JP2018516539A5 - - Google Patents
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- JP2018516539A5 JP2018516539A5 JP2017553320A JP2017553320A JP2018516539A5 JP 2018516539 A5 JP2018516539 A5 JP 2018516539A5 JP 2017553320 A JP2017553320 A JP 2017553320A JP 2017553320 A JP2017553320 A JP 2017553320A JP 2018516539 A5 JP2018516539 A5 JP 2018516539A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- group
- sequence
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510185602 | 2015-04-17 | ||
| CN201510185602.3 | 2015-04-17 | ||
| CN201510300885.1A CN106188293A (zh) | 2015-04-17 | 2015-06-04 | 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途 |
| CN201510300885.1 | 2015-06-04 | ||
| PCT/CN2016/078699 WO2016165580A1 (zh) | 2015-04-17 | 2016-04-07 | 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018516539A JP2018516539A (ja) | 2018-06-28 |
| JP2018516539A5 true JP2018516539A5 (https=) | 2019-04-25 |
Family
ID=57459461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553320A Pending JP2018516539A (ja) | 2015-04-17 | 2016-04-07 | 抗ｃ−Ｍｅｔ抗体および抗ｃ−Ｍｅｔ抗体−細胞毒性薬物複合体ならびにそれらの医薬用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10543284B2 (https=) |
| EP (1) | EP3284751A4 (https=) |
| JP (1) | JP2018516539A (https=) |
| KR (1) | KR20170138451A (https=) |
| CN (3) | CN106188293A (https=) |
| AU (1) | AU2016248357A1 (https=) |
| BR (1) | BR112017021245A2 (https=) |
| CA (1) | CA2982777A1 (https=) |
| MX (1) | MX2017012965A (https=) |
| RU (1) | RU2017135257A (https=) |
| TW (1) | TWI731856B (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2017010102A (es) * | 2015-02-15 | 2017-11-23 | Jiangsu Hengrui Medicine Co | Conjugado farmaco citotoxico-ligando, metodo de preparacion del mismo, y sus aplicaciones. |
| KR20180115743A (ko) * | 2016-02-26 | 2018-10-23 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 신규 독소, 및 이의 중간체를 제조하는 방법 |
| RS61659B1 (sr) * | 2016-05-17 | 2021-04-29 | Abbvie Biotherapeutics Inc | Konjugati antitelo lek anti-cmet i metode za njihovu upotrebu |
| TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法 |
| WO2018129029A1 (en) * | 2017-01-04 | 2018-07-12 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
| CN110177569A (zh) * | 2017-03-30 | 2019-08-27 | 江苏恒瑞医药股份有限公司 | 抗体药物偶联物的制备方法 |
| US20200129633A1 (en) * | 2017-06-06 | 2020-04-30 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition comprising c-met antibody-drug conjugate and use thereof |
| JP7264831B2 (ja) * | 2017-06-15 | 2023-04-25 | ディベロップメント センター フォー バイオテクノロジー | 抗ｇｌｏｂｏ ｈ抗体を含有する抗体－薬物コンジュゲートおよびその使用 |
| CN109106951A (zh) * | 2017-08-18 | 2019-01-01 | 四川百利药业有限责任公司 | 一种喜树碱-抗体偶联物 |
| CN110090306B (zh) * | 2018-01-31 | 2023-04-07 | 江苏恒瑞医药股份有限公司 | 双醛连接臂的配体-药物偶联物、其制备方法及其应用 |
| KR102221755B1 (ko) * | 2018-05-02 | 2021-03-02 | (주)에임드바이오 | c-Met에 특이적으로 결합하는 항체 및 그의 용도 |
