 2022-11-22 |
Family
ID=59626223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018543090A Active JP7176737B2 (ja) | 2016-02-15 | 2017-02-13 | レトロウイルス核酸配列の切除 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12122997B2 (https=) |
| EP (1) | EP3417062B1 (https=) |
| JP (1) | JP7176737B2 (https=) |
| CN (1) | CN109415728A (https=) |
| AU (1) | AU2017219605B2 (https=) |
| CA (1) | CA3014631A1 (https=) |
| MX (2) | MX2018009904A (https=) |
| WO (1) | WO2017142835A1 (https=) |
| ZA (2) | ZA201806060B (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| JP7118588B2 (ja) | 2013-08-29 | 2022-08-16 | テンプル ユニヴァーシティ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | Ｈｉｖ感染のｒｎａガイド処置のための方法および組成物 |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| CN108025188A (zh) | 2015-06-01 | 2018-05-11 | 天普大学-联邦高等教育系统 | 用于hiv感染的rna导向治疗的方法和组合物 |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| AU2017219605B2 (en) | 2016-02-15 | 2023-04-13 | Temple University - Of The Commonwealth System Of Higher Education | Excision of retroviral nucleic acid sequences |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN116209756A (zh) | 2020-03-04 | 2023-06-02 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| CN113528514B (zh) * | 2020-04-22 | 2023-05-05 | 中国科学院分子植物科学卓越创新中心 | 基于CRISPR-Cas12a干预阻断病毒逆转录转座的技术 |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CA3189601A1 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| EP4221740A4 (en) * | 2020-10-02 | 2024-10-30 | Temple University of the Commonwealth System of Higher Education | RNA-GUIDED ERADICATION OF HERPES SIMPLEX TYPE I AND OTHER RELATED HUMAN HERPESVIRUSES |
| WO2022232442A2 (en) * | 2021-04-28 | 2022-11-03 | Salk Institute For Biological Studies | Multiplex crispr/cas9-mediated target gene activation system |
| WO2022256294A1 (en) * | 2021-06-01 | 2022-12-08 | University Of Massachusetts | Cas9 nickase-mediated gene editing |
| WO2023010061A1 (en) * | 2021-07-27 | 2023-02-02 | University Of Miami | Nanoparticles and uses thereof for treatment of human immunodeficiency virus |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| WO2026039311A1 (en) | 2024-08-10 | 2026-02-19 | Vectorgen | Lentiviral vector for treating human immunodeficiency virus infection |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| EP0745134A1 (en) | 1994-02-22 | 1996-12-04 | Danafarber Cancer Institute | Nucleic acid delivery system, method of synthesis and uses thereof |
| WO2011043830A2 (en) | 2009-10-09 | 2011-04-14 | New York University | Methods, agents and peptides for inducing an innate immune response in hiv vaccination |
| EP3031921B1 (en) | 2012-12-12 | 2025-03-12 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| EP2931899A1 (en) | 2012-12-12 | 2015-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| JP7118588B2 (ja) * | 2013-08-29 | 2022-08-16 | テンプル ユニヴァーシティ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | Ｈｉｖ感染のｒｎａガイド処置のための方法および組成物 |
| CN104726449A (zh) | 2015-03-23 | 2015-06-24 | 国家纳米科学中心 | 一种用于预防和/或治疗HIV的CRISPR-Cas9系统及其制备方法和用途 |
| AU2017219605B2 (en) | 2016-02-15 | 2023-04-13 | Temple University - Of The Commonwealth System Of Higher Education | Excision of retroviral nucleic acid sequences |
-
2017
- 2017-02-13 AU AU2017219605A patent/AU2017219605B2/en active Active
- 2017-02-13 EP EP17753686.9A patent/EP3417062B1/en active Active
- 2017-02-13 JP JP2018543090A patent/JP7176737B2/ja active Active
- 2017-02-13 CN CN201780023772.9A patent/CN109415728A/zh active Pending
- 2017-02-13 WO PCT/US2017/017652 patent/WO2017142835A1/en not_active Ceased
- 2017-02-13 CA CA3014631A patent/CA3014631A1/en active Pending
- 2017-02-13 US US15/998,558 patent/US12122997B2/en active Active
- 2017-02-13 MX MX2018009904A patent/MX2018009904A/es unknown
-
2018
- 2018-08-15 MX MX2023005397A patent/MX2023005397A/es unknown
- 2018-09-10 ZA ZA2018/06060A patent/ZA201806060B/en unknown
-
2020
- 2020-07-10 US US16/926,427 patent/US20200392487A1/en not_active Abandoned
-
2022
- 2022-06-01 ZA ZA2022/06102A patent/ZA202206102B/en unknown
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