KR20170138451A - 항-ｃ-ｍｅｔ 항체 및 항-ｃ-ｍｅｔ 항체-세포독성 약물 컨쥬게이트 및 이의 약학적 용도 - Google Patents

항-ｃ-ｍｅｔ 항체 및 항-ｃ-ｍｅｔ 항체-세포독성 약물 컨쥬게이트 및 이의 약학적 용도 Download PDF

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KR20170138451A
KR20170138451A KR1020177031260A KR20177031260A KR20170138451A KR 20170138451 A KR20170138451 A KR 20170138451A KR 1020177031260 A KR1020177031260 A KR 1020177031260A KR 20177031260 A KR20177031260 A KR 20177031260A KR 20170138451 A KR20170138451 A KR 20170138451A
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South Korea
Prior art keywords
antibody
ser
seq
met
val
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Korean (ko)
Inventor
지아지안 리우
리안샨 장
웨이캉 타오
야유안 푸
링 장
동 마
동빙 쿠이
얄리 왕
지안얀 쑤
진동 리앙
잉 장
구이양 지앙
전주안 치우
지용 쑨
지핑 자
징핑 웨이
Original Assignee
쑤저우 선카디아 바이오파마수티컬즈 컴퍼니 리미티드
샹하이 헨그루이 파마수티컬 컴퍼니 리미티드
지앙수 헨그루이 메디슨 컴퍼니 리미티드
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Application filed by 쑤저우 선카디아 바이오파마수티컬즈 컴퍼니 리미티드, 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드, 지앙수 헨그루이 메디슨 컴퍼니 리미티드 filed Critical 쑤저우 선카디아 바이오파마수티컬즈 컴퍼니 리미티드
Priority claimed from PCT/CN2016/078699 external-priority patent/WO2016165580A1/zh
Publication of KR20170138451A publication Critical patent/KR20170138451A/ko
Withdrawn legal-status Critical Current

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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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