| CN111867630B (zh) | 2018-06-17 | 2023-10-13 | 上海健信生物医药科技有限公司 | 靶向cldn18.2的抗体、双特异性抗体、adc和car及其应用 |
| CN112543771B (zh) * | 2018-09-30 | 2023-04-11 | 江苏豪森药业集团有限公司 | 抗b7h3抗体-依喜替康类似物偶联物及其医药用途 |
| KR102396194B1 (ko) * | 2018-12-07 | 2022-05-10 | 서울대학교 산학협력단 | 항 c-Met 아고니스트 항체 및 이의 용도 |
| MX2021014960A (es) * | 2019-06-06 | 2022-03-04 | Shanghai Hansoh Biomedical Co Ltd | Conjugado de farmaco-anticuerpos anti-b7-h4 y uso medicinal del mismo. |
| US11896682B2 (en) | 2019-09-16 | 2024-02-13 | Regeneron Pharmaceuticals, Inc. | Radiolabeled MET binding proteins for immuno-PET imaging and methods of use thereof |
| CN111328333B (zh) * | 2019-09-29 | 2023-10-03 | 烟台迈百瑞国际生物医药股份有限公司 | 一种酸法制备抗体药物偶联物中间体的方法及其应用 |
| BR112022019042A2 (pt) * | 2020-03-25 | 2022-11-01 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Método de preparação para conjugado anticorpo-fármaco |
| CN115279781B (zh) * | 2020-03-26 | 2025-05-09 | 上海翰森生物医药科技有限公司 | 抗体药物偶联物及其医药用途 |
| EP4146283A1 (en) * | 2020-05-03 | 2023-03-15 | Levena (Suzhou) Biopharma Co., Ltd. | Antibody-drug conjugates (adcs) comprising an anti-trop-2 antibody, compositions comprising such adcs, as well as methods of making and using the same |
| CN112521507B (zh) * | 2020-08-10 | 2021-06-08 | 北京鼎成肽源生物技术有限公司 | 抗人c-Met人鼠嵌合单克隆抗体及其应用 |
| US20220056111A1 (en) * | 2020-08-11 | 2022-02-24 | Yurogen Biosystems Llc | MONOCLONAL ANTIBODY AGAINST SPIKE S1 PROTEIN OF SARS-CoV-2 AND USE THEREOFOF |
| EP4129335A4 (en) * | 2020-09-01 | 2024-04-24 | RemeGen Co., Ltd. | ANTI C-MET DRUG-ANTIBODY CONJUGATE AND ITS APPLICATIONS |
| CN116472064A (zh) * | 2020-10-12 | 2023-07-21 | 昆山新蕴达生物科技有限公司 | 抗体-药物偶联物及其应用 |
| CN112683857B (zh) * | 2021-01-06 | 2022-10-14 | 上海药明生物医药有限公司 | 一种通过评估分析物的溶剂效应对亲和力实验的影响来指导spr检测前处理的方法 |
| CN112924665B (zh) * | 2021-02-19 | 2023-10-03 | 山东莱博生物科技有限公司 | 一种抗体辣根过氧化物酶标记物及其制备与应用 |
| EP4297798A4 (en) * | 2021-02-25 | 2025-11-12 | Allygen Group | Targeting Conjugates Comprising Effector Molecules and Their Uses |
| WO2022205316A1 (en) * | 2021-04-01 | 2022-10-06 | Shanghai Allygen Biologics Co., Ltd. | Targeting conjugates comprising effector molecules and uses thereof |
| TW202547842A (zh) * | 2021-04-29 | 2025-12-16 | 愛爾蘭商艾伯維製造管理無限公司 | 抗c-Met抗體藥物結合物 |
| TW202317635A (zh) * | 2021-07-14 | 2023-05-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 特異性結合ｈｇｆｒ和ｅｇｆｒ的抗原結合分子及其醫藥用途 |
| CN115975030B (zh) * | 2021-09-30 | 2023-09-26 | 杭州邦顺制药有限公司 | 抗cd39抗体-药物偶联物及其用途 |
| CN118159567A (zh) * | 2021-11-05 | 2024-06-07 | 正大天晴药业集团股份有限公司 | 抗c-Met抗体及其应用 |
| CN115963233B (zh) * | 2022-03-17 | 2025-06-03 | 南京药明康德新药开发有限公司 | 一种评估抗体偶联药物稳定性的方法 |
| CN120035608A (zh) * | 2022-11-24 | 2025-05-23 | 江苏恒瑞医药股份有限公司 | 一种包含特异性结合hgfr和egfr的双特异性抗体的药物组合物 |
| TW202434637A (zh) * | 2022-12-20 | 2024-09-01 | 美商翰森生物有限責任公司 | 抗體、抗原結合片段及其醫藥用途 |
| WO2024131835A1 (en) * | 2022-12-20 | 2024-06-27 | Hansoh Bio Llc | Ligand-cytotoxicity drug conjugates and pharmaceutical uses thereof |
| CR20250306A (es) * | 2022-12-23 | 2025-10-03 | Medilink Therapeutics Suzhou Co Ltd | ANTICUERPO ANTI-CM bxET, CONJUGADO ANTICUERPO-FÁRMACO Y MÉTODO DE PREPARACIÓN DE ESTOS Y USO DE ESTOS |
| AU2023448948A1 (en) * | 2023-05-24 | 2025-10-09 | Hangzhou Dac Biotech Co., Ltd | Targeted treatment of prostate cancers and other tumors by an antibody-drug conjugate |
| AU2024299729A1 (en) * | 2023-07-25 | 2026-02-19 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Antibody-drug conjugate targeting c-met and medical use thereof |
| AU2024346227A1 (en) * | 2023-09-21 | 2026-04-09 | Beijing Neox Biotech Limited | Multi-specific antibodies and uses thereof |
| WO2025108427A1 (zh) * | 2023-11-23 | 2025-05-30 | 橙帆生物医药公司 | 结合分子及抗体药物偶联物和用途 |
| WO2025146620A1 (ko) * | 2024-01-02 | 2025-07-10 | 주식회사 종근당 | 항 c-met 항체를 포함하는 항암 조합물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1545613T1 (sl) * | 2002-07-31 | 2011-11-30 | Seattle Genetics Inc | Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni |
| US7498298B2 (en) | 2003-11-06 | 2009-03-03 | Seattle Genetics, Inc. | Monomethylvaline compounds capable of conjugation to ligands |
| EP1773885B1 (en) * | 2004-08-05 | 2010-04-21 | Genentech, Inc. | Humanized anti-cmet antagonists |
| US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| TW201116297A (en) * | 2009-10-02 | 2011-05-16 | Sanofi Aventis | Antibodies that specifically bind to the EphA2 receptor |
| KR20130037153A (ko) * | 2011-10-05 | 2013-04-15 | 삼성전자주식회사 | 항 ｃ-Ｍｅｔ 항체 및 그의 용도 |
| AR090549A1 (es) * | 2012-03-30 | 2014-11-19 | Genentech Inc | Anticuerpos anti-lgr5 e inmunoconjugados |
| EP2992019B1 (en) * | 2013-04-30 | 2019-03-06 | Agency For Science, Technology And Research | Mab 2 anti-met antibody |
-
2015
- 2015-06-04 CN CN201510300885.1A patent/CN106188293A/zh active Pending
-
2016
- 2016-04-07 KR KR1020177031260A patent/KR20170138451A/ko not_active Withdrawn
- 2016-04-07 MX MX2017012965A patent/MX2017012965A/es unknown
- 2016-04-07 JP JP2017553320A patent/JP2018516539A/ja active Pending
- 2016-04-07 EP EP16779555.8A patent/EP3284751A4/en not_active Withdrawn
- 2016-04-07 CN CN201680001857.2A patent/CN106687480B/zh active Active
- 2016-04-07 RU RU2017135257A patent/RU2017135257A/ru not_active Application Discontinuation
- 2016-04-07 BR BR112017021245-5A patent/BR112017021245A2/pt not_active Application Discontinuation
- 2016-04-07 US US15/565,928 patent/US10543284B2/en active Active
- 2016-04-07 AU AU2016248357A patent/AU2016248357A1/en not_active Abandoned
- 2016-04-07 CN CN201910217709.XA patent/CN111196853A/zh active Pending
- 2016-04-07 CA CA2982777A patent/CA2982777A1/en not_active Abandoned
- 2016-04-15 TW TW105111792A patent/TWI731856B/zh not_active IP Right Cessation
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